3TPWA

Crystal structure of m-pmv dutpase - dupnpp complex revealing distorted ligand geometry (approach intermediate)
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
114
structure length
114
Chain Sequence
QKQPISKLTRATPGSAGLDLCSTSHTVLTPEMGPQALSTGIYGPLPPNTFGLILGRSSITMKGLQVYPGVIDNDYTGEIKIMAKAVNNIVTVSQGNRIAQLILLPLIETDNKVQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Snapshots of Enzyme-Catalysed Phosphate Ester Hydrolysis Directly Visualize In-line Attack and Inversion
rcsb
molecule tags Hydrolase
source organism Mason-pfizer monkey virus
molecule keywords DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDO HYDROLASE
total genus 21
structure length 114
sequence length 114
ec nomenclature ec 3.6.1.23: dUTP diphosphatase.
pdb deposition date 2011-09-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00692 dUTPase dUTPase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.40.10 Mainly Beta Distorted Sandwich Deoxyuridine 5'-Triphosphate Nucleotidohydrolase; Chain A Deoxyuridine 5'-Triphosphate Nucleotidohydrolase; Chain A 3tpwA01
4B0HA 1SIXA 2OKEA 3ZF3A 1XS6A 1Q5HA 1DUPA 4DHKA 1F7KA 2QLPA 3ZF4A 3ECYA 4OOQA 3CA9A 2XY3A 4GK6A 3P48A 2Y8CA 3TQ5A 3TRLA 3LOJA 2XCEA 1F7DA 3TTAA 2WE2A 4GV8A 2XX6A 3TQ3A 1VYQA 1SMCA 1EU5A 1F7PA 3TP1A 3I93A 2D4LA 1SLHA 2D4MA 2XCDA 3H6XA 4A6AA 2PC5A 1OGHA 3T64A 3TPWA 4AO5A 3ZF1A 2OL1A 3TRNA 2V9XA 1XS4A 3T6YA 5ECTA 1PKHA 3SO2A 2J4QA 1DUNA 1Q5UX 2HXBA 3H6DA 1EUWA 3TPSA 3ZEZA 4XJCA 3TPYA 2QXXA 3T70A 3MDXA 5CCTA 2ZDCA 1SEHA 2OKDA 3ZF0A 4AOZA 2R9QA 1PKKA 3ARNA 2HR6A 1F7NA 3TQZA 3F4FA 3C3IA 3GF0A 3KM3A 1DUCA 1XS1A 2OKBA 3TS6A 3ARAA 3HZAA 1MQ7A 5EDDA 5CCOA 2PY4A 4AOOA 4LHRA 2WE3A 2BT1A 3TQ4A 2J4HA 1SNFA 1DUTA 1RN8A 3ZF5A 3ZF2A 5F9KA 1F7RA 3ZF6A 2BAZA 4APZ1 3T60A 2HQUA 1PKJA 4WRKA 2OL0A 3LQWA 2WE1A 2WE0A 3MBQA 1SYLA 1F7QA 3C2TA 4GCYA 2D4NA 2Y1TA 1SM8A 3TSLA 2YZJA 4OOPA 3TPNA 3EHWA 1F7OA 1SJNA 2HRMA 2BSYA 3HHQA 2HXDA 1DUDA 1RNJA
