3X24A

Crystal structure of nitrile hydratase mutant br56k complexed with trimethylacetonitrile, photo-activated for 120 min
Total Genus 59
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
59
sequence length
197
structure length
195
Chain Sequence
ENAAPAQAPVSDRAWALFRALDGKGLVPDGYVEGWKKTFEEDFSPRRGAELVARAWTDPEFRQLLLTDGTAAVAQYGYLGPQGEYIVAVEDTPTLKNVIVCSLSTAWPILGLPPTWYKSFEYRARVVREPRKVLSEMGTEIASDIEIRVYDTTAETRYMVLPQRPAGTEGWSQEQLQEIVTKDCLIGVAIPQVPT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Time-Resolved Crystallography of the Reaction Intermediate of Nitrile Hydratase: Revealing a Role for the Cysteinesulfenic Acid Ligand as a Catalytic Nucleophile.
pubmed doi rcsb
molecule tags Lyase
source organism Rhodococcus erythropolis
molecule keywords Nitrile hydratase subunit alpha
total genus 59
structure length 195
sequence length 197
ec nomenclature ec 4.2.1.84: Nitrile hydratase.
pdb deposition date 2014-12-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02979 NHase_alpha Nitrile hydratase, alpha chain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.330.10 Alpha Beta Alpha-Beta Complex Nitrile Hydratase; Chain A Nitrile hydratase alpha /Thiocyanate hydrolase gamma 3x24A00
2ZPGA 1UGSA 3A8MA 3QZ5A 3A8GA 2DD5C 2ZZDC 4FM4A 2AHJA 4OB2A 3WVDA 1IREA 3X28A 2DPPA 1UGQA 2ZPBA 4OB3A 3X26A 3VYGC 2D0QA 3A8OA 2DD4C 2ZPEA 3X24A 2DXCC 4ZGDA 4OB1A 2DXBC 3A8LA 2ZPIA 4ZGEA 1AHJA 2ZPFA 3QYHA 3WVEA 4ZGJA 3QZ9A 3HHTA 3A8HA 2ZPHA 3QYGA 2QDYA 1UGPA 2CZ6A 1UGRA 2CZ0A 3QXEA 4OB0A 3X25A 1V29A 2CZ1A 3VYHA 2CYZA 2CZ7A 2ZCFA 3X20A
chains in the Genus database with same CATH superfamily
2ZPGA 1UGSA 3A8MA 3QZ5A 3A8GA 2DD5C 2ZZDC 4FM4A 2AHJA 4OB2A 3WVDA 1IREA 3X28A 2DPPA 1UGQA 2ZPBA 4OB3A 3X26A 3VYGC 2D0QA 3A8OA 2DD4C 2ZPEA 3X24A 2DXCC 4ZGDA 4OB1A 2DXBC 3A8LA 2ZPIA 4ZGEA 1AHJA 2ZPFA 3QYHA 3WVEA 4ZGJA 3QZ9A 3HHTA 3A8HA 2ZPHA 3QYGA 2QDYA 1UGPA 2CZ6A 1UGRA 2CZ0A 3QXEA 4OB0A 3X25A 1V29A 2CZ1A 3VYHA 2CYZA 2CZ7A 2ZCFA 3X20A
chains in the Genus database with same CATH topology
2ZPGA 1UGSA 3A8MA 3QZ5A 3A8GA 2DD5C 2ZZDC 4FM4A 2AHJA 4OB2A 3WVDA 1IREA 3X28A 2DPPA 1UGQA 2ZPBA 4OB3A 3X26A 3VYGC 2D0QA 3A8OA 2DD4C 2ZPEA 3X24A 2DXCC 4ZGDA 4OB1A 2DXBC 3A8LA 2ZPIA 4ZGEA 1AHJA 2ZPFA 3QYHA 3WVEA 4ZGJA 3QZ9A 3HHTA 3A8HA 2ZPHA 3QYGA 2QDYA 1UGPA 2CZ6A 1UGRA 2CZ0A 3QXEA 4OB0A 3X25A 1V29A 2CZ1A 3VYHA 2CYZA 2CZ7A 2ZCFA 3X20A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ZPG A;  1UGS A;  3A8M A;  3QZ5 A;  3A8G A;  2DD5 C;  2ZZD C;  4FM4 A;  2AHJ A;  4OB2 A;  3WVD A;  1IRE A;  3X28 A;  2DPP A;  1UGQ A;  2ZPB A;  4OB3 A;  3X26 A;  3VYG C;  2D0Q A;  3A8O A;  2DD4 C;  2ZPE A;  3X24 A;  2DXC C;  4ZGD A;  4OB1 A;  2DXB C;  3A8L A;  2ZPI A;  4ZGE A;  1AHJ A;  2ZPF A;  3QYH A;  3WVE A;  4ZGJ A;  3QZ9 A;  3HHT A;  3A8H A;  2ZPH A;  3QYG A;  2QDY A;  1UGP A;  2CZ6 A;  1UGR A;  2CZ0 A;  3QXE A;  4OB0 A;  3X25 A;  1V29 A;  2CZ1 A;  3VYH A;  2CYZ A;  2CZ7 A;  2ZCF A;  3X20 A; 
#chains in the Genus database with same CATH topology
 2ZPG A;  1UGS A;  3A8M A;  3QZ5 A;  3A8G A;  2DD5 C;  2ZZD C;  4FM4 A;  2AHJ A;  4OB2 A;  3WVD A;  1IRE A;  3X28 A;  2DPP A;  1UGQ A;  2ZPB A;  4OB3 A;  3X26 A;  3VYG C;  2D0Q A;  3A8O A;  2DD4 C;  2ZPE A;  3X24 A;  2DXC C;  4ZGD A;  4OB1 A;  2DXB C;  3A8L A;  2ZPI A;  4ZGE A;  1AHJ A;  2ZPF A;  3QYH A;  3WVE A;  4ZGJ A;  3QZ9 A;  3HHT A;  3A8H A;  2ZPH A;  3QYG A;  2QDY A;  1UGP A;  2CZ6 A;  1UGR A;  2CZ0 A;  3QXE A;  4OB0 A;  3X25 A;  1V29 A;  2CZ1 A;  3VYH A;  2CYZ A;  2CZ7 A;  2ZCF A;  3X20 A; 
#chains in the Genus database with same CATH homology
 2ZPG A;  1UGS A;  3A8M A;  3QZ5 A;  3A8G A;  2DD5 C;  2ZZD C;  4FM4 A;  2AHJ A;  4OB2 A;  3WVD A;  1IRE A;  3X28 A;  2DPP A;  1UGQ A;  2ZPB A;  4OB3 A;  3X26 A;  3VYG C;  2D0Q A;  3A8O A;  2DD4 C;  2ZPE A;  3X24 A;  2DXC C;  4ZGD A;  4OB1 A;  2DXB C;  3A8L A;  2ZPI A;  4ZGE A;  1AHJ A;  2ZPF A;  3QYH A;  3WVE A;  4ZGJ A;  3QZ9 A;  3HHT A;  3A8H A;  2ZPH A;  3QYG A;  2QDY A;  1UGP A;  2CZ6 A;  1UGR A;  2CZ0 A;  3QXE A;  4OB0 A;  3X25 A;  1V29 A;  2CZ1 A;  3VYH A;  2CYZ A;  2CZ7 A;  2ZCF A;  3X20 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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