3FRGA

Catalytic domain of human phosphodiesterase 4b2b in complex with a quinoline inhibitor
Total Genus 137
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
137
sequence length
335
structure length
335
Chain Sequence
ISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQAMIPQA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
publication title Quinolines as a novel structural class of potent and selective PDE4 inhibitors: optimisation for oral administration.
pubmed doi rcsb
molecule keywords cAMP-specific 3',5'-cyclic phosphodiesterase 4B
total genus 137
structure length 335
sequence length 335
ec nomenclature ec 3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase.
pdb deposition date 2009-01-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00233 PDEase_I 3'5'-cyclic nucleotide phosphodiesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1300.10 Mainly Alpha Orthogonal Bundle Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain 3frgA00
2QYNA 3DY8A 2FM5A 3HMVA 4W1OA 4FCDA 4PHWA 1Q9MA 4Y86A 3V9BA 1Y2CA 2PW3A 3HDZA 3JSWA 1XM4A 2O8HA 4IA0A 4BBXA 1XM6A 4NW7A 1XLXA 4OEWA 1Y2DA 5DH5A 4AJFA 4GH6A 1T9SA 4D08A 1UDTA 1XM4B 1Z1LA 3K3EA 3UUOA 2YY2A 2HD1A 2OUSA 3GWTA 4G2WA 4LM0A 5C28A 2QYMA 2OURA 1XOZA 4LLKA 1XORA 3I8VA 3G4LA 3G4GA 1PTWA 3B2RA 1TAZA 4OEXA 5C2AA 1XMYA 3N3ZA 5AXPA 1Y2KA 4MSEA 2OUPA 3IBJA 4E90A 3SL4A 4DDLA 1SO2A 4DFFA 3HQZA 3HR1A 2OVYA 4YQHA 4MSNA 2OUVA 1XONA 1XMYB 2OUUA 3G4KA 3QI3A 3QPNA 4G2LA 4LM3A 5DH4A 1MKDA 5K32A 2OUYA 3K3HA 4D09A 3K4SA 4XY2A 3IADA 4LLPA 4AJDA 3FRGA 5C1WA 3SHZA 2OUQA 5EDGA 5B4LA 5K1IA 4HEUA 3IAKA 4ZO5A 3ITMA 3WD9A 3WI2A 4AELA 4I9ZA 4MYQA 4MSHA 3ITUA 4KP6A 3QI4A 5K9RA 4NPVA 3O57A 1SOJA 1TB5A 5EDGB 2OUNA 3D3PA 4P1RA 5B4KA 4HTZA 5EDHA 4WCUA 1XP0A 3TGGA 1TBBA 4HTXA 3LXGA 1OYNA 1XOQA 3TGEA 2R8QA 1F0JA 4MD6A 4PM0A 3W5EA 4I15A 5EDEA 1XN0A 3WS8A 3SNIA 1UDUA 3HQWA 1RO6A 3SL5A 2OVVA 4G2YA 5I2RA 1RKPA 2H40A 3SIEA 1UHOA 4Y87A 2WEYA 3SL8A 4MUWA 1XOSA 1RORA 3BJCA 3SL3A 3UI7A 4LLXA 3HC8A 1TBFA 4QGEA 3SNLA 1XLZA 4MS0A 2FM0A 3DYQA 4LLJA 2CHMA 1XMUA 2H44A 3O56A 4Y8CA 5B25A 2Y0JA 1Y2HA 4WZIA 3JSIA 4MRZA 4HF4A 2QYLA 4MSCA 4JIBA 1Y2BA 1T9RA 3DYLA 4MRWA 3V93A 1XMUB 4LKQA 