3T70A

5'-diphenyl nucleoside inhibitors of plasmodium falciparum dutpase
Total Genus 34

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
34
sequence length
167
structure length
149
Chain Sequence
MHLKIVCLSDEVREMYKNHKGDSGLDLFIVKDEVLKPKSTTFVKLGIKAIALQYKSNYYYKNIVNTSFLLFPRSSISKTPLRLANSIGLIDAGYRGEIIAALDNTSDQEYHIKKNDKLVQLVSFTGEPLSFELVEELDETSRGEGGFGS
2040608010012014014012010080604020
051015202530Genus Matrix

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
S1 (2-7)S11 (134-141)AH1 (10-18)S2 (28-33)EMPTYTVIII1 (26-29)S9 (116-122)TI3 (109-112)S3 (37-39)TIV2 (103-106)S8 (106-108)TI2 (101-104)S4 (43-58)S7 (99-101)S5 (81-84)S6 (86-90)TI1 (94-97)S10 (128-130)TIV1 (40-43)TI4 (141-144)3H1 (92-94)TII1 (131-134)Updating...
connected with : NaN
molecule tags Hydrolase/hydrolase inhibitor
source organism Plasmodium falciparum
publication title Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase.
pubmed rcsb
molecule keywords Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative
total genus 34
structure length 149
sequence length 167
chains with identical sequence B, C
ec nomenclature ec 3.6.1.23: dUTP diphosphatase.
pdb deposition date 2011-07-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00692 dUTPase dUTPase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.40.10 Mainly Beta Distorted Sandwich Deoxyuridine 5'-Triphosphate Nucleotidohydrolase; Chain A Deoxyuridine 5'-Triphosphate Nucleotidohydrolase; Chain A 3t70A01
3MDXA 1F7RA 1DUPA 3ECYA 3MBQA 4OOPA 2J4QA 2XY3A 2OKEA 4OOQA 1EUWA 5CCOA 5EDDA 2ZDCA 2BAZA 3F4FA 3HHQA 2R9QA 4B0HA 4XJCA 2QLPA 4APZ1 1F7PA 3H6DA 2QXXA 2XX6A 1F7KA 1EU5A 3TQZA 2Y8CA 3SO2A 3T70A 4WRKA 2Y1TA 3ZEZA 3LOJA 3ZF5A 3ZF0A 3C2TA 1RN8A 3TQ4A 2PC5A 3HZAA 3I93A 2D4NA 4DHKA 2OKDA 1Q5HA 4GV8A 1PKHA 2OL1A 2BSYA 1RNJA 3ZF6A 3ARAA 2PY4A 1SJNA 3ARNA 1PKKA 4LHRA 1PKJA 1XS4A 3TTAA 1DUNA 4AOZA 4AOOA 3T60A 4AO5A 1DUTA 3TPYA 1OGHA 1XS1A 5F9KA 4GCYA 3LQWA 1F7OA 2D4LA 2WE3A 2WE2A 1SEHA 1MQ7A 1SMCA 2XCEA 3TQ3A 3ZF3A 2BT1A 5ECTA 3T6YA 1F7NA 1Q5UX 1SM8A 3TS6A 1XS6A 3T64A 3ZF4A 3C3IA 3TRNA 1DUCA 1F7QA 3TPSA 2D4MA 4A6AA 3GF0A 3CA9A 3TP1A 2HXBA 2HQUA 2HR6A 3EHWA 3TSLA 2V9XA 2J4HA 3H6XA 3TPWA 2WE0A 1SYLA 2YZJA 3ZF1A 1SIXA 2HRMA 4GK6A 1DUDA 1SLHA 2XCDA 3P48A 2OKBA 1F7DA 3ZF2A 3TPNA 5CCTA 2OL0A 3KM3A 3TRLA 2WE1A 1SNFA 2HXDA 1VYQA 3TQ5A
