2H42A

Crystal structure of pde5 in complex with sildenafil
Total Genus 131
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
131
sequence length
326
structure length
326
Chain Sequence
EETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQ
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords cGMP-specific 3',5'-cyclic phosphodiesterase
total genus 131
structure length 326
sequence length 326
chains with identical sequence B, C
ec nomenclature ec 3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase.
pdb deposition date 2006-05-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00233 PDEase_I 3'5'-cyclic nucleotide phosphodiesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1300.10 Mainly Alpha Orthogonal Bundle Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain 2h42A00
5EDGB 3SHYA 3QPOA 5AXQA 4D09A 1Y2HA 4I9ZA 3I8VA 3SN7A 4MSHA 1PTWA 3IBJA 3JSWA 3N3ZA 4MYQA 2OUNA 3V9BA 4BBXA 4TPMA 1XLXA 4QGEA 1RKPA 1XMUA 1XP0A 2CHMA 3G4GA 3QPPA 2OVYA 4MSNA 3G58A 1T9RA 2OUSA 1TB7A 1XLZA 3O57A 4LM0A 4DDLA 4G2JA 2H44A 1XM6A 4I15A 2QYKA 3ECNA 4LM4A 1RO9A 3WYMA 4MD6A 1UDUA 4XY2A 1UDTA 5EDGA 4LM1A 1XN0A 1Q9MA 3SIEA 5C28A 3WD9A 3V94A 3TGGA 3W5EA 4DFFA 4W1OA 1XOZA 3UUOA 3DYLA 3HDZA 3WI2A 3WS9A 3G3NA 4LLPA 3SL3A 4GH6A 1XMYA 3TGEA 3JWQA 3HQWA 1XOTA 4NPVA 1Y2DA 2WEYA 4OGBA 3B2RA 3K3EA 3DYSA 4LM3A 4LLJA 4OEWA 1XONA 1RORA 1MKDA 2HD1A 4HEUA 2H42A 4PHLA 3K3HA 3FRGA 3HR1A 3BJCA 4LLXA 3WS8A 4MVHA 4AELA 3O0JA 4LKQA 4KP6A 1SO2A 3G4IA 5EDEA 3IAKA 4TPPA 3DYNA 3IADA 3SHZA 2OVVA 3SNLA 4AJMA 3V93A 1XOSA 2FM0A 4G2YA 3LXGA 3DY8A 3QI3A 4WZIA 4MUWA 5EDIB 3JSIA 1OYNA 4FCDA 5K1IA 4NW7A 5K32A 5I2RA 5C2AA 4NPWA 2Y0JA 4E90A 5B4LA 3ITMA 3SNIA 2OUQA 5AXPA 4MSAA 2OUUA 5B25A 4WN1A 2QYNA 4MRZA 3WYKA 5C2EA 3LY2A 2OUPA 3G4LA 2OURA 2O8HA 5C1WA 4HTZA 1ZKLA 4X0FA 5DH5A 1F0JA 1XM4B 4P0NA 3GWTA 4YS7A 2QYMA 3ECMA 3QI4A 1Y2KA 2YY2A 3G4KA 1XOMA 1XOQA 3G45A 4FCBA 4G2LA 4HF4A 4Y87A 3SL6A 4AJGA 4WCUA 4AJDA 2PW3A 1SOJA 5EDIA 3QPNA 5DH4A 2OUVA 1Y2JA 3WYLA 1TBFA 3HC8A 4AJFA 3HMVA 4LM2A 3ITUA 4G2WA 4LLKA 4PM0A 4MRWA 1XMYB 1RO6A 1TAZA 2QYLA 3D3PA 5K9RA 4JIBA 1Y2EA 4P1RA 4PHWA 4Y2BA 1TBBA 2FM5A 3HQZA 4MSEA 4MS0A 2R8QA 5B4KA 3SL4A 3SL8A 4IA0A 3DYQA 1Z1LA 5C29A 4MSCA 3UI7A 2H40A 3HQYA 4Y86A 1XMUB 4D08A 1XM4A 5C2HA 1T9SA 4ZO5A 3SL5A 3K4SA 4YQHA 1Y2CA 1Y2BA 5EDEB 1ZKNA 1TB5A 3O56A 3TVXA 4OEXA 2OUYA 3KKTA 1UHOA 4Y8CA 4HTXA 5EDHA 3JWRA 4C1IA 1XORA