4YS7A 3WYLA 3SHYA 3G45A 4NPWA 1TB7A 3ECMA 2H42A 3HQYA 3SN7A 1RO9A 3DYSA 3QPOA 4MVHA 2QYKA 4P0NA 1Y2EA 3QPPA 4WN1A 3WYKA 3O0JA 3V94A 3KKTA 4AJGA 3ECNA 1ZKNA 5EDEB 5C29A 4Y2BA 1XOMA 4TPPA 4LM1A 3TVXA 3JWQA 5AXQA 4MSAA 4LM2A 5EDIA 1Y2JA 1ZKLA 4TPMA 4X0FA 4OGBA 1XOTA 3DYNA 4PHLA 4LM4A 3SL6A 4G2JA 3WYMA 3G3NA 5EDIB 3JWRA 4C1IA 5C2EA 5C2HA 3G4IA 4AJMA 3LY2A 3WS9A 3G58A 4FCBA
chains in the Genus database with same CATH superfamily
2QYNA 3DY8A 2FM5A 3HMVA 4W1OA 4FCDA 4PHWA 1Q9MA 4Y86A 3V9BA 1Y2CA 2PW3A 3HDZA 3JSWA 1XM4A 2O8HA 4IA0A 4BBXA 1XM6A 4NW7A 1XLXA 4OEWA 1Y2DA 5DH5A 4AJFA 4GH6A 1T9SA 4D08A 1UDTA 1XM4B 1Z1LA 3K3EA 3UUOA 2YY2A 2HD1A 2OUSA 3GWTA 4G2WA 4LM0A 5C28A 2QYMA 2OURA 1XOZA 4LLKA 1XORA 3I8VA 3G4LA 3G4GA 1PTWA 3B2RA 1TAZA 4OEXA 5C2AA 1XMYA 3N3ZA 5AXPA 1Y2KA 4MSEA 2OUPA 3IBJA 4E90A 3SL4A 4DDLA 1SO2A 4DFFA 3HQZA 3HR1A 2OVYA 4YQHA 4MSNA 2OUVA 1XONA 1XMYB 2OUUA 3G4KA 3QI3A 3QPNA 4G2LA 4LM3A 5DH4A 1MKDA 5K32A 2OUYA 3K3HA 4D09A 3K4SA 4XY2A 3IADA 4LLPA 4AJDA 3FRGA 5C1WA 3SHZA 2OUQA 5EDGA 5B4LA 5K1IA 4HEUA 3IAKA 4ZO5A 3ITMA 3WD9A 3WI2A 4AELA 4I9ZA 4MYQA 4MSHA 3ITUA 4KP6A 3QI4A 5K9RA 4NPVA 3O57A 1SOJA 1TB5A 5EDGB 2OUNA 3D3PA 4P1RA 5B4KA 4HTZA 5EDHA 4WCUA 1XP0A 3TGGA 1TBBA 4HTXA 3LXGA 1OYNA 1XOQA 3TGEA 2R8QA 1F0JA 4MD6A 4PM0A 3W5EA 4I15A 5EDEA 1XN0A 3WS8A 3SNIA 1UDUA 3HQWA 1RO6A 3SL5A 2OVVA 4G2YA 5I2RA 1RKPA 2H40A 3SIEA 1UHOA 4Y87A 2WEYA 3SL8A 4MUWA 1XOSA 1RORA 3BJCA 3SL3A 3UI7A 4LLXA 3HC8A 1TBFA 4QGEA 3SNLA 1XLZA 4MS0A 2FM0A 3DYQA 4LLJA 2CHMA 1XMUA 2H44A 3O56A 4Y8CA 5B25A 2Y0JA 1Y2HA 4WZIA 3JSIA 4MRZA 4HF4A 2QYLA 4MSCA 4JIBA 1Y2BA 1T9RA 3DYLA 4MRWA 3V93A 1XMUB 4LKQA 4YS7A 3WYLA 3SHYA 3G45A 4NPWA 1TB7A 3ECMA 2H42A 3HQYA 3SN7A 1RO9A 3DYSA 3QPOA 4MVHA 2QYKA 4P0NA 1Y2EA 3QPPA 4WN1A 3WYKA 3O0JA 3V94A 3KKTA 4AJGA 3ECNA 1ZKNA 5EDEB 5C29A 4Y2BA 1XOMA 4TPPA 4LM1A 3TVXA 3JWQA 5AXQA 4MSAA 4LM2A 5EDIA 1Y2JA 1ZKLA 4TPMA 4X0FA 4OGBA 1XOTA 3DYNA 4PHLA 4LM4A 3SL6A 4G2JA 3WYMA 3G3NA 5EDIB 3JWRA 4C1IA 5C2EA 5C2HA 3G4IA 4AJMA 3LY2A 3WS9A 3G58A 4FCBA
chains in the Genus database with same CATH topology
