4LSQG

Crystal structure of broadly and potently neutralizing antibody vrc-ch31 in complex with hiv-1 clade a/e gp120 93th057 with loop d and loop v5 from clade a strain 3415_v1_c1
Total Genus 84
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
84
sequence length
352
structure length
344
Chain Sequence
VWKDADTTLFCASDAKAHETEVHNVWATHACVPTDPNPQEIHLENVTENFNMWKNNMVEQMQEDVISLWDQSLQPCVKLTGGSVIKQACPKISFDPIPIHYCTPAGYVILKCNDKNFNGTGPCKNVSSVQCTHGIKPVVSTQLLLNGSLAEEEIIIRTENITDNAKTIIVHLNKSVEINCTRPSNGDIRKAYCEINGTKWNKVLKQVTEKLKEHFNNKTIIFQPPSGGDLEITMHHFNCRGEFFYCNTTQLFNNTCIETMKGCNGTITLPCKIKQIINMWQGTGQAMYAPPIDGKINCVSNITGILLTRDGGENNSTEIFRPGGGNIKDNWRSELYKYKVVQIE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies.
pubmed doi rcsb
molecule tags Viral protein/immune system
source organism Human immunodeficiency virus 1
molecule keywords ENVELOPE GLYCOPROTEIN GP120 WITH LOOP D AND V5 FROM STRAIN 3
total genus 84
structure length 344
sequence length 352
ec nomenclature
pdb deposition date 2013-07-23
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.40.20 Mainly Beta Beta Complex HIV Envelope Protein Gp120; Chain G Human immunodeficiency virus 1, Gp160, envelope glycoprotein 4lsqG01
2I60G 4RWYA 5CAYG 2NY1A 3JWDA 3NGBA 5KJRG 4JZWA 4H8WG 5I9QA 4LSRG 2BF1A 3SE9G 4LAJA 4LSTG 5T33G 4DVRG 4DKPA 1GC1G 4J6RG 1YYMG 5F4RA 4LSUG 4OM0G 4JB9G 4S1SG 3IDYA 5F96G 4RX4E 4XNZA 5FECC 3TGRA 4K0AA 4DVSA 2I5YG 2NXZA 4DKQA 5F4UA 4LSVG 4YDKG 3RJQA 4YDJG 4DKRA 4P9HG 3TIHA 4LSQG 3FUSA 4OLYG 4RFOG 5TE6G 4YFLE 2NXYA 5F4PA 1RZKG 4DKUA 5F4LA 4OLXG 4YDIG 4OLVG 4XMPG 4DVWA 4JZZA 3TGTA 4I53A 4YDLA 4JM2E 3SE8G 2NY3A 3JWOA 4DVXA 5F9OG 4LSSG 4OLZG 4LSPG 4OM1G 4S1RG 4JKPG 4KA2A 4OLUG 4S1QG 4DKOA 5CD5A 4DVVA 5FA2A 4DVTA 4XVTG 4RFNA 1YYLG 2NY4A 4R2GA 5IGXG 2NY6A 1RZJG 4DKVA 4JPVG 4RZ8A 3U7YG 4R4FA 3HI1G 4XVSG 4I54A 2NY0A 4XNYG 5F9WA 2B4CG 4YE4G 2NY7G 5TE7G 4JPWG 4JDTG 3TGQA 3IDXG 4R4NA 3TGSA 2NY2A 2NY5G 3LQAG 1G9MG 4OLWG 1G9NG 5TE4G 2QADA
chains in the Genus database with same CATH superfamily
2I60G 4RWYA 5CAYG 2NY1A 3JWDA 3NGBA 5KJRG 4JZWA 4H8WG 5I9QA 4LSRG 2BF1A 3SE9G 4LAJA 4LSTG 5T33G 4DVRG 4DKPA 1GC1G 4J6RG 1YYMG 5F4RA 4LSUG 4OM0G 4JB9G 4S1SG 3IDYA 5F96G 4RX4E 4XNZA 5FECC 3TGRA 4K0AA 4DVSA 2I5YG 2NXZA 4DKQA 5F4UA 4LSVG 4YDKG 3RJQA 4YDJG 4DKRA 4P9HG 3TIHA 4LSQG 3FUSA 4OLYG 4RFOG 5TE6G 4YFLE 2NXYA 5F4PA 1RZKG 4DKUA 5F4LA 4OLXG 4YDIG 4OLVG 4XMPG 4DVWA 4JZZA 