5LQFC

Cdk1/cyclinb1/cks2 in complex with nu6102
Total Genus 10
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
10
sequence length
74
structure length
74
Chain Sequence
MAHKQIYYSDKYFDEHYEYRHVMLPRELSKQVPKTHLMSEEEWRRLGVQQSLGWVHYMIHEPEPHILLFRRPLP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines.
pubmed doi rcsb
molecule tags Transferase
source organism Homo sapiens
molecule keywords Cyclin-dependent kinase 1
total genus 10
structure length 74
sequence length 74
chains with identical sequence F
ec nomenclature
pdb deposition date 2016-08-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF01111 CKS Cyclin-dependent kinase regulatory subunit
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.170.10 Alpha Beta 2-Layer Sandwich Cyclin-Dependent Kinase Subunit Type 2 Cyclin-dependent kinase, regulatory subunit 5lqfC00
1DKSA 4YC6B 2ASSC 3QY2A 1SCEA 1CKSA 5LQFC 1DKTA 2ASTC 5HQ0C 4LPAA 1QB3A 4Y72C 1PUCA 1BUHB 4YC3C
chains in the Genus database with same CATH superfamily
1DKSA 4YC6B 2ASSC 3QY2A 1SCEA 1CKSA 5LQFC 1DKTA 2ASTC 5HQ0C 4LPAA 1QB3A 4Y72C 1PUCA 1BUHB 4YC3C
chains in the Genus database with same CATH topology
1DKSA 4YC6B 2ASSC 3QY2A 1SCEA 1CKSA 5LQFC 1DKTA 2ASTC 5HQ0C 4LPAA 1QB3A 4Y72C 1PUCA 1BUHB 4YC3C
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1DKS A;  4YC6 B;  2ASS C;  3QY2 A;  1SCE A;  1CKS A;  5LQF C;  1DKT A;  2AST C;  5HQ0 C;  4LPA A;  1QB3 A;  4Y72 C;  1PUC A;  1BUH B;  4YC3 C; 
#chains in the Genus database with same CATH topology
 1DKS A;  4YC6 B;  2ASS C;  3QY2 A;  1SCE A;  1CKS A;  5LQF C;  1DKT A;  2AST C;  5HQ0 C;  4LPA A;  1QB3 A;  4Y72 C;  1PUC A;  1BUH B;  4YC3 C; 
#chains in the Genus database with same CATH homology
 1DKS A;  4YC6 B;  2ASS C;  3QY2 A;  1SCE A;  1CKS A;  5LQF C;  1DKT A;  2AST C;  5HQ0 C;  4LPA A;  1QB3 A;  4Y72 C;  1PUC A;  1BUH B;  4YC3 C; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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