3U8H | Genus

Total Genus 45

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus	45
sequence length	124
structure length	124
Chain Sequence	NLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

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Viewer cachePut cache://localLOAD_/file/5d032e97c9bb9836ae0d83fc/pdb.gz

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The Resolver thinks Pdb

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Time for openFile(/file/5d032e97c9bb9836ae0d83fc/pdb.gz): 1271 ms

reading 124 atoms

ModelSet: haveSymmetry:false haveUnitcells:false haveFractionalCoord:false

1 model in this collection. Use getProperty "modelInfo" or getProperty "auxiliaryInfo" to inspect them.

Default Van der Waals type for model set to Jmol

124 atoms created

ModelSet: autobonding; use autobond=false to not generate bonds automatically

Time for creating model: 20 ms

Adding embedded #jmolscript: select ({0:123});backbone only;select *;

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Genus data interpretation

Chord Diagram

molecule tags	Hydrolase
source organism	Homo sapiens
publication title	Selective Inhibition of Human Group IIA-secreted Phospholipase A2 (hGIIA) Signaling Reveals Arachidonic Acid Metabolism Is Associated with Colocalization of hGIIA to Vimentin in Rheumatoid Synoviocytes. pubmed doi rcsb
molecule keywords	Phospholipase A2, membrane associated
total genus	45
structure length	124
sequence length	124
chains with identical sequence	B
ec nomenclature	ec 3.1.1.4: Phospholipase A(2).
pdb deposition date	2011-10-17

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00068	Phospholip_A2_1	Phospholipase A2

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.20.90.10	Mainly Alpha	Up-down Bundle	Phospholipase A2	Phospholipase A2 domain	3u8hA00

