The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
21
|
sequence length |
125
|
structure length |
125
|
Chain Sequence |
MQLRFARLSEHATAPTRGSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKHFIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQAL
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Discovery of a novel class of potent human deoxyuridine triphosphatase inhibitors remarkably enhancing the antitumor activity of thymidylate synthase inhibitors
pubmed doi rcsb |
| molecule keywords |
Deoxyuridine 5'-triphosphate nucleotidohydrolase
|
| molecule tags |
Hydrolase/hydrolase inhibitor
|
| source organism |
Homo sapiens
|
| total genus |
21
|
| structure length |
125
|
| sequence length |
125
|
| chains with identical sequence |
B, C
|
| ec nomenclature |
ec
3.6.1.23: dUTP diphosphatase. |
| pdb deposition date | 2010-12-03 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00692 | dUTPase | dUTPase |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Beta | Distorted Sandwich | Deoxyuridine 5'-Triphosphate Nucleotidohydrolase; Chain A | Deoxyuridine 5'-Triphosphate Nucleotidohydrolase; Chain A |
#chains in the Genus database with same CATH superfamily 2XY3 A; 3H6X A; 2OKD A; 2WE3 A; 3MBQ A; 1SMC A; 2QXX A; 2OKB A; 2PC5 A; 2HQU A; 1SJN A; 2OKE A; 4AO5 A; 2QLP A; 3T60 A; 3TQ4 A; 3I93 A; 3ZF3 A; 4GK6 A; 1F7O A; 1RN8 A; 2BAZ A; 3HHQ A; 1F7Q A; 3ZF5 A; 1DUN A; 2D4N A; 3KM3 A; 3ZF4 A; 4AOO A; 2XCE A; 1SYL A; 2Y8C A; 2HXD A; 1PKH A; 3TQZ A; 1DUD A; 4WRK A; 3ARA A; 4LHR A; 2ZDC A; 3TPY A; 2OL1 A; 3F4F A; 1EU5 A; 1SIX A; 5CCO A; 1PKK A; 3ZF2 A; 3HZA A; 5ECT A; 1F7P A; 1F7N A; 2Y1T A; 2HRM A; 1F7D A; 3SO2 A; 1MQ7 A; 2D4L A; 1VYQ A; 2HR6 A; 1F7K A; 4OOP A; 1Q5H A; 1F7R A; 2J4Q A; 3TSL A; 1SM8 A; 3ECY A; 3TRL A; 3ARN A; 3C3I A; 2BT1 A; 4DHK A; 2V9X A; 1XS4 A; 2J4H A; 3P48 A; 3TPS A; 3TS6 A; 1EUW A; 4XJC A; 2OL0 A; 2HXB A; 3ZEZ A; 4OOQ A; 3ZF6 A; 3CA9 A; 1SNF A; 3LOJ A; 1OGH A; 3TTA A; 3TQ3 A; 3C2T A; 4APZ 1; 1XS1 A; 2R9Q A; 2XX6 A; 4A6A A; 3ZF0 A; 2XCD A; 3TPW A; 2PY4 A; 3T6Y A; 4AOZ A; 3GF0 A; 3TPN A; 1DUT A; 3TQ5 A; 4B0H A; 1XS6 A; 5CCT A; 1SEH A; 4GCY A; 2WE0 A; 1DUP A; 1RNJ A; 3TRN A; 1SLH A; 3T64 A; 3H6D A; 1Q5U X; 5EDD A; 3TP1 A; 2YZJ A; 4GV8 A; 3EHW A; 1DUC A; 2WE2 A; 3LQW A; 3ZF1 A; 2WE1 A; 3MDX A; 5F9K A; 3T70 A; 2BSY A; 2D4M A; 1PKJ A; #chains in the Genus database with same