4TQCA

The co-complex structure of the translation initiation factor eif4e with the inhibitor 4egi-1 reveals an allosteric mechanism for dissociating eif4g
Total Genus 56
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
56
sequence length
183
structure length
176
Chain Sequence
IKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTATKSKNRFVV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G.
pubmed doi rcsb
molecule tags Protein binding
source organism Homo sapiens
molecule keywords Eukaryotic translation initiation factor 4E
total genus 56
structure length 176
sequence length 183
chains with identical sequence B
ec nomenclature
pdb deposition date 2014-06-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01652 IF4E Eukaryotic initiation factor 4E
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.760.10 Alpha Beta 2-Layer Sandwich RNA Cap, Translation Initiation Factor Eif4e RNA Cap, Translation Initiation Factor Eif4e 4tqcA00
4DT6A 5ABUA 4TPWA 4AZAA 3HXGA 3M94A 1EJHA 2V8YA 2Q4KA 4BEAA 2JGBA 3M93A 2V8XA 2W97A 5EIRA 5ABXA 5T46A 4TQBA 4UECA 2W97B 5BXVA 5ABYA 4UE9A 4UEBA 4UE8A 4UEDA 2IDRA 5EKVA 2GPQA 3HXIA 1AP8A 5EI3A 1L8BA 1RF8A 1IPCA 1IPBA 2V8WA 2WMCA 4TQCA 5GW6A 5T47A 2IDVA 4B6UA 4DUMA 5EHCA 4AXGA 4B6VA 1EJ1A 3AM7A 2JGCA 5T48A 3U7XA 5ABVA 1ZTPA 1EJ4A 4UEAA 3TF2A 1WKWA
chains in the Genus database with same CATH superfamily
4DT6A 5ABUA 4TPWA 4AZAA 3HXGA 3M94A 1EJHA 2V8YA 2Q4KA 4BEAA 2JGBA 3M93A 2V8XA 2W97A 5EIRA 5ABXA 5T46A 4TQBA 4UECA 2W97B 5BXVA 5ABYA 4UE9A 4UEBA 4UE8A 4UEDA 2IDRA 5EKVA 2GPQA 3HXIA 1AP8A 5EI3A 1L8BA 1RF8A 1IPCA 1IPBA 2V8WA 2WMCA 4TQCA 5GW6A 5T47A 2IDVA 4B6UA 4DUMA 5EHCA 4AXGA 4B6VA 1EJ1A 3AM7A 2JGCA 5T48A 3U7XA 5ABVA 1ZTPA 1EJ4A 4UEAA 3TF2A 1WKWA
chains in the Genus database with same CATH topology
4DT6A 5ABUA 4TPWA 4AZAA 3HXGA 3M94A 1EJHA 2V8YA 2Q4KA 4BEAA 2JGBA 3M93A 2V8XA 2W97A 5EIRA 5ABXA 5T46A 4TQBA 4UECA 2W97B 5BXVA 5ABYA 4UE9A 4UEBA 4UE8A 4UEDA 2IDRA 5EKVA 2GPQA 3HXIA 1AP8A 5EI3A 1L8BA 1RF8A 1IPCA 1IPBA 2V8WA 2WMCA 4TQCA 5GW6A 5T47A 2IDVA 4B6UA 4DUMA 5EHCA 4AXGA 4B6VA 1EJ1A 3AM7A 2JGCA 5T48A 3U7XA 5ABVA 1ZTPA 1EJ4A 4UEAA 3TF2A 1WKWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4DT6 A;  5ABU A;  4TPW A;  4AZA A;  3HXG A;  3M94 A;  1EJH A;  2V8Y A;  2Q4K A;  4BEA A;  2JGB A;  3M93 A;  2V8X A;  2W97 A;  5EIR A;  5ABX A;  5T46 A;  4TQB A;  4UEC A;  2W97 B;  5BXV A;  5ABY A;  4UE9 A;  4UEB A;  4UE8 A;  4UED A;  2IDR A;  5EKV A;  2GPQ A;  3HXI A;  1AP8 A;  5EI3 A;  1L8B A;  1RF8 A;  1IPC A;  1IPB A;  2V8W A;  2WMC A;  4TQC A;  5GW6 A;  5T47 A;  2IDV A;  4B6U A;  4DUM A;  5EHC A;  4AXG A;  4B6V A;  1EJ1 A;  3AM7 A;  2JGC A;  5T48 A;  3U7X A;  5ABV A;  1ZTP A;  1EJ4 A;  4UEA A;  3TF2 A;  1WKW A; 
#chains in the Genus database with same CATH topology
 4DT6 A;  5ABU A;  4TPW A;  4AZA A;  3HXG A;  3M94 A;  1EJH A;  2V8Y A;  2Q4K A;  4BEA A;  2JGB A;  3M93 A;  2V8X A;  2W97 A;  5EIR A;  5ABX A;  5T46 A;  4TQB A;  4UEC A;  2W97 B;  5BXV A;  5ABY A;  4UE9 A;  4UEB A;  4UE8 A;  4UED A;  2IDR A;  5EKV A;  2GPQ A;  3HXI A;  1AP8 A;  5EI3 A;  1L8B A;  1RF8 A;  1IPC A;  1IPB A;  2V8W A;  2WMC A;  4TQC A;  5GW6 A;  5T47 A;  2IDV A;  4B6U A;  4DUM A;  5EHC A;  4AXG A;  4B6V A;  1EJ1 A;  3AM7 A;  2JGC A;  5T48 A;  3U7X A;  5ABV A;  1ZTP A;  1EJ4 A;  4UEA A;  3TF2 A;  1WKW A; 
#chains in the Genus database with same CATH homology
 4DT6 A;  5ABU A;  4TPW A;  4AZA A;  3HXG A;  3M94 A;  1EJH A;  2V8Y A;  2Q4K A;  4BEA A;  2JGB A;  3M93 A;  2V8X A;  2W97 A;  5EIR A;  5ABX A;  5T46 A;  4TQB A;  4UEC A;  2W97 B;  5BXV A;  5ABY A;  4UE9 A;  4UEB A;  4UE8 A;  4UED A;  2IDR A;  5EKV A;  2GPQ A;  3HXI A;  1AP8 A;  5EI3 A;  1L8B A;  1RF8 A;  1IPC A;  1IPB A;  2V8W A;  2WMC A;  4TQC A;  5GW6 A;  5T47 A;  2IDV A;  4B6U A;  4DUM A;  5EHC A;  4AXG A;  4B6V A;  1EJ1 A;  3AM7 A;  2JGC A;  5T48 A;  3U7X A;  5ABV A;  1ZTP A;  1EJ4 A;  4UEA A;  3TF2 A;  1WKW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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