chains in the Genus database with same CATH superfamily
5EDGB 3SHYA 3QPOA 5AXQA 4D09A 1Y2HA 4I9ZA 3I8VA 3SN7A 4MSHA 1PTWA 3IBJA 3JSWA 3N3ZA 4MYQA 2OUNA 3V9BA 4BBXA 4TPMA 1XLXA 4QGEA 1RKPA 1XMUA 1XP0A 2CHMA 3G4GA 3QPPA 2OVYA 4MSNA 3G58A 1T9RA 2OUSA 1TB7A 1XLZA 3O57A 4LM0A 4DDLA 4G2JA 2H44A 1XM6A 4I15A 2QYKA 3ECNA 4LM4A 1RO9A 3WYMA 4MD6A 1UDUA 4XY2A 1UDTA 5EDGA 4LM1A 1XN0A 1Q9MA 3SIEA 5C28A 3WD9A 3V94A 3TGGA 3W5EA 4DFFA 4W1OA 1XOZA 3UUOA 3DYLA 3HDZA 3WI2A 3WS9A 3G3NA 4LLPA 3SL3A 4GH6A 1XMYA 3TGEA 3JWQA 3HQWA 1XOTA 4NPVA 1Y2DA 2WEYA 4OGBA 3B2RA 3K3EA 3DYSA 4LM3A 4LLJA 4OEWA 1XONA 1RORA 1MKDA 2HD1A 4HEUA 2H42A 4PHLA 3K3HA 3FRGA 3HR1A 3BJCA 4LLXA 3WS8A 4MVHA 4AELA 3O0JA 4LKQA 4KP6A 1SO2A 3G4IA 5EDEA 3IAKA 4TPPA 3DYNA 3IADA 3SHZA 2OVVA 3SNLA 4AJMA 3V93A 1XOSA 2FM0A 4G2YA 3LXGA 3DY8A 3QI3A 4WZIA 4MUWA 5EDIB 3JSIA 1OYNA 4FCDA 5K1IA 4NW7A 5K32A 5I2RA 5C2AA 4NPWA 2Y0JA 4E90A 5B4LA 3ITMA 3SNIA 2OUQA 5AXPA 4MSAA 2OUUA 5B25A 4WN1A 2QYNA 4MRZA 3WYKA 5C2EA 3LY2A 2OUPA 3G4LA 2OURA 2O8HA 5C1WA 4HTZA 1ZKLA 4X0FA 5DH5A 1F0JA 1XM4B 4P0NA 3GWTA 4YS7A 2QYMA 3ECMA 3QI4A 1Y2KA 2YY2A 3G4KA 1XOMA 1XOQA 3G45A 4FCBA 4G2LA 4HF4A 4Y87A 3SL6A 4AJGA 4WCUA 4AJDA 2PW3A 1SOJA 5EDIA 3QPNA 5DH4A 2OUVA 1Y2JA 3WYLA 1TBFA 3HC8A 4AJFA 3HMVA 4LM2A 3ITUA 4G2WA 4LLKA 4PM0A 4MRWA 1XMYB 1RO6A 1TAZA 2QYLA 3D3PA 5K9RA 4JIBA 1Y2EA 4P1RA 4PHWA 4Y2BA 1TBBA 2FM5A 3HQZA 4MSEA 4MS0A 2R8QA 5B4KA 3SL4A 3SL8A 4IA0A 3DYQA 1Z1LA 5C29A 4MSCA 3UI7A 2H40A 3HQYA 4Y86A 1XMUB 4D08A 1XM4A 5C2HA 1T9SA 4ZO5A 3SL5A 3K4SA 4YQHA 1Y2CA 1Y2BA 5EDEB 1ZKNA 1TB5A 3O56A 3TVXA 4OEXA 2OUYA 3KKTA 1UHOA 4Y8CA 4HTXA 5EDHA 3JWRA 4C1IA 1XORA
chains in the Genus database with same CATH topology