2QYNA 3DY8A 2FM5A 3HMVA 4W1OA 4FCDA 4PHWA 1Q9MA 4Y86A 3V9BA 1Y2CA 2PW3A 3HDZA 3JSWA 1XM4A 2O8HA 4IA0A 4BBXA 1XM6A 4NW7A 1XLXA 4OEWA 1Y2DA 5DH5A 4AJFA 4GH6A 1T9SA 4D08A 1UDTA 1XM4B 1Z1LA 3K3EA 3UUOA 2YY2A 2HD1A 2OUSA 3GWTA 4G2WA 4LM0A 5C28A 2QYMA 2OURA 1XOZA 4LLKA 1XORA 3I8VA 3G4LA 3G4GA 1PTWA 3B2RA 1TAZA 4OEXA 5C2AA 1XMYA 3N3ZA 5AXPA 1Y2KA 4MSEA 2OUPA 3IBJA 4E90A 3SL4A 4DDLA 1SO2A 4DFFA 3HQZA 3HR1A 2OVYA 4YQHA 4MSNA 2OUVA 1XONA 1XMYB 2OUUA 3G4KA 3QI3A 3QPNA 4G2LA 4LM3A 5DH4A 1MKDA 5K32A 2OUYA 3K3HA 4D09A 3K4SA 4XY2A 3IADA 4LLPA 4AJDA 3FRGA 5C1WA 3SHZA 2OUQA 5EDGA 5B4LA 5K1IA 4HEUA 3IAKA 4ZO5A 3ITMA 3WD9A 3WI2A 4AELA 4I9ZA 4MYQA 4MSHA 3ITUA 4KP6A 3QI4A 5K9RA 4NPVA 3O57A 1SOJA 1TB5A 5EDGB 2OUNA 3D3PA 4P1RA 5B4KA 4HTZA 5EDHA 4WCUA 1XP0A 3TGGA 1TBBA 4HTXA 3LXGA 1OYNA 1XOQA 3TGEA 2R8QA 1F0JA 4MD6A 4PM0A 3W5EA 4I15A 5EDEA 1XN0A 3WS8A 3SNIA 1UDUA 3HQWA 1RO6A 3SL5A 2OVVA 4G2YA 5I2RA 1RKPA 2H40A 3SIEA 1UHOA 4Y87A 2WEYA 3SL8A 4MUWA 1XOSA 1RORA 3BJCA 3SL3A 3UI7A 4LLXA 3HC8A 1TBFA 4QGEA 3SNLA 1XLZA 4MS0A 2FM0A 3DYQA 4LLJA 2CHMA 1XMUA 2H44A 3O56A 4Y8CA 5B25A 2Y0JA 1Y2HA 4WZIA 3JSIA 4MRZA 4HF4A 2QYLA 4MSCA 4JIBA 1Y2BA 1T9RA 3DYLA 4MRWA 3V93A 1XMUB 4LKQA 4YS7A 3WYLA 3SHYA 3G45A 4NPWA 1TB7A 3ECMA 2H42A 3HQYA 3SN7A 1RO9A 3DYSA 3QPOA 4MVHA 2QYKA 4P0NA 1Y2EA 3QPPA 4WN1A 3WYKA 3O0JA 3V94A 3KKTA 4AJGA 3ECNA 1ZKNA 5EDEB 5C29A 4Y2BA 1XOMA 4TPPA 4LM1A 3TVXA 3JWQA 5AXQA 4MSAA 4LM2A 5EDIA 1Y2JA 1ZKLA 4TPMA 4X0FA 4OGBA 1XOTA 3DYNA 4PHLA 4LM4A 3SL6A 4G2JA 3WYMA 3G3NA 5EDIB 3JWRA 4C1IA 5C2EA 5C2HA 3G4IA 4AJMA 3LY2A 3WS9A 3G58A 4FCBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2QYN A;  3DY8 A;  2FM5 A;  3HMV A;  4W1O A;  4FCD A;  4PHW A;  1Q9M A;  4Y86 A;  3V9B A;  1Y2C A;  2PW3 A;  3HDZ A;  3JSW A;  1XM4 A;  2O8H A;  4IA0 A;  4BBX A;  1XM6 A;  4NW7 A;  1XLX A;  4OEW A;  1Y2D A;  5DH5 A;  4AJF A;  4GH6 A;  1T9S A;  4D08 A;  1UDT A;  1XM4 B;  1Z1L A;  3K3E A;  3UUO A;  2YY2 A;  2HD1 A;  2OUS A;  3GWT A;  4G2W A;  4LM0 A;  5C28 A;  2QYM A;  2OUR A;  1XOZ A;  4LLK A;  1XOR A;  3I8V A;  3G4L A;  3G4G A;  1PTW A;  3B2R A;  1TAZ A;  4OEX A;  5C2A A;  1XMY A;  3N3Z A;  5AXP A;  1Y2K A;  4MSE A;  2OUP A;  3IBJ A;  4E90 A;  3SL4 A;  4DDL A;  1SO2 A;  4DFF A;  3HQZ A;  3HR1 A;  2OVY A;  4YQH A;  4MSN A;  2OUV A;  1XON A;  1XMY B;  2OUU A;  3G4K A;  3QI3 A;  