4JZZA

Crystal structure of cd4-mimetic miniprotein m48u1 in complex with hiv-1 yu2 gp120 in c2221 space group
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
352
structure length
336
Chain Sequence
VWKEATTTLFCASDAKAYDTEVHNVWATHACVPTDPNPQEVKLENVTENFNMWKNNMVEQMHEDIISLWDQSLKPCVKLTGGSVITQACPKVSFEPIPIHYCAPAGFAILKCNDKKFNGTGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEEEIVIRSENFTNNAKTIIVQLNESVVINCTRPNNDIRQAHCNLSKTQWENTLEQIAIKLKEQFGNNKTIIFNPSSGGDPEIVTHSFNCGGEFFYCNSTQLFTWNDTGRNITLPCRIKQIINMWQEVGKAMYAPPIRGQIRCSSNITGLLLTRDGGNGTEIFRPGGGDMRDNWRSELYKYKVVKIE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis for Highly Effective HIV-1 Neutralization by CD4-Mimetic Miniproteins Revealed by 1.5 A Cocrystal Structure of gp120 and M48U1.
pubmed doi rcsb
molecule tags Viral protein/inhibitor
source organism Human immunodeficiency virus 1
molecule keywords HIV-1 YU2 gp120 glycoprotein
total genus 99
structure length 336
sequence length 352
ec nomenclature
pdb deposition date 2013-04-03
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.40.20 Mainly Beta Beta Complex HIV Envelope Protein Gp120; Chain G Human immunodeficiency virus 1, Gp160, envelope glycoprotein 4jzzA01
3TGSA 4S1RG 4JM2E 4R2GA 1G9MG 5F9WA 2NXYA 4XNYG 2NY7G 4XVTG 2NXZA 4JDTG 4YE4G 3RJQA 4YDIG 2NY5G 4LSRG 1RZKG 4RWYA 5F4LA 5F4UA 4JZZA 4J6RG 5I9QA 4OLZG 4DKUA 4YFLE 4I54A 4DVVA 2NY3A 3FUSA 4YDKG 4RFNA 5TE7G 3TIHA 4LSSG 3LQAG 4LAJA 4K0AA 1YYMG 4OM0G 4DKVA 4DVTA 3SE9G 4LSTG 4KA2A 4DVSA 2NY1A 5FECC 4XNZA 3TGTA 5IGXG 2NY6A 4XMPG 4LSUG 1GC1G 4JPWG 4P9HG 5KJRG 5CD5A 5F9OG 4XVSG 3U7YG 4RFOG 4DKQA 2I60G 4JZWA 3JWOA 2NY0A 2BF1A 5F96G 5FA2A 3JWDA 4OLVG 2I5YG 3HI1G 4OLWG 3SE8G 4DVXA 3NGBA 5TE6G 2NY2A 4OM1G 3TGRA 4OLXG 4LSVG 5T33G 5TE4G 3TGQA 4RX4E 4DKPA 1RZJG 4JB9G 4JKPG 4LSPG 2NY4A 4DKRA 4OLUG 3IDYA 4S1SG 1YYLG 5F4RA 4LSQG 5F4PA 4R4NA 4DVWA 4YDJG 5CAYG 4RZ8A 4R4FA 4DKOA 4H8WG 4OLYG 2QADA 4JPVG 4S1QG 4DVRG 4YDLA 2B4CG 1G9NG 3IDXG 4I53A
chains in the Genus database with same CATH superfamily
3TGSA 4S1RG 4JM2E 4R2GA 1G9MG 5F9WA 2NXYA 4XNYG 2NY7G 4XVTG 2NXZA 4JDTG 4YE4G 3RJQA 4YDIG 2NY5G 4LSRG 1RZKG 4RWYA 5F4LA 5F4UA 4JZZA 4J6RG 5I9QA 4OLZG 4DKUA 4YFLE 4I54A 4DVVA 2NY3A 3FUSA 4YDKG 4RFNA 5TE7G 3TIHA 4LSSG 3LQAG 4LAJA 4K0AA 1YYMG 4OM0G 4DKVA 4DVTA 3SE9G 4LSTG 4KA2A 4DVSA 2NY1A 5FECC 4XNZA 3TGTA 5IGXG 2NY6A 4XMPG 4LSUG 1GC1G 4JPWG 4P9HG 5KJRG 5CD5A 5F9OG 4XVSG 