4RFOG

Crystal structure of the adcc-potent antibody n60-i3 fab in complex with hiv-1 clade a/e gp120 and m48u1
Total Genus 72
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
72
sequence length
353
structure length
336
Chain Sequence
VWKDADTTLFCASDAKAHETEVHNVWATHACVPTDPNPQEIHLENVTENFNMWKNNMVEQMQEDVISLWDQSLQPCVKLTKQACPKISFDPIPIHYCTPAGYVILKCNDKNFNGTGPCKNVSSVQCTHGIKPVVSTQLLLNGSLAEEEIIIRSENLTNNAKTIIVHLNKSVEINCTRPSNDIRKAYCEINGTKWNKVLKQVTEKLKEHFNNKTIIFQPPSGGDLEITMHSFNCRGEFFYCNTTQLFNNTCIKGCNGTITLPCKIKQIINMWQGTGQAMYAPPIDGKINCVSNITGILLTRDGGANNTSNETFRPGGGNIKDNWRSELYKYKVVQIE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1.
pubmed doi rcsb
molecule tags Viral protein/immune system/inhibitor
source organism Human immunodeficiency virus 1
molecule keywords HIV-1 clade A/E gp120
total genus 72
structure length 336
sequence length 353
ec nomenclature
pdb deposition date 2014-09-26
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.40.20 Mainly Beta Beta Complex HIV Envelope Protein Gp120; Chain G Human immunodeficiency virus 1, Gp160, envelope glycoprotein 4rfoG01
4P9HG 3IDXG 4JB9G 4XMPG 4JZZA 2NY7G 4XVSG 1G9MG 4DVTA 4DKRA 4RFOG 1GC1G 3JWDA 3U7YG 5CD5A 4DVVA 4DKQA 4DVXA 5TE6G 1RZKG 4OLUG 5TE7G 4I54A 2NY5G 5T33G 4RWYA 4R4NA 2BF1A 5F9OG 5F4UA 1YYLG 2NXZA 5KJRG 5I9QA 2NY2A 4XVTG 4LSRG 4OLYG 4DKUA 4YE4G 5F4RA 3NGBA 4RX4E 4LSUG 2B4CG 4JPWG 4KA2A 3LQAG 4OM0G 2NY6A 3TGSA 3JWOA 4DVSA 4RFNA 4DVRG 4JZWA 4RZ8A 2NXYA 4LSVG 5F4LA 4DKOA 4S1RG 4YDIG 3TGRA 4JPVG 4LAJA 4LSQG 4YDKG 3TGQA 4LSTG 4DVWA 2NY0A 4XNYG 2NY1A 4R4FA 4JDTG 4LSSG 5FA2A 4LSPG 3IDYA 4S1SG 1G9NG 3HI1G 4YFLE 1YYMG 2QADA 4I53A 5FECC 3SE9G 5F9WA 4OLVG 2NY4A 2I60G 5IGXG 4OLXG 4J6RG 4H8WG 2NY3A 4DKPA 1RZJG 4S1QG 4K0AA 2I5YG 4JKPG 4DKVA 3TIHA 4OLWG 4XNZA 4OM1G 3FUSA 4JM2E 5F96G 3SE8G 3TGTA 3RJQA 5F4PA 5TE4G 4YDJG 4YDLA 5CAYG 4OLZG 4R2GA
chains in the Genus database with same CATH superfamily
4P9HG 3IDXG 4JB9G 4XMPG 4JZZA 2NY7G 4XVSG 1G9MG 4DVTA 4DKRA 4RFOG 1GC1G 3JWDA 3U7YG 5CD5A 4DVVA 4DKQA 4DVXA 5TE6G 1RZKG 4OLUG 5TE7G 4I54A 2NY5G 5T33G 4RWYA 4R4NA 2BF1A 5F9OG 5F4UA 1YYLG 2NXZA 5KJRG 5I9QA 2NY2A 4XVTG 4LSRG 4OLYG 4DKUA 4YE4G 5F4RA 3NGBA 4RX4E 4LSUG 2B4CG 4JPWG 4KA2A 3LQAG 4OM0G 2NY6A 3TGSA 3JWOA 4DVSA 4RFNA 4DVRG 4JZWA 4RZ8A 2NXYA 4LSVG 5F4LA 4DKOA 4S1RG 4YDIG 3TGRA 4JPVG 4LAJA 4LSQG 4YDKG 3TGQA 4LSTG 4DVWA 2NY0A 4XNYG 2NY1A 4R4FA 4JDTG 4LSSG 5FA2A 4LSPG 3IDYA 4S1SG 1G9NG 3HI1G 4YFLE 1YYMG 2QADA 4I53A 5FECC 3SE9G 5F9WA 4OLVG 2NY4A 2I60G 5IGXG 4OLXG 4J6RG 4H8WG 2NY3A 4DKPA 1RZJG 4S1QG 4K0AA 2I5YG 4JKPG 4DKVA 3TIHA 4OLWG 4XNZA 4OM1G 3FUSA 4JM2E 5F96G 3SE8G 3TGTA 3RJQA 5F4PA 5TE4G 4YDJG 4YDLA 5CAYG 4OLZG 4R2GA
