4AZAA

Improved eif4e binding peptides by phage display guided design.
Total Genus 58
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
58
sequence length
191
structure length
188
Chain Sequence
EVANPEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGKNRFVV
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Improved Eif4E Binding Peptides by Phage Display Guided Design: Plasticity of Interacting Surfaces Yield Collective Effects.
pubmed doi rcsb
molecule tags Translation
source organism Homo sapiens
molecule keywords EUKARYOTIC TRANSLATION INITIATION FACTOR 4E
total genus 58
structure length 188
sequence length 191
chains with identical sequence C
ec nomenclature
pdb deposition date 2012-06-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01652 IF4E Eukaryotic initiation factor 4E
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.760.10 Alpha Beta 2-Layer Sandwich RNA Cap, Translation Initiation Factor Eif4e RNA Cap, Translation Initiation Factor Eif4e 4azaA00
3HXIA 1AP8A 4UE8A 1EJ4A 2V8WA 3M94A 5BXVA 5ABUA 4DUMA 1RF8A 2WMCA 4UEDA 4UEAA 3M93A 1ZTPA 1IPBA 3HXGA 4TQBA 4B6UA 4UE9A 4AXGA 4UEBA 2IDRA 2W97B 5T46A 3TF2A 5GW6A 2V8XA 1L8BA 5ABXA 1IPCA 2JGCA 4TQCA 5EIRA 5EI3A 1WKWA 2V8YA 5ABVA 4AZAA 5EHCA 5ABYA 5T48A 4BEAA 2GPQA 4B6VA 2JGBA 4TPWA 1EJ1A 3AM7A 4UECA 2Q4KA 3U7XA 2W97A 1EJHA 5EKVA 2IDVA 4DT6A 5T47A
chains in the Genus database with same CATH superfamily
3HXIA 1AP8A 4UE8A 1EJ4A 2V8WA 3M94A 5BXVA 5ABUA 4DUMA 1RF8A 2WMCA 4UEDA 4UEAA 3M93A 1ZTPA 1IPBA 3HXGA 4TQBA 4B6UA 4UE9A 4AXGA 4UEBA 2IDRA 2W97B 5T46A 3TF2A 5GW6A 2V8XA 1L8BA 5ABXA 1IPCA 2JGCA 4TQCA 5EIRA 5EI3A 1WKWA 2V8YA 5ABVA 4AZAA 5EHCA 5ABYA 5T48A 4BEAA 2GPQA 4B6VA 2JGBA 4TPWA 1EJ1A 3AM7A 4UECA 2Q4KA 3U7XA 2W97A 1EJHA 5EKVA 2IDVA 4DT6A 5T47A
chains in the Genus database with same CATH topology
3HXIA 1AP8A 4UE8A 1EJ4A 2V8WA 3M94A 5BXVA 5ABUA 4DUMA 1RF8A 2WMCA 4UEDA 4UEAA 3M93A 1ZTPA 1IPBA 3HXGA 4TQBA 4B6UA 4UE9A 4AXGA 4UEBA 2IDRA 2W97B 5T46A 3TF2A 5GW6A 2V8XA 1L8BA 5ABXA 1IPCA 2JGCA 4TQCA 5EIRA 5EI3A 1WKWA 2V8YA 5ABVA 4AZAA 5EHCA 5ABYA 5T48A 4BEAA 2GPQA 4B6VA 2JGBA 4TPWA 1EJ1A 3AM7A 4UECA 2Q4KA 3U7XA 2W97A 1EJHA 5EKVA 2IDVA 4DT6A 5T47A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3HXI A;  1AP8 A;  4UE8 A;  1EJ4 A;  2V8W A;  3M94 A;  5BXV A;  5ABU A;  4DUM A;  1RF8 A;  2WMC A;  4UED A;  4UEA A;  3M93 A;  1ZTP A;  1IPB A;  3HXG A;  4TQB A;  4B6U A;  4UE9 A;  4AXG A;  4UEB A;  2IDR A;  2W97 B;  5T46 A;  3TF2 A;  5GW6 A;  2V8X A;  1L8B A;  5ABX A;  1IPC A;  2JGC A;  4TQC A;  5EIR A;  5EI3 A;  1WKW A;  2V8Y A;  5ABV A;  4AZA A;  5EHC A;  5ABY A;  5T48 A;  4BEA A;  2GPQ A;  4B6V A;  2JGB A;  4TPW A;  1EJ1 A;  3AM7 A;  4UEC A;  2Q4K A;  3U7X A;  2W97 A;  1EJH A;  5EKV A;  2IDV A;  4DT6 A;  5T47 A; 
#chains in the Genus database with same CATH topology
 3HXI A;  1AP8 A;  4UE8 A;  1EJ4 A;  2V8W A;  3M94 A;  5BXV A;  5ABU A;  4DUM A;  1RF8 A;  2WMC A;  4UED A;  4UEA A;  3M93 A;  1ZTP A;  1IPB A;  3HXG A;  4TQB A;  4B6U A;  4UE9 A;  4AXG A;  4UEB A;  2IDR A;  2W97 B;  5T46 A;  3TF2 A;  5GW6 A;  2V8X A;  1L8B A;  5ABX A;  1IPC A;  2JGC A;  4TQC A;  5EIR A;  5EI3 A;  1WKW A;  2V8Y A;  5ABV A;  4AZA A;  5EHC A;  5ABY A;  5T48 A;  4BEA A;  2GPQ A;  4B6V A;  2JGB A;  4TPW A;  1EJ1 A;  3AM7 A;  4UEC A;  2Q4K A;  3U7X A;  2W97 A;  1EJH A;  5EKV A;  2IDV A;  4DT6 A;  5T47 A; 
#chains in the Genus database with same CATH homology
 3HXI A;  1AP8 A;  4UE8 A;  1EJ4 A;  2V8W A;  3M94 A;  5BXV A;  5ABU A;  4DUM A;  1RF8 A;  2WMC A;  4UED A;  4UEA A;  3M93 A;  1ZTP A;  1IPB A;  3HXG A;  4TQB A;  4B6U A;  4UE9 A;  4AXG A;  4UEB A;  2IDR A;  2W97 B;  5T46 A;  3TF2 A;  5GW6 A;  2V8X A;  1L8B A;  5ABX A;  1IPC A;  2JGC A;  4TQC A;  5EIR A;  5EI3 A;  1WKW A;  2V8Y A;  5ABV A;  4AZA A;  5EHC A;  5ABY A;  5T48 A;  4BEA A;  2GPQ A;  4B6V A;  2JGB A;  4TPW A;  1EJ1 A;  3AM7 A;  4UEC A;  2Q4K A;  3U7X A;  2W97 A;  1EJH A;  5EKV A;  2IDV A;  4DT6 A;  5T47 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...