3U7YG 4RFOG 4DKQA 2I60G 4JZWA 3JWOA 2NY0A 2BF1A 5F96G 5FA2A 3JWDA 4OLVG 2I5YG 3HI1G 4OLWG 3SE8G 4DVXA 3NGBA 5TE6G 2NY2A 4OM1G 3TGRA 4OLXG 4LSVG 5T33G 5TE4G 3TGQA 4RX4E 4DKPA 1RZJG 4JB9G 4JKPG 4LSPG 2NY4A 4DKRA 4OLUG 3IDYA 4S1SG 1YYLG 5F4RA 4LSQG 5F4PA 4R4NA 4DVWA 4YDJG 5CAYG 4RZ8A 4R4FA 4DKOA 4H8WG 4OLYG 2QADA 4JPVG 4S1QG 4DVRG 4YDLA 2B4CG 1G9NG 3IDXG 4I53A
chains in the Genus database with same CATH topology
3TGSA 4S1RG 4JM2E 4R2GA 1G9MG 5F9WA 2NXYA 4XNYG 2NY7G 4XVTG 2NXZA 4JDTG 4YE4G 3RJQA 4YDIG 2NY5G 4LSRG 1RZKG 4RWYA 5F4LA 5F4UA 4JZZA 4J6RG 5I9QA 4OLZG 4DKUA 4YFLE 4I54A 4DVVA 2NY3A 3FUSA 4YDKG 4RFNA 5TE7G 3TIHA 4LSSG 3LQAG 4LAJA 4K0AA 1YYMG 4OM0G 4DKVA 4DVTA 3SE9G 4LSTG 4KA2A 4DVSA 2NY1A 5FECC 4XNZA 3TGTA 5IGXG 2NY6A 4XMPG 4LSUG 1GC1G 4JPWG 4P9HG 5KJRG 5CD5A 5F9OG 4XVSG 3U7YG 4RFOG 4DKQA 2I60G 4JZWA 3JWOA 2NY0A 2BF1A 5F96G 5FA2A 3JWDA 4OLVG 2I5YG 3HI1G 4OLWG 3SE8G 4DVXA 3NGBA 5TE6G 2NY2A 4OM1G 3TGRA 4OLXG 4LSVG 5T33G 5TE4G 3TGQA 4RX4E 4DKPA 1RZJG 4JB9G 4JKPG 4LSPG 2NY4A 4DKRA 4OLUG 3IDYA 4S1SG 1YYLG 5F4RA 4LSQG 5F4PA 4R4NA 4DVWA 4YDJG 5CAYG 4RZ8A 4R4FA 4DKOA 4H8WG 4OLYG 2QADA 4JPVG 4S1QG 4DVRG 4YDLA 2B4CG 1G9NG 3IDXG 4I53A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3TGS A;  4S1R G;  4JM2 E;  4R2G A;  1G9M G;  5F9W A;  2NXY A;  4XNY G;  2NY7 G;  4XVT G;  2NXZ A;  4JDT G;  4YE4 G;  3RJQ A;  4YDI G;  2NY5 G;  4LSR G;  1RZK G;  4RWY A;  5F4L A;  5F4U A;  4JZZ A;  4J6R G;  5I9Q A;  4OLZ G;  4DKU A;  4YFL E;  4I54 A;  4DVV A;  2NY3 A;  3FUS A;  4YDK G;  4RFN A;  5TE7 G;  3TIH A;  4LSS G;  3LQA G;  4LAJ A;  4K0A A;  1YYM G;  4OM0 G;  4DKV A;  4DVT A;  3SE9 G;  4LST G;  4KA2 A;  4DVS A;  2NY1 A;  5FEC C;  4XNZ A;  3TGT A;  5IGX G;  2NY6 A;  4XMP G;  4LSU G;  1GC1 G;  4JPW G;  4P9H G;  5KJR G;  5CD5 A;  5F9O G;  4XVS G;  3U7Y G;  4RFO G;  4DKQ A;  2I60 G;  4JZW A;  3JWO A;  2NY0 A;  2BF1 A;  5F96 G;  5FA2 A;  3JWD A;  4OLV G;  2I5Y G;  3HI1 G;  4OLW G;  3SE8 G;  4DVX A;  3NGB A;  5TE6 G;  2NY2 A;  4OM1 G;  3TGR A;  4OLX G;  4LSV G;  5T33 G;  5TE4 G;  3TGQ A;  4RX4 E;  4DKP A;  1RZJ G;  4JB9 G;  4JKP G;  4LSP G;  2NY4 A;  4DKR A;  4OLU G;  3IDY A;  4S1S G;  1YYL G;  5F4R A;  4LSQ G;  5F4P A;  4R4N A;  4DVW A;  4YDJ G;  5CAY G;  4RZ8 A;  4R4F A;  4DKO A;  4H8W G;  4OLY G;  2QAD A;  4JPV G;  4S1Q G;  4DVR G;  4YDL A;  2B4C G;  1G9N G;  3IDX G;  4I53 A; 
#chains in the Genus database with same CATH topology
