3X20A

Crystal structure of nitrile hydratase mutant br56k complexed with trimethylacetonitrile, photo-activated for 25 min
Total Genus 59
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
59
sequence length
197
structure length
195
Chain Sequence
ENAAPAQAPVSDRAWALFRALDGKGLVPDGYVEGWKKTFEEDFSPRRGAELVARAWTDPEFRQLLLTDGTAAVAQYGYLGPQGEYIVAVEDTPTLKNVIVCSLSTAWPILGLPPTWYKSFEYRARVVREPRKVLSEMGTEIASDIEIRVYDTTAETRYMVLPQRPAGTEGWSQEQLQEIVTKDCLIGVAIPQVPT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Time-Resolved Crystallography of the Reaction Intermediate of Nitrile Hydratase: Revealing a Role for the Cysteinesulfenic Acid Ligand as a Catalytic Nucleophile.
pubmed doi rcsb
molecule tags Lyase
source organism Rhodococcus erythropolis
molecule keywords Nitrile hydratase subunit alpha
total genus 59
structure length 195
sequence length 197
ec nomenclature ec 4.2.1.84: Nitrile hydratase.
pdb deposition date 2014-12-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02979 NHase_alpha Nitrile hydratase, alpha chain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.330.10 Alpha Beta Alpha-Beta Complex Nitrile Hydratase; Chain A Nitrile hydratase alpha /Thiocyanate hydrolase gamma 3x20A00
3A8LA 1UGPA 4ZGEA 2CZ0A 1UGQA 2D0QA 3VYGC 3X20A 2DPPA 3VYHA 2ZCFA 3QYGA 3WVEA 2CZ7A 4OB3A 2ZZDC 2CZ6A 3X25A 4ZGJA 1AHJA 2ZPHA 1V29A 4OB2A 4OB0A 2ZPFA 3QXEA 3WVDA 3X28A 3A8OA 2CYZA 2ZPEA 3A8GA 3A8HA 4FM4A 3QZ9A 3QYHA 2AHJA 2ZPIA 3HHTA 3X24A 3X26A 2QDYA 2DXBC 3A8MA 1IREA 2ZPGA 3QZ5A 4OB1A 4ZGDA 2ZPBA 2DD4C 1UGRA 2CZ1A 2DXCC 2DD5C 1UGSA
chains in the Genus database with same CATH superfamily
3A8LA 1UGPA 4ZGEA 2CZ0A 1UGQA 2D0QA 3VYGC 3X20A 2DPPA 3VYHA 2ZCFA 3QYGA 3WVEA 2CZ7A 4OB3A 2ZZDC 2CZ6A 3X25A 4ZGJA 1AHJA 2ZPHA 1V29A 4OB2A 4OB0A 2ZPFA 3QXEA 3WVDA 3X28A 3A8OA 2CYZA 2ZPEA 3A8GA 3A8HA 4FM4A 3QZ9A 3QYHA 2AHJA 2ZPIA 3HHTA 3X24A 3X26A 2QDYA 2DXBC 3A8MA 1IREA 2ZPGA 3QZ5A 4OB1A 4ZGDA 2ZPBA 2DD4C 1UGRA 2CZ1A 2DXCC 2DD5C 1UGSA
chains in the Genus database with same CATH topology
3A8LA 1UGPA 4ZGEA 2CZ0A 1UGQA 2D0QA 3VYGC 3X20A 2DPPA 3VYHA 2ZCFA 3QYGA 3WVEA 2CZ7A 4OB3A 2ZZDC 2CZ6A 3X25A 4ZGJA 1AHJA 2ZPHA 1V29A 4OB2A 4OB0A 2ZPFA 3QXEA 3WVDA 3X28A 3A8OA 2CYZA 2ZPEA 3A8GA 3A8HA 4FM4A 3QZ9A 3QYHA 2AHJA 2ZPIA 3HHTA 3X24A 3X26A 2QDYA 2DXBC 3A8MA 1IREA 2ZPGA 3QZ5A 4OB1A 4ZGDA 2ZPBA 2DD4C 1UGRA 2CZ1A 2DXCC 2DD5C 1UGSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3A8L A;  1UGP A;  4ZGE A;  2CZ0 A;  1UGQ A;  2D0Q A;  3VYG C;  3X20 A;  2DPP A;  3VYH A;  2ZCF A;  3QYG A;  3WVE A;  2CZ7 A;  4OB3 A;  2ZZD C;  2CZ6 A;  3X25 A;  4ZGJ A;  1AHJ A;  2ZPH A;  1V29 A;  4OB2 A;  4OB0 A;  2ZPF A;  3QXE A;  3WVD A;  3X28 A;  3A8O A;  2CYZ A;  2ZPE A;  3A8G A;  3A8H A;  4FM4 A;  3QZ9 A;  3QYH A;  2AHJ A;  2ZPI A;  3HHT A;  3X24 A;  3X26 A;  2QDY A;  2DXB C;  3A8M A;  1IRE A;  2ZPG A;  3QZ5 A;  4OB1 A;  4ZGD A;  2ZPB A;  2DD4 C;  1UGR A;  2CZ1 A;  2DXC C;  2DD5 C;  1UGS A; 
#chains in the Genus database with same CATH topology
 3A8L A;  1UGP A;  4ZGE A;  2CZ0 A;  1UGQ A;  2D0Q A;  3VYG C;  3X20 A;  2DPP A;  3VYH A;  2ZCF A;  3QYG A;  3WVE A;  2CZ7 A;  4OB3 A;  2ZZD C;  2CZ6 A;  3X25 A;  4ZGJ A;  1AHJ A;  2ZPH A;  1V29 A;  4OB2 A;  4OB0 A;  2ZPF A;  3QXE A;  3WVD A;  3X28 A;  3A8O A;  2CYZ A;  2ZPE A;  3A8G A;  3A8H A;  4FM4 A;  3QZ9 A;  3QYH A;  2AHJ A;  2ZPI A;  3HHT A;  3X24 A;  3X26 A;  2QDY A;  2DXB C;  3A8M A;  1IRE A;  2ZPG A;  3QZ5 A;  4OB1 A;  4ZGD A;  2ZPB A;  2DD4 C;  1UGR A;  2CZ1 A;  2DXC C;  2DD5 C;  1UGS A; 
#chains in the Genus database with same CATH homology
 3A8L A;  1UGP A;  4ZGE A;  2CZ0 A;  1UGQ A;  2D0Q A;  3VYG C;  3X20 A;  2DPP A;  3VYH A;  2ZCF A;  3QYG A;  3WVE A;  2CZ7 A;  4OB3 A;  2ZZD C;  2CZ6 A;  3X25 A;  4ZGJ A;  1AHJ A;  2ZPH A;  1V29 A;  4OB2 A;  4OB0 A;  2ZPF A;  3QXE A;  3WVD A;  3X28 A;  3A8O A;  2CYZ A;  2ZPE A;  3A8G A;  3A8H A;  4FM4 A;  3QZ9 A;  3QYH A;  2AHJ A;  2ZPI A;  3HHT A;  3X24 A;  3X26 A;  2QDY A;  2DXB C;  3A8M A;  1IRE A;  2ZPG A;  3QZ5 A;  4OB1 A;  4ZGD A;  2ZPB A;  2DD4 C;  1UGR A;  2CZ1 A;  2DXC C;  2DD5 C;  1UGS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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