3FVIA 1PO8A 2OSNA 2QOGA 1MH7A 1OYFB 3CBIA 1TDVA 1Q5TA 1N28A 3U8HA 2PHIA 1XXWA 3HSWA 4HMBA 1IT4A 1ZLBA 1Y6PA 4BP2A 1M8SA 1A2AA 2B17A 4NTWC 3UX7A 1OXLA 4K09A 1PSHA 2B04A 1POCA 1MF4A 1TG1A 4FGAA 1P2PA 2QHWA 1OWSB 1P7OA 2B96A 4G5IA 1G4IA 1GH4A 1JQ8A 2BPPA 4YU7A 2BP2A 3BP2A 1GMZA 1KPMA 1MH2A 2OSHA 1LE7A 3T0RA 5G3MA 1FAZA 3VC0A 1SQZA 4WTBA 3Q4YA 1LN8A 1MG6A 1A3DA 2B03A 1TGMA 2DO2A 1CLPA 1PISA 4UY1A 4QGDA 2QVDA 2PWSA 2AZZA 1Y4LA 2ZP5A 1MKVA 2ZP4A 1FB2A 2I0UA 1SV3A 1DB4A 1O2EA 3BJWA 2NOTA 1SZ8A 1O3WA 1OQSA 1XXSA 1SV9A 1MC2A 4O1YA 1VAPA 1Y75B 1FV0A 1BK9A 2PMJA 3G8HA 3H1XA 2WG8B 3FG5A 1OZ6A 1SFVA 1S8GA 1BJJA 1TC8A 1KVWA 1AOKA 1T37A 1DB5A 2RD4B 4P2PA 1N29A 3GCIA 4GLDA 1ZWPA 4YV5A 3R0LD 1IRBA 2B01A 2DPZA 1SFWA 1KP4A 2OYFA 4RFPA 2WQ5A 2PB8A 1Y6OA 1FE5A 2QOGB 1B4WA 1IT5A 1C1JA 3VBZA 1Q7AA 1M8RA 1XXWB 1KVXA 1PIRA 1SKGA 2AOZA 1CEHA 1LWBA 1S6BA 1TG4A 1S8IA 2H8IA 1OZYA 3QLMA 3I03A 4DCFA 1KVYA 1LE6A 2OTHA 3IQ3A 3I3HA 3MLMA 4E4CA 1BPQA 1BP2A 1J1AA 1OXRA 3NJUA 2QU9A 4EIXA 1DPYA 1OYFA 1C74A 1YXHA 4GFYA 3QNLA 1MH2B 1POAA 1TK4A 2PVTA 2OK9A 4QMCA 1ZYXA 1U4JA 1TJ9A 1GP7A 1PODA 2Q2JA 4K06A 3FVJA 3JR8A 1VL9A 1RGBA 1ZM6A 1IJLA 1Q6VA 1Z76A 2GNSA 4QF8A 1G0ZA 4YZ7A 2BAXA 2FNXA 1BVMA 1U73A 2OQDA 4KF3A 1TD7A 3DIHA 1OWSA 1S8HA 1VKQA 1UNEA 3P2PA 1QLLA 1ZL7A 3G8GA 3U8IA 1DCYA 3L30A 1JQ9A 2ZBHA 2WG7A 2H4CB 2PH4A 3CYLA 1L8SA 3O4MA 4QERA 1FX9A 1MKSA 1M8TA 2ARMA 1PPAA 1YXLA 1CL5A 1JLTB 3HZWA 4H0SA 1FDKA 3FO7A 3OSHA 1PC9A 2OTFA 1OQSB 1A3FA 1PSJA 2B00A 2QUEA 3ELOA 2ZP3A 1POBA 1GODA 4NTYC 2AZYA 1BBCA 1SXKA 1HN4A 1AOKB 1AE7A 2BD1A 5P2PA 1MKTA 2PYCA 2OUBA 3I3IA 1JIAA 1KQUA 2O1NA 4QF7A 1G2XA 1MKUA 2QHEA 2OLIA 1Y38A 1PP2L 1VPIA 3V9MA 2BCHA 2QHDA 1FXFA 3JTIA 4NTXC 1PWOA 1ZR8A 2Q1PA 1Y75A 4DBKA 1TP2A 3HZDA 2WG9A 1TH6A 1VIPA 4QEMA 3U8DA 3CXIA 3G8FA 1S6BB 2WG8A 1AYPA 5G3NA 1PA0A 3JQ5A 3JQLA 1UMVX 1TJKA 2RD4A 2G58A 2H4CA 1BUNA 4AUPA 3U8BA 1KVOA 4HG9A 1POEA 1MH8A 1JLTA
chains in the Genus database with same CATH superfamily

