5F4LA

Hiv-1 gp120 complex with jp-iii-048
Total Genus 91
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
91
sequence length
350
structure length
336
Chain Sequence
KTTLFCASDAKAYEKEVHNVWATHACVPTDPNPQEMVLANVTENFNMWKNDMVEQMHEDIISLWDESLKPCVKLTGGSAITQACPKVSFDPIPLHYCAPAGFAILKCNNKTFNGTGPCRNVSTVQCTHGIKPVVSTQLLLNGSLAEEEIIIRSENLTNNAKTIIVHLNESVNIVCTRPNNIRQAHCNINESKWNNTLQKVGEELAKHFPSKTIKFEPSSGGDLEITTHSFNCRGEFFYCNTSDLFNGTYRNGTYNHTGRSSNGTITLQCKIKQIINMWQEVGRAIYAPPIEGEITCNSNITGLLLLRDDTETFRPGGGDMRDNWRSELYKYKVVEI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition.
pubmed doi rcsb
molecule tags Viral protein
source organism Human immunodeficiency virus 1
molecule keywords ENVELOPE GLYCOPROTEIN GP120 of HIV-1 clade C
total genus 91
structure length 336
sequence length 350
chains with identical sequence B
ec nomenclature
pdb deposition date 2015-12-03
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.40.20 Mainly Beta Beta Complex HIV Envelope Protein Gp120; Chain G Human immunodeficiency virus 1, Gp160, envelope glycoprotein 5f4lA01
5F4UA 3HI1G 3IDXG 4LSRG 1RZJG 2NY4A 4LSTG 4DKOA 3U7YG 1GC1G 2NY7G 4S1QG 4YDJG 5TE7G 4OM1G 4XNZA 4OLVG 4P9HG 4XVTG 4DKQA 5CD5A 5FA2A 4JZWA 4I53A 3JWOA 4RFOG 4LSPG 4XMPG 4JZZA 2NY6A 4RWYA 1G9MG 2BF1A 5T33G 4LSVG 4OLZG 5I9QA 4YFLE 5CAYG 5TE4G 4RX4E 1YYMG 3NGBA 4RFNA 4H8WG 4XNYG 5F9OG 4DKUA 4JPWG 4DKVA 4OLXG 5F9WA 4XVSG 3TGSA 4JKPG 4YDIG 2NY5G 4R4NA 4DVTA 4LSUG 2QADA 3SE8G 4KA2A 1YYLG 4DVRG 3JWDA 4S1SG 2B4CG 1G9NG 2I60G 4JDTG 3TGTA 4YE4G 3LQAG 1RZKG 2I5YG 2NY2A 3FUSA 4DVVA 4K0AA 3RJQA 5F4LA 4JM2E 4LAJA 5KJRG 5FECC 4OM0G 4J6RG 4DKRA 5F4PA 2NY3A 3SE9G 4JB9G 3IDYA 4YDKG 2NY0A 4LSQG 2NXZA 4DVWA 4DVSA 3TIHA 4YDLA 5F4RA 4I54A 2NXYA 4OLYG 3TGRA 4DKPA 4OLWG 5TE6G 3TGQA 4R4FA 4S1RG 5F96G 4R2GA 4OLUG 4LSSG 4JPVG 5IGXG 4DVXA 4RZ8A 2NY1A
chains in the Genus database with same CATH superfamily
