3WVEA

Crystal structure of nitrile hydratase mutant br56k complexed with trimethylacetonitrile, before photo-activation
Total Genus 59
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
59
sequence length
192
structure length
190
Chain Sequence
AQAPVSDRAWALFRALDGKGLVPDGYVEGWKKTFEEDFSPRRGAELVARAWTDPEFRQLLLTDGTAAVAQYGYLGPQGEYIVAVEDTPTLKNVIVCSLSTAWPILGLPPTWYKSFEYRARVVREPRKVLSEMGTEIASDIEIRVYDTTAETRYMVLPQRPAGTEGWSQEQLQEIVTKDCLIGVAIPQVPT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Time-Resolved Crystallography of the Reaction Intermediate of Nitrile Hydratase: Revealing a Role for the Cysteinesulfenic Acid Ligand as a Catalytic Nucleophile.
pubmed doi rcsb
molecule tags Lyase
source organism Rhodococcus erythropolis
molecule keywords Nitrile hydratase subunit alpha
total genus 59
structure length 190
sequence length 192
ec nomenclature ec 4.2.1.84: Nitrile hydratase.
pdb deposition date 2014-05-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02979 NHase_alpha Nitrile hydratase, alpha chain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.330.10 Alpha Beta Alpha-Beta Complex Nitrile Hydratase; Chain A Nitrile hydratase alpha /Thiocyanate hydrolase gamma 3wveA00
3QYGA 2DD5C 4ZGDA 2ZZDC 2D0QA 3A8HA 3X28A 3QXEA 3A8GA 3VYHA 3X20A 2ZPGA 3X25A 2QDYA 3X26A 3VYGC 3HHTA 1UGRA 3QZ9A 2CYZA 3QZ5A 2CZ7A 2CZ0A 2ZPIA 2ZPHA 4OB0A 4OB1A 2ZCFA 3WVDA 2CZ6A 1IREA 2ZPFA 1UGPA 4OB3A 3WVEA 4FM4A 3A8OA 2ZPBA 3QYHA 4OB2A 2DXCC 4ZGEA 2DPPA 3A8LA 2CZ1A 2DXBC 4ZGJA 1V29A 1UGQA 2AHJA 1AHJA 1UGSA 2DD4C 3A8MA 3X24A 2ZPEA
chains in the Genus database with same CATH superfamily
3QYGA 2DD5C 4ZGDA 2ZZDC 2D0QA 3A8HA 3X28A 3QXEA 3A8GA 3VYHA 3X20A 2ZPGA 3X25A 2QDYA 3X26A 3VYGC 3HHTA 1UGRA 3QZ9A 2CYZA 3QZ5A 2CZ7A 2CZ0A 2ZPIA 2ZPHA 4OB0A 4OB1A 2ZCFA 3WVDA 2CZ6A 1IREA 2ZPFA 1UGPA 4OB3A 3WVEA 4FM4A 3A8OA 2ZPBA 3QYHA 4OB2A 2DXCC 4ZGEA 2DPPA 3A8LA 2CZ1A 2DXBC 4ZGJA 1V29A 1UGQA 2AHJA 1AHJA 1UGSA 2DD4C 3A8MA 3X24A 2ZPEA
chains in the Genus database with same CATH topology
3QYGA 2DD5C 4ZGDA 2ZZDC 2D0QA 3A8HA 3X28A 3QXEA 3A8GA 3VYHA 3X20A 2ZPGA 3X25A 2QDYA 3X26A 3VYGC 3HHTA 1UGRA 3QZ9A 2CYZA 3QZ5A 2CZ7A 2CZ0A 2ZPIA 2ZPHA 4OB0A 4OB1A 2ZCFA 3WVDA 2CZ6A 1IREA 2ZPFA 1UGPA 4OB3A 3WVEA 4FM4A 3A8OA 2ZPBA 3QYHA 4OB2A 2DXCC 4ZGEA 2DPPA 3A8LA 2CZ1A 2DXBC 4ZGJA 1V29A 1UGQA 2AHJA 1AHJA 1UGSA 2DD4C 3A8MA 3X24A 2ZPEA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3QYG A;  2DD5 C;  4ZGD A;  2ZZD C;  2D0Q A;  3A8H A;  3X28 A;  3QXE A;  3A8G A;  3VYH A;  3X20 A;  2ZPG A;  3X25 A;  2QDY A;  3X26 A;  3VYG C;  3HHT A;  1UGR A;  3QZ9 A;  2CYZ A;  3QZ5 A;  2CZ7 A;  2CZ0 A;  2ZPI A;  2ZPH A;  4OB0 A;  4OB1 A;  2ZCF A;  3WVD A;  2CZ6 A;  1IRE A;  2ZPF A;  1UGP A;  4OB3 A;  3WVE A;  4FM4 A;  3A8O A;  2ZPB A;  3QYH A;  4OB2 A;  2DXC C;  4ZGE A;  2DPP A;  3A8L A;  2CZ1 A;  2DXB C;  4ZGJ A;  1V29 A;  1UGQ A;  2AHJ A;  1AHJ A;  1UGS A;  2DD4 C;  3A8M A;  3X24 A;  2ZPE A; 
#chains in the Genus database with same CATH topology
 3QYG A;  2DD5 C;  4ZGD A;  2ZZD C;  2D0Q A;  3A8H A;  3X28 A;  3QXE A;  3A8G A;  3VYH A;  3X20 A;  2ZPG A;  3X25 A;  2QDY A;  3X26 A;  3VYG C;  3HHT A;  1UGR A;  3QZ9 A;  2CYZ A;  3QZ5 A;  2CZ7 A;  2CZ0 A;  2ZPI A;  2ZPH A;  4OB0 A;  4OB1 A;  2ZCF A;  3WVD A;  2CZ6 A;  1IRE A;  2ZPF A;  1UGP A;  4OB3 A;  3WVE A;  4FM4 A;  3A8O A;  2ZPB A;  3QYH A;  4OB2 A;  2DXC C;  4ZGE A;  2DPP A;  3A8L A;  2CZ1 A;  2DXB C;  4ZGJ A;  1V29 A;  1UGQ A;  2AHJ A;  1AHJ A;  1UGS A;  2DD4 C;  3A8M A;  3X24 A;  2ZPE A; 
#chains in the Genus database with same CATH homology
 3QYG A;  2DD5 C;  4ZGD A;  2ZZD C;  2D0Q A;  3A8H A;  3X28 A;  3QXE A;  3A8G A;  3VYH A;  3X20 A;  2ZPG A;  3X25 A;  2QDY A;  3X26 A;  3VYG C;  3HHT A;  1UGR A;  3QZ9 A;  2CYZ A;  3QZ5 A;  2CZ7 A;  2CZ0 A;  2ZPI A;  2ZPH A;  4OB0 A;  4OB1 A;  2ZCF A;  3WVD A;  2CZ6 A;  1IRE A;  2ZPF A;  1UGP A;  4OB3 A;  3WVE A;  4FM4 A;  3A8O A;  2ZPB A;  3QYH A;  4OB2 A;  2DXC C;  4ZGE A;  2DPP A;  3A8L A;  2CZ1 A;  2DXB C;  4ZGJ A;  1V29 A;  1UGQ A;  2AHJ A;  1AHJ A;  1UGS A;  2DD4 C;  3A8M A;  3X24 A;  2ZPE A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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