chains in the Genus database with same CATH superfamily
4B0HA 1SIXA 2OKEA 3ZF3A 1XS6A 1Q5HA 1DUPA 4DHKA 1F7KA 2QLPA 3ZF4A 3ECYA 4OOQA 3CA9A 2XY3A 4GK6A 3P48A 2Y8CA 3TQ5A 3TRLA 3LOJA 2XCEA 1F7DA 3TTAA 2WE2A 4GV8A 2XX6A 3TQ3A 1VYQA 1SMCA 1EU5A 1F7PA 3TP1A 3I93A 2D4LA 1SLHA 1TULA 2D4MA 2XCDA 3H6XA 4A6AA 2PC5A 1OGHA 3T64A 3TPWA 4AO5A 3ZF1A 2OL1A 3TRNA 2V9XA 1XS4A 3T6YA 5ECTA 1PKHA 3SO2A 2J4QA 1DUNA 1Q5UX 2HXBA 3H6DA 1EUWA 3TPSA 3ZEZA 4XJCA 3TPYA 2QXXA 3T70A 3MDXA 5CCTA 2ZDCA 1SEHA 2OKDA 3ZF0A 4AOZA 2R9QA 1PKKA 3ARNA 2HR6A 1F7NA 3TQZA 3F4FA 3C3IA 3GF0A 3KM3A 1DUCA 1XS1A 2OKBA 3TS6A 3ARAA 3HZAA 1MQ7A 5EDDA 5CCOA 2PY4A 4AOOA 4LHRA 2WE3A 2BT1A 3TQ4A 2J4HA 1SNFA 1DUTA 1RN8A 3ZF5A 3ZF2A 5F9KA 1F7RA 3ZF6A 2BAZA 4APZ1 3T60A 2HQUA 1PKJA 4WRKA 2OL0A 3LQWA 2WE1A 2WE0A 3MBQA 1SYLA 1F7QA 3C2TA 4GCYA 2D4NA 2Y1TA 1SM8A 3TSLA 2YZJA 4OOPA 3TPNA 3EHWA 1F7OA 1SJNA 2HRMA 2BSYA 3HHQA 2HXDA 1DUDA 1RNJA
chains in the Genus database with same CATH topology
4B0HA 1SIXA 2OKEA 3ZF3A 1XS6A 1Q5HA 1DUPA 4DHKA 1F7KA 2QLPA 3ZF4A 3ECYA 4OOQA 3CA9A 2XY3A 4GK6A 3P48A 2Y8CA 3TQ5A 3TRLA 3LOJA 2XCEA 1F7DA 3TTAA 2WE2A 4GV8A 2XX6A 3TQ3A 1VYQA 1SMCA 1EU5A 1F7PA 3TP1A 3I93A 2D4LA 1SLHA 2D4MA 2XCDA 3H6XA 4A6AA 2PC5A 1OGHA 3T64A 3TPWA 4AO5A 3ZF1A 2OL1A 3TRNA 2V9XA 1XS4A 3T6YA 5ECTA 1PKHA 3SO2A 2J4QA 1DUNA 1Q5UX 2HXBA 3H6DA 1EUWA 3TPSA 3ZEZA 4XJCA 3TPYA 2QXXA 3T70A 3MDXA 5CCTA 2ZDCA 1SEHA 2OKDA 3ZF0A 4AOZA 2R9QA 1PKKA 3ARNA 2HR6A 1F7NA 3TQZA 3F4FA 3C3IA 3GF0A 3KM3A 1DUCA 1XS1A 2OKBA 3TS6A 3ARAA 3HZAA 1MQ7A 5EDDA 5CCOA 2PY4A 4AOOA 4LHRA 2WE3A 2BT1A 3TQ4A 2J4HA 1SNFA 1DUTA 1RN8A 3ZF5A 3ZF2A 5F9KA 1F7RA 3ZF6A 2BAZA 4APZ1 3T60A 2HQUA 1PKJA 4WRKA 2OL0A 3LQWA 2WE1A 2WE0A 3MBQA 1SYLA 1F7QA 3C2TA 4GCYA 2D4NA 2Y1TA 1SM8A 3TSLA 2YZJA 4OOPA 3TPNA 3EHWA 1F7OA 1SJNA 2HRMA 2BSYA 3HHQA 2HXDA 1DUDA 1RNJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4B0H A;  1SIX A;  2OKE A;  3ZF3 A;  1XS6 A;  1Q5H A;  1DUP A;  4DHK A;  1F7K A;  2QLP A;  3ZF4 A;  3ECY A;  4OOQ A;  