3UI7A

Discovery of orally active pyrazoloquinoline as a potent pde10 inhibitor for the management of schizophrenia
Total Genus 124
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
124
sequence length
315
structure length
315
Chain Sequence
WQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Discovery of orally active pyrazoloquinolines as potent PDE10 inhibitors for the management of schizophrenia.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase
total genus 124
structure length 315
sequence length 315
chains with identical sequence B
ec nomenclature ec 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
pdb deposition date 2011-11-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00233 PDEase_I 3'5'-cyclic nucleotide phosphodiesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1300.10 Mainly Alpha Orthogonal Bundle Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain 3ui7A00
4GH6A 3ECNA 1XN0A 1Z1LA 5B4LA 1XLZA 3WI2A 1Q9MA 4MVHA 3K4SA 3IADA 3SHZA 4MRWA 4YQHA 1MKDA 1XM6A 1Y2KA 2OURA 2HD1A 3SL6A 3HC8A 2CHMA 3UI7A 3V94A 4BBXA 3G4GA 5K32A 4AJMA 1UDTA 4NPVA 3HQYA 4PM0A 3DYNA 3G4KA 3BJCA 5AXPA 2FM5A 2WEYA 4NPWA 4W1OA 3V93A 1XM4B 1Y2CA 3SL5A 3QPOA 3G58A 3IBJA 1T9SA 1F0JA 5EDEA 5AXQA 3JSWA 4TPMA 3G4IA 2O8HA 2QYLA 3HQZA 4DFFA 1TBFA 1ZKLA 3WS8A 4MSNA 2OUPA 1XLXA 4C1IA 3O56A 4LM2A 2H44A 2R8QA 1XMUA 1Y2HA 3JWQA 2QYMA 4FCBA 4LM3A 3SL3A 3KKTA 3FRGA 5C2HA 3SHYA 3N3ZA 4OEWA 1TAZA 4FCDA 4LLPA 4MSHA 1RO6A 3K3HA 3LXGA 4MS0A 3ITMA 3JSIA 3SNLA 3DY8A 3DYSA 4ZO5A 3B2RA 4XY2A 3QPNA 5EDIA 1Y2DA 2Y0JA 4AJDA 1RKPA 2OUYA 4I15A 4Y86A 4KP6A 4HTXA 4AJFA 5DH4A 4MRZA 3W5EA 3TGEA 4PHWA 3DYLA 1XMYB 4LLJA 4P0NA 2QYNA 4TPPA 5C1WA 4LM0A 1TB7A 3SL4A 3GWTA 5EDEB 1XOZA 1XORA 2OUVA 2H42A 4MYQA 1XOQA 3SNIA 4PHLA 3UUOA 2PW3A 3TGGA 3SL8A 3I8VA 3O57A 3O0JA 1XP0A 2FM0A 1T9RA 1XOSA 3SIEA 3WS9A 3WYMA 4D08A 1XOTA 3IAKA 1TB5A 3HQWA 2QYKA 4MSCA 4YS7A 2OUNA 5C2AA 2OVYA 4X0FA 1SOJA 1XONA 1XMUB 4HF4A 4OEXA 4QGEA 4P1RA 5EDGA 4WCUA 2YY2A 5B4KA 4HTZA 5B25A 1XM4A 3HR1A 4LM1A 1Y2JA 3G4LA 4IA0A 4AJGA 3V9BA 4LKQA 2H40A 4LM4A 4MSEA 3G45A 4LLXA 4MD6A 4LLKA 3WYLA 1RO9A 5K9RA 4Y87A 4OGBA 3QI4A 4NW7A 5C28A 2OVVA 1Y2BA 1OYNA 3ITUA 4DDLA 4MUWA 1XOMA 4E90A 3QPPA 5I2RA 1SO2A 5C29A 3G3NA 4G2YA 1Y2EA 4D09A 5K1IA 3ECMA 1UDUA 2OUUA 3LY2A 4I9ZA 5EDHA 3HMVA 3JWRA 3K3EA 1TBBA 4Y8CA 3SN7A 5C2EA 3WD9A 4G2WA 4G2JA 1ZKNA 3DYQA 5EDGB 4AELA 1XMYA 3WYKA 4WN1A 4G2LA 4JIBA 4Y2BA 2OUSA 1PTWA 1RORA 1UHOA 2OUQA 4WZIA 3TVXA 4MSAA 5DH5A 3QI3A 5EDIB 3HDZA 3D3PA 4HEUA