3QPN A;  4G2L A;  4LM3 A;  5DH4 A;  1MKD A;  5K32 A;  2OUY A;  3K3H A;  4D09 A;  3K4S A;  4XY2 A;  3IAD A;  4LLP A;  4AJD A;  3FRG A;  5C1W A;  3SHZ A;  2OUQ A;  5EDG A;  5B4L A;  5K1I A;  4HEU A;  3IAK A;  4ZO5 A;  3ITM A;  3WD9 A;  3WI2 A;  4AEL A;  4I9Z A;  4MYQ A;  4MSH A;  3ITU A;  4KP6 A;  3QI4 A;  5K9R A;  4NPV A;  3O57 A;  1SOJ A;  1TB5 A;  5EDG B;  2OUN A;  3D3P A;  4P1R A;  5B4K A;  4HTZ A;  5EDH A;  4WCU A;  1XP0 A;  3TGG A;  1TBB A;  4HTX A;  3LXG A;  1OYN A;  1XOQ A;  3TGE A;  2R8Q A;  1F0J A;  4MD6 A;  4PM0 A;  3W5E A;  4I15 A;  5EDE A;  1XN0 A;  3WS8 A;  3SNI A;  1UDU A;  3HQW A;  1RO6 A;  3SL5 A;  2OVV A;  4G2Y A;  5I2R A;  1RKP A;  2H40 A;  3SIE A;  1UHO A;  4Y87 A;  2WEY A;  3SL8 A;  4MUW A;  1XOS A;  1ROR A;  3BJC A;  3SL3 A;  3UI7 A;  4LLX A;  3HC8 A;  1TBF A;  4QGE A;  3SNL A;  1XLZ A;  4MS0 A;  2FM0 A;  3DYQ A;  4LLJ A;  2CHM A;  1XMU A;  2H44 A;  3O56 A;  4Y8C A;  5B25 A;  2Y0J A;  1Y2H A;  4WZI A;  3JSI A;  4MRZ A;  4HF4 A;  2QYL A;  4MSC A;  4JIB A;  1Y2B A;  1T9R A;  3DYL A;  4MRW A;  3V93 A;  1XMU B;  4LKQ A;  4YS7 A;  3WYL A;  3SHY A;  3G45 A;  4NPW A;  1TB7 A;  3ECM A;  2H42 A;  3HQY A;  3SN7 A;  1RO9 A;  3DYS A;  3QPO A;  4MVH A;  2QYK A;  4P0N A;  1Y2E A;  3QPP A;  4WN1 A;  3WYK A;  3O0J A;  3V94 A;  3KKT A;  4AJG A;  3ECN A;  1ZKN A;  5EDE B;  5C29 A;  4Y2B A;  1XOM A;  4TPP A;  4LM1 A;  3TVX A;  3JWQ A;  5AXQ A;  4MSA A;  4LM2 A;  5EDI A;  1Y2J A;  1ZKL A;  4TPM A;  4X0F A;  4OGB A;  1XOT A;  3DYN A;  4PHL A;  4LM4 A;  3SL6 A;  4G2J A;  3WYM A;  3G3N A;  5EDI B;  3JWR A;  4C1I A;  5C2E A;  5C2H A;  3G4I A;  4AJM A;  3LY2 A;  3WS9 A;  3G58 A;  4FCB A; 
#chains in the Genus database with same CATH topology
 2QYN A;  3DY8 A;  2FM5 A;  3HMV A;  4W1O A;  4FCD A;  4PHW A;  1Q9M A;  4Y86 A;  3V9B A;  1Y2C A;  2PW3 A;  3HDZ A;  3JSW A;  1XM4 A;  2O8H A;  4IA0 A;  4BBX A;  1XM6 A;  4NW7 A;  1XLX A;  4OEW A;  1Y2D A;  5DH5 A;  4AJF A;  4GH6 A;  1T9S A;  4D08 A;  1UDT A;  1XM4 B;  1Z1L A;  3K3E A;  3UUO A;  2YY2 A;  2HD1 A;  2OUS A;  3GWT A;  4G2W A;  4LM0 A;  5C28 A;  2QYM A;  2OUR A;  1XOZ A;  4LLK A;  1XOR A;  3I8V A;  3G4L A;  3G4G A;  1PTW A;  3B2R A;  1TAZ A;  4OEX A;  5C2A