chains in the Genus database with same CATH superfamily
3MDXA 1F7RA 1DUPA 3ECYA 3MBQA 4OOPA 2J4QA 2XY3A 2OKEA 4OOQA 1EUWA 5CCOA 5EDDA 2ZDCA 2BAZA 3F4FA 3HHQA 2R9QA 4B0HA 4XJCA 2QLPA 4APZ1 1F7PA 3H6DA 2QXXA 2XX6A 1F7KA 1EU5A 3TQZA 2Y8CA 3SO2A 3T70A 4WRKA 2Y1TA 3ZEZA 3LOJA 3ZF5A 3ZF0A 3C2TA 1RN8A 3TQ4A 2PC5A 3HZAA 3I93A 2D4NA 4DHKA 2OKDA 1Q5HA 4GV8A 1PKHA 2OL1A 2BSYA 1RNJA 1TULA 3ARAA 2PY4A 1SJNA 3ZF6A 3ARNA 1PKKA 4LHRA 1PKJA 1XS4A 3TTAA 1DUNA 4AOZA 4AOOA 3T60A 4AO5A 1DUTA 3TPYA 1OGHA 1XS1A 5F9KA 4GCYA 3LQWA 1F7OA 2D4LA 2WE3A 2WE2A 1SEHA 1MQ7A 1SMCA 2XCEA 3TQ3A 3ZF3A 2BT1A 5ECTA 3T6YA 1F7NA 1Q5UX 1SM8A 3TS6A 1XS6A 3T64A 3ZF4A 3C3IA 3TRNA 1DUCA 1F7QA 3TPSA 2D4MA 4A6AA 3GF0A 3CA9A 3TP1A 2HXBA 2HQUA 2HR6A 3EHWA 3TSLA 2V9XA 2J4HA 3H6XA 3TPWA 2WE0A 1SYLA 2YZJA 3ZF1A 1SIXA 2HRMA 4GK6A 1DUDA 1SLHA 2XCDA 3P48A 2OKBA 1F7DA 3ZF2A 3TPNA 5CCTA 2OL0A 3KM3A 3TRLA 2WE1A 1SNFA 2HXDA 1VYQA 3TQ5A
chains in the Genus database with same CATH topology
3MDXA 1F7RA 1DUPA 3ECYA 3MBQA 4OOPA 2J4QA 2XY3A 2OKEA 4OOQA 1EUWA 5CCOA 5EDDA 2ZDCA 2BAZA 3F4FA 3HHQA 2R9QA 4B0HA 4XJCA 2QLPA 4APZ1 1F7PA 3H6DA 2QXXA 2XX6A 1F7KA 1EU5A 3TQZA 2Y8CA 3SO2A 3T70A 4WRKA 2Y1TA 3ZEZA 3LOJA 3ZF5A 3ZF0A 3C2TA 1RN8A 3TQ4A 2PC5A 3HZAA 3I93A 2D4NA 4DHKA 2OKDA 1Q5HA 4GV8A 1PKHA 2OL1A 2BSYA 1RNJA 3ZF6A 3ARAA 2PY4A 1SJNA 3ARNA 1PKKA 4LHRA 1PKJA 1XS4A 3TTAA 1DUNA 4AOZA 4AOOA 3T60A 4AO5A 1DUTA 3TPYA 1OGHA 1XS1A 5F9KA 4GCYA 3LQWA 1F7OA 2D4LA 2WE3A 2WE2A 1SEHA 1MQ7A 1SMCA 2XCEA 3TQ3A 3ZF3A 2BT1A 5ECTA 3T6YA 1F7NA 1Q5UX 1SM8A 3TS6A 1XS6A 3T64A 3ZF4A 3C3IA 3TRNA 1DUCA 1F7QA 3TPSA 2D4MA 4A6AA 3GF0A 3CA9A 3TP1A 2HXBA 2HQUA 2HR6A 3EHWA 3TSLA 2V9XA 2J4HA 3H6XA 3TPWA 2WE0A 1SYLA 2YZJA 3ZF1A 1SIXA 2HRMA 4GK6A 1DUDA 1SLHA 2XCDA 3P48A 2OKBA 1F7DA 3ZF2A 3TPNA 