3CA9 A;  2XY3 A;  4GK6 A;  3P48 A;  2Y8C A;  3TQ5 A;  3TRL A;  3LOJ A;  2XCE A;  1F7D A;  3TTA A;  2WE2 A;  4GV8 A;  2XX6 A;  3TQ3 A;  1VYQ A;  1SMC A;  1EU5 A;  1F7P A;  3TP1 A;  3I93 A;  2D4L A;  1SLH A;  2D4M A;  2XCD A;  3H6X A;  4A6A A;  2PC5 A;  1OGH A;  3T64 A;  3TPW A;  4AO5 A;  3ZF1 A;  2OL1 A;  3TRN A;  2V9X A;  1XS4 A;  3T6Y A;  5ECT A;  1PKH A;  3SO2 A;  2J4Q A;  1DUN A;  1Q5U X;  2HXB A;  3H6D A;  1EUW A;  3TPS A;  3ZEZ A;  4XJC A;  3TPY A;  2QXX A;  3T70 A;  3MDX A;  5CCT A;  2ZDC A;  1SEH A;  2OKD A;  3ZF0 A;  4AOZ A;  2R9Q A;  1PKK A;  3ARN A;  2HR6 A;  1F7N A;  3TQZ A;  3F4F A;  3C3I A;  3GF0 A;  3KM3 A;  1DUC A;  1XS1 A;  2OKB A;  3TS6 A;  3ARA A;  3HZA A;  1MQ7 A;  5EDD A;  5CCO A;  2PY4 A;  4AOO A;  4LHR A;  2WE3 A;  2BT1 A;  3TQ4 A;  2J4H A;  1SNF A;  1DUT A;  1RN8 A;  3ZF5 A;  3ZF2 A;  5F9K A;  1F7R A;  3ZF6 A;  2BAZ A;  4APZ 1;  3T60 A;  2HQU A;  1PKJ A;  4WRK A;  2OL0 A;  3LQW A;  2WE1 A;  2WE0 A;  3MBQ A;  1SYL A;  1F7Q A;  3C2T A;  4GCY A;  2D4N A;  2Y1T A;  1SM8 A;  3TSL A;  2YZJ A;  4OOP A;  3TPN A;  3EHW A;  1F7O A;  1SJN A;  2HRM A;  2BSY A;  3HHQ A;  2HXD A;  1DUD A;  1RNJ A; 
#chains in the Genus database with same CATH topology
 4B0H A;  1SIX A;  2OKE A;  3ZF3 A;  1XS6 A;  1Q5H A;  1DUP A;  4DHK A;  1F7K A;  2QLP A;  3ZF4 A;  3ECY A;  4OOQ A;  3CA9 A;  2XY3 A;  4GK6 A;  3P48 A;  2Y8C A;  3TQ5 A;  3TRL A;  3LOJ A;  2XCE A;  1F7D A;  3TTA A;  2WE2 A;  4GV8 A;  2XX6 A;  3TQ3 A;  1VYQ A;  1SMC A;  1EU5 A;  1F7P A;  3TP1 A;  3I93 A;  2D4L A;  1SLH A;  1TUL A;  2D4M A;  2XCD A;  3H6X A;  4A6A A;  2PC5 A;  1OGH A;  3T64 A;  3TPW A;  4AO5 A;  3ZF1 A;  2OL1 A;  3TRN A;  2V9X A;  1XS4 A;  3T6Y A;  5ECT A;  1PKH A;  3SO2 A;  2J4Q A;  1DUN A;  1Q5U X;  2HXB A;  3H6D A;  1EUW A;  3TPS A;  3ZEZ A;  4XJC A;  3TPY A;  2QXX A;  3T70 A;  3MDX A;  5CCT A;  2ZDC A;  1SEH A;  2OKD A;  3ZF0 A;  4AOZ A;  2R9Q A;  1PKK A;  3ARN A;  2HR6 A;  1F7N A;  3TQZ A;  3F4F A;  3C3I