The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
125
|
sequence length |
315
|
structure length |
315
|
Chain Sequence |
EWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGE
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Discovery of 1‑[2-Fluoro-4-(1H‑pyrazol-1-yl)phenyl]-5-methoxy-3-(1-pheny‑1H‑pyrazol-5-yl)pyridazin-4(1H)‑one (TAK-063), a Highly Potent, Selective, and Orally Active Phosphodiesterase 10A (PDE10A)Inhibitor
doi rcsb |
| molecule keywords |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase
|
| molecule tags |
Hydrolase/hydrolase inhibitor
|
| source organism |
Homo sapiens
|
| total genus |
125
|
| structure length |
315
|
| sequence length |
315
|
| chains with identical sequence |
B
|
| ec nomenclature |
ec
3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase. |
| pdb deposition date | 2014-09-01 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00233 | PDEase_I | 3'5'-cyclic nucleotide phosphodiesterase |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Alpha | Orthogonal Bundle | Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain |
#chains in the Genus database with same CATH superfamily 3LXG A; 4TPP A; 4AJM A; 2QYK A; 3WI2 A; 4BBX A; 5DH4 A; 3DYQ A; 2OUN A; 5EDE A; 4I9Z A; 1XOT A; 2O8H A; 4KP6 A; 3SL3 A; 4I15 A; 3WS8 A; 3HQZ A; 1RO9 A; 3QPN A; 4D09 A; 3SL4 A; 5C28 A; 3QPP A; 3GWT A; 4NPW A; 5AXQ A; 4DDL A; 1RO6 A; 3ITM A; 1XMY A; 2OVY A; 3SIE A; 1TBF A; 3WYK A; 2OUQ A; 4G2Y A; 4PM0 A; 3JSI A; 5K32 A; 4OGB A; 3I8V A; 3KKT A; 5K1I A; 3ECN A; 3UI7 A; 4LM0 A; 5EDE B; 3G4G A; 5C2A A; 1ROR A; 3WYM A; 2QYL A; 3TGG A; 3SL8 A; 4QGE A; 1XM4 A; 4IA0 A; 4YQH A; 3TVX A; 1UDT A; 3WYL A; 1TBB A; 1RKP A; 1Y2J A; 4PHW A; 3JSW A; 3JWR A; 3SNI A; 3HMV A; 3O0J A; 4MRW A; 1XMY B; 4LM3 A; 3SHY A; 3QI3 A; 3W5E A; 4MYQ A; 3TGE A; 1F0J A; 3G45 A; 4ZO5 A; 3SN7 A; 1SOJ A; 3QPO A; 4YS7 A; 4Y2B A; 2OUS A; 4FCD A; 1TB7 A; 1XN0 A; 3QI4 A; 3WD9 A; 1TB5 A; 3HC8 A; 4MRZ A; 4MUW A; 1TAZ A; 3IBJ A; 2WEY A; 4LM2 A; 1XOS A; 2PW3 A; 5C2E A; 2H44 A; 4OEX A; 3IAK A; 3K4S A; 1XM4 B; 5EDH A; 2H42 A; 4G2J A; 4LM1 A; 4W1O A; 4Y8C A; 3SL6 A; 1XOR A; 3IAD A; 1XLX A; 4LKQ A; 3D3P A; 4MSH A; 4WCU A; 3G4I A; 5C2H A; 4PHL A; 4HTZ A; 1Y2B A; 1Y2E A; 1OYN A; 3BJC A; 4WZI A; 4AJD A; 4HF4 A; 4NPV A; 4NW7 A; 3LY2 A; 3UUO A; 2YY2 A; 2QYN A; 4X0F A; 3HDZ A; 5B25 A; 3K3H A; 1XMU A; 4LLX A; 5B4L A; 4OEW A; 3G58 A; 5EDI A; 1XLZ A; 5AXP A; 3N3Z A; 3V93 A; 1Y2D A; 3WS9 A; 5K9R A; 4LLJ A; 5B4K A; 2HD1 A; 2FM5 A; 4LLP A; 2OUY A; 1MKD A; 1UDU