4RFNA

Crystal structure of adcc-potent rhesus macaque antibody jr4 in complex with hiv-1 clade a/e gp120 and m48
Total Genus 71
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
71
sequence length
353
structure length
337
Chain Sequence
VWKDADTTLFCASDAKAHETEVHNVWATHACVPTDPNPQEIHLENVTENFNMWKNNMVEQMQEDVISLWDQSLQPCVKLTGSVIKQACPKISFDPIPIHYCTPAGYVILKCNDKNFNGTGPCKNVSSVQCTHGIKPVVSTQLLLNGSLAEEEIIIRSENLTNNAKTIIVHLNKSVEINCTRPSNDIRKAYCEINGTKWNKVLKQVTEKLKEHFNNKTIIFQPPSGGDLEITMHSFNCRGEFFYCNTTQLFNNTCIKGCNGTITLPCKIKQIINMWQGTGQAMYAPPIDGKINCVSNITGILLTRDGNTSNETFRPGGGNIKDNWRSELYKYKVVQIE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1.
pubmed doi rcsb
molecule tags Viral protein/immune system
source organism Human immunodeficiency virus 1
molecule keywords HIV-1 CLADE A/E 93TH057 (H375S) GP120
total genus 71
structure length 337
sequence length 353
chains with identical sequence G
ec nomenclature
pdb deposition date 2014-09-26
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.40.20 Mainly Beta Beta Complex HIV Envelope Protein Gp120; Chain G Human immunodeficiency virus 1, Gp160, envelope glycoprotein 4rfnA01
5I9QA 4RFNA 4RWYA 4S1QG 5CAYG 3TGQA 2BF1A 5F4RA 4DVTA 4JPWG 3JWOA 4LSVG 4JDTG 4YDIG 5FECC 4DKUA 2QADA 4KA2A 4DKQA 5CD5A 2I60G 3IDYA 4OLXG 2NY2A 4I53A 4JM2E 4YDJG 2NY1A 4LSSG 5F4LA 2NXZA 5IGXG 4OLWG 4LSPG 1G9MG 4DKPA 3LQAG 2NY4A 4DVXA 5F9WA 4JZWA 4LSQG 1YYMG 4DVVA 4RX4E 4YFLE 5F96G 3RJQA 3IDXG 3HI1G 4XVSG 5TE7G 2NY5G 3TGSA 1YYLG 4XNZA 2NY6A 5KJRG 4DKOA 5TE6G 5FA2A 5TE4G 4JKPG 2B4CG 1RZJG 4LSTG 5F4PA 4DKVA 4RZ8A 2NXYA 1G9NG 4XMPG 4J6RG 2NY0A 4I54A 4P9HG 3SE8G 4R2GA 4DVRG 4YDLA 4OLVG 4H8WG 4XNYG 5F9OG 4OM0G 4LSUG 3NGBA 4R4NA 4DVSA 4LSRG 4OM1G 4YDKG 1RZKG 4JB9G 3U7YG 1GC1G 4OLUG 5F4UA 3TGTA 2I5YG 3TIHA 4OLZG 4DKRA 4K0AA 3TGRA 3SE9G 3FUSA 4S1SG 4DVWA 4RFOG 4XVTG 4OLYG 4YE4G 4S1RG 2NY7G 4LAJA 2NY3A 5T33G 3JWDA 4R4FA 4JZZA 4JPVG
chains in the Genus database with same CATH superfamily
5I9QA 4RFNA 4RWYA 4S1QG 5CAYG 3TGQA 2BF1A 5F4RA 4DVTA 4JPWG 3JWOA 4LSVG 4JDTG 4YDIG 5FECC 4DKUA 2QADA 4KA2A 4DKQA 5CD5A 2I60G 3IDYA 4OLXG 2NY2A 4I53A 4JM2E 4YDJG 2NY1A 4LSSG 5F4LA 2NXZA 5IGXG 4OLWG 4LSPG 1G9MG 4DKPA 3LQAG 2NY4A 4DVXA 5F9WA 4JZWA 4LSQG 1YYMG 4DVVA 4RX4E 4YFLE 5F96G 3RJQA 3IDXG 3HI1G 4XVSG 5TE7G 2NY5G 3TGSA 1YYLG 4XNZA 2NY6A 5KJRG 4DKOA 5TE6G 5FA2A 5TE4G 4JKPG 2B4CG 1RZJG 4LSTG 5F4PA 4DKVA 4RZ8A 2NXYA 1G9NG 4XMPG 4J6RG 2NY0A 4I54A 4P9HG 3SE8G 4R2GA 4DVRG 4YDLA 4OLVG 4H8WG 4XNYG 5F9OG 4OM0G 4LSUG 3NGBA 4R4NA 4DVSA 4LSRG 4OM1G 4YDKG 1RZKG 4JB9G 3U7YG 1GC1G 4OLUG 5F4UA 3TGTA 2I5YG 3TIHA 4OLZG 4DKRA 4K0AA 3TGRA 3SE9G 3FUSA 4S1SG 4DVWA 4RFOG 4XVTG 4OLYG 4YE4G 4S1RG 2NY7G 4LAJA 2NY3A 5T33G 3JWDA 4R4FA 4JZZA 4JPVG
