4HF4A

Crystal structure of pde10a with a biaryl ether inhibitor (1-(1-(3-(4-(benzo[d]thiazol-2-ylamino)phenoxy)pyrazin-2-yl)piperidin-4-yl)ethanol)
Total Genus 129
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
129
sequence length
318
structure length
318
Chain Sequence
TSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase
total genus 129
structure length 318
sequence length 318
chains with identical sequence B
ec nomenclature ec 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
pdb deposition date 2012-10-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00233 PDEase_I 3'5'-cyclic nucleotide phosphodiesterase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1300.10 Mainly Alpha Orthogonal Bundle Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain 4hf4A00
1Z1LA 4G2JA 1XP0A 4HEUA 4AELA 4P1RA 3I8VA 1RKPA 4LM4A 4X0FA 5I2RA 4MSAA 1SO2A 3SNLA 4HF4A 4E90A 1XORA 4LKQA 5DH5A 2QYKA 3QPOA 4PHWA 4W1OA 3V9BA 2OUQA 4MSHA 5B25A 1F0JA 2FM0A 1TBBA 4MSNA 1XMYB 5EDGB 1Y2BA 2OUYA 4MRZA 1XMYA 5EDEB 5EDGA 5EDHA 4C1IA 5EDEA 4HTXA 1UHOA 1TBFA 3K4SA 3SNIA 4HTZA 3G45A 3SL6A 1XM6A 3UUOA 2Y0JA 3SHZA 5C2EA 1MKDA 2H44A 4MSCA 3SL3A 3G4GA 1Y2KA 3G4LA 4ZO5A 4AJMA 2H40A 3FRGA 1ZKNA 4YS7A 4BBXA 4AJDA 3SL8A 1Y2CA 4LM3A 4MD6A 3SL4A 2FM5A 3UI7A 5C1WA 1T9SA 3QI3A 2QYMA 4P0NA 1XOSA 3WS8A 2QYNA 3SIEA 4YQHA 2YY2A 2CHMA 5DH4A 1XM4A 2OUSA 3JWRA 3SL5A 3WD9A 1XOMA 3WI2A 2OUNA 3SN7A 3QPPA 4MS0A 4FCDA 3HDZA 3LY2A 1XOTA 3D3PA 1ZKLA 3HQWA 3WYLA 3BJCA 1XLZA 1UDUA 3K3HA 3O57A 4LLJA 4MUWA 1XOZA 4D09A 4I9ZA 1Y2EA 4LLXA 3HC8A 4OGBA 4LM0A 3B2RA 5C28A 4Y87A 2PW3A 2R8QA 2OVYA 4LM2A 3SHYA 2O8HA 3ECMA 3HQYA 3TVXA 3TGGA 4DFFA 1UDTA 2WEYA 3IAKA 4LM1A 3DYNA 4D08A 3ITUA 5C29A 4WN1A 3WYKA 4AJGA 2OUVA 3IADA 2OURA 3KKTA 3G58A 5K32A 2OVVA 1XM4B 3QPNA 3JWQA 1Q9MA 1XMUB 3ITMA 3JSWA 4KP6A 4LLKA 4OEXA 1XOQA 3HQZA 3TGEA 1XMUA 4MVHA 1XLXA 1SOJA 4OEWA 5B4LA 3HMVA 3W5EA 4Y8CA 1Y2HA 4WZIA 3WS9A 3HR1A 1RO9A 3G4IA 5C2HA 4Y86A 5K9RA 3V94A 4MRWA 1OYNA 3DY8A 3JSIA 3G4KA 4GH6A 1RORA 4I15A 1PTWA 4JIBA 4MYQA 3O56A 4NW7A 5B4KA 2H42A 4LLPA 1TAZA 4QGEA 4NPVA 5AXPA 4TPPA 3LXGA 2QYLA 3K3EA 3O0JA 1Y2DA 2OUUA 4XY2A 3DYLA 3N3ZA 5EDIB 3DYQA 4G2YA 4Y2BA 5EDIA 1RO6A 2HD1A 3QI4A 4MSEA 1TB5A 3DYSA 4WCUA 3ECNA 1XONA 4G2LA 3IBJA 4FCBA 4TPMA 1T9RA 5C2AA 5AXQA 3WYMA 3G3NA 4NPWA 4PM0A 4DDLA 3GWTA 4G2WA 4IA0A 2OUPA 1XN0A 5K1IA 1TB7A 4AJFA 3V93A 4PHLA 1Y2JA