#chains in the Genus database with same CATH superfamily
 3FVI A;  1PO8 A;  2OSN A;  2QOG A;  1MH7 A;  1OYF B;  3CBI A;  1TDV A;  1Q5T A;  1N28 A;  3U8H A;  2PHI A;  1XXW A;  3HSW A;  4HMB A;  1IT4 A;  1ZLB A;  1Y6P A;  4BP2 A;  1M8S A;  1A2A A;  2B17 A;  4NTW C;  3UX7 A;  1OXL A;  4K09 A;  1PSH A;  2B04 A;  1POC A;  1MF4 A;  1TG1 A;  4FGA A;  1P2P A;  2QHW A;  1OWS B;  1P7O A;  2B96 A;  4G5I A;  1G4I A;  1GH4 A;  1JQ8 A;  2BPP A;  4YU7 A;  2BP2 A;  3BP2 A;  1GMZ A;  1KPM A;  1MH2 A;  2OSH A;  1LE7 A;  3T0R A;  5G3M A;  1FAZ A;  3VC0 A;  1SQZ A;  4WTB A;  3Q4Y A;  1LN8 A;  1MG6 A;  1A3D A;  2B03 A;  1TGM A;  2DO2 A;  1CLP A;  1PIS A;  4UY1 A;  4QGD A;  2QVD A;  2PWS A;  2AZZ A;  1Y4L A;  2ZP5 A;  1MKV A;  2ZP4 A;  1FB2 A;  2I0U A;  1SV3 A;  1DB4 A;  1O2E A;  3BJW A;  2NOT A;  1SZ8 A;  1O3W A;  1OQS A;  1XXS A;  1SV9 A;  1MC2 A;  4O1Y A;  1VAP A;  1Y75 B;  1FV0 A;  1BK9 A;  2PMJ A;  3G8H A;  3H1X A;  2WG8 B;  3FG5 A;  1OZ6 A;  1SFV A;  1S8G A;  1BJJ A;  1TC8 A;  1KVW A;  1AOK A;  1T37 A;  1DB5 A;  2RD4 B;  4P2P A;  1N29 A;  3GCI A;  4GLD A;  1ZWP A;  4YV5 A;  3R0L D;  1IRB A;  2B01 A;  2DPZ A;  1SFW A;  1KP4 A;  2OYF A;  4RFP A;  2WQ5 A;  2PB8 A;  1Y6O A;  1FE5 A;  2QOG B;  1B4W A;  1IT5 A;  1C1J A;  3VBZ A;  1Q7A A;  1M8R A;  1XXW B;  1KVX A;  1PIR A;  1SKG A;  2AOZ A;  1CEH A;  1LWB A;  1S6B A;  1TG4 A;  1S8I A;  2H8I A;  1OZY A;  3QLM A;  3I03 A;  4DCF A;  1KVY A;  1LE6 A;  2OTH A;  3IQ3 A;  3I3H A;  3MLM A;  4E4C A;  1BPQ A;  1BP2 A;  1J1A A;  1OXR A;  3NJU A;  2QU9 A;  4EIX A;  1DPY A;  1OYF A;  1C74 A;  1YXH A;  4GFY A;  3QNL A;  1MH2 B;  1POA A;  1TK4 A;  2PVT A;  2OK9 A;  4QMC A;  1ZYX A;  1U4J A;  1TJ9 A;  1GP7 A;  1POD A;  2Q2J A;  4K06 A;  3FVJ A;  3JR8 A;  1VL9 A;  1RGB A;  1ZM6 A;  1IJL A;  1Q6V A;  1Z76 A;  2GNS A;  4QF8 A;  1G0Z A;  4YZ7 A;  2BAX A;  2FNX A;  1BVM A;  1U73 A;  2OQD A;  4KF3 A;  1TD7 A;  3DIH A;  1OWS A;  1S8H A;  1VKQ A;  1UNE A;  3P2P A;  1QLL A;  1ZL7 A;  3G8G A;  3U8I A;  1DCY A;  3L30 A;  1JQ9 A;  2ZBH A;  2WG7 A;  2H4C B;  2PH4 A;  3CYL A;  1L8S A;  3O4M A;  4QER A;  1FX9 A;  1MKS A;  1M8T A;  2ARM A;  1PPA A;  1YXL A;  1CL5 A;  1JLT B;  3HZW A;  4H0S A;  1FDK A;  3FO7 A;  3OSH A;  1PC9 A;  2OTF A;  1OQS B;  1A3F A;  1PSJ A;  2B00 A;  