3WVDA

Crystal structure of nitrile hydratase mutant br56k complexed with trimethylacetonitrile, photo-activated for 50 min
Total Genus 59
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
59
sequence length
196
structure length
194
Chain Sequence
NAAPAQAPVSDRAWALFRALDGKGLVPDGYVEGWKKTFEEDFSPRRGAELVARAWTDPEFRQLLLTDGTAAVAQYGYLGPQGEYIVAVEDTPTLKNVIVCSLSTAWPILGLPPTWYKSFEYRARVVREPRKVLSEMGTEIASDIEIRVYDTTAETRYMVLPQRPAGTEGWSQEQLQEIVTKDCLIGVAIPQVPT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Time-Resolved Crystallography of the Reaction Intermediate of Nitrile Hydratase: Revealing a Role for the Cysteinesulfenic Acid Ligand as a Catalytic Nucleophile.
pubmed doi rcsb
molecule tags Lyase
source organism Rhodococcus erythropolis
molecule keywords Nitrile hydratase subunit alpha
total genus 59
structure length 194
sequence length 196
ec nomenclature ec 4.2.1.84: Nitrile hydratase.
pdb deposition date 2014-05-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02979 NHase_alpha Nitrile hydratase, alpha chain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.330.10 Alpha Beta Alpha-Beta Complex Nitrile Hydratase; Chain A Nitrile hydratase alpha /Thiocyanate hydrolase gamma 3wvdA00
2DD4C 2ZPIA 2DXBC 2DPPA 2ZPHA 2QDYA 1UGSA 3X25A 1AHJA 4OB2A 3HHTA 3QZ9A 2CZ1A 4FM4A 3X28A 3X20A 2D0QA 3WVDA 2ZZDC 3QXEA 1V29A 2ZPFA 3VYGC 3VYHA 3QYGA 2CZ0A 3A8HA 2ZPGA 3A8MA 3X24A 4OB3A 4ZGDA 4OB0A 3A8OA 2CZ6A 2CZ7A 2DD5C 1IREA 2ZCFA 1UGRA 2CYZA 3A8LA 4ZGJA 2ZPBA 2AHJA 2ZPEA 4ZGEA 3QZ5A 3X26A 2DXCC 4OB1A 1UGPA 3A8GA 3QYHA 3WVEA 1UGQA
chains in the Genus database with same CATH superfamily
2DD4C 2ZPIA 2DXBC 2DPPA 2ZPHA 2QDYA 1UGSA 3X25A 1AHJA 4OB2A 3HHTA 3QZ9A 2CZ1A 4FM4A 3X28A 3X20A 2D0QA 3WVDA 2ZZDC 3QXEA 1V29A 2ZPFA 3VYGC 3VYHA 3QYGA 2CZ0A 3A8HA 2ZPGA 3A8MA 3X24A 4OB3A 4ZGDA 4OB0A 3A8OA 2CZ6A 2CZ7A 2DD5C 1IREA 2ZCFA 1UGRA 2CYZA 3A8LA 4ZGJA 2ZPBA 2AHJA 2ZPEA 4ZGEA 3QZ5A 3X26A 2DXCC 4OB1A 1UGPA 3A8GA 3QYHA 3WVEA 1UGQA
chains in the Genus database with same CATH topology
2DD4C 2ZPIA 2DXBC 2DPPA 2ZPHA 2QDYA 1UGSA 3X25A 1AHJA 4OB2A 3HHTA 3QZ9A 2CZ1A 4FM4A 3X28A 3X20A 2D0QA 3WVDA 2ZZDC 3QXEA 1V29A 2ZPFA 3VYGC 3VYHA 3QYGA 2CZ0A 3A8HA 2ZPGA 3A8MA 3X24A 4OB3A 4ZGDA 4OB0A 3A8OA 2CZ6A 2CZ7A 2DD5C 1IREA 2ZCFA 1UGRA 2CYZA 3A8LA 4ZGJA 2ZPBA 2AHJA 2ZPEA 4ZGEA 3QZ5A 3X26A 2DXCC 4OB1A 1UGPA 3A8GA 3QYHA 3WVEA 1UGQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2DD4 C;  2ZPI A;  2DXB C;  2DPP A;  2ZPH A;  2QDY A;  1UGS A;  3X25 A;  1AHJ A;  4OB2 A;  3HHT A;  3QZ9 A;  2CZ1 A;  4FM4 A;  3X28 A;  3X20 A;  2D0Q A;  3WVD A;  2ZZD C;  3QXE A;  1V29 A;  2ZPF A;  3VYG C;  3VYH A;  3QYG A;  2CZ0 A;  3A8H A;  2ZPG A;  3A8M A;  3X24 A;  4OB3 A;  4ZGD A;  4OB0 A;  3A8O A;  2CZ6 A;  2CZ7 A;  2DD5 C;  1IRE A;  2ZCF A;  1UGR A;  2CYZ A;  3A8L A;  4ZGJ A;  2ZPB A;  2AHJ A;  2ZPE A;  4ZGE A;  3QZ5 A;  3X26 A;  2DXC C;  4OB1 A;  1UGP A;  3A8G A;  3QYH A;  3WVE A;  1UGQ A; 
#chains in the Genus database with same CATH topology
 2DD4 C;  2ZPI A;  2DXB C;  2DPP A;  2ZPH A;  2QDY A;  1UGS A;  3X25 A;  1AHJ A;  4OB2 A;  3HHT A;  3QZ9 A;  2CZ1 A;  4FM4 A;  3X28 A;  3X20 A;  2D0Q A;  3WVD A;  2ZZD C;  3QXE A;  1V29 A;  2ZPF A;  3VYG C;  3VYH A;  3QYG A;  2CZ0 A;  3A8H A;  2ZPG A;  3A8M A;  3X24 A;  4OB3 A;  4ZGD A;  4OB0 A;  3A8O A;  2CZ6 A;  2CZ7 A;  2DD5 C;  1IRE A;  2ZCF A;  1UGR A;  2CYZ A;  3A8L A;  4ZGJ A;  2ZPB A;  2AHJ A;  2ZPE A;  4ZGE A;  3QZ5 A;  3X26 A;  2DXC C;  4OB1 A;  1UGP A;  3A8G A;  3QYH A;  3WVE A;  1UGQ A; 
#chains in the Genus database with same CATH homology
 2DD4 C;  2ZPI A;  2DXB C;  2DPP A;  2ZPH A;  2QDY A;  1UGS A;  3X25 A;  1AHJ A;  4OB2 A;  3HHT A;  3QZ9 A;  2CZ1 A;  4FM4 A;  3X28 A;  3X20 A;  2D0Q A;  3WVD A;  2ZZD C;  3QXE A;  1V29 A;  2ZPF A;  3VYG C;  3VYH A;  3QYG A;  2CZ0 A;  3A8H A;  2ZPG A;  3A8M A;  3X24 A;  4OB3 A;  4ZGD A;  4OB0 A;  3A8O A;  2CZ6 A;  2CZ7 A;  2DD5 C;  1IRE A;  2ZCF A;  1UGR A;  2CYZ A;  3A8L A;  4ZGJ A;  2ZPB A;  2AHJ A;  2ZPE A;  4ZGE A;  3QZ5 A;  3X26 A;  2DXC C;  4OB1 A;  1UGP A;  3A8G A;  3QYH A;  3WVE A;  1UGQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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