4B6VA

The third member of the eif4e family represses gene expression via a novel mode of recognition of the methyl-7 guanosine cap moiety
Total Genus 28
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
28
sequence length
207
structure length
207
Chain Sequence
MALPPAAAPPGANEPLDKALSALPPEPGGVPLHSPWTFWLDRSLPGATAAECASNLKKIYTVQTVQIFWSVYNNIPPVTSLPLRCSYHLMRGERRPLWEEESNAKGGVWKMKVPKDSTSTVWKELLLATIGEQFTDCAAADDEIIGVSVSVRDREDVVQVWNVNASLVGEATVLEKIHQLLPHIAFKAVFYKPHEEHHAFEGGRGKH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Eif4E3 Acts as a Tumor Suppressor by Utilizing an Atypical Mode of Methyl-7-Guanosine CAP Recognition.
pubmed doi rcsb
molecule keywords EUKARYOTIC TRANSLATION INITIATION FACTOR 4E TYPE 3
molecule tags Translation
source organism Mus musculus
total genus 28
structure length 207
sequence length 207
ec nomenclature
pdb deposition date 2012-08-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01652 IF4E Eukaryotic initiation factor 4E
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.760.10 Alpha Beta 2-Layer Sandwich RNA Cap, Translation Initiation Factor Eif4e RNA Cap, Translation Initiation Factor Eif4e 4b6vA00
4UEBA 2GPQA 1EJ1A 4BEAA 3M93A 5EI3A 4DT6A 4UECA 5ABXA 2V8YA 1L8BA 4TQBA 4B6VA 4UE8A 1IPCA 1IPBA 4B6UA 2IDVA 5EKVA 1EJ4A 5ABUA 1EJHA 2W97A 3TF2A 5GW6A 1WKWA 4UE9A 2JGCA 5T47A 3U7XA 3AM7A 2W97B 2WMCA 2V8WA 4UEAA 4DUMA 5T48A 4TPWA 5BXVA 4TQCA 5EHCA 1RF8A 5T46A 4AZAA 5ABYA 1AP8A 4UEDA 5ABVA 3M94A 2JGBA 3HXIA 2V8XA 4AXGA 5EIRA 2Q4KA 3HXGA 1ZTPA 2IDRA
chains in the Genus database with same CATH superfamily
4UEBA 2GPQA 1EJ1A 4BEAA 3M93A 5EI3A 4DT6A 4UECA 5ABXA 2V8YA 1L8BA 4TQBA 4B6VA 4UE8A 1IPCA 1IPBA 4B6UA 2IDVA 5EKVA 1EJ4A 5ABUA 1EJHA 2W97A 3TF2A 5GW6A 1WKWA 4UE9A 2JGCA 5T47A 3U7XA 3AM7A 2W97B 2WMCA 2V8WA 4UEAA 4DUMA 5T48A 4TPWA 5BXVA 4TQCA 5EHCA 1RF8A 5T46A 4AZAA 5ABYA 1AP8A 4UEDA 5ABVA 3M94A 2JGBA 3HXIA 2V8XA 4AXGA 5EIRA 2Q4KA 3HXGA 1ZTPA 2IDRA
chains in the Genus database with same CATH topology
4UEBA 2GPQA 1EJ1A 4BEAA 3M93A 5EI3A 4DT6A 4UECA 5ABXA 2V8YA 1L8BA 4TQBA 4B6VA 4UE8A 1IPCA 1IPBA 4B6UA 2IDVA 5EKVA 1EJ4A 5ABUA 1EJHA 2W97A 3TF2A 5GW6A 1WKWA 4UE9A 2JGCA 5T47A 3U7XA 3AM7A 2W97B 2WMCA 2V8WA 4UEAA 4DUMA 5T48A 4TPWA 5BXVA 4TQCA 5EHCA 1RF8A 5T46A 4AZAA 5ABYA 1AP8A 4UEDA 5ABVA 3M94A 2JGBA 3HXIA 2V8XA 4AXGA 5EIRA 2Q4KA 3HXGA 1ZTPA 2IDRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4UEB A;  2GPQ A;  1EJ1 A;  4BEA A;  3M93 A;  5EI3 A;  4DT6 A;  4UEC A;  5ABX A;  2V8Y A;  1L8B A;  4TQB A;  4B6V A;  4UE8 A;  1IPC A;  1IPB A;  4B6U A;  2IDV A;  5EKV A;  1EJ4 A;  5ABU A;  1EJH A;  2W97 A;  3TF2 A;  5GW6 A;  1WKW A;  4UE9 A;  2JGC A;  5T47 A;  3U7X A;  3AM7 A;  2W97 B;  2WMC A;  2V8W A;  4UEA A;  4DUM A;  5T48 A;  4TPW A;  5BXV A;  4TQC A;  5EHC A;  1RF8 A;  5T46 A;  4AZA A;  5ABY A;  1AP8 A;  4UED A;  5ABV A;  3M94 A;  2JGB A;  3HXI A;  2V8X A;  4AXG A;  5EIR A;  2Q4K A;  3HXG A;  1ZTP A;  2IDR A; 
#chains in the Genus database with same CATH topology
 4UEB A;  2GPQ A;  1EJ1 A;  4BEA A;  3M93 A;  5EI3 A;  4DT6 A;  4UEC A;  5ABX A;  2V8Y A;  1L8B A;  4TQB A;  4B6V A;  4UE8 A;  1IPC A;  1IPB A;  4B6U A;  2IDV A;  5EKV A;  1EJ4 A;  5ABU A;  1EJH A;  2W97 A;  3TF2 A;  5GW6 A;  1WKW A;  4UE9 A;  2JGC A;  5T47 A;  3U7X A;  3AM7 A;  2W97 B;  2WMC A;  2V8W A;  4UEA A;  4DUM A;  5T48 A;  4TPW A;  5BXV A;  4TQC A;  5EHC A;  1RF8 A;  5T46 A;  4AZA A;  5ABY A;  1AP8 A;  4UED A;  5ABV A;  3M94 A;  2JGB A;  3HXI A;  2V8X A;  4AXG A;  5EIR A;  2Q4K A;  3HXG A;  1ZTP A;  2IDR A; 
#chains in the Genus database with same CATH homology
 4UEB A;  2GPQ A;  1EJ1 A;  4BEA A;  3M93 A;  5EI3 A;  4DT6 A;  4UEC A;  5ABX A;  2V8Y A;  1L8B A;  4TQB A;  4B6V A;  4UE8 A;  1IPC A;  1IPB A;  4B6U A;  2IDV A;  5EKV A;  1EJ4 A;  5ABU A;  1EJH A;  2W97 A;  3TF2 A;  5GW6 A;  1WKW A;  4UE9 A;  2JGC A;  5T47 A;  3U7X A;  3AM7 A;  2W97 B;  2WMC A;  2V8W A;  4UEA A;  4DUM A;  5T48 A;  4TPW A;  5BXV A;  4TQC A;  5EHC A;  1RF8 A;  5T46 A;  4AZA A;  5ABY A;  1AP8 A;  4UED A;  5ABV A;  3M94 A;  2JGB A;  3HXI A;  2V8X A;  4AXG A;  5EIR A;  2Q4K A;  3HXG A;  1ZTP A;  2IDR A; 
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similar chains in the Genus database (?% sequence similarity)
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