2QUE A;  3ELO A;  2ZP3 A;  1POB A;  1GOD A;  4NTY C;  2AZY A;  1BBC A;  1SXK A;  1HN4 A;  1AOK B;  1AE7 A;  2BD1 A;  5P2P A;  1MKT A;  2PYC A;  2OUB A;  3I3I A;  1JIA A;  1KQU A;  2O1N A;  4QF7 A;  1G2X A;  1MKU A;  2QHE A;  2OLI A;  1Y38 A;  1PP2 L;  1VPI A;  3V9M A;  2BCH A;  2QHD A;  1FXF A;  3JTI A;  4NTX C;  1PWO A;  1ZR8 A;  2Q1P A;  1Y75 A;  4DBK A;  1TP2 A;  3HZD A;  2WG9 A;  1TH6 A;  1VIP A;  4QEM A;  3U8D A;  3CXI A;  3G8F A;  1S6B B;  2WG8 A;  1AYP A;  5G3N A;  1PA0 A;  3JQ5 A;  3JQL A;  1UMV X;  1TJK A;  2RD4 A;  2G58 A;  2H4C A;  1BUN A;  4AUP A;  3U8B A;  1KVO A;  4HG9 A;  1POE A;  1MH8 A;  1JLT A; 
#chains in the Genus database with same CATH topology
 3FVI A;  1PO8 A;  2OSN A;  2QOG A;  1MH7 A;  1OYF B;  3CBI A;  1TDV A;  1Q5T A;  1N28 A;  3U8H A;  2PHI A;  1XXW A;  3HSW A;  4HMB A;  1IT4 A;  1ZLB A;  1Y6P A;  4BP2 A;  1M8S A;  1A2A A;  2B17 A;  4NTW C;  3UX7 A;  1OXL A;  4K09 A;  1PSH A;  2B04 A;  1POC A;  1MF4 A;  1TG1 A;  4FGA A;  1P2P A;  2QHW A;  1OWS B;  1P7O A;  2B96 A;  4G5I A;  1G4I A;  1GH4 A;  1JQ8 A;  2BPP A;  4YU7 A;  2BP2 A;  3BP2 A;  1GMZ A;  1KPM A;  1MH2 A;  2OSH A;  1LE7 A;  3T0R A;  5G3M A;  1FAZ A;  3VC0 A;  1SQZ A;  4WTB A;  3Q4Y A;  1LN8 A;  1MG6 A;  1A3D A;  2B03 A;  1TGM A;  2DO2 A;  1CLP A;  1PIS A;  4UY1 A;  4QGD A;  2QVD A;  2PWS A;  2AZZ A;  1Y4L A;  2ZP5 A;  1MKV A;  2ZP4 A;  1FB2 A;  2I0U A;  1SV3 A;  1DB4 A;  1O2E A;  3BJW A;  2NOT A;  1SZ8 A;  1O3W A;  1OQS A;  1XXS A;  1SV9 A;  1MC2 A;  4O1Y A;  1VAP A;  1Y75 B;  1FV0 A;  1BK9 A;  2PMJ A;  3G8H A;  3H1X A;  2WG8 B;  3FG5 A;  1OZ6 A;  1SFV A;  1S8G A;  1BJJ A;  1TC8 A;  1KVW A;  1AOK A;  1T37 A;  1DB5 A;  2RD4 B;  4P2P A;  1N29 A;  3GCI A;  4GLD A;  1ZWP A;  4YV5 A;  3R0L D;  1IRB A;  2B01 A;  2DPZ A;  1SFW A;  1KP4 A;  2OYF A;  4RFP A;  2WQ5 A;  2PB8 A;  1Y6O A;  1FE5 A;  2QOG B;  1B4W A;  1IT5 A;  1C1J A;  3VBZ A;  1Q7A A;  1M8R A;  1XXW B;  1KVX A;  1PIR A;  1SKG A;  2AOZ A;  1CEH A;  1LWB A;  1S6B A;  1TG4 A;  1S8I A;  2H8I A;  1OZY A;  3QLM A;  3I03 A;  4DCF A;  1KVY A;  1LE6 A;  2OTH A;  3IQ3 A;  3I3H A;  3MLM A;  4E4C A;  1BPQ A;  1BP2 A;  1J1A A;  1OXR A;  3NJU A;  2QU9 A;  4EIX A;  1DPY A;  1OYF A;  1C74 A;  1YXH A;  4GFY A;  3QNL A;  1MH2 B;  1POA A;  1TK4 A;  2PVT