chains in the Genus database with same CATH topology
4P9HG 3IDXG 4JB9G 4XMPG 4JZZA 2NY7G 4XVSG 1G9MG 4DVTA 4DKRA 4RFOG 1GC1G 3JWDA 3U7YG 5CD5A 4DVVA 4DKQA 4DVXA 5TE6G 1RZKG 4OLUG 5TE7G 4I54A 2NY5G 5T33G 4RWYA 4R4NA 2BF1A 5F9OG 5F4UA 1YYLG 2NXZA 5KJRG 5I9QA 2NY2A 4XVTG 4LSRG 4OLYG 4DKUA 4YE4G 5F4RA 3NGBA 4RX4E 4LSUG 2B4CG 4JPWG 4KA2A 3LQAG 4OM0G 2NY6A 3TGSA 3JWOA 4DVSA 4RFNA 4DVRG 4JZWA 4RZ8A 2NXYA 4LSVG 5F4LA 4DKOA 4S1RG 4YDIG 3TGRA 4JPVG 4LAJA 4LSQG 4YDKG 3TGQA 4LSTG 4DVWA 2NY0A 4XNYG 2NY1A 4R4FA 4JDTG 4LSSG 5FA2A 4LSPG 3IDYA 4S1SG 1G9NG 3HI1G 4YFLE 1YYMG 2QADA 4I53A 5FECC 3SE9G 5F9WA 4OLVG 2NY4A 2I60G 5IGXG 4OLXG 4J6RG 4H8WG 2NY3A 4DKPA 1RZJG 4S1QG 4K0AA 2I5YG 4JKPG 4DKVA 3TIHA 4OLWG 4XNZA 4OM1G 3FUSA 4JM2E 5F96G 3SE8G 3TGTA 3RJQA 5F4PA 5TE4G 4YDJG 4YDLA 5CAYG 4OLZG 4R2GA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4P9H G;  3IDX G;  4JB9 G;  4XMP G;  4JZZ A;  2NY7 G;  4XVS G;  1G9M G;  4DVT A;  4DKR A;  4RFO G;  1GC1 G;  3JWD A;  3U7Y G;  5CD5 A;  4DVV A;  4DKQ A;  4DVX A;  5TE6 G;  1RZK G;  4OLU G;  5TE7 G;  4I54 A;  2NY5 G;  5T33 G;  4RWY A;  4R4N A;  2BF1 A;  5F9O G;  5F4U A;  1YYL G;  2NXZ A;  5KJR G;  5I9Q A;  2NY2 A;  4XVT G;  4LSR G;  4OLY G;  4DKU A;  4YE4 G;  5F4R A;  3NGB A;  4RX4 E;  4LSU G;  2B4C G;  4JPW G;  4KA2 A;  3LQA G;  4OM0 G;  2NY6 A;  3TGS A;  3JWO A;  4DVS A;  4RFN A;  4DVR G;  4JZW A;  4RZ8 A;  2NXY A;  4LSV G;  5F4L A;  4DKO A;  4S1R G;  4YDI G;  3TGR A;  4JPV G;  4LAJ A;  4LSQ G;  4YDK G;  3TGQ A;  4LST G;  4DVW A;  2NY0 A;  4XNY G;  2NY1 A;  4R4F A;  4JDT G;  4LSS G;  5FA2 A;  4LSP G;  3IDY A;  4S1S G;  1G9N G;  3HI1 G;  4YFL E;  1YYM G;  2QAD A;  4I53 A;  5FEC C;  3SE9 G;  5F9W A;  4OLV G;  2NY4 A;  2I60 G;  5IGX G;  4OLX G;  4J6R G;  4H8W G;  2NY3 A;  4DKP A;  1RZJ G;  4S1Q G;  4K0A A;  2I5Y G;  4JKP G;  4DKV A;  3TIH A;  4OLW G;  4XNZ A;  4OM1 G;  3FUS A;  4JM2 E;  5F96 G;  3SE8 G;  3TGT A;  3RJQ A;  5F4P A;  5TE4 G;  4YDJ G;  4YDL A;  5CAY G;  4OLZ G;  4R2G A; 
#chains in the Genus database with same CATH topology