chains in the Genus database with same CATH superfamily
1Z1LA 4G2JA 1XP0A 4HEUA 4AELA 4P1RA 3I8VA 1RKPA 4LM4A 4X0FA 5I2RA 4MSAA 1SO2A 3SNLA 4HF4A 4E90A 1XORA 4LKQA 5DH5A 2QYKA 3QPOA 4PHWA 4W1OA 3V9BA 2OUQA 4MSHA 5B25A 1F0JA 2FM0A 1TBBA 4MSNA 1XMYB 5EDGB 1Y2BA 2OUYA 4MRZA 1XMYA 5EDEB 5EDGA 5EDHA 4C1IA 5EDEA 4HTXA 1UHOA 1TBFA 3K4SA 3SNIA 4HTZA 3G45A 3SL6A 1XM6A 3UUOA 2Y0JA 3SHZA 5C2EA 1MKDA 2H44A 4MSCA 3SL3A 3G4GA 1Y2KA 3G4LA 4ZO5A 4AJMA 2H40A 3FRGA 1ZKNA 4YS7A 4BBXA 4AJDA 3SL8A 1Y2CA 4LM3A 4MD6A 3SL4A 2FM5A 3UI7A 5C1WA 1T9SA 3QI3A 2QYMA 4P0NA 1XOSA 3WS8A 2QYNA 3SIEA 4YQHA 2YY2A 2CHMA 5DH4A 1XM4A 2OUSA 3JWRA 3SL5A 3WD9A 1XOMA 3WI2A 2OUNA 3SN7A 3QPPA 4MS0A 4FCDA 3HDZA 3LY2A 1XOTA 3D3PA 1ZKLA 3HQWA 3WYLA 3BJCA 1XLZA 1UDUA 3K3HA 3O57A 4LLJA 4MUWA 1XOZA 4D09A 4I9ZA 1Y2EA 4LLXA 3HC8A 4OGBA 4LM0A 3B2RA 5C28A 4Y87A 2PW3A 2R8QA 2OVYA 4LM2A 3SHYA 2O8HA 3ECMA 3HQYA 3TVXA 3TGGA 4DFFA 1UDTA 2WEYA 3IAKA 4LM1A 3DYNA 4D08A 3ITUA 5C29A 4WN1A 3WYKA 4AJGA 2OUVA 3IADA 2OURA 3KKTA 3G58A 5K32A 2OVVA 1XM4B 3QPNA 3JWQA 1Q9MA 1XMUB 3ITMA 3JSWA 4KP6A 4LLKA 4OEXA 1XOQA 3HQZA 3TGEA 1XMUA 4MVHA 1XLXA 1SOJA 4OEWA 5B4LA 3HMVA 3W5EA 4Y8CA 1Y2HA 4WZIA 3WS9A 3HR1A 1RO9A 3G4IA 5C2HA 4Y86A 5K9RA 3V94A 4MRWA 1OYNA 3DY8A 3JSIA 3G4KA 4GH6A 1RORA 4I15A 1PTWA 4JIBA 4MYQA 3O56A 4NW7A 5B4KA 2H42A 4LLPA 1TAZA 4QGEA 4NPVA 5AXPA 4TPPA 3LXGA 2QYLA 3K3EA 3O0JA 1Y2DA 2OUUA 4XY2A 3DYLA 3N3ZA 5EDIB 3DYQA 4G2YA 4Y2BA 5EDIA 1RO6A 2HD1A 3QI4A 4MSEA 1TB5A 3DYSA 4WCUA 3ECNA 1XONA 4G2LA 3IBJA 4FCBA 4TPMA 1T9RA 5C2AA 5AXQA 3WYMA 3G3NA 4NPWA 4PM0A 4DDLA 3GWTA 4G2WA 4IA0A 2OUPA 1XN0A 5K1IA 1TB7A 4AJFA 3V93A 4PHLA 1Y2JA
chains in the Genus database with same CATH topology