A;  2OK9 A;  4QMC A;  1ZYX A;  1U4J A;  1TJ9 A;  1GP7 A;  1POD A;  2Q2J A;  4K06 A;  3FVJ A;  3JR8 A;  1VL9 A;  1RGB A;  1ZM6 A;  1IJL A;  1Q6V A;  1Z76 A;  2GNS A;  4QF8 A;  1G0Z A;  4YZ7 A;  2BAX A;  2FNX A;  1BVM A;  1U73 A;  2OQD A;  4KF3 A;  1TD7 A;  3DIH A;  1OWS A;  1S8H A;  1VKQ A;  1UNE A;  3P2P A;  1QLL A;  1ZL7 A;  3G8G A;  3U8I A;  1DCY A;  3L30 A;  1JQ9 A;  2ZBH A;  2WG7 A;  2H4C B;  2PH4 A;  3CYL A;  1L8S A;  3O4M A;  4QER A;  1FX9 A;  1MKS A;  1M8T A;  2ARM A;  1PPA A;  1YXL A;  1CL5 A;  1JLT B;  3HZW A;  4H0S A;  1FDK A;  3FO7 A;  3OSH A;  1PC9 A;  2OTF A;  1OQS B;  1A3F A;  1PSJ A;  2B00 A;  2QUE A;  3ELO A;  2ZP3 A;  1POB A;  1GOD A;  4NTY C;  2AZY A;  1BBC A;  1SXK A;  1HN4 A;  1AOK B;  1AE7 A;  2BD1 A;  5P2P A;  1MKT A;  2PYC A;  2OUB A;  3I3I A;  1JIA A;  1KQU A;  2O1N A;  4QF7 A;  1G2X A;  1MKU A;  2QHE A;  2OLI A;  1Y38 A;  1PP2 L;  1VPI A;  3V9M A;  2BCH A;  2QHD A;  1FXF A;  3JTI A;  4NTX C;  1PWO A;  1ZR8 A;  2Q1P A;  1Y75 A;  4DBK A;  1TP2 A;  3HZD A;  2WG9 A;  1TH6 A;  1VIP A;  4QEM A;  3U8D A;  3CXI A;  3G8F A;  1S6B B;  2WG8 A;  1AYP A;  5G3N A;  1PA0 A;  3JQ5 A;  3JQL A;  1UMV X;  1TJK A;  2RD4 A;  2G58 A;  2H4C A;  1BUN A;  4AUP A;  3U8B A;  1KVO A;  4HG9 A;  1POE A;  1MH8 A;  1JLT A; 
#chains in the Genus database with same CATH homology
 3FVI A;  1PO8 A;  2OSN A;  2QOG A;  1MH7 A;  1OYF B;  3CBI A;  1TDV A;  1Q5T A;  1N28 A;  3U8H A;  2PHI A;  1XXW A;  3HSW A;  4HMB A;  1IT4 A;  1ZLB A;  1Y6P A;  4BP2 A;  1M8S A;  1A2A A;  2B17 A;  4NTW C;  3UX7 A;  1OXL A;  4K09 A;  1PSH A;  2B04 A;  1POC A;  1MF4 A;  1TG1 A;  4FGA A;  1P2P A;  2QHW A;  1OWS B;  1P7O A;  2B96 A;  4G5I A;  1G4I A;  1GH4 A;  1JQ8 A;  2BPP A;  4YU7 A;  2BP2 A;  3BP2 A;  1GMZ A;  1KPM A;  1MH2 A;  2OSH A;  1LE7 A;  3T0R A;  5G3M A;  1FAZ A;  3VC0 A;  1SQZ A;  4WTB A;  3Q4Y A;  1LN8 A;  1MG6 A;  1A3D A;  2B03 A;  1TGM A;  2DO2 A;  1CLP A;  1PIS A;  4UY1 A;  4QGD A;  2QVD A;  2PWS A;  2AZZ A;  1Y4L A;  2ZP5 A;  1MKV A;  2ZP4 A;  1FB2 A;  2I0U A;  1SV3 A;  1DB4 A;  1O2E A;  3BJW A;  2NOT A;  1SZ8 A;  1O3W A;  1OQS A;  1XXS A;  1SV9 A;  1MC2 A;  4O1Y A;  1VAP A;  1Y75 B;  1FV0 A;  1BK9 A;  2PMJ A;  3G8H A;  3H1X A;  2WG8 B;  3FG5 A;  1OZ6 A;  1SFV A;  1S8G A;  1BJJ A;  1TC8 