A;  1XMY A;  3N3Z A;  5AXP A;  1Y2K A;  4MSE A;  2OUP A;  3IBJ A;  4E90 A;  3SL4 A;  4DDL A;  1SO2 A;  4DFF A;  3HQZ A;  3HR1 A;  2OVY A;  4YQH A;  4MSN A;  2OUV A;  1XON A;  1XMY B;  2OUU A;  3G4K A;  3QI3 A;  3QPN A;  4G2L A;  4LM3 A;  5DH4 A;  1MKD A;  5K32 A;  2OUY A;  3K3H A;  4D09 A;  3K4S A;  4XY2 A;  3IAD A;  4LLP A;  4AJD A;  3FRG A;  5C1W A;  3SHZ A;  2OUQ A;  5EDG A;  5B4L A;  5K1I A;  4HEU A;  3IAK A;  4ZO5 A;  3ITM A;  3WD9 A;  3WI2 A;  4AEL A;  4I9Z A;  4MYQ A;  4MSH A;  3ITU A;  4KP6 A;  3QI4 A;  5K9R A;  4NPV A;  3O57 A;  1SOJ A;  1TB5 A;  5EDG B;  2OUN A;  3D3P A;  4P1R A;  5B4K A;  4HTZ A;  5EDH A;  4WCU A;  1XP0 A;  3TGG A;  1TBB A;  4HTX A;  3LXG A;  1OYN A;  1XOQ A;  3TGE A;  2R8Q A;  1F0J A;  4MD6 A;  4PM0 A;  3W5E A;  4I15 A;  5EDE A;  1XN0 A;  3WS8 A;  3SNI A;  1UDU A;  3HQW A;  1RO6 A;  3SL5 A;  2OVV A;  4G2Y A;  5I2R A;  1RKP A;  2H40 A;  3SIE A;  1UHO A;  4Y87 A;  2WEY A;  3SL8 A;  4MUW A;  1XOS A;  1ROR A;  3BJC A;  3SL3 A;  3UI7 A;  4LLX A;  3HC8 A;  1TBF A;  4QGE A;  3SNL A;  1XLZ A;  4MS0 A;  2FM0 A;  3DYQ A;  4LLJ A;  2CHM A;  1XMU A;  2H44 A;  3O56 A;  4Y8C A;  5B25 A;  2Y0J A;  1Y2H A;  4WZI A;  3JSI A;  4MRZ A;  4HF4 A;  2QYL A;  4MSC A;  4JIB A;  1Y2B A;  1T9R A;  3DYL A;  4MRW A;  3V93 A;  1XMU B;  4LKQ A;  4YS7 A;  3WYL A;  3SHY A;  3G45 A;  4NPW A;  1TB7 A;  3ECM A;  2H42 A;  3HQY A;  3SN7 A;  1RO9 A;  3DYS A;  3QPO A;  4MVH A;  2QYK A;  4P0N A;  1Y2E A;  3QPP A;  4WN1 A;  3WYK A;  3O0J A;  3V94 A;  3KKT A;  4AJG A;  3ECN A;  1ZKN A;  5EDE B;  5C29 A;  4Y2B A;  1XOM A;  4TPP A;  4LM1 A;  3TVX A;  3JWQ A;  5AXQ A;  4MSA A;  4LM2 A;  5EDI A;  1Y2J A;  1ZKL A;  4TPM A;  4X0F A;  4OGB A;  1XOT A;  3DYN A;  4PHL A;  4LM4 A;  3SL6 A;  4G2J A;  3WYM A;  3G3N A;  5EDI B;  3JWR A;  4C1I A;  5C2E A;  5C2H A;  3G4I A;  4AJM A;  3LY2 A;  3WS9 A;  3G58 A;  4FCB A; 
#chains in the Genus database with same CATH homology