3TGTA 4I53A 4YDLA 4JM2E 3SE8G 2NY3A 3JWOA 4DVXA 5F9OG 4LSSG 4OLZG 4LSPG 4OM1G 4S1RG 4JKPG 4KA2A 4OLUG 4S1QG 4DKOA 5CD5A 4DVVA 5FA2A 4DVTA 4XVTG 4RFNA 1YYLG 2NY4A 4R2GA 5IGXG 2NY6A 1RZJG 4DKVA 4JPVG 4RZ8A 3U7YG 4R4FA 3HI1G 4XVSG 4I54A 2NY0A 4XNYG 5F9WA 2B4CG 4YE4G 2NY7G 5TE7G 4JPWG 4JDTG 3TGQA 3IDXG 4R4NA 3TGSA 2NY2A 2NY5G 3LQAG 1G9MG 4OLWG 1G9NG 5TE4G 2QADA
chains in the Genus database with same CATH topology
2I60G 4RWYA 5CAYG 2NY1A 3JWDA 3NGBA 5KJRG 4JZWA 4H8WG 5I9QA 4LSRG 2BF1A 3SE9G 4LAJA 4LSTG 5T33G 4DVRG 4DKPA 1GC1G 4J6RG 1YYMG 5F4RA 4LSUG 4OM0G 4JB9G 4S1SG 3IDYA 5F96G 4RX4E 4XNZA 5FECC 3TGRA 4K0AA 4DVSA 2I5YG 2NXZA 4DKQA 5F4UA 4LSVG 4YDKG 3RJQA 4YDJG 4DKRA 4P9HG 3TIHA 4LSQG 3FUSA 4OLYG 4RFOG 5TE6G 4YFLE 2NXYA 5F4PA 1RZKG 4DKUA 5F4LA 4OLXG 4YDIG 4OLVG 4XMPG 4DVWA 4JZZA 3TGTA 4I53A 4YDLA 4JM2E 3SE8G 2NY3A 3JWOA 4DVXA 5F9OG 4LSSG 4OLZG 4LSPG 4OM1G 4S1RG 4JKPG 4KA2A 4OLUG 4S1QG 4DKOA 5CD5A 4DVVA 5FA2A 4DVTA 4XVTG 4RFNA 1YYLG 2NY4A 4R2GA 5IGXG 2NY6A 1RZJG 4DKVA 4JPVG 4RZ8A 3U7YG 4R4FA 3HI1G 4XVSG 4I54A 2NY0A 4XNYG 5F9WA 2B4CG 4YE4G 2NY7G 5TE7G 4JPWG 4JDTG 3TGQA 3IDXG 4R4NA 3TGSA 2NY2A 2NY5G 3LQAG 1G9MG 4OLWG 1G9NG 5TE4G 2QADA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2I60 G;  4RWY A;  5CAY G;  2NY1 A;  3JWD A;  3NGB A;  5KJR G;  4JZW A;  4H8W G;  5I9Q A;  4LSR G;  2BF1 A;  3SE9 G;  4LAJ A;  4LST G;  5T33 G;  4DVR G;  4DKP A;  1GC1 G;  4J6R G;  1YYM G;  5F4R A;  4LSU G;  4OM0 G;  4JB9 G;  4S1S G;  3IDY A;  5F96 G;  4RX4 E;  4XNZ A;  5FEC C;  3TGR A;  4K0A A;  4DVS A;  2I5Y G;  2NXZ A;  4DKQ A;  5F4U A;  4LSV G;  4YDK G;  3RJQ A;  4YDJ G;  4DKR A;  4P9H G;  3TIH A;  4LSQ G;  3FUS A;  4OLY G;  4RFO G;  5TE6 G;  4YFL E;  2NXY A;  5F4P A;  1RZK G;  4DKU A;  5F4L A;  4OLX G;  4YDI G;  4OLV G;  4XMP G;  4DVW A;  4JZZ A;  3TGT A;  4I53 A;  4YDL A;  4JM2 E;  3SE8 G;  2NY3 A;  3JWO A;  4DVX A;  5F9O G;  4LSS G;  4OLZ G;  4LSP G;  4OM1 G;  4S1R G;  4JKP G;  4KA2 A;  4OLU G;  4S1Q G;  4DKO A;  5CD5 A;  4DVV A;  5FA2 A;  4DVT A;  4XVT G;  4RFN A;  1YYL G;  2NY4 A;  4R2G A;  5IGX G;  2NY6 A;  1RZJ G;  4DKV A;  4JPV G;  4RZ8 A;  3U7Y G;  4R4F A;  3HI1 G;  4XVS G;  4I54 A;  2NY0 A;  4XNY G;  5F9W A;  2B4C G;  4YE4 G;  2NY7 G;  5TE7 G;  4JPW G;  4JDT G;  3TGQ A;  3IDX G;  4R4N A;  3TGS A;  2NY2 A;  2NY5 G;  3LQA G;  1G9M G;  4OLW G;  1G9N G;  5TE4 G;  2QAD A; 
#chains in the Genus database with same CATH topology