chains in the Genus database with same CATH superfamily
4GH6A 3ECNA 1XN0A 1Z1LA 5B4LA 1XLZA 3WI2A 1Q9MA 4MVHA 3K4SA 3IADA 3SHZA 4MRWA 4YQHA 1MKDA 1XM6A 1Y2KA 2OURA 2HD1A 3SL6A 3HC8A 2CHMA 3UI7A 3V94A 4BBXA 3G4GA 5K32A 4AJMA 1UDTA 4NPVA 3HQYA 4PM0A 3DYNA 3G4KA 3BJCA 5AXPA 2FM5A 2WEYA 4NPWA 4W1OA 3V93A 1XM4B 1Y2CA 3SL5A 3QPOA 3G58A 3IBJA 1T9SA 1F0JA 5EDEA 5AXQA 3JSWA 4TPMA 3G4IA 2O8HA 2QYLA 3HQZA 4DFFA 1TBFA 1ZKLA 3WS8A 4MSNA 2OUPA 1XLXA 4C1IA 3O56A 4LM2A 2H44A 2R8QA 1XMUA 1Y2HA 3JWQA 2QYMA 4FCBA 4LM3A 3SL3A 3KKTA 3FRGA 5C2HA 3SHYA 3N3ZA 4OEWA 1TAZA 4FCDA 4LLPA 4MSHA 1RO6A 3K3HA 3LXGA 4MS0A 3ITMA 3JSIA 3SNLA 3DY8A 3DYSA 4ZO5A 3B2RA 4XY2A 3QPNA 5EDIA 1Y2DA 2Y0JA 4AJDA 1RKPA 2OUYA 4I15A 4Y86A 4KP6A 4HTXA 4AJFA 5DH4A 4MRZA 3W5EA 3TGEA 4PHWA 3DYLA 1XMYB 4LLJA 4P0NA 2QYNA 4TPPA 5C1WA 4LM0A 1TB7A 3SL4A 3GWTA 5EDEB 1XOZA 1XORA 2OUVA 2H42A 4MYQA 1XOQA 3SNIA 4PHLA 3UUOA 2PW3A 3TGGA 3SL8A 3I8VA 3O57A 3O0JA 1XP0A 2FM0A 1T9RA 1XOSA 3SIEA 3WS9A 3WYMA 4D08A 1XOTA 3IAKA 1TB5A 3HQWA 2QYKA 4MSCA 4YS7A 2OUNA 5C2AA 2OVYA 4X0FA 1SOJA 1XONA 1XMUB 4HF4A 4OEXA 4QGEA 4P1RA 5EDGA 4WCUA 2YY2A 5B4KA 4HTZA 5B25A 1XM4A 3HR1A 4LM1A 1Y2JA 3G4LA 4IA0A 4AJGA 3V9BA 4LKQA 2H40A 4LM4A 4MSEA 3G45A 4LLXA 4MD6A 4LLKA 3WYLA 1RO9A 5K9RA 4Y87A 4OGBA 3QI4A 4NW7A 5C28A 2OVVA 1Y2BA 1OYNA 3ITUA 4DDLA 4MUWA 1XOMA 4E90A 3QPPA 5I2RA 1SO2A 5C29A 3G3NA 4G2YA 1Y2EA 4D09A 5K1IA 3ECMA 1UDUA 2OUUA 3LY2A 4I9ZA 5EDHA 3HMVA 3JWRA 3K3EA 1TBBA 4Y8CA 3SN7A 5C2EA 3WD9A 4G2WA 4G2JA 1ZKNA 3DYQA 5EDGB 4AELA 1XMYA 3WYKA 4WN1A 4G2LA 4JIBA 4Y2BA 2OUSA 1PTWA 1RORA 1UHOA 2OUQA 4WZIA 3TVXA 4MSAA 5DH5A 3QI3A 5EDIB 3HDZA 3D3PA 4HEUA
chains in the Genus database with same CATH topology