A;  1KVW A;  1AOK A;  1T37 A;  1DB5 A;  2RD4 B;  4P2P A;  1N29 A;  3GCI A;  4GLD A;  1ZWP A;  4YV5 A;  3R0L D;  1IRB A;  2B01 A;  2DPZ A;  1SFW A;  1KP4 A;  2OYF A;  4RFP A;  2WQ5 A;  2PB8 A;  1Y6O A;  1FE5 A;  2QOG B;  1B4W A;  1IT5 A;  1C1J A;  3VBZ A;  1Q7A A;  1M8R A;  1XXW B;  1KVX A;  1PIR A;  1SKG A;  2AOZ A;  1CEH A;  1LWB A;  1S6B A;  1TG4 A;  1S8I A;  2H8I A;  1OZY A;  3QLM A;  3I03 A;  4DCF A;  1KVY A;  1LE6 A;  2OTH A;  3IQ3 A;  3I3H A;  3MLM A;  4E4C A;  1BPQ A;  1BP2 A;  1J1A A;  1OXR A;  3NJU A;  2QU9 A;  4EIX A;  1DPY A;  1OYF A;  1C74 A;  1YXH A;  4GFY A;  3QNL A;  1MH2 B;  1POA A;  1TK4 A;  2PVT A;  2OK9 A;  4QMC A;  1ZYX A;  1U4J A;  1TJ9 A;  1GP7 A;  1POD A;  2Q2J A;  4K06 A;  3FVJ A;  3JR8 A;  1VL9 A;  1RGB A;  1ZM6 A;  1IJL A;  1Q6V A;  1Z76 A;  2GNS A;  4QF8 A;  1G0Z A;  4YZ7 A;  2BAX A;  2FNX A;  1BVM A;  1U73 A;  2OQD A;  4KF3 A;  1TD7 A;  3DIH A;  1OWS A;  1S8H A;  1VKQ A;  1UNE A;  3P2P A;  1QLL A;  1ZL7 A;  3G8G A;  3U8I A;  1DCY A;  3L30 A;  1JQ9 A;  2ZBH A;  2WG7 A;  2H4C B;  2PH4 A;  3CYL A;  1L8S A;  3O4M A;  4QER A;  1FX9 A;  1MKS A;  1M8T A;  2ARM A;  1PPA A;  1YXL A;  1CL5 A;  1JLT B;  3HZW A;  4H0S A;  1FDK A;  3FO7 A;  3OSH A;  1PC9 A;  2OTF A;  1OQS B;  1A3F A;  1PSJ A;  2B00 A;  2QUE A;  3ELO A;  2ZP3 A;  1POB A;  1GOD A;  4NTY C;  2AZY A;  1BBC A;  1SXK A;  1HN4 A;  1AOK B;  1AE7 A;  2BD1 A;  5P2P A;  1MKT A;  2PYC A;  2OUB A;  3I3I A;  1JIA A;  1KQU A;  2O1N A;  4QF7 A;  1G2X A;  1MKU A;  2QHE A;  2OLI A;  1Y38 A;  1PP2 L;  1VPI A;  3V9M A;  2BCH A;  2QHD A;  1FXF A;  3JTI A;  4NTX C;  1PWO A;  1ZR8 A;  2Q1P A;  1Y75 A;  4DBK A;  1TP2 A;  3HZD A;  2WG9 A;  1TH6 A;  1VIP A;  4QEM A;  3U8D A;  3CXI A;  3G8F A;  1S6B B;  2WG8 A;  1AYP A;  5G3N A;  1PA0 A;  3JQ5 A;  3JQL A;  1UMV X;  1TJK A;  2RD4 A;  2G58 A;  2H4C A;  1BUN A;  4AUP A;  3U8B A;  1KVO A;  4HG9 A;  1POE A;  1MH8 A;  1JLT A;

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similar chains in the Genus database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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3U8HA

Total Genus

sequence length

structure length

Chain Sequence

Structure visualization

Chord Diagram

connected with : NaN

pfam database annotations