 4P9H G;  3IDX G;  4JB9 G;  4XMP G;  4JZZ A;  2NY7 G;  4XVS G;  1G9M G;  4DVT A;  4DKR A;  4RFO G;  1GC1 G;  3JWD A;  3U7Y G;  5CD5 A;  4DVV A;  4DKQ A;  4DVX A;  5TE6 G;  1RZK G;  4OLU G;  5TE7 G;  4I54 A;  2NY5 G;  5T33 G;  4RWY A;  4R4N A;  2BF1 A;  5F9O G;  5F4U A;  1YYL G;  2NXZ A;  5KJR G;  5I9Q A;  2NY2 A;  4XVT G;  4LSR G;  4OLY G;  4DKU A;  4YE4 G;  5F4R A;  3NGB A;  4RX4 E;  4LSU G;  2B4C G;  4JPW G;  4KA2 A;  3LQA G;  4OM0 G;  2NY6 A;  3TGS A;  3JWO A;  4DVS A;  4RFN A;  4DVR G;  4JZW A;  4RZ8 A;  2NXY A;  4LSV G;  5F4L A;  4DKO A;  4S1R G;  4YDI G;  3TGR A;  4JPV G;  4LAJ A;  4LSQ G;  4YDK G;  3TGQ A;  4LST G;  4DVW A;  2NY0 A;  4XNY G;  2NY1 A;  4R4F A;  4JDT G;  4LSS G;  5FA2 A;  4LSP G;  3IDY A;  4S1S G;  1G9N G;  3HI1 G;  4YFL E;  1YYM G;  2QAD A;  4I53 A;  5FEC C;  3SE9 G;  5F9W A;  4OLV G;  2NY4 A;  2I60 G;  5IGX G;  4OLX G;  4J6R G;  4H8W G;  2NY3 A;  4DKP A;  1RZJ G;  4S1Q G;  4K0A A;  2I5Y G;  4JKP G;  4DKV A;  3TIH A;  4OLW G;  4XNZ A;  4OM1 G;  3FUS A;  4JM2 E;  5F96 G;  3SE8 G;  3TGT A;  3RJQ A;  5F4P A;  5TE4 G;  4YDJ G;  4YDL A;  5CAY G;  4OLZ G;  4R2G A; 
#chains in the Genus database with same CATH homology
 4P9H G;  3IDX G;  4JB9 G;  4XMP G;  4JZZ A;  2NY7 G;  4XVS G;  1G9M G;  4DVT A;  4DKR A;  4RFO G;  1GC1 G;  3JWD A;  3U7Y G;  5CD5 A;  4DVV A;  4DKQ A;  4DVX A;  5TE6 G;  1RZK G;  4OLU G;  5TE7 G;  4I54 A;  2NY5 G;  5T33 G;  4RWY A;  4R4N A;  2BF1 A;  5F9O G;  5F4U A;  1YYL G;  2NXZ A;  5KJR G;  5I9Q A;  2NY2 A;  4XVT G;  4LSR G;  4OLY G;  4DKU A;  4YE4 G;  5F4R A;  3NGB A;  4RX4 E;  4LSU G;  2B4C G;  4JPW G;  4KA2 A;  3LQA G;  4OM0 G;  2NY6 A;  3TGS A;  3JWO A;  4DVS A;  4RFN A;  4DVR G;  4JZW A;  4RZ8 A;  2NXY A;  4LSV G;  5F4L A;  4DKO A;  4S1R G;  4YDI G;  3TGR A;  4JPV G;  4LAJ A;  4LSQ G;  4YDK G;  3TGQ A;  4LST G;  4DVW A;  2NY0 A;  4XNY G;  2NY1 A;  4R4F A;  4JDT G;  4LSS G;  5FA2 A;  4LSP G;  3IDY A;  4S1S G;  1G9N G;  3HI1 G;  4YFL E;  1YYM G;  2QAD A;  4I53 A;  5FEC C;  3SE9 G;  5F9W A;  4OLV G;  2NY4 A;  2I60 G;  5IGX G;  4OLX G;  4J6R G;  4H8W G;  2NY3 A;  4DKP A;  1RZJ G;  4S1Q G;  4K0A A;  2I5Y G;  4JKP G;  4DKV A;  3TIH A;  4OLW G;  4XNZ A;  4OM1 G;  3FUS A;  4JM2 E;  5F96 G;  3SE8 G;  3TGT A;  3RJQ A;  5F4P A;  5TE4 G;  4YDJ G;  4YDL A;  5CAY G;  4OLZ G;  4R2G A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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