4UEDA

Complex of human eif4e with the 4e binding protein 4e-bp1
Total Genus 60
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
60
sequence length
185
structure length
178
Chain Sequence
PHMKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTAKNRFVV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Molecular Architecture of 4E-BP Translational Inhibitors Bound to Eif4E.
pubmed doi rcsb
molecule tags Translation
source organism Homo sapiens
molecule keywords EUKARYOTIC TRANSLATION INITIATION FACTOR 4E
total genus 60
structure length 178
sequence length 185
ec nomenclature
pdb deposition date 2014-12-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01652 IF4E Eukaryotic initiation factor 4E
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.760.10 Alpha Beta 2-Layer Sandwich RNA Cap, Translation Initiation Factor Eif4e RNA Cap, Translation Initiation Factor Eif4e 4uedA00
5ABVA 2V8YA 1AP8A 3M93A 2JGCA 5T46A 1L8BA 2IDVA 2JGBA 3M94A 3TF2A 4DUMA 3U7XA 4TQBA 5GW6A 4UEBA 4B6VA 1ZTPA 4UE8A 5ABUA 4BEAA 1WKWA 1IPBA 4B6UA 1RF8A 1EJ4A 5BXVA 2W97A 5EHCA 5ABYA 5EKVA 1IPCA 1EJ1A 5EI3A 4DT6A 2IDRA 2W97B 3HXGA 2Q4KA 4AZAA 4AXGA 2GPQA 5T47A 4UEDA 5ABXA 2WMCA 4TPWA 4UECA 3AM7A 5T48A 5EIRA 3HXIA 4UEAA 2V8XA 2V8WA 1EJHA 4UE9A 4TQCA
chains in the Genus database with same CATH superfamily
5ABVA 2V8YA 1AP8A 3M93A 2JGCA 5T46A 1L8BA 2IDVA 2JGBA 3M94A 3TF2A 4DUMA 3U7XA 4TQBA 5GW6A 4UEBA 4B6VA 1ZTPA 4UE8A 5ABUA 4BEAA 1WKWA 1IPBA 4B6UA 1RF8A 1EJ4A 5BXVA 2W97A 5EHCA 5ABYA 5EKVA 1IPCA 1EJ1A 5EI3A 4DT6A 2IDRA 2W97B 3HXGA 2Q4KA 4AZAA 4AXGA 2GPQA 5T47A 4UEDA 5ABXA 2WMCA 4TPWA 4UECA 3AM7A 5T48A 5EIRA 3HXIA 4UEAA 2V8XA 2V8WA 1EJHA 4UE9A 4TQCA
chains in the Genus database with same CATH topology
5ABVA 2V8YA 1AP8A 3M93A 2JGCA 5T46A 1L8BA 2IDVA 2JGBA 3M94A 3TF2A 4DUMA 3U7XA 4TQBA 5GW6A 4UEBA 4B6VA 1ZTPA 4UE8A 5ABUA 4BEAA 1WKWA 1IPBA 4B6UA 1RF8A 1EJ4A 5BXVA 2W97A 5EHCA 5ABYA 5EKVA 1IPCA 1EJ1A 5EI3A 4DT6A 2IDRA 2W97B 3HXGA 2Q4KA 4AZAA 4AXGA 2GPQA 5T47A 4UEDA 5ABXA 2WMCA 4TPWA 4UECA 3AM7A 5T48A 5EIRA 3HXIA 4UEAA 2V8XA 2V8WA 1EJHA 4UE9A 4TQCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5ABV A;  2V8Y A;  1AP8 A;  3M93 A;  2JGC A;  5T46 A;  1L8B A;  2IDV A;  2JGB A;  3M94 A;  3TF2 A;  4DUM A;  3U7X A;  4TQB A;  5GW6 A;  4UEB A;  4B6V A;  1ZTP A;  4UE8 A;  5ABU A;  4BEA A;  1WKW A;  1IPB A;  4B6U A;  1RF8 A;  1EJ4 A;  5BXV A;  2W97 A;  5EHC A;  5ABY A;  5EKV A;  1IPC A;  1EJ1 A;  5EI3 A;  4DT6 A;  2IDR A;  2W97 B;  3HXG A;  2Q4K A;  4AZA A;  4AXG A;  2GPQ A;  5T47 A;  4UED A;  5ABX A;  2WMC A;  4TPW A;  4UEC A;  3AM7 A;  5T48 A;  5EIR A;  3HXI A;  4UEA A;  2V8X A;  2V8W A;  1EJH A;  4UE9 A;  4TQC A; 
#chains in the Genus database with same CATH topology
 5ABV A;  2V8Y A;  1AP8 A;  3M93 A;  2JGC A;  5T46 A;  1L8B A;  2IDV A;  2JGB A;  3M94 A;  3TF2 A;  4DUM A;  3U7X A;  4TQB A;  5GW6 A;  4UEB A;  4B6V A;  1ZTP A;  4UE8 A;  5ABU A;  4BEA A;  1WKW A;  1IPB A;  4B6U A;  1RF8 A;  1EJ4 A;  5BXV A;  2W97 A;  5EHC A;  5ABY A;  5EKV A;  1IPC A;  1EJ1 A;  5EI3 A;  4DT6 A;  2IDR A;  2W97 B;  3HXG A;  2Q4K A;  4AZA A;  4AXG A;  2GPQ A;  5T47 A;  4UED A;  5ABX A;  2WMC A;  4TPW A;  4UEC A;  3AM7 A;  5T48 A;  5EIR A;  3HXI A;  4UEA A;  2V8X A;  2V8W A;  1EJH A;  4UE9 A;  4TQC A; 
#chains in the Genus database with same CATH homology
 5ABV A;  2V8Y A;  1AP8 A;  3M93 A;  2JGC A;  5T46 A;  1L8B A;  2IDV A;  2JGB A;  3M94 A;  3TF2 A;  4DUM A;  3U7X A;  4TQB A;  5GW6 A;  4UEB A;  4B6V A;  1ZTP A;  4UE8 A;  5ABU A;  4BEA A;  1WKW A;  1IPB A;  4B6U A;  1RF8 A;  1EJ4 A;  5BXV A;  2W97 A;  5EHC A;  5ABY A;  5EKV A;  1IPC A;  1EJ1 A;  5EI3 A;  4DT6 A;  2IDR A;  2W97 B;  3HXG A;  2Q4K A;  4AZA A;  4AXG A;  2GPQ A;  5T47 A;  4UED A;  5ABX A;  2WMC A;  4TPW A;  4UEC A;  3AM7 A;  5T48 A;  5EIR A;  3HXI A;  4UEA A;  2V8X A;  2V8W A;  1EJH A;  4UE9 A;  4TQC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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