5EDGB 3SHYA 3QPOA 5AXQA 4D09A 1Y2HA 4I9ZA 3I8VA 3SN7A 4MSHA 1PTWA 3IBJA 3JSWA 3N3ZA 4MYQA 2OUNA 3V9BA 4BBXA 4TPMA 1XLXA 4QGEA 1RKPA 1XMUA 1XP0A 2CHMA 3G4GA 3QPPA 2OVYA 4MSNA 3G58A 1T9RA 2OUSA 1TB7A 1XLZA 3O57A 4LM0A 4DDLA 4G2JA 2H44A 1XM6A 4I15A 2QYKA 3ECNA 4LM4A 1RO9A 3WYMA 4MD6A 1UDUA 4XY2A 1UDTA 5EDGA 4LM1A 1XN0A 1Q9MA 3SIEA 5C28A 3WD9A 3V94A 3TGGA 3W5EA 4DFFA 4W1OA 1XOZA 3UUOA 3DYLA 3HDZA 3WI2A 3WS9A 3G3NA 4LLPA 3SL3A 4GH6A 1XMYA 3TGEA 3JWQA 3HQWA 1XOTA 4NPVA 1Y2DA 2WEYA 4OGBA 3B2RA 3K3EA 3DYSA 4LM3A 4LLJA 4OEWA 1XONA 1RORA 1MKDA 2HD1A 4HEUA 2H42A 4PHLA 3K3HA 3FRGA 3HR1A 3BJCA 4LLXA 3WS8A 4MVHA 4AELA 3O0JA 4LKQA 4KP6A 1SO2A 3G4IA 5EDEA 3IAKA 4TPPA 3DYNA 3IADA 3SHZA 2OVVA 3SNLA 4AJMA 3V93A 1XOSA 2FM0A 4G2YA 3LXGA 3DY8A 3QI3A 4WZIA 4MUWA 5EDIB 3JSIA 1OYNA 4FCDA 5K1IA 4NW7A 5K32A 5I2RA 5C2AA 4NPWA 2Y0JA 4E90A 5B4LA 3ITMA 3SNIA 2OUQA 5AXPA 4MSAA 2OUUA 5B25A 4WN1A 2QYNA 4MRZA 3WYKA 5C2EA 3LY2A 2OUPA 3G4LA 2OURA 2O8HA 5C1WA 4HTZA 1ZKLA 4X0FA 5DH5A 1F0JA 1XM4B 4P0NA 3GWTA 4YS7A 2QYMA 3ECMA 3QI4A 1Y2KA 2YY2A 3G4KA 1XOMA 1XOQA 3G45A 4FCBA 4G2LA 4HF4A 4Y87A 3SL6A 4AJGA 4WCUA 4AJDA 2PW3A 1SOJA 5EDIA 3QPNA 5DH4A 2OUVA 1Y2JA 3WYLA 1TBFA 3HC8A 4AJFA 3HMVA 4LM2A 3ITUA 4G2WA 4LLKA 4PM0A 4MRWA 1XMYB 1RO6A 1TAZA 2QYLA 3D3PA 5K9RA 4JIBA 1Y2EA 4P1RA 4PHWA 4Y2BA 1TBBA 2FM5A 3HQZA 4MSEA 4MS0A 2R8QA 5B4KA 3SL4A 3SL8A 4IA0A 3DYQA 1Z1LA 5C29A 4MSCA 3UI7A 2H40A 3HQYA 4Y86A 1XMUB 4D08A 1XM4A 5C2HA 1T9SA 4ZO5A 3SL5A 3K4SA 4YQHA 1Y2CA 1Y2BA 5EDEB 1ZKNA 1TB5A 3O56A 3TVXA 4OEXA 2OUYA 3KKTA 1UHOA 4Y8CA 4HTXA 5EDHA 3JWRA 4C1IA 1XORA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5EDG B;  3SHY A;  3QPO A;  5AXQ A;  4D09 A;  1Y2H A;  4I9Z A;  3I8V A;  3SN7 A;  4MSH A;  1PTW A;  3IBJ A;  3JSW A;  3N3Z A;  4MYQ A;  2OUN A;  3V9B A;  4BBX A;  4TPM A;  1XLX A;  4QGE A;  1RKP A;  1XMU A;  1XP0 A;  2CHM A;  3G4G A;  3QPP A;  2OVY A;  4MSN A;  3G58 A;  1T9R A;  2OUS A;  1TB7 A;  1XLZ A;  3O57 A;  4LM0 A;  4DDL A;  4G2J A;  2H44 A;  1XM6 A;  4I15 A;  2QYK A;  3ECN A;  4LM4 A;  1RO9 A;  3WYM A;  4MD6 A;  1UDU A;  4XY2 A;  1UDT A;  5EDG A;  4LM1 A;  1XN0 A;  1Q9M A;  3SIE A;  5C28 A;  3WD9 A;  3V94 A;  3TGG A;  3W5E A;  4DFF A;  4W1O A;  1XOZ A;  3UUO A;  3DYL A;  3HDZ A;  3WI2 A;  3WS9 A;  3G3N A;  4LLP A;  3SL3 A;  4GH6 A;  1XMY A;  3TGE A;  3JWQ A;  3HQW A;  1XOT A;  4NPV A;  1Y2D A;  2WEY A;  4OGB A;  3B2R A;  3K3E A;  3DYS A;  4LM3 A;  4LLJ A;  4OEW A;  1XON A;  1ROR A;  1MKD A;  2HD1 A;  4HEU A;  2H42 A;  4PHL A;  3K3H A;  3FRG A;  3HR1 A;  3BJC A;  4LLX A;  3WS8 A;  4MVH A;  4AEL A;  3O0J A;  4LKQ A;  4KP6 A;  1SO2 A;  3G4I A;  5EDE A;  3IAK A;  4TPP A;  3DYN A;  3IAD A;  3SHZ A;  2OVV A;  3SNL A;  4AJM A;  3V93 A;  1XOS A;  2FM0 A;  4G2Y A;  3LXG A;  3DY8 A;  3QI3 A;  4WZI A;  4MUW A;  5EDI B;  3JSI A;  1OYN A;  4FCD A;  5K1I A;  4NW7 A;  5K32 A;  5I2R A;  5C2A A;  4NPW A;  2Y0J A;  4E90 A;  5B4L A;  3ITM A;  3SNI A;  2OUQ A;  5AXP A;  4MSA A;  2OUU A;  5B25 A;  4WN1 A;  2QYN A;  4MRZ A;  3WYK A;  5C2E A;  3LY2 A;  2OUP A;  3G4L A;  2OUR A;  2O8H A;  5C1W A;  4HTZ A;  1ZKL A;  4X0F A;  5DH5 A;  1F0J A;  1XM4 B;  4P0N A;  3GWT A;  4YS7 A;  2QYM A;  3ECM A;  3QI4 A;  1Y2K A;  2YY2 A;  3G4K A;  1XOM A;  1XOQ A;  3G45 A;  4FCB A;  4G2L A;  4HF4 A;  4Y87 A;  3SL6 A;  4AJG A;  4WCU A;  4AJD A;  2PW3 A;  1SOJ A;  5EDI A;  3QPN A;  5DH4 A;  2OUV A;  1Y2J A;  3WYL A;  1TBF A;  3HC8 A;  4AJF A;  3HMV A;  4LM2 A;  3ITU A;  4G2W A;  4LLK A;  4PM0 A;  4MRW A;  1XMY B;  1RO6 A;  1TAZ A;  2QYL A;  3D3P A;  5K9R A;  4JIB A;  1Y2E A;  4P1R A;  4PHW A;  4Y2B A;  1TBB A;  2FM5 A;  3HQZ A;  4MSE A;  4MS0 A;  2R8Q A;  5B4K A;  3SL4 A;  3SL8 A;  4IA0 A;  3DYQ A;  1Z1L A;  5C29 A;  4MSC A;  3UI7 A;  2H40 A;  3HQY A;  4Y86 A;  1XMU B;  4D08 A;  1XM4 A;  5C2H A;  1T9S A;  4ZO5 A;  3SL5 A;  3K4S A;  4YQH A;  1Y2C A;  1Y2B A;  5EDE B;  1ZKN A;  1TB5 A;  3O56 A;  3TVX A;  4OEX A;  2OUY A;  3KKT A;  1UHO A;  4Y8C A;  4HTX A;  5EDH A;  3JWR A;  4C1I A;  1XOR A; 
#chains in the Genus database with same CATH topology
 5EDG B;  3SHY A;  3QPO A;  5AXQ A;  4D09 A;  1Y2H A;  4I9Z A;  3I8V A;  3SN7 A;  4MSH A;  1PTW A;  3IBJ A;  3JSW A;  3N3Z A;  4MYQ A;  2OUN A;  3V9B A;  4BBX A;  4TPM A;  1XLX A;  4QGE A;  1RKP A;  1XMU A;  1XP0 A;  2CHM A;  3G4G A;  3QPP A;  2OVY A;  4MSN A;  3G58 A;  1T9R A;  2OUS A;  1TB7 A;  1XLZ A;  3O57 A;  4LM0 A;  4DDL A;  4G2J A;  2H44 A;  1XM6 A;  4I15 A;  2QYK A;  3ECN A;  4LM4 A;  1RO9 A;  3WYM A;  4MD6 A;  1UDU A;  4XY2 A;  1UDT A;  5EDG A;  4LM1 A;  1XN0 A;  1Q9M A;  3SIE A;  5C28 A;  3WD9 A;  3V94 A;  3TGG