4GH6A 3ECNA 1XN0A 1Z1LA 5B4LA 1XLZA 3WI2A 1Q9MA 4MVHA 3K4SA 3IADA 3SHZA 4MRWA 4YQHA 1MKDA 1XM6A 1Y2KA 2OURA 2HD1A 3SL6A 3HC8A 2CHMA 3UI7A 3V94A 4BBXA 3G4GA 5K32A 4AJMA 1UDTA 4NPVA 3HQYA 4PM0A 3DYNA 3G4KA 3BJCA 5AXPA 2FM5A 2WEYA 4NPWA 4W1OA 3V93A 1XM4B 1Y2CA 3SL5A 3QPOA 3G58A 3IBJA 1T9SA 1F0JA 5EDEA 5AXQA 3JSWA 4TPMA 3G4IA 2O8HA 2QYLA 3HQZA 4DFFA 1TBFA 1ZKLA 3WS8A 4MSNA 2OUPA 1XLXA 4C1IA 3O56A 4LM2A 2H44A 2R8QA 1XMUA 1Y2HA 3JWQA 2QYMA 4FCBA 4LM3A 3SL3A 3KKTA 3FRGA 5C2HA 3SHYA 3N3ZA 4OEWA 1TAZA 4FCDA 4LLPA 4MSHA 1RO6A 3K3HA 3LXGA 4MS0A 3ITMA 3JSIA 3SNLA 3DY8A 3DYSA 4ZO5A 3B2RA 4XY2A 3QPNA 5EDIA 1Y2DA 2Y0JA 4AJDA 1RKPA 2OUYA 4I15A 4Y86A 4KP6A 4HTXA 4AJFA 5DH4A 4MRZA 3W5EA 3TGEA 4PHWA 3DYLA 1XMYB 4LLJA 4P0NA 2QYNA 4TPPA 5C1WA 4LM0A 1TB7A 3SL4A 3GWTA 5EDEB 1XOZA 1XORA 2OUVA 2H42A 4MYQA 1XOQA 3SNIA 4PHLA 3UUOA 2PW3A 3TGGA 3SL8A 3I8VA 3O57A 3O0JA 1XP0A 2FM0A 1T9RA 1XOSA 3SIEA 3WS9A 3WYMA 4D08A 1XOTA 3IAKA 1TB5A 3HQWA 2QYKA 4MSCA 4YS7A 2OUNA 5C2AA 2OVYA 4X0FA 1SOJA 1XONA 1XMUB 4HF4A 4OEXA 4QGEA 4P1RA 5EDGA 4WCUA 2YY2A 5B4KA 4HTZA 5B25A 1XM4A 3HR1A 4LM1A 1Y2JA 3G4LA 4IA0A 4AJGA 3V9BA 4LKQA 2H40A 4LM4A 4MSEA 3G45A 4LLXA 4MD6A 4LLKA 3WYLA 1RO9A 5K9RA 4Y87A 4OGBA 3QI4A 4NW7A 5C28A 2OVVA 1Y2BA 1OYNA 3ITUA 4DDLA 4MUWA 1XOMA 4E90A 3QPPA 5I2RA 1SO2A 5C29A 3G3NA 4G2YA 1Y2EA 4D09A 5K1IA 3ECMA 1UDUA 2OUUA 3LY2A 4I9ZA 5EDHA 3HMVA 3JWRA 3K3EA 1TBBA 4Y8CA 3SN7A 5C2EA 3WD9A 4G2WA 4G2JA 1ZKNA 3DYQA 5EDGB 4AELA 1XMYA 3WYKA 4WN1A 4G2LA 4JIBA 4Y2BA 2OUSA 1PTWA 1RORA 1UHOA 2OUQA 4WZIA 3TVXA 4MSAA 5DH5A 3QI3A 5EDIB 3HDZA 3D3PA 4HEUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4GH6 A;  3ECN A;  1XN0 A;  1Z1L A;  5B4L A;  1XLZ A;  3WI2 A;  1Q9M A;  4MVH A;  3K4S A;  3IAD A;  3SHZ A;  4MRW A;  4YQH A;  1MKD A;  1XM6 A;  1Y2K A;  2OUR A;  2HD1 A;  3SL6 A;  3HC8 A;  2CHM A;  3UI7 A;  3V94 A;  4BBX A;  3G4G A;  5K32 A;  4AJM A;  1UDT A;  4NPV A;  3HQY A;  4PM0 A;  3DYN A;  3G4K A;  3BJC A;  5AXP A;  2FM5 A;  2WEY A;  4NPW A;  4W1O A;  3V93 A;  1XM4 B;  1Y2C A;  3SL5 A;  3QPO A;  3G58 A;  3IBJ A;  1T9S A;  1F0J A;  5EDE A;  5AXQ A;  3JSW A;  4TPM A;  3G4I A;  2O8H A;  2QYL A;  3HQZ A;  4DFF A;  1TBF A;  1ZKL A;  3WS8 A;  4MSN A;  2OUP A;  1XLX A;  4C1I A;  3O56 A;  4LM2 A;  2H44 A;  2R8Q A;  1XMU A;  1Y2H A;  3JWQ A;  2QYM A;  4FCB A;  4LM3 A;  3SL3 A;  3KKT A;  3FRG A;  5C2H A;  3SHY