A; 3V94 A; 1XM6 A; 3ECM A; 1UHO A; 5EDG A; 4MSC A; 5DH5 A; 2QYM A; 3ITU A; 2OUP A; 3V9B A; 4C1I A; 1XP0 A; 4D08 A; 3G3N A; 4DFF A; 4HEU A; 1ZKN A; 4P1R A; 1Y2H A; 1XON A; 2FM0 A; 1Y2C A; 4LLK A; 4MD6 A; 4MSA A; 1T9S A; 3SNL A; 4AJF A; 1PTW A; 4G2W A; 4E90 A; 4HTX A; 5I2R A; 2OUV A; 1Z1L A; 3HQW A; 1XMU B; 3DYN A; 2H40 A; 1XOZ A; 3HQY A; 3JWQ A; 4G2L A; 4LM4 A; 5EDI B; 3HR1 A; 3O56 A; 3DYL A; 4WN1 A; 2OVV A; 5C1W A; 4MSE A; 1T9R A; 5C29 A; 1XOQ A; 2R8Q A; 2Y0J A; 4MSN A; 1Y2K A; 5EDG B; 1XOM A; 3G4L A; 4AJG A; 1SO2 A; 3DY8 A; 3O57 A; 1ZKL A; 4JIB A; 4Y87 A; 3K3E A; 4GH6 A; 4Y86 A; 3SHZ A; 4MVH A; 4MS0 A; 4P0N A; 3G4K A; 4FCB A; 3B2R A; 4AEL A; 2OUU A; 1Q9M A; 4XY2 A; 3FRG A; 2OUR A; 3DYS A; 2CHM A; 4TPM A; 3SL5 A; #chains in the Genus database with same CATH topology 3LXG A; 4TPP A; 4AJM A; 2QYK A; 3WI2 A; 4BBX A; 5DH4 A; 3DYQ A; 2OUN A; 5EDE A; 4I9Z A; 1XOT A; 2O8H A; 4KP6 A; 3SL3 A; 4I15 A; 3WS8 A; 3HQZ A; 1RO9 A; 3QPN A; 4D09 A; 3SL4 A; 5C28 A; 3QPP A; 3GWT A; 4NPW A; 5AXQ A; 4DDL A; 1RO6 A; 3ITM A; 1XMY A; 2OVY A; 3SIE A; 1TBF A; 3WYK A; 2OUQ A; 4G2Y A; 4PM0 A; 3JSI A; 5K32 A; 4OGB A; 3I8V A; 3KKT A; 5K1I A; 3ECN A; 3UI7 A; 4LM0 A; 5EDE B; 3G4G A; 5C2A A; 1ROR A; 3WYM A; 2QYL A; 3TGG A; 3SL8 A; 4QGE A; 1XM4 A; 4IA0 A; 4YQH A; 3TVX A; 1UDT A; 3WYL A; 1TBB A; 1RKP A; 1Y2J A; 4PHW A; 3JSW A; 3JWR A; 3SNI A; 3HMV A; 3O0J A; 4MRW A; 1XMY B; 4LM3 A; 3SHY A; 3QI3 A; 3W5E A; 4MYQ A; 3TGE A; 1F0J A; 3G45 A; 4ZO5 A; 3SN7 A; 1SOJ A; 3QPO A; 4YS7 A; 4Y2B A; 2OUS A; 4FCD A; 1TB7 A; 1XN0 A; 3QI4 A; 3WD9 A; 1TB5 A; 3HC8 A; 4MRZ A; 4MUW A; 1TAZ A; 3IBJ A; 2WEY A; 4LM2 A; 1XOS A; 2PW3 A; 5C2E A; 2H44 A; 4OEX A; 3IAK A; 3K4S A; 1XM4 B; 5EDH A; 2H42 A; 4G2J A; 4LM1 A; 4W1O A; 4Y8C A; 3SL6 A; 1XOR A; 3IAD A; 1XLX A; 4LKQ A; 3D3P A; 4MSH A; 4WCU A; 3G4I A; 5C2H A; 4PHL A; 4HTZ A; 1Y2B A; 1Y2E A; 1OYN A; 3BJC A; 4WZI A; 4AJD A; 4HF4 A; 4NPV A; 4NW7 A; 3LY2 A; 3UUO A; 2YY2 A; 2QYN A; 4X0F A; 3HDZ A; 5B25 A; 3K3H A; 1XMU A; 4LLX A; 5B4L A; 4OEW A; 3G58 A; 5EDI A; 1XLZ A; 5AXP A; 3N3Z A; 3V93 A; 1Y2D A; 3WS9 A; 5K9R A; 4LLJ A; 5B4K A; 2HD1 A; 2FM5 A; 4LLP A; 2OUY A; 1MKD A; 1UDU A; 3V94 A; 1XM6 A; 3ECM A; 1UHO A; 5EDG A; 4MSC A; 5DH5 A; 2QYM A; 3ITU A; 2OUP A; 3V9B A; 4C1I A; 1XP0 A; 4D08 A; 3G3N A; 4DFF A; 4HEU A; 1ZKN A; 4P1R A; 1Y2H A; 1XON A; 2FM0 A; 1Y2C A; 4LLK A; 4MD6 A; 4MSA A; 1T9S A; 3SNL A; 4AJF A; 1PTW A; 4G2W A; 4E90 A; 4HTX A; 5I2R A; 2OUV A; 1Z1L A; 3HQW A; 1XMU B; 3DYN A; 2H40 A; 1XOZ A; 3HQY A; 3JWQ A; 4G2L A; 4LM4 A; 5EDI B; 3HR1 A; 3O56 A; 