1Z1LA 4G2JA 1XP0A 4HEUA 4AELA 4P1RA 3I8VA 1RKPA 4LM4A 4X0FA 5I2RA 4MSAA 1SO2A 3SNLA 4HF4A 4E90A 1XORA 4LKQA 5DH5A 2QYKA 3QPOA 4PHWA 4W1OA 3V9BA 2OUQA 4MSHA 5B25A 1F0JA 2FM0A 1TBBA 4MSNA 1XMYB 5EDGB 1Y2BA 2OUYA 4MRZA 1XMYA 5EDEB 5EDGA 5EDHA 4C1IA 5EDEA 4HTXA 1UHOA 1TBFA 3K4SA 3SNIA 4HTZA 3G45A 3SL6A 1XM6A 3UUOA 2Y0JA 3SHZA 5C2EA 1MKDA 2H44A 4MSCA 3SL3A 3G4GA 1Y2KA 3G4LA 4ZO5A 4AJMA 2H40A 3FRGA 1ZKNA 4YS7A 4BBXA 4AJDA 3SL8A 1Y2CA 4LM3A 4MD6A 3SL4A 2FM5A 3UI7A 5C1WA 1T9SA 3QI3A 2QYMA 4P0NA 1XOSA 3WS8A 2QYNA 3SIEA 4YQHA 2YY2A 2CHMA 5DH4A 1XM4A 2OUSA 3JWRA 3SL5A 3WD9A 1XOMA 3WI2A 2OUNA 3SN7A 3QPPA 4MS0A 4FCDA 3HDZA 3LY2A 1XOTA 3D3PA 1ZKLA 3HQWA 3WYLA 3BJCA 1XLZA 1UDUA 3K3HA 3O57A 4LLJA 4MUWA 1XOZA 4D09A 4I9ZA 1Y2EA 4LLXA 3HC8A 4OGBA 4LM0A 3B2RA 5C28A 4Y87A 2PW3A 2R8QA 2OVYA 4LM2A 3SHYA 2O8HA 3ECMA 3HQYA 3TVXA 3TGGA 4DFFA 1UDTA 2WEYA 3IAKA 4LM1A 3DYNA 4D08A 3ITUA 5C29A 4WN1A 3WYKA 4AJGA 2OUVA 3IADA 2OURA 3KKTA 3G58A 5K32A 2OVVA 1XM4B 3QPNA 3JWQA 1Q9MA 1XMUB 3ITMA 3JSWA 4KP6A 4LLKA 4OEXA 1XOQA 3HQZA 3TGEA 1XMUA 4MVHA 1XLXA 1SOJA 4OEWA 5B4LA 3HMVA 3W5EA 4Y8CA 1Y2HA 4WZIA 3WS9A 3HR1A 1RO9A 3G4IA 5C2HA 4Y86A 5K9RA 3V94A 4MRWA 1OYNA 3DY8A 3JSIA 3G4KA 4GH6A 1RORA 4I15A 1PTWA 4JIBA 4MYQA 3O56A 4NW7A 5B4KA 2H42A 4LLPA 1TAZA 4QGEA 4NPVA 5AXPA 4TPPA 3LXGA 2QYLA 3K3EA 3O0JA 1Y2DA 2OUUA 4XY2A 3DYLA 3N3ZA 5EDIB 3DYQA 4G2YA 4Y2BA 5EDIA 1RO6A 2HD1A 3QI4A 4MSEA 1TB5A 3DYSA 4WCUA 3ECNA 1XONA 4G2LA 3IBJA 4FCBA 4TPMA 1T9RA 5C2AA 5AXQA 3WYMA 3G3NA 4NPWA 4PM0A 4DDLA 3GWTA 4G2WA 4IA0A 2OUPA 1XN0A 5K1IA 1TB7A 4AJFA 3V93A 4PHLA 1Y2JA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Z1L A;  4G2J A;  1XP0 A;  4HEU A;  4AEL A;  4P1R A;  3I8V A;  1RKP A;  4LM4 A;  4X0F A;  5I2R A;  4MSA A;  1SO2 A;  3SNL A;  4HF4 A;  4E90 A;  1XOR A;  4LKQ A;  5DH5 A;  2QYK A;  3QPO A;  4PHW A;  4W1O A;  3V9B A;  2OUQ A;  4MSH A;  5B25 A;  1F0J A;  2FM0 A;  1TBB A;  4MSN A;  1XMY B;  5EDG B;  1Y2B A;  2OUY A;  4MRZ A;  1XMY A;  5EDE B;  5EDG A;  5EDH A;  4C1I A;  5EDE A;  4HTX A;  1UHO A;  1TBF A;  3K4S A;  3SNI A;  4HTZ A;  3G45 A;  3SL6 A;  1XM6 A;  3UUO A;  2Y0J A;  3SHZ A;  5C2E A;  1MKD A;  2H44 A;  4MSC A;  3SL3 A;  3G4G A;  1Y2K A;  3G4L A;  4ZO5 A;  4AJM A;  2H40 A;  3FRG A;  1ZKN A;  4YS7 A;  4BBX A;  4AJD A;  3SL8 A;  1Y2C A;  4LM3 A;  4MD6 A;  3SL4 A;  2FM5 A;  3UI7 A;  5C1W A;  1T9S A;  3QI3 A;  2QYM A;  4P0N A;  1XOS A;  3WS8 A;  2QYN A;  3SIE A;  4YQH