A;  3N3Z A;  4OEW A;  1TAZ A;  4FCD A;  4LLP A;  4MSH A;  1RO6 A;  3K3H A;  3LXG A;  4MS0 A;  3ITM A;  3JSI A;  3SNL A;  3DY8 A;  3DYS A;  4ZO5 A;  3B2R A;  4XY2 A;  3QPN A;  5EDI A;  1Y2D A;  2Y0J A;  4AJD A;  1RKP A;  2OUY A;  4I15 A;  4Y86 A;  4KP6 A;  4HTX A;  4AJF A;  5DH4 A;  4MRZ A;  3W5E A;  3TGE A;  4PHW A;  3DYL A;  1XMY B;  4LLJ A;  4P0N A;  2QYN A;  4TPP A;  5C1W A;  4LM0 A;  1TB7 A;  3SL4 A;  3GWT A;  5EDE B;  1XOZ A;  1XOR A;  2OUV A;  2H42 A;  4MYQ A;  1XOQ A;  3SNI A;  4PHL A;  3UUO A;  2PW3 A;  3TGG A;  3SL8 A;  3I8V A;  3O57 A;  3O0J A;  1XP0 A;  2FM0 A;  1T9R A;  1XOS A;  3SIE A;  3WS9 A;  3WYM A;  4D08 A;  1XOT A;  3IAK A;  1TB5 A;  3HQW A;  2QYK A;  4MSC A;  4YS7 A;  2OUN A;  5C2A A;  2OVY A;  4X0F A;  1SOJ A;  1XON A;  1XMU B;  4HF4 A;  4OEX A;  4QGE A;  4P1R A;  5EDG A;  4WCU A;  2YY2 A;  5B4K A;  4HTZ A;  5B25 A;  1XM4 A;  3HR1 A;  4LM1 A;  1Y2J A;  3G4L A;  4IA0 A;  4AJG A;  3V9B A;  4LKQ A;  2H40 A;  4LM4 A;  4MSE A;  3G45 A;  4LLX A;  4MD6 A;  4LLK A;  3WYL A;  1RO9 A;  5K9R A;  4Y87 A;  4OGB A;  3QI4 A;  4NW7 A;  5C28 A;  2OVV A;  1Y2B A;  1OYN A;  3ITU A;  4DDL A;  4MUW A;  1XOM A;  4E90 A;  3QPP A;  5I2R A;  1SO2 A;  5C29 A;  3G3N A;  4G2Y A;  1Y2E A;  4D09 A;  5K1I A;  3ECM A;  1UDU A;  2OUU A;  3LY2 A;  4I9Z A;  5EDH A;  3HMV A;  3JWR A;  3K3E A;  1TBB A;  4Y8C A;  3SN7 A;  5C2E A;  3WD9 A;  4G2W A;  4G2J A;  1ZKN A;  3DYQ A;  5EDG B;  4AEL A;  1XMY A;  3WYK A;  4WN1 A;  4G2L A;  4JIB A;  4Y2B A;  2OUS A;  1PTW A;  1ROR A;  1UHO A;  2OUQ A;  4WZI A;  3TVX A;  4MSA A;  5DH5 A;  3QI3 A;  5EDI B;  3HDZ A;  3D3P A;  4HEU A; 
#chains in the Genus database with same CATH topology
 4GH6 A;  3ECN A;  1XN0 A;  1Z1L A;  5B4L A;  1XLZ A;  3WI2 A;  1Q9M A;  4MVH A;  3K4S A;  3IAD A;  3SHZ A;  4MRW A;  4YQH A;  1MKD A;  1XM6 A;  1Y2K A;  2OUR A;  2HD1 A;  3SL6 A;  3HC8 A;  2CHM A;  3UI7 A;  3V94 A;  4BBX A;  3G4G A;  5K32 A;  4AJM A;  1UDT A;  4NPV A;  3HQY A;  4PM0 A;  3DYN A;  3G4K A;  3BJC A;  5AXP A;  2FM5 A;  2WEY A;  4NPW A;  4W1O A;  3V93 A;  1XM4 B;  1Y2C A;  3SL5 A;  3QPO A;  3G58 A;  3IBJ A;  1T9S A;  1F0J A;  5EDE A;  5AXQ A;  3JSW A;  4TPM A;  3G4I A;  2O8H