4AXGA

Structure of eif4e-cup complex
Total Genus 50
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
50
sequence length
183
structure length
181
Chain Sequence
HLYKHPLMNVWTLWYLENDRSKSWEDMQNEITSFDTVEDFWSLYNHIKPPSEIKLGSDYSLFKKNIRPMWEDAANKQGGRWVITLNKSSKTDLDNLWLDVLLCLIGEAFDHSDQICGAVINIRGKSNKISIWTADGNNEEAALEIGHKLRDALRLGRNNSLQYQLHKDTMVKQNVKSIYTL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structure of a Minimal Eif4E-Cup Complex Revelas a General Mechanism of Eif4E Regulation in Translational Repression
pubmed doi rcsb
molecule tags Translation
source organism Drosophila melanogaster
molecule keywords EUKARYOTIC TRANSLATION INITIATION FACTOR 4E
total genus 50
structure length 181
sequence length 183
chains with identical sequence B
ec nomenclature
pdb deposition date 2012-06-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01652 IF4E Eukaryotic initiation factor 4E
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.760.10 Alpha Beta 2-Layer Sandwich RNA Cap, Translation Initiation Factor Eif4e RNA Cap, Translation Initiation Factor Eif4e 4axgA00
5T47A 2IDRA 3AM7A 4UEDA 5EI3A 2V8YA 2IDVA 1RF8A 5T48A 2JGBA 4AXGA 4BEAA 1EJ1A 1WKWA 2WMCA 1AP8A 2W97A 3TF2A 2V8XA 5BXVA 5EIRA 5ABVA 4UEBA 4DUMA 2GPQA 1EJHA 2Q4KA 5ABYA 3M93A 3M94A 4UE9A 4TQCA 1IPCA 3U7XA 1L8BA 2V8WA 5EHCA 4B6UA 3HXGA 4AZAA 5ABUA 1IPBA 4UECA 5ABXA 1EJ4A 3HXIA 4UE8A 4DT6A 5GW6A 2JGCA 1ZTPA 5T46A 2W97B 4TPWA 5EKVA 4B6VA 4TQBA 4UEAA
chains in the Genus database with same CATH superfamily
5T47A 2IDRA 3AM7A 4UEDA 5EI3A 2V8YA 2IDVA 1RF8A 5T48A 2JGBA 4AXGA 4BEAA 1EJ1A 1WKWA 2WMCA 1AP8A 2W97A 3TF2A 2V8XA 5BXVA 5EIRA 5ABVA 4UEBA 4DUMA 2GPQA 1EJHA 2Q4KA 5ABYA 3M93A 3M94A 4UE9A 4TQCA 1IPCA 3U7XA 1L8BA 2V8WA 5EHCA 4B6UA 3HXGA 4AZAA 5ABUA 1IPBA 4UECA 5ABXA 1EJ4A 3HXIA 4UE8A 4DT6A 5GW6A 2JGCA 1ZTPA 5T46A 2W97B 4TPWA 5EKVA 4B6VA 4TQBA 4UEAA
chains in the Genus database with same CATH topology
5T47A 2IDRA 3AM7A 4UEDA 5EI3A 2V8YA 2IDVA 1RF8A 5T48A 2JGBA 4AXGA 4BEAA 1EJ1A 1WKWA 2WMCA 1AP8A 2W97A 3TF2A 2V8XA 5BXVA 5EIRA 5ABVA 4UEBA 4DUMA 2GPQA 1EJHA 2Q4KA 5ABYA 3M93A 3M94A 4UE9A 4TQCA 1IPCA 3U7XA 1L8BA 2V8WA 5EHCA 4B6UA 3HXGA 4AZAA 5ABUA 1IPBA 4UECA 5ABXA 1EJ4A 3HXIA 4UE8A 4DT6A 5GW6A 2JGCA 1ZTPA 5T46A 2W97B 4TPWA 5EKVA 4B6VA 4TQBA 4UEAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5T47 A;  2IDR A;  3AM7 A;  4UED A;  5EI3 A;  2V8Y A;  2IDV A;  1RF8 A;  5T48 A;  2JGB A;  4AXG A;  4BEA A;  1EJ1 A;  1WKW A;  2WMC A;  1AP8 A;  2W97 A;  3TF2 A;  2V8X A;  5BXV A;  5EIR A;  5ABV A;  4UEB A;  4DUM A;  2GPQ A;  1EJH A;  2Q4K A;  5ABY A;  3M93 A;  3M94 A;  4UE9 A;  4TQC A;  1IPC A;  3U7X A;  1L8B A;  2V8W A;  5EHC A;  4B6U A;  3HXG A;  4AZA A;  5ABU A;  1IPB A;  4UEC A;  5ABX A;  1EJ4 A;  3HXI A;  4UE8 A;  4DT6 A;  5GW6 A;  2JGC A;  1ZTP A;  5T46 A;  2W97 B;  4TPW A;  5EKV A;  4B6V A;  4TQB A;  4UEA A; 
#chains in the Genus database with same CATH topology
 5T47 A;  2IDR A;  3AM7 A;  4UED A;  5EI3 A;  2V8Y A;  2IDV A;  1RF8 A;  5T48 A;  2JGB A;  4AXG A;  4BEA A;  1EJ1 A;  1WKW A;  2WMC A;  1AP8 A;  2W97 A;  3TF2 A;  2V8X A;  5BXV A;  5EIR A;  5ABV A;  4UEB A;  4DUM A;  2GPQ A;  1EJH A;  2Q4K A;  5ABY A;  3M93 A;  3M94 A;  4UE9 A;  4TQC A;  1IPC A;  3U7X A;  1L8B A;  2V8W A;  5EHC A;  4B6U A;  3HXG A;  4AZA A;  5ABU A;  1IPB A;  4UEC A;  5ABX A;  1EJ4 A;  3HXI A;  4UE8 A;  4DT6 A;  5GW6 A;  2JGC A;  1ZTP A;  5T46 A;  2W97 B;  4TPW A;  5EKV A;  4B6V A;  4TQB A;  4UEA A; 
#chains in the Genus database with same CATH homology
 5T47 A;  2IDR A;  3AM7 A;  4UED A;  5EI3 A;  2V8Y A;  2IDV A;  1RF8 A;  5T48 A;  2JGB A;  4AXG A;  4BEA A;  1EJ1 A;  1WKW A;  2WMC A;  1AP8 A;  2W97 A;  3TF2 A;  2V8X A;  5BXV A;  5EIR A;  5ABV A;  4UEB A;  4DUM A;  2GPQ A;  1EJH A;  2Q4K A;  5ABY A;  3M93 A;  3M94 A;  4UE9 A;  4TQC A;  1IPC A;  3U7X A;  1L8B A;  2V8W A;  5EHC A;  4B6U A;  3HXG A;  4AZA A;  5ABU A;  1IPB A;  4UEC A;  5ABX A;  1EJ4 A;  3HXI A;  4UE8 A;  4DT6 A;  5GW6 A;  2JGC A;  1ZTP A;  5T46 A;  2W97 B;  4TPW A;  5EKV A;  4B6V A;  4TQB A;  4UEA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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