A;  3GF0 A;  3KM3 A;  1DUC A;  1XS1 A;  2OKB A;  3TS6 A;  3ARA A;  3HZA A;  1MQ7 A;  5EDD A;  5CCO A;  2PY4 A;  4AOO A;  4LHR A;  2WE3 A;  2BT1 A;  3TQ4 A;  2J4H A;  1SNF A;  1DUT A;  1RN8 A;  3ZF5 A;  3ZF2 A;  5F9K A;  1F7R A;  3ZF6 A;  2BAZ A;  4APZ 1;  3T60 A;  2HQU A;  1PKJ A;  4WRK A;  2OL0 A;  3LQW A;  2WE1 A;  2WE0 A;  3MBQ A;  1SYL A;  1F7Q A;  3C2T A;  4GCY A;  2D4N A;  2Y1T A;  1SM8 A;  3TSL A;  2YZJ A;  4OOP A;  3TPN A;  3EHW A;  1F7O A;  1SJN A;  2HRM A;  2BSY A;  3HHQ A;  2HXD A;  1DUD A;  1RNJ A; 
#chains in the Genus database with same CATH homology
 4B0H A;  1SIX A;  2OKE A;  3ZF3 A;  1XS6 A;  1Q5H A;  1DUP A;  4DHK A;  1F7K A;  2QLP A;  3ZF4 A;  3ECY A;  4OOQ A;  3CA9 A;  2XY3 A;  4GK6 A;  3P48 A;  2Y8C A;  3TQ5 A;  3TRL A;  3LOJ A;  2XCE A;  1F7D A;  3TTA A;  2WE2 A;  4GV8 A;  2XX6 A;  3TQ3 A;  1VYQ A;  1SMC A;  1EU5 A;  1F7P A;  3TP1 A;  3I93 A;  2D4L A;  1SLH A;  2D4M A;  2XCD A;  3H6X A;  4A6A A;  2PC5 A;  1OGH A;  3T64 A;  3TPW A;  4AO5 A;  3ZF1 A;  2OL1 A;  3TRN A;  2V9X A;  1XS4 A;  3T6Y A;  5ECT A;  1PKH A;  3SO2 A;  2J4Q A;  1DUN A;  1Q5U X;  2HXB A;  3H6D A;  1EUW A;  3TPS A;  3ZEZ A;  4XJC A;  3TPY A;  2QXX A;  3T70 A;  3MDX A;  5CCT A;  2ZDC A;  1SEH A;  2OKD A;  3ZF0 A;  4AOZ A;  2R9Q A;  1PKK A;  3ARN A;  2HR6 A;  1F7N A;  3TQZ A;  3F4F A;  3C3I A;  3GF0 A;  3KM3 A;  1DUC A;  1XS1 A;  2OKB A;  3TS6 A;  3ARA A;  3HZA A;  1MQ7 A;  5EDD A;  5CCO A;  2PY4 A;  4AOO A;  4LHR A;  2WE3 A;  2BT1 A;  3TQ4 A;  2J4H A;  1SNF A;  1DUT A;  1RN8 A;  3ZF5 A;  3ZF2 A;  5F9K A;  1F7R A;  3ZF6 A;  2BAZ A;  4APZ 1;  3T60 A;  2HQU A;  1PKJ A;  4WRK A;  2OL0 A;  3LQW A;  2WE1 A;  2WE0 A;  3MBQ A;  1SYL A;  1F7Q A;  3C2T A;  4GCY A;  2D4N A;  2Y1T A;  1SM8 A;  3TSL A;  2YZJ A;  4OOP A;  3TPN A;  3EHW A;  1F7O A;  1SJN A;  2HRM A;  2BSY A;  3HHQ A;  2HXD A;  1DUD A;  1RNJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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