CATH topology 2XY3 A; 3H6X A; 2OKD A; 2WE3 A; 3MBQ A; 1SMC A; 2QXX A; 2OKB A; 2PC5 A; 2HQU A; 1SJN A; 2OKE A; 4AO5 A; 2QLP A; 3T60 A; 3TQ4 A; 3I93 A; 3ZF3 A; 4GK6 A; 1F7O A; 1RN8 A; 2BAZ A; 3HHQ A; 1F7Q A; 3ZF5 A; 1DUN A; 2D4N A; 3KM3 A; 3ZF4 A; 4AOO A; 2XCE A; 1SYL A; 2Y8C A; 2HXD A; 1PKH A; 3TQZ A; 1DUD A; 4WRK A; 3ARA A; 4LHR A; 2ZDC A; 3TPY A; 2OL1 A; 3F4F A; 1TUL A; 1EU5 A; 1SIX A; 5CCO A; 1PKK A; 3ZF2 A; 3HZA A; 5ECT A; 1F7P A; 1F7N A; 2Y1T A; 2HRM A; 1F7D A; 3SO2 A; 1MQ7 A; 2D4L A; 1VYQ A; 2HR6 A; 1F7K A; 4OOP A; 1Q5H A; 1F7R A; 2J4Q A; 3TSL A; 1SM8 A; 3ECY A; 3TRL A; 3ARN A; 3C3I A; 2BT1 A; 4DHK A; 2V9X A; 1XS4 A; 2J4H A; 3P48 A; 3TPS A; 3TS6 A; 1EUW A; 4XJC A; 2OL0 A; 2HXB A; 3ZEZ A; 4OOQ A; 3ZF6 A; 3CA9 A; 1SNF A; 3LOJ A; 1OGH A; 3TTA A; 3TQ3 A; 3C2T A; 4APZ 1; 1XS1 A; 2R9Q A; 2XX6 A; 4A6A A; 3ZF0 A; 2XCD A; 3TPW A; 2PY4 A; 3T6Y A; 4AOZ A; 3GF0 A; 3TPN A; 1DUT A; 3TQ5 A; 4B0H A; 1XS6 A; 5CCT A; 1SEH A; 4GCY A; 2WE0 A; 1DUP A; 1RNJ A; 3TRN A; 1SLH A; 3T64 A; 3H6D A; 1Q5U X; 5EDD A; 3TP1 A; 2YZJ A; 4GV8 A; 3EHW A; 1DUC A; 2WE2 A; 3LQW A; 3ZF1 A; 2WE1 A; 3MDX A; 5F9K A; 3T70 A; 2BSY A; 2D4M A; 1PKJ A; #chains in the Genus database with same CATH homology 2XY3 A; 3H6X A; 2OKD A; 2WE3 A; 3MBQ A; 1SMC A; 2QXX A; 2OKB A; 2PC5 A; 2HQU A; 1SJN A; 2OKE A; 4AO5 A; 2QLP A; 3T60 A; 3TQ4 A; 3I93 A; 3ZF3 A; 4GK6 A; 1F7O A; 1RN8 A; 2BAZ A; 3HHQ A; 1F7Q A; 3ZF5 A; 1DUN A; 2D4N A; 3KM3 A; 3ZF4 A; 4AOO A; 2XCE A; 1SYL A; 2Y8C A; 2HXD A; 1PKH A; 3TQZ A; 1DUD A; 4WRK A; 3ARA A; 4LHR A; 2ZDC A; 3TPY A; 2OL1 A; 3F4F A; 1EU5 A; 1SIX A; 5CCO A; 1PKK A; 3ZF2 A; 3HZA A; 5ECT A; 1F7P A; 1F7N A; 2Y1T A; 2HRM A; 1F7D A; 3SO2 A; 1MQ7 A; 2D4L A; 1VYQ A; 2HR6 A; 1F7K A; 4OOP A; 1Q5H A; 1F7R A; 2J4Q A; 3TSL A; 1SM8 A; 3ECY A; 3TRL A; 3ARN A; 3C3I A; 2BT1 A; 4DHK A; 2V9X A; 1XS4 A; 2J4H A; 3P48 A; 3TPS A; 3TS6 A; 1EUW A; 4XJC A; 2OL0 A; 2HXB A; 3ZEZ A; 4OOQ A; 3ZF6 A; 3CA9 A; 1SNF A; 3LOJ A; 1OGH A; 3TTA A; 3TQ3 A; 3C2T A; 4APZ 1; 1XS1 A; 2R9Q A; 2XX6 A; 4A6A A; 3ZF0 A; 2XCD A; 3TPW A; 2PY4 A; 3T6Y A; 4AOZ A; 3GF0 A; 3TPN A; 1DUT A; 3TQ5 A; 4B0H A; 1XS6 A; 5CCT A; 1SEH A; 4GCY A; 2WE0 A; 1DUP A; 1RNJ A; 3TRN A; 1SLH A; 3T64 A; 3H6D A; 1Q5U X; 5EDD A; 3TP1 A; 2YZJ A; 4GV8 A; 3EHW A; 1DUC A; 2WE2 A; 3LQW A; 3ZF1 A; 2WE1 A; 3MDX A; 5F9K A; 3T70 A; 2BSY A; 2D4M A; 1PKJ A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
