4HIRA

Solution structure of recombinant hirudin and the lys-47 (right arrow) glu mutant. a nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing study
Total Genus 4
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
4
sequence length
49
structure length
49
Chain Sequence
VVYTDCTESGQNLCLCEGSNVCGQGNKCILGSDGEKNQCVTGEGTPEPQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Solution structure of recombinant hirudin and the Lys-47----Glu mutant: a nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing study.
pubmed doi rcsb
molecule tags Coagulation inhibitor
source organism Hirudo medicinalis
molecule keywords HIRUDIN VARIANT-1
total genus 4
structure length 49
sequence length 49
ec nomenclature
pdb deposition date 1988-12-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00713 Hirudin Hirudin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.10.10 Mainly Beta Distorted Sandwich Thrombin Inhibitor (Hirudin); Chain I Thrombin Inhibitor (Hirudin), subunit I 4hirA00
1HRTI 6HIRA 1E0FI 2PW8I 2JOOA 1HICA 2HIRA 4HIRA 4HTCI 4MLFD 5HIRA
chains in the Genus database with same CATH superfamily
1HRTI 6HIRA 1E0FI 2PW8I 2JOOA 1HICA 2HIRA 4HIRA 4HTCI 4MLFD 5HIRA
chains in the Genus database with same CATH topology
1HRTI 6HIRA 1E0FI 2PW8I 2JOOA 1HICA 2HIRA 4HIRA 4HTCI 4MLFD 5HIRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1HRT I;  6HIR A;  1E0F I;  2PW8 I;  2JOO A;  1HIC A;  2HIR A;  4HIR A;  4HTC I;  4MLF D;  5HIR A; 
#chains in the Genus database with same CATH topology
 1HRT I;  6HIR A;  1E0F I;  2PW8 I;  2JOO A;  1HIC A;  2HIR A;  4HIR A;  4HTC I;  4MLF D;  5HIR A; 
#chains in the Genus database with same CATH homology
 1HRT I;  6HIR A;  1E0F I;  2PW8 I;  2JOO A;  1HIC A;  2HIR A;  4HIR A;  4HTC I;  4MLF D;  5HIR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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