A;  2YY2 A;  2CHM A;  5DH4 A;  1XM4 A;  2OUS A;  3JWR A;  3SL5 A;  3WD9 A;  1XOM A;  3WI2 A;  2OUN A;  3SN7 A;  3QPP A;  4MS0 A;  4FCD A;  3HDZ A;  3LY2 A;  1XOT A;  3D3P A;  1ZKL A;  3HQW A;  3WYL A;  3BJC A;  1XLZ A;  1UDU A;  3K3H A;  3O57 A;  4LLJ A;  4MUW A;  1XOZ A;  4D09 A;  4I9Z A;  1Y2E A;  4LLX A;  3HC8 A;  4OGB A;  4LM0 A;  3B2R A;  5C28 A;  4Y87 A;  2PW3 A;  2R8Q A;  2OVY A;  4LM2 A;  3SHY A;  2O8H A;  3ECM A;  3HQY A;  3TVX A;  3TGG A;  4DFF A;  1UDT A;  2WEY A;  3IAK A;  4LM1 A;  3DYN A;  4D08 A;  3ITU A;  5C29 A;  4WN1 A;  3WYK A;  4AJG A;  2OUV A;  3IAD A;  2OUR A;  3KKT A;  3G58 A;  5K32 A;  2OVV A;  1XM4 B;  3QPN A;  3JWQ A;  1Q9M A;  1XMU B;  3ITM A;  3JSW A;  4KP6 A;  4LLK A;  4OEX A;  1XOQ A;  3HQZ A;  3TGE A;  1XMU A;  4MVH A;  1XLX A;  1SOJ A;  4OEW A;  5B4L A;  3HMV A;  3W5E A;  4Y8C A;  1Y2H A;  4WZI A;  3WS9 A;  3HR1 A;  1RO9 A;  3G4I A;  5C2H A;  4Y86 A;  5K9R A;  3V94 A;  4MRW A;  1OYN A;  3DY8 A;  3JSI A;  3G4K A;  4GH6 A;  1ROR A;  4I15 A;  1PTW A;  4JIB A;  4MYQ A;  3O56 A;  4NW7 A;  5B4K A;  2H42 A;  4LLP A;  1TAZ A;  4QGE A;  4NPV A;  5AXP A;  4TPP A;  3LXG A;  2QYL A;  3K3E A;  3O0J A;  1Y2D A;  2OUU A;  4XY2 A;  3DYL A;  3N3Z A;  5EDI B;  3DYQ A;  4G2Y A;  4Y2B A;  5EDI A;  1RO6 A;  2HD1 A;  3QI4 A;  4MSE A;  1TB5 A;  3DYS A;  4WCU A;  3ECN A;  1XON A;  4G2L A;  3IBJ A;  4FCB A;  4TPM A;  1T9R A;  5C2A A;  5AXQ A;  3WYM A;  3G3N A;  4NPW A;  4PM0 A;  4DDL A;  3GWT A;  4G2W A;  4IA0 A;  2OUP A;  1XN0 A;  5K1I A;  1TB7 A;  4AJF A;  3V93 A;  4PHL A;  1Y2J A; 
#chains in the Genus database with same CATH topology
 1Z1L A;  4G2J A;  1XP0 A;  4HEU A;  4AEL A;  4P1R A;  3I8V A;  1RKP A;  4LM4 A;  4X0F A;  5I2R A;  4MSA A;  1SO2 A;  3SNL A;  4HF4 A;  4E90 A;  1XOR A;  4LKQ A;  5DH5 A;  2QYK A;  3QPO A;  4PHW A;  4W1O A;  3V9B A;  2OUQ A;  4MSH A;  5B25 A;  1F0J A;  2FM0 A;  1TBB A;  4MSN A;  1XMY B;  5EDG B;  1Y2B A;  2OUY A;  4MRZ A;  1XMY A;  5EDE B;  5EDG A;  5EDH A;  4C1I A;  5EDE A;  4HTX A;  1UHO A;  1TBF A;  3K4S A;  3SNI A;  4HTZ A;  3G45 A;  3SL6 A;  1XM6 A;  3UUO A;  2Y0J A;  3SHZ A;  5C2E A;  1MKD A;  2H44 A;  4MSC A;  3SL3 A;  3G4G