chains in the Genus database with same CATH topology
5I9QA 4RFNA 4RWYA 4S1QG 5CAYG 3TGQA 2BF1A 5F4RA 4DVTA 4JPWG 3JWOA 4LSVG 4JDTG 4YDIG 5FECC 4DKUA 2QADA 4KA2A 4DKQA 5CD5A 2I60G 3IDYA 4OLXG 2NY2A 4I53A 4JM2E 4YDJG 2NY1A 4LSSG 5F4LA 2NXZA 5IGXG 4OLWG 4LSPG 1G9MG 4DKPA 3LQAG 2NY4A 4DVXA 5F9WA 4JZWA 4LSQG 1YYMG 4DVVA 4RX4E 4YFLE 5F96G 3RJQA 3IDXG 3HI1G 4XVSG 5TE7G 2NY5G 3TGSA 1YYLG 4XNZA 2NY6A 5KJRG 4DKOA 5TE6G 5FA2A 5TE4G 4JKPG 2B4CG 1RZJG 4LSTG 5F4PA 4DKVA 4RZ8A 2NXYA 1G9NG 4XMPG 4J6RG 2NY0A 4I54A 4P9HG 3SE8G 4R2GA 4DVRG 4YDLA 4OLVG 4H8WG 4XNYG 5F9OG 4OM0G 4LSUG 3NGBA 4R4NA 4DVSA 4LSRG 4OM1G 4YDKG 1RZKG 4JB9G 3U7YG 1GC1G 4OLUG 5F4UA 3TGTA 2I5YG 3TIHA 4OLZG 4DKRA 4K0AA 3TGRA 3SE9G 3FUSA 4S1SG 4DVWA 4RFOG 4XVTG 4OLYG 4YE4G 4S1RG 2NY7G 4LAJA 2NY3A 5T33G 3JWDA 4R4FA 4JZZA 4JPVG
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5I9Q A;  4RFN A;  4RWY A;  4S1Q G;  5CAY G;  3TGQ A;  2BF1 A;  5F4R A;  4DVT A;  4JPW G;  3JWO A;  4LSV G;  4JDT G;  4YDI G;  5FEC C;  4DKU A;  2QAD A;  4KA2 A;  4DKQ A;  5CD5 A;  2I60 G;  3IDY A;  4OLX G;  2NY2 A;  4I53 A;  4JM2 E;  4YDJ G;  2NY1 A;  4LSS G;  5F4L A;  2NXZ A;  5IGX G;  4OLW G;  4LSP G;  1G9M G;  4DKP A;  3LQA G;  2NY4 A;  4DVX A;  5F9W A;  4JZW A;  4LSQ G;  1YYM G;  4DVV A;  4RX4 E;  4YFL E;  5F96 G;  3RJQ A;  3IDX G;  3HI1 G;  4XVS G;  5TE7 G;  2NY5 G;  3TGS A;  1YYL G;  4XNZ A;  2NY6 A;  5KJR G;  4DKO A;  5TE6 G;  5FA2 A;  5TE4 G;  4JKP G;  2B4C G;  1RZJ G;  4LST G;  5F4P A;  4DKV A;  4RZ8 A;  2NXY A;  1G9N G;  4XMP G;  4J6R G;  2NY0 A;  4I54 A;  4P9H G;  3SE8 G;  4R2G A;  4DVR G;  4YDL A;  4OLV G;  4H8W G;  4XNY G;  5F9O G;  4OM0 G;  4LSU G;  3NGB A;  4R4N A;  4DVS A;  4LSR G;  4OM1 G;  4YDK G;  1RZK G;  4JB9 G;  3U7Y G;  1GC1 G;  4OLU G;  5F4U A;  3TGT A;  2I5Y G;  3TIH A;  4OLZ G;  4DKR A;  4K0A A;  3TGR A;  3SE9 G;  3FUS A;  4S1S G;  4DVW A;  4RFO G;  4XVT G;  4OLY G;  4YE4 G;  4S1R G;  2NY7 G;  4LAJ A;  2NY3 A;  5T33 G;  3JWD A;  4R4F A;  4JZZ A;  4JPV G; 
#chains in the Genus database with same CATH topology