A;  3W5E A;  4DFF A;  4W1O A;  1XOZ A;  3UUO A;  3DYL A;  3HDZ A;  3WI2 A;  3WS9 A;  3G3N A;  4LLP A;  3SL3 A;  4GH6 A;  1XMY A;  3TGE A;  3JWQ A;  3HQW A;  1XOT A;  4NPV A;  1Y2D A;  2WEY A;  4OGB A;  3B2R A;  3K3E A;  3DYS A;  4LM3 A;  4LLJ A;  4OEW A;  1XON A;  1ROR A;  1MKD A;  2HD1 A;  4HEU A;  2H42 A;  4PHL A;  3K3H A;  3FRG A;  3HR1 A;  3BJC A;  4LLX A;  3WS8 A;  4MVH A;  4AEL A;  3O0J A;  4LKQ A;  4KP6 A;  1SO2 A;  3G4I A;  5EDE A;  3IAK A;  4TPP A;  3DYN A;  3IAD A;  3SHZ A;  2OVV A;  3SNL A;  4AJM A;  3V93 A;  1XOS A;  2FM0 A;  4G2Y A;  3LXG A;  3DY8 A;  3QI3 A;  4WZI A;  4MUW A;  5EDI B;  3JSI A;  1OYN A;  4FCD A;  5K1I A;  4NW7 A;  5K32 A;  5I2R A;  5C2A A;  4NPW A;  2Y0J A;  4E90 A;  5B4L A;  3ITM A;  3SNI A;  2OUQ A;  5AXP A;  4MSA A;  2OUU A;  5B25 A;  4WN1 A;  2QYN A;  4MRZ A;  3WYK A;  5C2E A;  3LY2 A;  2OUP A;  3G4L A;  2OUR A;  2O8H A;  5C1W A;  4HTZ A;  1ZKL A;  4X0F A;  5DH5 A;  1F0J A;  1XM4 B;  4P0N A;  3GWT A;  4YS7 A;  2QYM A;  3ECM A;  3QI4 A;  1Y2K A;  2YY2 A;  3G4K A;  1XOM A;  1XOQ A;  3G45 A;  4FCB A;  4G2L A;  4HF4 A;  4Y87 A;  3SL6 A;  4AJG A;  4WCU A;  4AJD A;  2PW3 A;  1SOJ A;  5EDI A;  3QPN A;  5DH4 A;  2OUV A;  1Y2J A;  3WYL A;  1TBF A;  3HC8 A;  4AJF A;  3HMV A;  4LM2 A;  3ITU A;  4G2W A;  4LLK A;  4PM0 A;  4MRW A;  1XMY B;  1RO6 A;  1TAZ A;  2QYL A;  3D3P A;  5K9R A;  4JIB A;  1Y2E A;  4P1R A;  4PHW A;  4Y2B A;  1TBB A;  2FM5 A;  3HQZ A;  4MSE A;  4MS0 A;  2R8Q A;  5B4K A;  3SL4 A;  3SL8 A;  4IA0 A;  3DYQ A;  1Z1L A;  5C29 A;  4MSC A;  3UI7 A;  2H40 A;  3HQY A;  4Y86 A;  1XMU B;  4D08 A;  1XM4 A;  5C2H A;  1T9S A;  4ZO5 A;  3SL5 A;  3K4S A;  4YQH A;  1Y2C A;  1Y2B A;  5EDE B;  1ZKN A;  1TB5 A;  3O56 A;  3TVX A;  4OEX A;  2OUY A;  3KKT A;  1UHO A;  4Y8C A;  4HTX A;  5EDH A;  3JWR A;  4C1I A;  1XOR A; 
#chains in the Genus database with same CATH homology
