4RDOA

Structure of yth-ythdf2 in the free state
Total Genus 46
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
46
sequence length
149
structure length
149
Chain Sequence
ENLYFQHMKHGRVFIIKSYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGKGPVYLLFSVNGSGHFCGVAEMKSAVDYNTCAGVWSQDKWKGRFDVRWIFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIASYK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structure of the YTH domain of human YTHDF2 in complex with an m(6)A mononucleotide reveals an aromatic cage for m(6)A recognition.
pubmed doi rcsb
molecule tags Rna binding protein
source organism Homo sapiens
molecule keywords YTH domain-containing family protein 2
total genus 46
structure length 149
sequence length 149
chains with identical sequence B, C, D, E, F
ec nomenclature
pdb deposition date 2014-09-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF04146 YTH YT521-B-like domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.590.10 Alpha Beta Roll ph1033 like fold ph1033 like domains 4rdoA00
2HD9A 4RCJA 3EOPA 4RCIA 5J3EA 2EVEA 5DNOA 2AR1A 4RDOA 2ZBNA 2YU6A 4U8TA 2G2XA 4RDNA 4WQNA 2P5DA 1ZCEA 1WMMA 2GBSA 2YUDA 4RCMA
chains in the Genus database with same CATH superfamily
2HD9A 4RCJA 3EOPA 4RCIA 5J3EA 2EVEA 5DNOA 2AR1A 4RDOA 2ZBNA 2YU6A 4U8TA 2G2XA 4RDNA 4WQNA 2P5DA 1ZCEA 1WMMA 2GBSA 2YUDA 4RCMA
chains in the Genus database with same CATH topology
2HD9A 4RCJA 3EOPA 4RCIA 5J3EA 2EVEA 5DNOA 2AR1A 4RDOA 2ZBNA 2YU6A 4U8TA 2G2XA 4RDNA 4WQNA 2P5DA 1ZCEA 1WMMA 2GBSA 2YUDA 4RCMA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2HD9 A;  4RCJ A;  3EOP A;  4RCI A;  5J3E A;  2EVE A;  5DNO A;  2AR1 A;  4RDO A;  2ZBN A;  2YU6 A;  4U8T A;  2G2X A;  4RDN A;  4WQN A;  2P5D A;  1ZCE A;  1WMM A;  2GBS A;  2YUD A;  4RCM A; 
#chains in the Genus database with same CATH topology
 2HD9 A;  4RCJ A;  3EOP A;  4RCI A;  5J3E A;  2EVE A;  5DNO A;  2AR1 A;  4RDO A;  2ZBN A;  2YU6 A;  4U8T A;  2G2X A;  4RDN A;  4WQN A;  2P5D A;  1ZCE A;  1WMM A;  2GBS A;  2YUD A;  4RCM A; 
#chains in the Genus database with same CATH homology
 2HD9 A;  4RCJ A;  3EOP A;  4RCI A;  5J3E A;  2EVE A;  5DNO A;  2AR1 A;  4RDO A;  2ZBN A;  2YU6 A;  4U8T A;  2G2X A;  4RDN A;  4WQN A;  2P5D A;  1ZCE A;  1WMM A;  2GBS A;  2YUD A;  4RCM A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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