 2QYN A;  3DY8 A;  2FM5 A;  3HMV A;  4W1O A;  4FCD A;  4PHW A;  1Q9M A;  4Y86 A;  3V9B A;  1Y2C A;  2PW3 A;  3HDZ A;  3JSW A;  1XM4 A;  2O8H A;  4IA0 A;  4BBX A;  1XM6 A;  4NW7 A;  1XLX A;  4OEW A;  1Y2D A;  5DH5 A;  4AJF A;  4GH6 A;  1T9S A;  4D08 A;  1UDT A;  1XM4 B;  1Z1L A;  3K3E A;  3UUO A;  2YY2 A;  2HD1 A;  2OUS A;  3GWT A;  4G2W A;  4LM0 A;  5C28 A;  2QYM A;  2OUR A;  1XOZ A;  4LLK A;  1XOR A;  3I8V A;  3G4L A;  3G4G A;  1PTW A;  3B2R A;  1TAZ A;  4OEX A;  5C2A A;  1XMY A;  3N3Z A;  5AXP A;  1Y2K A;  4MSE A;  2OUP A;  3IBJ A;  4E90 A;  3SL4 A;  4DDL A;  1SO2 A;  4DFF A;  3HQZ A;  3HR1 A;  2OVY A;  4YQH A;  4MSN A;  2OUV A;  1XON A;  1XMY B;  2OUU A;  3G4K A;  3QI3 A;  3QPN A;  4G2L A;  4LM3 A;  5DH4 A;  1MKD A;  5K32 A;  2OUY A;  3K3H A;  4D09 A;  3K4S A;  4XY2 A;  3IAD A;  4LLP A;  4AJD A;  3FRG A;  5C1W A;  3SHZ A;  2OUQ A;  5EDG A;  5B4L A;  5K1I A;  4HEU A;  3IAK A;  4ZO5 A;  3ITM A;  3WD9 A;  3WI2 A;  4AEL A;  4I9Z A;  4MYQ A;  4MSH A;  3ITU A;  4KP6 A;  3QI4 A;  5K9R A;  4NPV A;  3O57 A;  1SOJ A;  1TB5 A;  5EDG B;  2OUN A;  3D3P A;  4P1R A;  5B4K A;  4HTZ A;  5EDH A;  4WCU A;  1XP0 A;  3TGG A;  1TBB A;  4HTX A;  3LXG A;  1OYN A;  1XOQ A;  3TGE A;  2R8Q A;  1F0J A;  4MD6 A;  4PM0 A;  3W5E A;  4I15 A;  5EDE A;  1XN0 A;  3WS8 A;  3SNI A;  1UDU A;  3HQW A;  1RO6 A;  3SL5 A;  2OVV A;  4G2Y A;  5I2R A;  1RKP A;  2H40 A;  3SIE A;  1UHO A;  4Y87 A;  2WEY A;  3SL8 A;  4MUW A;  1XOS A;  1ROR A;  3BJC A;  3SL3 A;  3UI7 A;  4LLX A;  3HC8 A;  1TBF A;  4QGE A;  3SNL A;  1XLZ A;  4MS0 A;  2FM0 A;  3DYQ A;  4LLJ A;  2CHM A;  1XMU A;  2H44 A;  3O56 A;  4Y8C A;  5B25 A;  2Y0J A;  1Y2H A;  4WZI A;  3JSI A;  4MRZ A;  4HF4 A;  2QYL A;  4MSC A;  4JIB A;  1Y2B A;  1T9R A;  3DYL A;  4MRW A;  3V93 A;  1XMU B;  4LKQ A;  4YS7 A;  3WYL A;  3SHY A;  3G45 A;  4NPW A;  1TB7 A;  3ECM A;  2H42 A;  3HQY A;  3SN7 A;  1RO9 A;  3DYS A;  3QPO A;  4MVH A;  2QYK A;  4P0N A;  1Y2E A;  3QPP A;  4WN1 A;  3WYK A;  3O0J A;  3V94 A;  3KKT A;  4AJG A;  3ECN A;  1ZKN A;  5EDE B;  5C29 A;  4Y2B A;  1XOM A;  4TPP A;  4LM1 A;  3TVX A;  3JWQ A;  5AXQ A;  4MSA A;  4LM2 A;  5EDI A;  1Y2J A;  1ZKL A;  4TPM A;  4X0F A;  4OGB A;  1XOT A;  3DYN A;  4PHL A;  4LM4 A;  3SL6 A;  4G2J A;  3WYM A;  3G3N A;  5EDI B;  3JWR A;  4C1I A;  5C2E A;  5C2H A;  3G4I A;  4AJM A;  3LY2 A;  3WS9 A;  3G58 A;  4FCB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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