3DYL A; 4WN1 A; 2OVV A; 5C1W A; 4MSE A; 1T9R A; 5C29 A; 1XOQ A; 2R8Q A; 2Y0J A; 4MSN A; 1Y2K A; 5EDG B; 1XOM A; 3G4L A; 4AJG A; 1SO2 A; 3DY8 A; 3O57 A; 1ZKL A; 4JIB A; 4Y87 A; 3K3E A; 4GH6 A; 4Y86 A; 3SHZ A; 4MVH A; 4MS0 A; 4P0N A; 3G4K A; 4FCB A; 3B2R A; 4AEL A; 2OUU A; 1Q9M A; 4XY2 A; 3FRG A; 2OUR A; 3DYS A; 2CHM A; 4TPM A; 3SL5 A; #chains in the Genus database with same CATH homology 3LXG A; 4TPP A; 4AJM A; 2QYK A; 3WI2 A; 4BBX A; 5DH4 A; 3DYQ A; 2OUN A; 5EDE A; 4I9Z A; 1XOT A; 2O8H A; 4KP6 A; 3SL3 A; 4I15 A; 3WS8 A; 3HQZ A; 1RO9 A; 3QPN A; 4D09 A; 3SL4 A; 5C28 A; 3QPP A; 3GWT A; 4NPW A; 5AXQ A; 4DDL A; 1RO6 A; 3ITM A; 1XMY A; 2OVY A; 3SIE A; 1TBF A; 3WYK A; 2OUQ A; 4G2Y A; 4PM0 A; 3JSI A; 5K32 A; 4OGB A; 3I8V A; 3KKT A; 5K1I A; 3ECN A; 3UI7 A; 4LM0 A; 5EDE B; 3G4G A; 5C2A A; 1ROR A; 3WYM A; 2QYL A; 3TGG A; 3SL8 A; 4QGE A; 1XM4 A; 4IA0 A; 4YQH A; 3TVX A; 1UDT A; 3WYL A; 1TBB A; 1RKP A; 1Y2J A; 4PHW A; 3JSW A; 3JWR A; 3SNI A; 3HMV A; 3O0J A; 4MRW A; 1XMY B; 4LM3 A; 3SHY A; 3QI3 A; 3W5E A; 4MYQ A; 3TGE A; 1F0J A; 3G45 A; 4ZO5 A; 3SN7 A; 1SOJ A; 3QPO A; 4YS7 A; 4Y2B A; 2OUS A; 4FCD A; 1TB7 A; 1XN0 A; 3QI4 A; 3WD9 A; 1TB5 A; 3HC8 A; 4MRZ A; 4MUW A; 1TAZ A; 3IBJ A; 2WEY A; 4LM2 A; 1XOS A; 2PW3 A; 5C2E A; 2H44 A; 4OEX A; 3IAK A; 3K4S A; 1XM4 B; 5EDH A; 2H42 A; 4G2J A; 4LM1 A; 4W1O A; 4Y8C A; 3SL6 A; 1XOR A; 3IAD A; 1XLX A; 4LKQ A; 3D3P A; 4MSH A; 4WCU A; 3G4I A; 5C2H A; 4PHL A; 4HTZ A; 1Y2B A; 1Y2E A; 1OYN A; 3BJC A; 4WZI A; 4AJD A; 4HF4 A; 4NPV A; 4NW7 A; 3LY2 A; 3UUO A; 2YY2 A; 2QYN A; 4X0F A; 3HDZ A; 5B25 A; 3K3H A; 1XMU A; 4LLX A; 5B4L A; 4OEW A; 3G58 A; 5EDI A; 1XLZ A; 5AXP A; 3N3Z A; 3V93 A; 1Y2D A; 3WS9 A; 5K9R A; 4LLJ A; 5B4K A; 2HD1 A; 2FM5 A; 4LLP A; 2OUY A; 1MKD A; 1UDU A; 3V94 A; 1XM6 A; 3ECM A; 1UHO A; 5EDG A; 4MSC A; 5DH5 A; 2QYM A; 3ITU A; 2OUP A; 3V9B A; 4C1I A; 1XP0 A; 4D08 A; 3G3N A; 4DFF A; 4HEU A; 1ZKN A; 4P1R A; 1Y2H A; 1XON A; 2FM0 A; 1Y2C A; 4LLK A; 4MD6 A; 4MSA A; 1T9S A; 3SNL A; 4AJF A; 1PTW A; 4G2W A; 4E90 A; 4HTX A; 5I2R A; 2OUV A; 1Z1L A; 3HQW A; 1XMU B; 3DYN A; 2H40 A; 1XOZ A; 3HQY A; 3JWQ A; 4G2L A; 4LM4 A; 5EDI B; 3HR1 A; 3O56 A; 3DYL A; 4WN1 A; 2OVV A; 5C1W A; 4MSE A; 1T9R A; 5C29 A; 1XOQ A; 2R8Q A; 2Y0J A; 4MSN A; 1Y2K A; 5EDG B; 1XOM A; 3G4L A; 4AJG A; 1SO2 A; 3DY8 A; 3O57 A; 1ZKL A; 4JIB A; 4Y87 A; 3K3E A; 4GH6 A; 4Y86 A; 3SHZ A; 4MVH A; 4MS0 A; 4P0N A; 3G4K A; 4FCB A; 3B2R A; 4AEL A; 2OUU A; 1Q9M A; 4XY2 A; 3FRG A; 2OUR A; 3DYS A; 2CHM A; 4TPM A; 3SL5 A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