 5I9Q A;  4RFN A;  4RWY A;  4S1Q G;  5CAY G;  3TGQ A;  2BF1 A;  5F4R A;  4DVT A;  4JPW G;  3JWO A;  4LSV G;  4JDT G;  4YDI G;  5FEC C;  4DKU A;  2QAD A;  4KA2 A;  4DKQ A;  5CD5 A;  2I60 G;  3IDY A;  4OLX G;  2NY2 A;  4I53 A;  4JM2 E;  4YDJ G;  2NY1 A;  4LSS G;  5F4L A;  2NXZ A;  5IGX G;  4OLW G;  4LSP G;  1G9M G;  4DKP A;  3LQA G;  2NY4 A;  4DVX A;  5F9W A;  4JZW A;  4LSQ G;  1YYM G;  4DVV A;  4RX4 E;  4YFL E;  5F96 G;  3RJQ A;  3IDX G;  3HI1 G;  4XVS G;  5TE7 G;  2NY5 G;  3TGS A;  1YYL G;  4XNZ A;  2NY6 A;  5KJR G;  4DKO A;  5TE6 G;  5FA2 A;  5TE4 G;  4JKP G;  2B4C G;  1RZJ G;  4LST G;  5F4P A;  4DKV A;  4RZ8 A;  2NXY A;  1G9N G;  4XMP G;  4J6R G;  2NY0 A;  4I54 A;  4P9H G;  3SE8 G;  4R2G A;  4DVR G;  4YDL A;  4OLV G;  4H8W G;  4XNY G;  5F9O G;  4OM0 G;  4LSU G;  3NGB A;  4R4N A;  4DVS A;  4LSR G;  4OM1 G;  4YDK G;  1RZK G;  4JB9 G;  3U7Y G;  1GC1 G;  4OLU G;  5F4U A;  3TGT A;  2I5Y G;  3TIH A;  4OLZ G;  4DKR A;  4K0A A;  3TGR A;  3SE9 G;  3FUS A;  4S1S G;  4DVW A;  4RFO G;  4XVT G;  4OLY G;  4YE4 G;  4S1R G;  2NY7 G;  4LAJ A;  2NY3 A;  5T33 G;  3JWD A;  4R4F A;  4JZZ A;  4JPV G; 
#chains in the Genus database with same CATH homology
 5I9Q A;  4RFN A;  4RWY A;  4S1Q G;  5CAY G;  3TGQ A;  2BF1 A;  5F4R A;  4DVT A;  4JPW G;  3JWO A;  4LSV G;  4JDT G;  4YDI G;  5FEC C;  4DKU A;  2QAD A;  4KA2 A;  4DKQ A;  5CD5 A;  2I60 G;  3IDY A;  4OLX G;  2NY2 A;  4I53 A;  4JM2 E;  4YDJ G;  2NY1 A;  4LSS G;  5F4L A;  2NXZ A;  5IGX G;  4OLW G;  4LSP G;  1G9M G;  4DKP A;  3LQA G;  2NY4 A;  4DVX A;  5F9W A;  4JZW A;  4LSQ G;  1YYM G;  4DVV A;  4RX4 E;  4YFL E;  5F96 G;  3RJQ A;  3IDX G;  3HI1 G;  4XVS G;  5TE7 G;  2NY5 G;  3TGS A;  1YYL G;  4XNZ A;  2NY6 A;  5KJR G;  4DKO A;  5TE6 G;  5FA2 A;  5TE4 G;  4JKP G;  2B4C G;  1RZJ G;  4LST G;  5F4P A;  4DKV A;  4RZ8 A;  2NXY A;  1G9N G;  4XMP G;  4J6R G;  2NY0 A;  4I54 A;  4P9H G;  3SE8 G;  4R2G A;  4DVR G;  4YDL A;  4OLV G;  4H8W G;  4XNY G;  5F9O G;  4OM0 G;  4LSU G;  3NGB A;  4R4N A;  4DVS A;  4LSR G;  4OM1 G;  4YDK G;  1RZK G;  4JB9 G;  3U7Y G;  1GC1 G;  4OLU G;  5F4U A;  3TGT A;  2I5Y G;  3TIH A;  4OLZ G;  4DKR A;  4K0A A;  3TGR A;  3SE9 G;  3FUS A;  4S1S G;  4DVW A;  4RFO G;  4XVT G;  4OLY G;  4YE4 G;  4S1R G;  2NY7 G;  4LAJ A;  2NY3 A;  5T33 G;  3JWD A;  4R4F A;  4JZZ A;  4JPV G; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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