5CCTA 2OL0A 3KM3A 3TRLA 2WE1A 1SNFA 2HXDA 1VYQA 3TQ5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3MDX A;  1F7R A;  1DUP A;  3ECY A;  3MBQ A;  4OOP A;  2J4Q A;  2XY3 A;  2OKE A;  4OOQ A;  1EUW A;  5CCO A;  5EDD A;  2ZDC A;  2BAZ A;  3F4F A;  3HHQ A;  2R9Q A;  4B0H A;  4XJC A;  2QLP A;  4APZ 1;  1F7P A;  3H6D A;  2QXX A;  2XX6 A;  1F7K A;  1EU5 A;  3TQZ A;  2Y8C A;  3SO2 A;  3T70 A;  4WRK A;  2Y1T A;  3ZEZ A;  3LOJ A;  3ZF5 A;  3ZF0 A;  3C2T A;  1RN8 A;  3TQ4 A;  2PC5 A;  3HZA A;  3I93 A;  2D4N A;  4DHK A;  2OKD A;  1Q5H A;  4GV8 A;  1PKH A;  2OL1 A;  2BSY A;  1RNJ A;  3ZF6 A;  3ARA A;  2PY4 A;  1SJN A;  3ARN A;  1PKK A;  4LHR A;  1PKJ A;  1XS4 A;  3TTA A;  1DUN A;  4AOZ A;  4AOO A;  3T60 A;  4AO5 A;  1DUT A;  3TPY A;  1OGH A;  1XS1 A;  5F9K A;  4GCY A;  3LQW A;  1F7O A;  2D4L A;  2WE3 A;  2WE2 A;  1SEH A;  1MQ7 A;  1SMC A;  2XCE A;  3TQ3 A;  3ZF3 A;  2BT1 A;  5ECT A;  3T6Y A;  1F7N A;  1Q5U X;  1SM8 A;  3TS6 A;  1XS6 A;  3T64 A;  3ZF4 A;  3C3I A;  3TRN A;  1DUC A;  1F7Q A;  3TPS A;  2D4M A;  4A6A A;  3GF0 A;  3CA9 A;  3TP1 A;  2HXB A;  2HQU A;  2HR6 A;  3EHW A;  3TSL A;  2V9X A;  2J4H A;  3H6X A;  3TPW A;  2WE0 A;  1SYL A;  2YZJ A;  3ZF1 A;  1SIX A;  2HRM A;  4GK6 A;  1DUD A;  1SLH A;  2XCD A;  3P48 A;  2OKB A;  1F7D A;  3ZF2 A;  3TPN A;  5CCT A;  2OL0 A;  3KM3 A;  3TRL A;  2WE1 A;  1SNF A;  2HXD A;  1VYQ A;  3TQ5 A; 
#chains in the Genus database with same CATH topology
 3MDX A;  1F7R A;  1DUP A;  3ECY A;  3MBQ A;  4OOP A;  2J4Q A;  2XY3 A;  2OKE A;  4OOQ A;  1EUW A;  5CCO A;  5EDD A;  2ZDC A;  2BAZ A;  3F4F A;  3HHQ A;  2R9Q A;  4B0H A;  4XJC A;  2QLP A;  4APZ 1;  1F7P A;  3H6D A;  2QXX A;  2XX6 A;  1F7K A;  1EU5 A;  3TQZ A;  2Y8C A;  3SO2 A;  3T70 A;  4WRK A;  2Y1T A;  3ZEZ A;  3LOJ A;  3ZF5 A;  3ZF0 A;  3C2T A;  1RN8 A;  3TQ4 A;  2PC5 A;  3HZA A;  3I93 A;  2D4N A;  4DHK A;  2OKD A;  1Q5H A;  4GV8 A;  1PKH A;  2OL1 A;  2BSY A;  1RNJ A;  1TUL A;  3ARA A;  2PY4 A;  1SJN A;  3ZF6 A;  3ARN A;  1PKK A;  4LHR A;  1PKJ A;  1XS4 A;  3TTA A;  1DUN A;  4AOZ A;  4AOO