3X25A

Crystal structure of nitrile hydratase mutant br56k complexed with trimethylacetonitrile, photo-activated for 700 min
Total Genus 59
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
59
sequence length
197
structure length
195
Chain Sequence
ENAAPAQAPVSDRAWALFRALDGKGLVPDGYVEGWKKTFEEDFSPRRGAELVARAWTDPEFRQLLLTDGTAAVAQYGYLGPQGEYIVAVEDTPTLKNVIVCSLSTAWPILGLPPTWYKSFEYRARVVREPRKVLSEMGTEIASDIEIRVYDTTAETRYMVLPQRPAGTEGWSQEQLQEIVTKDCLIGVAIPQVPT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Time-Resolved Crystallography of the Reaction Intermediate of Nitrile Hydratase: Revealing a Role for the Cysteinesulfenic Acid Ligand as a Catalytic Nucleophile.
pubmed doi rcsb
molecule tags Lyase
source organism Rhodococcus erythropolis
molecule keywords Nitrile hydratase subunit alpha
total genus 59
structure length 195
sequence length 197
ec nomenclature ec 4.2.1.84: Nitrile hydratase.
pdb deposition date 2014-12-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02979 NHase_alpha Nitrile hydratase, alpha chain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.330.10 Alpha Beta Alpha-Beta Complex Nitrile Hydratase; Chain A Nitrile hydratase alpha /Thiocyanate hydrolase gamma 3x25A00
2ZZDC 2D0QA 3QZ9A 1UGSA 2DD4C 1AHJA 4ZGDA 2AHJA 4ZGJA 1V29A 2ZCFA 2CYZA 2ZPHA 3X24A 2DXBC 3HHTA 3QZ5A 2CZ0A 2ZPBA 3WVEA 2ZPIA 4FM4A 1IREA 3A8GA 3X28A 4OB2A 2CZ6A 2CZ7A 3A8MA 3VYGC 3QYGA 3QYHA 4OB1A 3X20A 2DPPA 3WVDA 2DXCC 2CZ1A 2ZPFA 3A8HA 4ZGEA 2DD5C 3X26A 1UGQA 1UGRA 4OB0A 1UGPA 2ZPEA 3X25A 3VYHA 3QXEA 4OB3A 2QDYA 2ZPGA 3A8LA 3A8OA
chains in the Genus database with same CATH superfamily
2ZZDC 2D0QA 3QZ9A 1UGSA 2DD4C 1AHJA 4ZGDA 2AHJA 4ZGJA 1V29A 2ZCFA 2CYZA 2ZPHA 3X24A 2DXBC 3HHTA 3QZ5A 2CZ0A 2ZPBA 3WVEA 2ZPIA 4FM4A 1IREA 3A8GA 3X28A 4OB2A 2CZ6A 2CZ7A 3A8MA 3VYGC 3QYGA 3QYHA 4OB1A 3X20A 2DPPA 3WVDA 2DXCC 2CZ1A 2ZPFA 3A8HA 4ZGEA 2DD5C 3X26A 1UGQA 1UGRA 4OB0A 1UGPA 2ZPEA 3X25A 3VYHA 3QXEA 4OB3A 2QDYA 2ZPGA 3A8LA 3A8OA
chains in the Genus database with same CATH topology
2ZZDC 2D0QA 3QZ9A 1UGSA 2DD4C 1AHJA 4ZGDA 2AHJA 4ZGJA 1V29A 2ZCFA 2CYZA 2ZPHA 3X24A 2DXBC 3HHTA 3QZ5A 2CZ0A 2ZPBA 3WVEA 2ZPIA 4FM4A 1IREA 3A8GA 3X28A 4OB2A 2CZ6A 2CZ7A 3A8MA 3VYGC 3QYGA 3QYHA 4OB1A 3X20A 2DPPA 3WVDA 2DXCC 2CZ1A 2ZPFA 3A8HA 4ZGEA 2DD5C 3X26A 1UGQA 1UGRA 4OB0A 1UGPA 2ZPEA 3X25A 3VYHA 3QXEA 4OB3A 2QDYA 2ZPGA 3A8LA 3A8OA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ZZD C;  2D0Q A;  3QZ9 A;  1UGS A;  2DD4 C;  1AHJ A;  4ZGD A;  2AHJ A;  4ZGJ A;  1V29 A;  2ZCF A;  2CYZ A;  2ZPH A;  3X24 A;  2DXB C;  3HHT A;  3QZ5 A;  2CZ0 A;  2ZPB A;  3WVE A;  2ZPI A;  4FM4 A;  1IRE A;  3A8G A;  3X28 A;  4OB2 A;  2CZ6 A;  2CZ7 A;  3A8M A;  3VYG C;  3QYG A;  3QYH A;  4OB1 A;  3X20 A;  2DPP A;  3WVD A;  2DXC C;  2CZ1 A;  2ZPF A;  3A8H A;  4ZGE A;  2DD5 C;  3X26 A;  1UGQ A;  1UGR A;  4OB0 A;  1UGP A;  2ZPE A;  3X25 A;  3VYH A;  3QXE A;  4OB3 A;  2QDY A;  2ZPG A;  3A8L A;  3A8O A; 
#chains in the Genus database with same CATH topology
 2ZZD C;  2D0Q A;  3QZ9 A;  1UGS A;  2DD4 C;  1AHJ A;  4ZGD A;  2AHJ A;  4ZGJ A;  1V29 A;  2ZCF A;  2CYZ A;  2ZPH A;  3X24 A;  2DXB C;  3HHT A;  3QZ5 A;  2CZ0 A;  2ZPB A;  3WVE A;  2ZPI A;  4FM4 A;  1IRE A;  3A8G A;  3X28 A;  4OB2 A;  2CZ6 A;  2CZ7 A;  3A8M A;  3VYG C;  3QYG A;  3QYH A;  4OB1 A;  3X20 A;  2DPP A;  3WVD A;  2DXC C;  2CZ1 A;  2ZPF A;  3A8H A;  4ZGE A;  2DD5 C;  3X26 A;  1UGQ A;  1UGR A;  4OB0 A;  1UGP A;  2ZPE A;  3X25 A;  3VYH A;  3QXE A;  4OB3 A;  2QDY A;  2ZPG A;  3A8L A;  3A8O A; 
#chains in the Genus database with same CATH homology
 2ZZD C;  2D0Q A;  3QZ9 A;  1UGS A;  2DD4 C;  1AHJ A;  4ZGD A;  2AHJ A;  4ZGJ A;  1V29 A;  2ZCF A;  2CYZ A;  2ZPH A;  3X24 A;  2DXB C;  3HHT A;  3QZ5 A;  2CZ0 A;  2ZPB A;  3WVE A;  2ZPI A;  4FM4 A;  1IRE A;  3A8G A;  3X28 A;  4OB2 A;  2CZ6 A;  2CZ7 A;  3A8M A;  3VYG C;  3QYG A;  3QYH A;  4OB1 A;  3X20 A;  2DPP A;  3WVD A;  2DXC C;  2CZ1 A;  2ZPF A;  3A8H A;  4ZGE A;  2DD5 C;  3X26 A;  1UGQ A;  1UGR A;  4OB0 A;  1UGP A;  2ZPE A;  3X25 A;  3VYH A;  3QXE A;  4OB3 A;  2QDY A;  2ZPG A;  3A8L A;  3A8O A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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