4U48A

Crystal structure of salmonella alpha-2-macroglobulin
Total Genus 297
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
297
sequence length
1595
structure length
1538
Chain Sequence
LAQQSQGKALTLLDASEAQLDGAATLVLTFSIPLDPEQDFSRVVHVVDAASGSVDGAWELAPNLKELRLRHLEPERVLVVTVDPAVKALNNATFGKSYEKTITTRDVQPSVGFASRGSLLPGKIAEGLPVMALNVNHVDVNFFRVKPGSLASFVSQWEYMADLVYTGRFDLNPARNTREKLLLPLSDIKPLQQAGVYVAVMNSNAATLFTLSDIGVSAHRYHNRLDIFTQSLENGAAQSGIEIVLLNDKGQTLAQATSDAQGHVQLEADKAAALLLARKEEQTTLLDLTLPALDLSEFNVAGAPGYSKQFFMFGPRDLYRPGETVILNGLLRDSDGKTLPDQPVKLEVVKPDGQVMRTVVSQPENGLYRLNYPLDINAPTGLWHVRANTGDNLLRSWDFHVEDFMPERMALNLTAQKTPLAPADEVKFSVVGYYLYGAPANGNTLQGQLFLRPLRDAVAALPGFQFGNIAEENLSRSLDEVQLTLDKGGRGEVSAASQWQEAHSPLQVILQASLLESGGRPVTRRVEQAIWPADTLPGIRPQFAAKAVYDYRTDTTVNQPIVDEDSNAAFDIVYANAQGEKKAVSGLQVRLIRERRDYYWNWSESEGWQSQFDQKDLVEGEQTLDLNADETGKVSFPVEWGAYRLEVKAPNETVSSVRFWAGYSWPDRVTLKLDKANYRPGDTMKLHIAAPVAGKGYAMVESSDGPLWWQAIDVPAQGLELTIPVDKTWNRHDLYLSTLVVRPGDKSRSATPKRAVGLLHLPLGDDNRRLDLALESPAKMRPNQPLTVRVKASVKHGEMPKQINVLVSAVDSGVLNITDYATPDPWQAFFGQKRYGADIYDIYGQVIEGQGRLAALRHVNIIAQQAQPITLNEQGEGVVTLPIGDFNGELRVMAQAWTADDFGRGESKVVVAAPVIAELNMPRFLAGGDVSRLVLDVTNLTDRPQTLNIALAASGLLELLSQQPQPVNLAPGVRTTLFVPVRALEGFGEGEIQATISGLNLPGETLDAQHKQWQIGVRPAWPAQTVNSGIALAPGESWHVPEQHLANISPATLQGQLLLSGKPPLNLARYIRELKAYPYGCLEQTTSGLFPALYTNAAQLQSLGITGDSDEKRRAAVDIGISRILQMQRDNGGFALWDENGAEEPWLTAYAMDFLIRAGEQGYSVPPEAINRGNERLLRYLQDPGTMLIRYSDNTQASTFAAQAYAALVLARQQKAPLGTLREIWERRSQAASGLPLMQLGIALNTMGDARRGEEAITLALNTPRQDERQWIADYGSSLRDNALMLSLLEENNLRPDAQNALLSSLSEQAFGQRWLSTQENNALFLAAHSRQASAGAWQVQTSLEAQPLSGDKALTRNLDADQLAALEVTNTGSQPLWLRLDSSGYPSSAPEPASNVLQIERQILGTDGQRKSLSSLRSGELVLVWLTVVADRNVPDALVVDLLPAGLELENQNLASGSEVQNLLNQMQQADIQYMEFRDDRFVAAVVVNEGQPVTLVYLARAVTPGTYQLAQPQVESMYAPQWRATGASEGLLIVTP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Hydrolase inhibitor
molecule keywords Putative inner membrane lipoprotein
publication title Structure of a bacterial alpha 2-macroglobulin reveals mimicry of eukaryotic innate immunity.
pubmed doi rcsb
source organism Salmonella enterica subsp. enterica serovar typhimurium str. lt2
total genus 297
structure length 1538
sequence length 1595
ec nomenclature
pdb deposition date 2014-07-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00207 A2M Alpha-2-macroglobulin family
A PF01835 MG2 MG2 domain
A PF07678 TED_complement A-macroglobulin TED domain
A PF07703 A2M_BRD Alpha-2-macroglobulin bait region domain
A PF11974 bMG3 Bacterial alpha-2-macroglobulin MG3 domain
A PF17962 bMG6 Bacterial macroglobulin domain 6
A PF17970 bMG1 Bacterial Alpha-2-macroglobulin MG1 domain
A PF17972 bMG5 Bacterial Alpha-2-macroglobulin MG5 domain
A PF17973 bMG10 Bacterial Alpha-2-macroglobulin MG10 domain
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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