A;  3T60 A;  4AO5 A;  1DUT A;  3TPY A;  1OGH A;  1XS1 A;  5F9K A;  4GCY A;  3LQW A;  1F7O A;  2D4L A;  2WE3 A;  2WE2 A;  1SEH A;  1MQ7 A;  1SMC A;  2XCE A;  3TQ3 A;  3ZF3 A;  2BT1 A;  5ECT A;  3T6Y A;  1F7N A;  1Q5U X;  1SM8 A;  3TS6 A;  1XS6 A;  3T64 A;  3ZF4 A;  3C3I A;  3TRN A;  1DUC A;  1F7Q A;  3TPS A;  2D4M A;  4A6A A;  3GF0 A;  3CA9 A;  3TP1 A;  2HXB A;  2HQU A;  2HR6 A;  3EHW A;  3TSL A;  2V9X A;  2J4H A;  3H6X A;  3TPW A;  2WE0 A;  1SYL A;  2YZJ A;  3ZF1 A;  1SIX A;  2HRM A;  4GK6 A;  1DUD A;  1SLH A;  2XCD A;  3P48 A;  2OKB A;  1F7D A;  3ZF2 A;  3TPN A;  5CCT A;  2OL0 A;  3KM3 A;  3TRL A;  2WE1 A;  1SNF A;  2HXD A;  1VYQ A;  3TQ5 A; 
#chains in the Genus database with same CATH homology
 3MDX A;  1F7R A;  1DUP A;  3ECY A;  3MBQ A;  4OOP A;  2J4Q A;  2XY3 A;  2OKE A;  4OOQ A;  1EUW A;  5CCO A;  5EDD A;  2ZDC A;  2BAZ A;  3F4F A;  3HHQ A;  2R9Q A;  4B0H A;  4XJC A;  2QLP A;  4APZ 1;  1F7P A;  3H6D A;  2QXX A;  2XX6 A;  1F7K A;  1EU5 A;  3TQZ A;  2Y8C A;  3SO2 A;  3T70 A;  4WRK A;  2Y1T A;  3ZEZ A;  3LOJ A;  3ZF5 A;  3ZF0 A;  3C2T A;  1RN8 A;  3TQ4 A;  2PC5 A;  3HZA A;  3I93 A;  2D4N A;  4DHK A;  2OKD A;  1Q5H A;  4GV8 A;  1PKH A;  2OL1 A;  2BSY A;  1RNJ A;  3ZF6 A;  3ARA A;  2PY4 A;  1SJN A;  3ARN A;  1PKK A;  4LHR A;  1PKJ A;  1XS4 A;  3TTA A;  1DUN A;  4AOZ A;  4AOO A;  3T60 A;  4AO5 A;  1DUT A;  3TPY A;  1OGH A;  1XS1 A;  5F9K A;  4GCY A;  3LQW A;  1F7O A;  2D4L A;  2WE3 A;  2WE2 A;  1SEH A;  1MQ7 A;  1SMC A;  2XCE A;  3TQ3 A;  3ZF3 A;  2BT1 A;  5ECT A;  3T6Y A;  1F7N A;  1Q5U X;  1SM8 A;  3TS6 A;  1XS6 A;  3T64 A;  3ZF4 A;  3C3I A;  3TRN A;  1DUC A;  1F7Q A;  3TPS A;  2D4M A;  4A6A A;  3GF0 A;  3CA9 A;  3TP1 A;  2HXB A;  2HQU A;  2HR6 A;  3EHW A;  3TSL A;  2V9X A;  2J4H A;  3H6X A;  3TPW A;  2WE0 A;  1SYL A;  2YZJ A;  3ZF1 A;  1SIX A;  2HRM A;  4GK6 A;  1DUD A;  1SLH A;  2XCD A;  3P48 A;  2OKB A;  1F7D A;  3ZF2 A;  3TPN A;  5CCT A;  2OL0 A;  3KM3 A;  3TRL A;  2WE1 A;  1SNF A;  2HXD A;  1VYQ A;  3TQ5 A; 
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