3X26A

Crystal structure of nitrile hydratase mutant br56k complexed with trimethylacetonitrile, photo-activated for 5 min
Total Genus 59
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
59
sequence length
197
structure length
195
Chain Sequence
ENAAPAQAPVSDRAWALFRALDGKGLVPDGYVEGWKKTFEEDFSPRRGAELVARAWTDPEFRQLLLTDGTAAVAQYGYLGPQGEYIVAVEDTPTLKNVIVCSLSTAWPILGLPPTWYKSFEYRARVVREPRKVLSEMGTEIASDIEIRVYDTTAETRYMVLPQRPAGTEGWSQEQLQEIVTKDCLIGVAIPQVPT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Time-Resolved Crystallography of the Reaction Intermediate of Nitrile Hydratase: Revealing a Role for the Cysteinesulfenic Acid Ligand as a Catalytic Nucleophile.
pubmed doi rcsb
molecule tags Lyase
source organism Rhodococcus erythropolis
molecule keywords Nitrile hydratase subunit alpha
total genus 59
structure length 195
sequence length 197
ec nomenclature ec 4.2.1.84: Nitrile hydratase.
pdb deposition date 2014-12-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02979 NHase_alpha Nitrile hydratase, alpha chain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.330.10 Alpha Beta Alpha-Beta Complex Nitrile Hydratase; Chain A Nitrile hydratase alpha /Thiocyanate hydrolase gamma 3x26A00
3WVDA 2DXBC 3X24A 2CZ1A 2CZ6A 3QYGA 3VYHA 2D0QA 2ZPHA 4OB1A 1AHJA 4FM4A 4ZGDA 2CZ7A 3HHTA 3QXEA 2DPPA 2ZZDC 3QZ5A 2ZPFA 4OB3A 2CZ0A 4OB0A 3WVEA 3VYGC 4ZGJA 3A8OA 1UGRA 2ZPBA 1V29A 2AHJA 2QDYA 3A8HA 2ZCFA 3X20A 2ZPGA 1IREA 2DXCC 3A8MA 2DD4C 3QZ9A 1UGQA 3X28A 3A8LA 4OB2A 4ZGEA 1UGPA 2ZPEA 1UGSA 2ZPIA 3X25A 2DD5C 3QYHA 3X26A 3A8GA 2CYZA
chains in the Genus database with same CATH superfamily
3WVDA 2DXBC 3X24A 2CZ1A 2CZ6A 3QYGA 3VYHA 2D0QA 2ZPHA 4OB1A 1AHJA 4FM4A 4ZGDA 2CZ7A 3HHTA 3QXEA 2DPPA 2ZZDC 3QZ5A 2ZPFA 4OB3A 2CZ0A 4OB0A 3WVEA 3VYGC 4ZGJA 3A8OA 1UGRA 2ZPBA 1V29A 2AHJA 2QDYA 3A8HA 2ZCFA 3X20A 2ZPGA 1IREA 2DXCC 3A8MA 2DD4C 3QZ9A 1UGQA 3X28A 3A8LA 4OB2A 4ZGEA 1UGPA 2ZPEA 1UGSA 2ZPIA 3X25A 2DD5C 3QYHA 3X26A 3A8GA 2CYZA
chains in the Genus database with same CATH topology
3WVDA 2DXBC 3X24A 2CZ1A 2CZ6A 3QYGA 3VYHA 2D0QA 2ZPHA 4OB1A 1AHJA 4FM4A 4ZGDA 2CZ7A 3HHTA 3QXEA 2DPPA 2ZZDC 3QZ5A 2ZPFA 4OB3A 2CZ0A 4OB0A 3WVEA 3VYGC 4ZGJA 3A8OA 1UGRA 2ZPBA 1V29A 2AHJA 2QDYA 3A8HA 2ZCFA 3X20A 2ZPGA 1IREA 2DXCC 3A8MA 2DD4C 3QZ9A 1UGQA 3X28A 3A8LA 4OB2A 4ZGEA 1UGPA 2ZPEA 1UGSA 2ZPIA 3X25A 2DD5C 3QYHA 3X26A 3A8GA 2CYZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3WVD A;  2DXB C;  3X24 A;  2CZ1 A;  2CZ6 A;  3QYG A;  3VYH A;  2D0Q A;  2ZPH A;  4OB1 A;  1AHJ A;  4FM4 A;  4ZGD A;  2CZ7 A;  3HHT A;  3QXE A;  2DPP A;  2ZZD C;  3QZ5 A;  2ZPF A;  4OB3 A;  2CZ0 A;  4OB0 A;  3WVE A;  3VYG C;  4ZGJ A;  3A8O A;  1UGR A;  2ZPB A;  1V29 A;  2AHJ A;  2QDY A;  3A8H A;  2ZCF A;  3X20 A;  2ZPG A;  1IRE A;  2DXC C;  3A8M A;  2DD4 C;  3QZ9 A;  1UGQ A;  3X28 A;  3A8L A;  4OB2 A;  4ZGE A;  1UGP A;  2ZPE A;  1UGS A;  2ZPI A;  3X25 A;  2DD5 C;  3QYH A;  3X26 A;  3A8G A;  2CYZ A; 
#chains in the Genus database with same CATH topology
 3WVD A;  2DXB C;  3X24 A;  2CZ1 A;  2CZ6 A;  3QYG A;  3VYH A;  2D0Q A;  2ZPH A;  4OB1 A;  1AHJ A;  4FM4 A;  4ZGD A;  2CZ7 A;  3HHT A;  3QXE A;  2DPP A;  2ZZD C;  3QZ5 A;  2ZPF A;  4OB3 A;  2CZ0 A;  4OB0 A;  3WVE A;  3VYG C;  4ZGJ A;  3A8O A;  1UGR A;  2ZPB A;  1V29 A;  2AHJ A;  2QDY A;  3A8H A;  2ZCF A;  3X20 A;  2ZPG A;  1IRE A;  2DXC C;  3A8M A;  2DD4 C;  3QZ9 A;  1UGQ A;  3X28 A;  3A8L A;  4OB2 A;  4ZGE A;  1UGP A;  2ZPE A;  1UGS A;  2ZPI A;  3X25 A;  2DD5 C;  3QYH A;  3X26 A;  3A8G A;  2CYZ A; 
#chains in the Genus database with same CATH homology
 3WVD A;  2DXB C;  3X24 A;  2CZ1 A;  2CZ6 A;  3QYG A;  3VYH A;  2D0Q A;  2ZPH A;  4OB1 A;  1AHJ A;  4FM4 A;  4ZGD A;  2CZ7 A;  3HHT A;  3QXE A;  2DPP A;  2ZZD C;  3QZ5 A;  2ZPF A;  4OB3 A;  2CZ0 A;  4OB0 A;  3WVE A;  3VYG C;  4ZGJ A;  3A8O A;  1UGR A;  2ZPB A;  1V29 A;  2AHJ A;  2QDY A;  3A8H A;  2ZCF A;  3X20 A;  2ZPG A;  1IRE A;  2DXC C;  3A8M A;  2DD4 C;  3QZ9 A;  1UGQ A;  3X28 A;  3A8L A;  4OB2 A;  4ZGE A;  1UGP A;  2ZPE A;  1UGS A;  2ZPI A;  3X25 A;  2DD5 C;  3QYH A;  3X26 A;  3A8G A;  2CYZ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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