5HIRA

Solution structure of recombinant hirudin and the lys-47 (right arrow) glu mutant. a nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing study
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
49
structure length
49
Chain Sequence
VVYTDCTESGQNLCLCEGSNVCGQGNKCILGSDGEKNQCVTGEGTPKPQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Solution structure of recombinant hirudin and the Lys-47----Glu mutant: a nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing study.
pubmed doi rcsb
molecule tags Coagulation inhibitor
source organism Hirudo medicinalis
molecule keywords HIRUDIN VARIANT-1
total genus 3
structure length 49
sequence length 49
ec nomenclature
pdb deposition date 1990-01-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00713 Hirudin Hirudin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.10.10 Mainly Beta Distorted Sandwich Thrombin Inhibitor (Hirudin); Chain I Thrombin Inhibitor (Hirudin), subunit I 5hirA00
6HIRA 1HRTI 2JOOA 5HIRA 1E0FI 4HTCI 4HIRA 4MLFD 1HICA 2PW8I 2HIRA
chains in the Genus database with same CATH superfamily
6HIRA 1HRTI 2JOOA 5HIRA 1E0FI 4HTCI 4HIRA 4MLFD 1HICA 2PW8I 2HIRA
chains in the Genus database with same CATH topology
6HIRA 1HRTI 2JOOA 5HIRA 1E0FI 4HTCI 4HIRA 4MLFD 1HICA 2PW8I 2HIRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 6HIR A;  1HRT I;  2JOO A;  5HIR A;  1E0F I;  4HTC I;  4HIR A;  4MLF D;  1HIC A;  2PW8 I;  2HIR A; 
#chains in the Genus database with same CATH topology
 6HIR A;  1HRT I;  2JOO A;  5HIR A;  1E0F I;  4HTC I;  4HIR A;  4MLF D;  1HIC A;  2PW8 I;  2HIR A; 
#chains in the Genus database with same CATH homology
 6HIR A;  1HRT I;  2JOO A;  5HIR A;  1E0F I;  4HTC I;  4HIR A;  4MLF D;  1HIC A;  2PW8 I;  2HIR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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