4HTCI

The refined structure of the hirudin-thrombin complex
Total Genus 10
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
10
sequence length
65
structure length
61
Chain Sequence
ITYTDCTESGQNLCLCEGSNVCGKGNKCILGGNQCVTGEGTPKPESHNNGDFEEIPEEYLQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Refined structure of the hirudin-thrombin complex.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords ALPHA-THROMBIN (SMALL SUBUNIT)
total genus 10
structure length 61
sequence length 65
ec nomenclature
pdb deposition date 1993-06-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00713 Hirudin Hirudin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.10.10 Mainly Beta Distorted Sandwich Thrombin Inhibitor (Hirudin); Chain I Thrombin Inhibitor (Hirudin), subunit I 4htcI00
1HRTI 4HTCI 2PW8I 2HIRA 1E0FI 1HICA 6HIRA 4MLFD 4HIRA 5HIRA 2JOOA
chains in the Genus database with same CATH superfamily
1HRTI 4HTCI 2PW8I 2HIRA 1E0FI 1HICA 6HIRA 4MLFD 4HIRA 5HIRA 2JOOA
chains in the Genus database with same CATH topology
1HRTI 4HTCI 2PW8I 2HIRA 1E0FI 1HICA 6HIRA 4MLFD 4HIRA 5HIRA 2JOOA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1HRT I;  4HTC I;  2PW8 I;  2HIR A;  1E0F I;  1HIC A;  6HIR A;  4MLF D;  4HIR A;  5HIR A;  2JOO A; 
#chains in the Genus database with same CATH topology
 1HRT I;  4HTC I;  2PW8 I;  2HIR A;  1E0F I;  1HIC A;  6HIR A;  4MLF D;  4HIR A;  5HIR A;  2JOO A; 
#chains in the Genus database with same CATH homology
 1HRT I;  4HTC I;  2PW8 I;  2HIR A;  1E0F I;  1HIC A;  6HIR A;  4MLF D;  4HIR A;  5HIR A;  2JOO A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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