A;  1Y2K A;  3G4L A;  4ZO5 A;  4AJM A;  2H40 A;  3FRG A;  1ZKN A;  4YS7 A;  4BBX A;  4AJD A;  3SL8 A;  1Y2C A;  4LM3 A;  4MD6 A;  3SL4 A;  2FM5 A;  3UI7 A;  5C1W A;  1T9S A;  3QI3 A;  2QYM A;  4P0N A;  1XOS A;  3WS8 A;  2QYN A;  3SIE A;  4YQH A;  2YY2 A;  2CHM A;  5DH4 A;  1XM4 A;  2OUS A;  3JWR A;  3SL5 A;  3WD9 A;  1XOM A;  3WI2 A;  2OUN A;  3SN7 A;  3QPP A;  4MS0 A;  4FCD A;  3HDZ A;  3LY2 A;  1XOT A;  3D3P A;  1ZKL A;  3HQW A;  3WYL A;  3BJC A;  1XLZ A;  1UDU A;  3K3H A;  3O57 A;  4LLJ A;  4MUW A;  1XOZ A;  4D09 A;  4I9Z A;  1Y2E A;  4LLX A;  3HC8 A;  4OGB A;  4LM0 A;  3B2R A;  5C28 A;  4Y87 A;  2PW3 A;  2R8Q A;  2OVY A;  4LM2 A;  3SHY A;  2O8H A;  3ECM A;  3HQY A;  3TVX A;  3TGG A;  4DFF A;  1UDT A;  2WEY A;  3IAK A;  4LM1 A;  3DYN A;  4D08 A;  3ITU A;  5C29 A;  4WN1 A;  3WYK A;  4AJG A;  2OUV A;  3IAD A;  2OUR A;  3KKT A;  3G58 A;  5K32 A;  2OVV A;  1XM4 B;  3QPN A;  3JWQ A;  1Q9M A;  1XMU B;  3ITM A;  3JSW A;  4KP6 A;  4LLK A;  4OEX A;  1XOQ A;  3HQZ A;  3TGE A;  1XMU A;  4MVH A;  1XLX A;  1SOJ A;  4OEW A;  5B4L A;  3HMV A;  3W5E A;  4Y8C A;  1Y2H A;  4WZI A;  3WS9 A;  3HR1 A;  1RO9 A;  3G4I A;  5C2H A;  4Y86 A;  5K9R A;  3V94 A;  4MRW A;  1OYN A;  3DY8 A;  3JSI A;  3G4K A;  4GH6 A;  1ROR A;  4I15 A;  1PTW A;  4JIB A;  4MYQ A;  3O56 A;  4NW7 A;  5B4K A;  2H42 A;  4LLP A;  1TAZ A;  4QGE A;  4NPV A;  5AXP A;  4TPP A;  3LXG A;  2QYL A;  3K3E A;  3O0J A;  1Y2D A;  2OUU A;  4XY2 A;  3DYL A;  3N3Z A;  5EDI B;  3DYQ A;  4G2Y A;  4Y2B A;  5EDI A;  1RO6 A;  2HD1 A;  3QI4 A;  4MSE A;  1TB5 A;  3DYS A;  4WCU A;  3ECN A;  1XON A;  4G2L A;  3IBJ A;  4FCB A;  4TPM A;  1T9R A;  5C2A A;  5AXQ A;  3WYM A;  3G3N A;  4NPW A;  4PM0 A;  4DDL A;  3GWT A;  4G2W A;  4IA0 A;  2OUP A;  1XN0 A;  5K1I A;  1TB7 A;  4AJF A;  3V93 A;  4PHL A;  1Y2J A; 
#chains in the Genus database with same CATH homology
