4TPWA

The co-complex structure of the translation initiation factor eif4e with the inhibitor 4egi-1 reveals an allosteric mechanism for dissociating eif4g
Total Genus 59
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
59
sequence length
185
structure length
185
Chain Sequence
HYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G.
pubmed doi rcsb
molecule tags Protein binding
source organism Homo sapiens
molecule keywords Eukaryotic translation initiation factor 4E
total genus 59
structure length 185
sequence length 185
chains with identical sequence B
ec nomenclature
pdb deposition date 2014-06-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01652 IF4E Eukaryotic initiation factor 4E
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.760.10 Alpha Beta 2-Layer Sandwich RNA Cap, Translation Initiation Factor Eif4e RNA Cap, Translation Initiation Factor Eif4e 4tpwA00
4UE9A 5ABXA 4UEBA 1L8BA 2V8XA 3M94A 5EIRA 1ZTPA 1EJ1A 5EI3A 2JGCA 5GW6A 1EJHA 3M93A 2Q4KA 5EHCA 4AXGA 4B6VA 2GPQA 1EJ4A 4TQBA 3TF2A 2JGBA 4B6UA 3HXGA 4UE8A 4UECA 4UEDA 5BXVA 5ABYA 3HXIA 1AP8A 4TQCA 4AZAA 5ABUA 5ABVA 1IPBA 2IDRA 2IDVA 2V8YA 5EKVA 3AM7A 2V8WA 1IPCA 5T46A 3U7XA 4UEAA 1WKWA 5T47A 4DUMA 5T48A 1RF8A 4TPWA 2W97A 2W97B 4BEAA 2WMCA 4DT6A
chains in the Genus database with same CATH superfamily
4UE9A 5ABXA 4UEBA 1L8BA 2V8XA 3M94A 5EIRA 1ZTPA 1EJ1A 5EI3A 2JGCA 5GW6A 1EJHA 3M93A 2Q4KA 5EHCA 4AXGA 4B6VA 2GPQA 1EJ4A 4TQBA 3TF2A 2JGBA 4B6UA 3HXGA 4UE8A 4UECA 4UEDA 5BXVA 5ABYA 3HXIA 1AP8A 4TQCA 4AZAA 5ABUA 5ABVA 1IPBA 2IDRA 2IDVA 2V8YA 5EKVA 3AM7A 2V8WA 1IPCA 5T46A 3U7XA 4UEAA 1WKWA 5T47A 4DUMA 5T48A 1RF8A 4TPWA 2W97A 2W97B 4BEAA 2WMCA 4DT6A
chains in the Genus database with same CATH topology
4UE9A 5ABXA 4UEBA 1L8BA 2V8XA 3M94A 5EIRA 1ZTPA 1EJ1A 5EI3A 2JGCA 5GW6A 1EJHA 3M93A 2Q4KA 5EHCA 4AXGA 4B6VA 2GPQA 1EJ4A 4TQBA 3TF2A 2JGBA 4B6UA 3HXGA 4UE8A 4UECA 4UEDA 5BXVA 5ABYA 3HXIA 1AP8A 4TQCA 4AZAA 5ABUA 5ABVA 1IPBA 2IDRA 2IDVA 2V8YA 5EKVA 3AM7A 2V8WA 1IPCA 5T46A 3U7XA 4UEAA 1WKWA 5T47A 4DUMA 5T48A 1RF8A 4TPWA 2W97A 2W97B 4BEAA 2WMCA 4DT6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4UE9 A;  5ABX A;  4UEB A;  1L8B A;  2V8X A;  3M94 A;  5EIR A;  1ZTP A;  1EJ1 A;  5EI3 A;  2JGC A;  5GW6 A;  1EJH A;  3M93 A;  2Q4K A;  5EHC A;  4AXG A;  4B6V A;  2GPQ A;  1EJ4 A;  4TQB A;  3TF2 A;  2JGB A;  4B6U A;  3HXG A;  4UE8 A;  4UEC A;  4UED A;  5BXV A;  5ABY A;  3HXI A;  1AP8 A;  4TQC A;  4AZA A;  5ABU A;  5ABV A;  1IPB A;  2IDR A;  2IDV A;  2V8Y A;  5EKV A;  3AM7 A;  2V8W A;  1IPC A;  5T46 A;  3U7X A;  4UEA A;  1WKW A;  5T47 A;  4DUM A;  5T48 A;  1RF8 A;  4TPW A;  2W97 A;  2W97 B;  4BEA A;  2WMC A;  4DT6 A; 
#chains in the Genus database with same CATH topology
 4UE9 A;  5ABX A;  4UEB A;  1L8B A;  2V8X A;  3M94 A;  5EIR A;  1ZTP A;  1EJ1 A;  5EI3 A;  2JGC A;  5GW6 A;  1EJH A;  3M93 A;  2Q4K A;  5EHC A;  4AXG A;  4B6V A;  2GPQ A;  1EJ4 A;  4TQB A;  3TF2 A;  2JGB A;  4B6U A;  3HXG A;  4UE8 A;  4UEC A;  4UED A;  5BXV A;  5ABY A;  3HXI A;  1AP8 A;  4TQC A;  4AZA A;  5ABU A;  5ABV A;  1IPB A;  2IDR A;  2IDV A;  2V8Y A;  5EKV A;  3AM7 A;  2V8W A;  1IPC A;  5T46 A;  3U7X A;  4UEA A;  1WKW A;  5T47 A;  4DUM A;  5T48 A;  1RF8 A;  4TPW A;  2W97 A;  2W97 B;  4BEA A;  2WMC A;  4DT6 A; 
#chains in the Genus database with same CATH homology
 4UE9 A;  5ABX A;  4UEB A;  1L8B A;  2V8X A;  3M94 A;  5EIR A;  1ZTP A;  1EJ1 A;  5EI3 A;  2JGC A;  5GW6 A;  1EJH A;  3M93 A;  2Q4K A;  5EHC A;  4AXG A;  4B6V A;  2GPQ A;  1EJ4 A;  4TQB A;  3TF2 A;  2JGB A;  4B6U A;  3HXG A;  4UE8 A;  4UEC A;  4UED A;  5BXV A;  5ABY A;  3HXI A;  1AP8 A;  4TQC A;  4AZA A;  5ABU A;  5ABV A;  1IPB A;  2IDR A;  2IDV A;  2V8Y A;  5EKV A;  3AM7 A;  2V8W A;  1IPC A;  5T46 A;  3U7X A;  4UEA A;  1WKW A;  5T47 A;  4DUM A;  5T48 A;  1RF8 A;  4TPW A;  2W97 A;  2W97 B;  4BEA A;  2WMC A;  4DT6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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