4B6UA

Solution structure of eif4e3 in complex with m7gdp
Total Genus 33
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
33
sequence length
207
structure length
207
Chain Sequence
MALPPAAAPPGANEPLDKALSALPPEPGGVPLHSPWTFWLDRSLPGATAAECASNLKKIYTVQTVQIFWSVYNNIPPVTSLPLRCSYHLMRGERRPLWEEESNAKGGVWKMKVPKDSTSTVWKELLLATIGEQFTDCAAADDEIIGVSVSVRDREDVVQVWNVNASLVGEATVLEKIHQLLPHIAFKAVFYKPHEEHHAFEGGRGKH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Eif4E3 Acts as a Tumor Suppressor by Utilizing an Atypical Mode of Methyl-7-Guanosine CAP Recognition
pubmed doi rcsb
molecule tags Translation
source organism Mus musculus
molecule keywords EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 3
total genus 33
structure length 207
sequence length 207
ec nomenclature
pdb deposition date 2012-08-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01652 IF4E Eukaryotic initiation factor 4E
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.760.10 Alpha Beta 2-Layer Sandwich RNA Cap, Translation Initiation Factor Eif4e RNA Cap, Translation Initiation Factor Eif4e 4b6uA00
2Q4KA 1EJ4A 4TQBA 5ABXA 4TPWA 4UECA 4TQCA 4DT6A 5ABYA 4AXGA 4DUMA 5EHCA 5T48A 2JGBA 2V8XA 4UEAA 5GW6A 1AP8A 3AM7A 3M94A 5EIRA 2JGCA 1EJHA 2W97B 3HXGA 1IPBA 4UE9A 4B6VA 4BEAA 2WMCA 1RF8A 5ABUA 5ABVA 2W97A 4B6UA 5T47A 1WKWA 2V8WA 2IDRA 1EJ1A 4UEDA 5EKVA 3HXIA 4AZAA 4UE8A 2IDVA 4UEBA 5EI3A 5BXVA 3U7XA 2GPQA 1L8BA 3TF2A 5T46A 3M93A 1ZTPA 1IPCA 2V8YA
chains in the Genus database with same CATH superfamily
2Q4KA 1EJ4A 4TQBA 5ABXA 4TPWA 4UECA 4TQCA 4DT6A 5ABYA 4AXGA 4DUMA 5EHCA 5T48A 2JGBA 2V8XA 4UEAA 5GW6A 1AP8A 3AM7A 3M94A 5EIRA 2JGCA 1EJHA 2W97B 3HXGA 1IPBA 4UE9A 4B6VA 4BEAA 2WMCA 1RF8A 5ABUA 5ABVA 2W97A 4B6UA 5T47A 1WKWA 2V8WA 2IDRA 1EJ1A 4UEDA 5EKVA 3HXIA 4AZAA 4UE8A 2IDVA 4UEBA 5EI3A 5BXVA 3U7XA 2GPQA 1L8BA 3TF2A 5T46A 3M93A 1ZTPA 1IPCA 2V8YA
chains in the Genus database with same CATH topology
2Q4KA 1EJ4A 4TQBA 5ABXA 4TPWA 4UECA 4TQCA 4DT6A 5ABYA 4AXGA 4DUMA 5EHCA 5T48A 2JGBA 2V8XA 4UEAA 5GW6A 1AP8A 3AM7A 3M94A 5EIRA 2JGCA 1EJHA 2W97B 3HXGA 1IPBA 4UE9A 4B6VA 4BEAA 2WMCA 1RF8A 5ABUA 5ABVA 2W97A 4B6UA 5T47A 1WKWA 2V8WA 2IDRA 1EJ1A 4UEDA 5EKVA 3HXIA 4AZAA 4UE8A 2IDVA 4UEBA 5EI3A 5BXVA 3U7XA 2GPQA 1L8BA 3TF2A 5T46A 3M93A 1ZTPA 1IPCA 2V8YA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2Q4K A;  1EJ4 A;  4TQB A;  5ABX A;  4TPW A;  4UEC A;  4TQC A;  4DT6 A;  5ABY A;  4AXG A;  4DUM A;  5EHC A;  5T48 A;  2JGB A;  2V8X A;  4UEA A;  5GW6 A;  1AP8 A;  3AM7 A;  3M94 A;  5EIR A;  2JGC A;  1EJH A;  2W97 B;  3HXG A;  1IPB A;  4UE9 A;  4B6V A;  4BEA A;  2WMC A;  1RF8 A;  5ABU A;  5ABV A;  2W97 A;  4B6U A;  5T47 A;  1WKW A;  2V8W A;  2IDR A;  1EJ1 A;  4UED A;  5EKV A;  3HXI A;  4AZA A;  4UE8 A;  2IDV A;  4UEB A;  5EI3 A;  5BXV A;  3U7X A;  2GPQ A;  1L8B A;  3TF2 A;  5T46 A;  3M93 A;  1ZTP A;  1IPC A;  2V8Y A; 
#chains in the Genus database with same CATH topology
 2Q4K A;  1EJ4 A;  4TQB A;  5ABX A;  4TPW A;  4UEC A;  4TQC A;  4DT6 A;  5ABY A;  4AXG A;  4DUM A;  5EHC A;  5T48 A;  2JGB A;  2V8X A;  4UEA A;  5GW6 A;  1AP8 A;  3AM7 A;  3M94 A;  5EIR A;  2JGC A;  1EJH A;  2W97 B;  3HXG A;  1IPB A;  4UE9 A;  4B6V A;  4BEA A;  2WMC A;  1RF8 A;  5ABU A;  5ABV A;  2W97 A;  4B6U A;  5T47 A;  1WKW A;  2V8W A;  2IDR A;  1EJ1 A;  4UED A;  5EKV A;  3HXI A;  4AZA A;  4UE8 A;  2IDV A;  4UEB A;  5EI3 A;  5BXV A;  3U7X A;  2GPQ A;  1L8B A;  3TF2 A;  5T46 A;  3M93 A;  1ZTP A;  1IPC A;  2V8Y A; 
#chains in the Genus database with same CATH homology
 2Q4K A;  1EJ4 A;  4TQB A;  5ABX A;  4TPW A;  4UEC A;  4TQC A;  4DT6 A;  5ABY A;  4AXG A;  4DUM A;  5EHC A;  5T48 A;  2JGB A;  2V8X A;  4UEA A;  5GW6 A;  1AP8 A;  3AM7 A;  3M94 A;  5EIR A;  2JGC A;  1EJH A;  2W97 B;  3HXG A;  1IPB A;  4UE9 A;  4B6V A;  4BEA A;  2WMC A;  1RF8 A;  5ABU A;  5ABV A;  2W97 A;  4B6U A;  5T47 A;  1WKW A;  2V8W A;  2IDR A;  1EJ1 A;  4UED A;  5EKV A;  3HXI A;  4AZA A;  4UE8 A;  2IDV A;  4UEB A;  5EI3 A;  5BXV A;  3U7X A;  2GPQ A;  1L8B A;  3TF2 A;  5T46 A;  3M93 A;  1ZTP A;  1IPC A;  2V8Y A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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