 3TGS A;  4S1R G;  4JM2 E;  4R2G A;  1G9M G;  5F9W A;  2NXY A;  4XNY G;  2NY7 G;  4XVT G;  2NXZ A;  4JDT G;  4YE4 G;  3RJQ A;  4YDI G;  2NY5 G;  4LSR G;  1RZK G;  4RWY A;  5F4L A;  5F4U A;  4JZZ A;  4J6R G;  5I9Q A;  4OLZ G;  4DKU A;  4YFL E;  4I54 A;  4DVV A;  2NY3 A;  3FUS A;  4YDK G;  4RFN A;  5TE7 G;  3TIH A;  4LSS G;  3LQA G;  4LAJ A;  4K0A A;  1YYM G;  4OM0 G;  4DKV A;  4DVT A;  3SE9 G;  4LST G;  4KA2 A;  4DVS A;  2NY1 A;  5FEC C;  4XNZ A;  3TGT A;  5IGX G;  2NY6 A;  4XMP G;  4LSU G;  1GC1 G;  4JPW G;  4P9H G;  5KJR G;  5CD5 A;  5F9O G;  4XVS G;  3U7Y G;  4RFO G;  4DKQ A;  2I60 G;  4JZW A;  3JWO A;  2NY0 A;  2BF1 A;  5F96 G;  5FA2 A;  3JWD A;  4OLV G;  2I5Y G;  3HI1 G;  4OLW G;  3SE8 G;  4DVX A;  3NGB A;  5TE6 G;  2NY2 A;  4OM1 G;  3TGR A;  4OLX G;  4LSV G;  5T33 G;  5TE4 G;  3TGQ A;  4RX4 E;  4DKP A;  1RZJ G;  4JB9 G;  4JKP G;  4LSP G;  2NY4 A;  4DKR A;  4OLU G;  3IDY A;  4S1S G;  1YYL G;  5F4R A;  4LSQ G;  5F4P A;  4R4N A;  4DVW A;  4YDJ G;  5CAY G;  4RZ8 A;  4R4F A;  4DKO A;  4H8W G;  4OLY G;  2QAD A;  4JPV G;  4S1Q G;  4DVR G;  4YDL A;  2B4C G;  1G9N G;  3IDX G;  4I53 A; 
#chains in the Genus database with same CATH homology
 3TGS A;  4S1R G;  4JM2 E;  4R2G A;  1G9M G;  5F9W A;  2NXY A;  4XNY G;  2NY7 G;  4XVT G;  2NXZ A;  4JDT G;  4YE4 G;  3RJQ A;  4YDI G;  2NY5 G;  4LSR G;  1RZK G;  4RWY A;  5F4L A;  5F4U A;  4JZZ A;  4J6R G;  5I9Q A;  4OLZ G;  4DKU A;  4YFL E;  4I54 A;  4DVV A;  2NY3 A;  3FUS A;  4YDK G;  4RFN A;  5TE7 G;  3TIH A;  4LSS G;  3LQA G;  4LAJ A;  4K0A A;  1YYM G;  4OM0 G;  4DKV A;  4DVT A;  3SE9 G;  4LST G;  4KA2 A;  4DVS A;  2NY1 A;  5FEC C;  4XNZ A;  3TGT A;  5IGX G;  2NY6 A;  4XMP G;  4LSU G;  1GC1 G;  4JPW G;  4P9H G;  5KJR G;  5CD5 A;  5F9O G;  4XVS G;  3U7Y G;  4RFO G;  4DKQ A;  2I60 G;  4JZW A;  3JWO A;  2NY0 A;  2BF1 A;  5F96 G;  5FA2 A;  3JWD A;  4OLV G;  2I5Y G;  3HI1 G;  4OLW G;  3SE8 G;  4DVX A;  3NGB A;  5TE6 G;  2NY2 A;  4OM1 G;  3TGR A;  4OLX G;  4LSV G;  5T33 G;  5TE4 G;  3TGQ A;  4RX4 E;  4DKP A;  1RZJ G;  4JB9 G;  4JKP G;  4LSP G;  2NY4 A;  4DKR A;  4OLU G;  3IDY A;  4S1S G;  1YYL G;  5F4R A;  4LSQ G;  5F4P A;  4R4N A;  4DVW A;  4YDJ G;  5CAY G;  4RZ8 A;  4R4F A;  4DKO A;  4H8W G;  4OLY G;  2QAD A;  4JPV G;  4S1Q G;  4DVR G;  4YDL A;  2B4C G;  1G9N G;  3IDX G;  4I53 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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