 2I60 G;  4RWY A;  5CAY G;  2NY1 A;  3JWD A;  3NGB A;  5KJR G;  4JZW A;  4H8W G;  5I9Q A;  4LSR G;  2BF1 A;  3SE9 G;  4LAJ A;  4LST G;  5T33 G;  4DVR G;  4DKP A;  1GC1 G;  4J6R G;  1YYM G;  5F4R A;  4LSU G;  4OM0 G;  4JB9 G;  4S1S G;  3IDY A;  5F96 G;  4RX4 E;  4XNZ A;  5FEC C;  3TGR A;  4K0A A;  4DVS A;  2I5Y G;  2NXZ A;  4DKQ A;  5F4U A;  4LSV G;  4YDK G;  3RJQ A;  4YDJ G;  4DKR A;  4P9H G;  3TIH A;  4LSQ G;  3FUS A;  4OLY G;  4RFO G;  5TE6 G;  4YFL E;  2NXY A;  5F4P A;  1RZK G;  4DKU A;  5F4L A;  4OLX G;  4YDI G;  4OLV G;  4XMP G;  4DVW A;  4JZZ A;  3TGT A;  4I53 A;  4YDL A;  4JM2 E;  3SE8 G;  2NY3 A;  3JWO A;  4DVX A;  5F9O G;  4LSS G;  4OLZ G;  4LSP G;  4OM1 G;  4S1R G;  4JKP G;  4KA2 A;  4OLU G;  4S1Q G;  4DKO A;  5CD5 A;  4DVV A;  5FA2 A;  4DVT A;  4XVT G;  4RFN A;  1YYL G;  2NY4 A;  4R2G A;  5IGX G;  2NY6 A;  1RZJ G;  4DKV A;  4JPV G;  4RZ8 A;  3U7Y G;  4R4F A;  3HI1 G;  4XVS G;  4I54 A;  2NY0 A;  4XNY G;  5F9W A;  2B4C G;  4YE4 G;  2NY7 G;  5TE7 G;  4JPW G;  4JDT G;  3TGQ A;  3IDX G;  4R4N A;  3TGS A;  2NY2 A;  2NY5 G;  3LQA G;  1G9M G;  4OLW G;  1G9N G;  5TE4 G;  2QAD A; 
#chains in the Genus database with same CATH homology
 2I60 G;  4RWY A;  5CAY G;  2NY1 A;  3JWD A;  3NGB A;  5KJR G;  4JZW A;  4H8W G;  5I9Q A;  4LSR G;  2BF1 A;  3SE9 G;  4LAJ A;  4LST G;  5T33 G;  4DVR G;  4DKP A;  1GC1 G;  4J6R G;  1YYM G;  5F4R A;  4LSU G;  4OM0 G;  4JB9 G;  4S1S G;  3IDY A;  5F96 G;  4RX4 E;  4XNZ A;  5FEC C;  3TGR A;  4K0A A;  4DVS A;  2I5Y G;  2NXZ A;  4DKQ A;  5F4U A;  4LSV G;  4YDK G;  3RJQ A;  4YDJ G;  4DKR A;  4P9H G;  3TIH A;  4LSQ G;  3FUS A;  4OLY G;  4RFO G;  5TE6 G;  4YFL E;  2NXY A;  5F4P A;  1RZK G;  4DKU A;  5F4L A;  4OLX G;  4YDI G;  4OLV G;  4XMP G;  4DVW A;  4JZZ A;  3TGT A;  4I53 A;  4YDL A;  4JM2 E;  3SE8 G;  2NY3 A;  3JWO A;  4DVX A;  5F9O G;  4LSS G;  4OLZ G;  4LSP G;  4OM1 G;  4S1R G;  4JKP G;  4KA2 A;  4OLU G;  4S1Q G;  4DKO A;  5CD5 A;  4DVV A;  5FA2 A;  4DVT A;  4XVT G;  4RFN A;  1YYL G;  2NY4 A;  4R2G A;  5IGX G;  2NY6 A;  1RZJ G;  4DKV A;  4JPV G;  4RZ8 A;  3U7Y G;  4R4F A;  3HI1 G;  4XVS G;  4I54 A;  2NY0 A;  4XNY G;  5F9W A;  2B4C G;  4YE4 G;  2NY7 G;  5TE7 G;  4JPW G;  4JDT G;  3TGQ A;  3IDX G;  4R4N A;  3TGS A;  2NY2 A;  2NY5 G;  3LQA G;  1G9M G;  4OLW G;  1G9N G;  5TE4 G;  2QAD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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