 1Z1L A;  4G2J A;  1XP0 A;  4HEU A;  4AEL A;  4P1R A;  3I8V A;  1RKP A;  4LM4 A;  4X0F A;  5I2R A;  4MSA A;  1SO2 A;  3SNL A;  4HF4 A;  4E90 A;  1XOR A;  4LKQ A;  5DH5 A;  2QYK A;  3QPO A;  4PHW A;  4W1O A;  3V9B A;  2OUQ A;  4MSH A;  5B25 A;  1F0J A;  2FM0 A;  1TBB A;  4MSN A;  1XMY B;  5EDG B;  1Y2B A;  2OUY A;  4MRZ A;  1XMY A;  5EDE B;  5EDG A;  5EDH A;  4C1I A;  5EDE A;  4HTX A;  1UHO A;  1TBF A;  3K4S A;  3SNI A;  4HTZ A;  3G45 A;  3SL6 A;  1XM6 A;  3UUO A;  2Y0J A;  3SHZ A;  5C2E A;  1MKD A;  2H44 A;  4MSC A;  3SL3 A;  3G4G A;  1Y2K A;  3G4L A;  4ZO5 A;  4AJM A;  2H40 A;  3FRG A;  1ZKN A;  4YS7 A;  4BBX A;  4AJD A;  3SL8 A;  1Y2C A;  4LM3 A;  4MD6 A;  3SL4 A;  2FM5 A;  3UI7 A;  5C1W A;  1T9S A;  3QI3 A;  2QYM A;  4P0N A;  1XOS A;  3WS8 A;  2QYN A;  3SIE A;  4YQH A;  2YY2 A;  2CHM A;  5DH4 A;  1XM4 A;  2OUS A;  3JWR A;  3SL5 A;  3WD9 A;  1XOM A;  3WI2 A;  2OUN A;  3SN7 A;  3QPP A;  4MS0 A;  4FCD A;  3HDZ A;  3LY2 A;  1XOT A;  3D3P A;  1ZKL A;  3HQW A;  3WYL A;  3BJC A;  1XLZ A;  1UDU A;  3K3H A;  3O57 A;  4LLJ A;  4MUW A;  1XOZ A;  4D09 A;  4I9Z A;  1Y2E A;  4LLX A;  3HC8 A;  4OGB A;  4LM0 A;  3B2R A;  5C28 A;  4Y87 A;  2PW3 A;  2R8Q A;  2OVY A;  4LM2 A;  3SHY A;  2O8H A;  3ECM A;  3HQY A;  3TVX A;  3TGG A;  4DFF A;  1UDT A;  2WEY A;  3IAK A;  4LM1 A;  3DYN A;  4D08 A;  3ITU A;  5C29 A;  4WN1 A;  3WYK A;  4AJG A;  2OUV A;  3IAD A;  2OUR A;  3KKT A;  3G58 A;  5K32 A;  2OVV A;  1XM4 B;  3QPN A;  3JWQ A;  1Q9M A;  1XMU B;  3ITM A;  3JSW A;  4KP6 A;  4LLK A;  4OEX A;  1XOQ A;  3HQZ A;  3TGE A;  1XMU A;  4MVH A;  1XLX A;  1SOJ A;  4OEW A;  5B4L A;  3HMV A;  3W5E A;  4Y8C A;  1Y2H A;  4WZI A;  3WS9 A;  3HR1 A;  1RO9 A;  3G4I A;  5C2H A;  4Y86 A;  5K9R A;  3V94 A;  4MRW A;  1OYN A;  3DY8 A;  3JSI A;  3G4K A;  4GH6 A;  1ROR A;  4I15 A;  1PTW A;  4JIB A;  4MYQ A;  3O56 A;  4NW7 A;  5B4K A;  2H42 A;  4LLP A;  1TAZ A;  4QGE A;  4NPV A;  5AXP A;  4TPP A;  3LXG A;  2QYL A;  3K3E A;  3O0J A;  1Y2D A;  2OUU A;  4XY2 A;  3DYL A;  3N3Z A;  5EDI B;  3DYQ A;  4G2Y A;  4Y2B A;  5EDI A;  1RO6 A;  2HD1 A;  3QI4 A;  4MSE A;  1TB5 A;  3DYS A;  4WCU A;  3ECN A;  1XON A;  4G2L A;  3IBJ A;  4FCB A;  4TPM A;  1T9R A;  5C2A A;  5AXQ A;  3WYM A;  3G3N A;  4NPW A;  4PM0 A;  4DDL A;  3GWT A;  4G2W A;  4IA0 A;  2OUP A;  1XN0 A;  5K1I A;  1TB7 A;  4AJF A;  3V93 A;  4PHL A;  1Y2J A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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