 5EDG B;  3SHY A;  3QPO A;  5AXQ A;  4D09 A;  1Y2H A;  4I9Z A;  3I8V A;  3SN7 A;  4MSH A;  1PTW A;  3IBJ A;  3JSW A;  3N3Z A;  4MYQ A;  2OUN A;  3V9B A;  4BBX A;  4TPM A;  1XLX A;  4QGE A;  1RKP A;  1XMU A;  1XP0 A;  2CHM A;  3G4G A;  3QPP A;  2OVY A;  4MSN A;  3G58 A;  1T9R A;  2OUS A;  1TB7 A;  1XLZ A;  3O57 A;  4LM0 A;  4DDL A;  4G2J A;  2H44 A;  1XM6 A;  4I15 A;  2QYK A;  3ECN A;  4LM4 A;  1RO9 A;  3WYM A;  4MD6 A;  1UDU A;  4XY2 A;  1UDT A;  5EDG A;  4LM1 A;  1XN0 A;  1Q9M A;  3SIE A;  5C28 A;  3WD9 A;  3V94 A;  3TGG A;  3W5E A;  4DFF A;  4W1O A;  1XOZ A;  3UUO A;  3DYL A;  3HDZ A;  3WI2 A;  3WS9 A;  3G3N A;  4LLP A;  3SL3 A;  4GH6 A;  1XMY A;  3TGE A;  3JWQ A;  3HQW A;  1XOT A;  4NPV A;  1Y2D A;  2WEY A;  4OGB A;  3B2R A;  3K3E A;  3DYS A;  4LM3 A;  4LLJ A;  4OEW A;  1XON A;  1ROR A;  1MKD A;  2HD1 A;  4HEU A;  2H42 A;  4PHL A;  3K3H A;  3FRG A;  3HR1 A;  3BJC A;  4LLX A;  3WS8 A;  4MVH A;  4AEL A;  3O0J A;  4LKQ A;  4KP6 A;  1SO2 A;  3G4I A;  5EDE A;  3IAK A;  4TPP A;  3DYN A;  3IAD A;  3SHZ A;  2OVV A;  3SNL A;  4AJM A;  3V93 A;  1XOS A;  2FM0 A;  4G2Y A;  3LXG A;  3DY8 A;  3QI3 A;  4WZI A;  4MUW A;  5EDI B;  3JSI A;  1OYN A;  4FCD A;  5K1I A;  4NW7 A;  5K32 A;  5I2R A;  5C2A A;  4NPW A;  2Y0J A;  4E90 A;  5B4L A;  3ITM A;  3SNI A;  2OUQ A;  5AXP A;  4MSA A;  2OUU A;  5B25 A;  4WN1 A;  2QYN A;  4MRZ A;  3WYK A;  5C2E A;  3LY2 A;  2OUP A;  3G4L A;  2OUR A;  2O8H A;  5C1W A;  4HTZ A;  1ZKL A;  4X0F A;  5DH5 A;  1F0J A;  1XM4 B;  4P0N A;  3GWT A;  4YS7 A;  2QYM A;  3ECM A;  3QI4 A;  1Y2K A;  2YY2 A;  3G4K A;  1XOM A;  1XOQ A;  3G45 A;  4FCB A;  4G2L A;  4HF4 A;  4Y87 A;  3SL6 A;  4AJG A;  4WCU A;  4AJD A;  2PW3 A;  1SOJ A;  5EDI A;  3QPN A;  5DH4 A;  2OUV A;  1Y2J A;  3WYL A;  1TBF A;  3HC8 A;  4AJF A;  3HMV A;  4LM2 A;  3ITU A;  4G2W A;  4LLK A;  4PM0 A;  4MRW A;  1XMY B;  1RO6 A;  1TAZ A;  2QYL A;  3D3P A;  5K9R A;  4JIB A;  1Y2E A;  4P1R A;  4PHW A;  4Y2B A;  1TBB A;  2FM5 A;  3HQZ A;  4MSE A;  4MS0 A;  2R8Q A;  5B4K A;  3SL4 A;  3SL8 A;  4IA0 A;  3DYQ A;  1Z1L A;  5C29 A;  4MSC A;  3UI7 A;  2H40 A;  3HQY A;  4Y86 A;  1XMU B;  4D08 A;  1XM4 A;  5C2H A;  1T9S A;  4ZO5 A;  3SL5 A;  3K4S A;  4YQH A;  1Y2C A;  1Y2B A;  5EDE B;  1ZKN A;  1TB5 A;  3O56 A;  3TVX A;  4OEX A;  2OUY A;  3KKT A;  1UHO A;  4Y8C A;  4HTX A;  5EDH A;  3JWR A;  4C1I A;  1XOR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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