A;  2QYL A;  3HQZ A;  4DFF A;  1TBF A;  1ZKL A;  3WS8 A;  4MSN A;  2OUP A;  1XLX A;  4C1I A;  3O56 A;  4LM2 A;  2H44 A;  2R8Q A;  1XMU A;  1Y2H A;  3JWQ A;  2QYM A;  4FCB A;  4LM3 A;  3SL3 A;  3KKT A;  3FRG A;  5C2H A;  3SHY A;  3N3Z A;  4OEW A;  1TAZ A;  4FCD A;  4LLP A;  4MSH A;  1RO6 A;  3K3H A;  3LXG A;  4MS0 A;  3ITM A;  3JSI A;  3SNL A;  3DY8 A;  3DYS A;  4ZO5 A;  3B2R A;  4XY2 A;  3QPN A;  5EDI A;  1Y2D A;  2Y0J A;  4AJD A;  1RKP A;  2OUY A;  4I15 A;  4Y86 A;  4KP6 A;  4HTX A;  4AJF A;  5DH4 A;  4MRZ A;  3W5E A;  3TGE A;  4PHW A;  3DYL A;  1XMY B;  4LLJ A;  4P0N A;  2QYN A;  4TPP A;  5C1W A;  4LM0 A;  1TB7 A;  3SL4 A;  3GWT A;  5EDE B;  1XOZ A;  1XOR A;  2OUV A;  2H42 A;  4MYQ A;  1XOQ A;  3SNI A;  4PHL A;  3UUO A;  2PW3 A;  3TGG A;  3SL8 A;  3I8V A;  3O57 A;  3O0J A;  1XP0 A;  2FM0 A;  1T9R A;  1XOS A;  3SIE A;  3WS9 A;  3WYM A;  4D08 A;  1XOT A;  3IAK A;  1TB5 A;  3HQW A;  2QYK A;  4MSC A;  4YS7 A;  2OUN A;  5C2A A;  2OVY A;  4X0F A;  1SOJ A;  1XON A;  1XMU B;  4HF4 A;  4OEX A;  4QGE A;  4P1R A;  5EDG A;  4WCU A;  2YY2 A;  5B4K A;  4HTZ A;  5B25 A;  1XM4 A;  3HR1 A;  4LM1 A;  1Y2J A;  3G4L A;  4IA0 A;  4AJG A;  3V9B A;  4LKQ A;  2H40 A;  4LM4 A;  4MSE A;  3G45 A;  4LLX A;  4MD6 A;  4LLK A;  3WYL A;  1RO9 A;  5K9R A;  4Y87 A;  4OGB A;  3QI4 A;  4NW7 A;  5C28 A;  2OVV A;  1Y2B A;  1OYN A;  3ITU A;  4DDL A;  4MUW A;  1XOM A;  4E90 A;  3QPP A;  5I2R A;  1SO2 A;  5C29 A;  3G3N A;  4G2Y A;  1Y2E A;  4D09 A;  5K1I A;  3ECM A;  1UDU A;  2OUU A;  3LY2 A;  4I9Z A;  5EDH A;  3HMV A;  3JWR A;  3K3E A;  1TBB A;  4Y8C A;  3SN7 A;  5C2E A;  3WD9 A;  4G2W A;  4G2J A;  1ZKN A;  3DYQ A;  5EDG B;  4AEL A;  1XMY A;  3WYK A;  4WN1 A;  4G2L A;  4JIB A;  4Y2B A;  2OUS A;  1PTW A;  1ROR A;  1UHO A;  2OUQ A;  4WZI A;  3TVX A;  4MSA A;  5DH5 A;  3QI3 A;  5EDI B;  3HDZ A;  3D3P A;  4HEU A; 
#chains in the Genus database with same CATH homology
 4GH6 A;  3ECN A;  1XN0 A;  1Z1L A;  5B4L A;  1XLZ A;  3WI2 A;  1Q9M A;  4MVH A;  3K4S A;  3IAD A;  3SHZ A;  4MRW A;  4YQH A;  1MKD A;  1XM6 A;  1Y2K A;  2OUR A;  2HD1 A;  3SL6 A;  3HC8 A;  2CHM A;  3UI7 A;  3V94 A;  4BBX A;  3G4G A;  5K32 A;  4AJM A;  1UDT A;  4NPV A;  3HQY A;  4PM0 A;  3DYN A;  3G4K A;  3BJC A;  5AXP A;  2FM5 A;  2WEY A;  4NPW A;  4W1O A;  3V93 A;  1XM4 B;  1Y2C A;  3SL5 A;  3QPO A;  3G58 A;  3IBJ A;  1T9S A;  1F0J A;  5EDE A;  5AXQ A;  3JSW A;  4TPM A;  3G4I A;  2O8H A;  2QYL A;  3HQZ A;  4DFF A;  1TBF A;  1ZKL A;  3WS8 A;  4MSN A;  2OUP A;  1XLX A;  4C1I A;  3O56 A;  4LM2 A;  2H44 A;  2R8Q A;  1XMU A;  1Y2H A;  3JWQ A;  2QYM A;  4FCB A;  4LM3 A;  3SL3 A;  3KKT A;  3FRG A;  5C2H A;  3SHY A;  3N3Z A;  4OEW A;  1TAZ A;  4FCD A;  4LLP A;  4MSH A;  1RO6 A;  3K3H A;  3LXG A;  4MS0 A;  3ITM A;  3JSI A;  3SNL A;  3DY8 A;  3DYS A;  4ZO5 A;  3B2R A;  4XY2 A;  3QPN A;  5EDI A;  1Y2D A;  2Y0J A;  4AJD A;  1RKP A;  2OUY A;  4I15 A;  4Y86 A;  4KP6 A;  4HTX A;  4AJF A;  5DH4 A;  4MRZ A;  3W5E A;  3TGE A;  4PHW A;  3DYL A;  1XMY B;  4LLJ A;  4P0N A;  2QYN A;  4TPP A;  5C1W A;  4LM0 A;  1TB7 A;  3SL4 A;  3GWT A;  5EDE B;  1XOZ A;  1XOR A;  2OUV A;  2H42 A;  4MYQ A;  1XOQ A;  3SNI A;  4PHL A;  3UUO A;  2PW3 A;  3TGG A;  3SL8 A;  3I8V A;  3O57 A;  3O0J A;  1XP0 A;  2FM0 A;  1T9R A;  1XOS A;  3SIE A;  3WS9 A;  3WYM A;  4D08 A;  1XOT A;  3IAK A;  1TB5 A;  3HQW A;  2QYK A;  4MSC A;  4YS7 A;  2OUN A;  5C2A A;  2OVY A;  4X0F A;  1SOJ A;  1XON A;  1XMU B;  4HF4 A;  4OEX A;  4QGE A;  4P1R A;  5EDG A;  4WCU A;  2YY2 A;  5B4K A;  4HTZ A;  5B25 A;  1XM4 A;  3HR1 A;  4LM1 A;  1Y2J A;  3G4L A;  4IA0 A;  4AJG A;  3V9B A;  4LKQ A;  2H40 A;  4LM4 A;  4MSE A;  3G45 A;  4LLX A;  4MD6 A;  4LLK A;  3WYL A;  1RO9 A;  5K9R A;  4Y87 A;  4OGB A;  3QI4 A;  4NW7 A;  5C28 A;  2OVV A;  1Y2B A;  1OYN A;  3ITU A;  4DDL A;  4MUW A;  1XOM A;  4E90 A;  3QPP A;  5I2R A;  1SO2 A;  5C29 A;  3G3N A;  4G2Y A;  1Y2E A;  4D09 A;  5K1I A;  3ECM A;  1UDU A;  2OUU A;  3LY2 A;  4I9Z A;  5EDH A;  3HMV A;  3JWR A;  3K3E A;  1TBB A;  4Y8C A;  3SN7 A;  5C2E A;  3WD9 A;  4G2W A;  4G2J A;  1ZKN A;  3DYQ A;  5EDG B;  4AEL A;  1XMY A;  3WYK A;  4WN1 A;  4G2L A;  4JIB A;  4Y2B A;  2OUS A;  1PTW A;  1ROR A;  1UHO A;  2OUQ A;  4WZI A;  3TVX A;  4MSA A;  5DH5 A;  3QI3 A;  5EDI B;  3HDZ A;  3D3P A;  4HEU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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