5F4UA 3HI1G 3IDXG 4LSRG 1RZJG 2NY4A 4LSTG 4DKOA 3U7YG 1GC1G 2NY7G 4S1QG 4YDJG 5TE7G 4OM1G 4XNZA 4OLVG 4P9HG 4XVTG 4DKQA 5CD5A 5FA2A 4JZWA 4I53A 3JWOA 4RFOG 4LSPG 4XMPG 4JZZA 2NY6A 4RWYA 1G9MG 2BF1A 5T33G 4LSVG 4OLZG 5I9QA 4YFLE 5CAYG 5TE4G 4RX4E 1YYMG 3NGBA 4RFNA 4H8WG 4XNYG 5F9OG 4DKUA 4JPWG 4DKVA 4OLXG 5F9WA 4XVSG 3TGSA 4JKPG 4YDIG 2NY5G 4R4NA 4DVTA 4LSUG 2QADA 3SE8G 4KA2A 1YYLG 4DVRG 3JWDA 4S1SG 2B4CG 1G9NG 2I60G 4JDTG 3TGTA 4YE4G 3LQAG 1RZKG 2I5YG 2NY2A 3FUSA 4DVVA 4K0AA 3RJQA 5F4LA 4JM2E 4LAJA 5KJRG 5FECC 4OM0G 4J6RG 4DKRA 5F4PA 2NY3A 3SE9G 4JB9G 3IDYA 4YDKG 2NY0A 4LSQG 2NXZA 4DVWA 4DVSA 3TIHA 4YDLA 5F4RA 4I54A 2NXYA 4OLYG 3TGRA 4DKPA 4OLWG 5TE6G 3TGQA 4R4FA 4S1RG 5F96G 4R2GA 4OLUG 4LSSG 4JPVG 5IGXG 4DVXA 4RZ8A 2NY1A
chains in the Genus database with same CATH topology
5F4UA 3HI1G 3IDXG 4LSRG 1RZJG 2NY4A 4LSTG 4DKOA 3U7YG 1GC1G 2NY7G 4S1QG 4YDJG 5TE7G 4OM1G 4XNZA 4OLVG 4P9HG 4XVTG 4DKQA 5CD5A 5FA2A 4JZWA 4I53A 3JWOA 4RFOG 4LSPG 4XMPG 4JZZA 2NY6A 4RWYA 1G9MG 2BF1A 5T33G 4LSVG 4OLZG 5I9QA 4YFLE 5CAYG 5TE4G 4RX4E 1YYMG 3NGBA 4RFNA 4H8WG 4XNYG 5F9OG 4DKUA 4JPWG 4DKVA 4OLXG 5F9WA 4XVSG 3TGSA 4JKPG 4YDIG 2NY5G 4R4NA 4DVTA 4LSUG 2QADA 3SE8G 4KA2A 1YYLG 4DVRG 3JWDA 4S1SG 2B4CG 1G9NG 2I60G 4JDTG 3TGTA 4YE4G 3LQAG 1RZKG 2I5YG 2NY2A 3FUSA 4DVVA 4K0AA 3RJQA 5F4LA 4JM2E 4LAJA 5KJRG 5FECC 4OM0G 4J6RG 4DKRA 5F4PA 2NY3A 3SE9G 4JB9G 3IDYA 4YDKG 2NY0A 4LSQG 2NXZA 4DVWA 4DVSA 3TIHA 4YDLA 5F4RA 4I54A 2NXYA 4OLYG 3TGRA 4DKPA 4OLWG 5TE6G 3TGQA 4R4FA 4S1RG 5F96G 4R2GA 4OLUG 4LSSG 4JPVG 5IGXG 4DVXA 4RZ8A 2NY1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5F4U A;  3HI1 G;  3IDX G;  4LSR G;  1RZJ G;  2NY4 A;  4LST G;  4DKO A;  3U7Y G;  1GC1 G;  2NY7 G;  4S1Q G;  4YDJ G;  5TE7 G;  4OM1 G;  4XNZ A;  4OLV G;  4P9H G;  4XVT G;  4DKQ A;  5CD5 A;  5FA2 A;  4JZW A;  4I53 A;  3JWO A;  4RFO G;  4LSP G;  4XMP G;  4JZZ A;  2NY6 A;  4RWY A;  1G9M G;  2BF1 A;  5T33 G;  4LSV G;  4OLZ G;  5I9Q A;  4YFL E;  5CAY G;  5TE4 G;  4RX4 E;  1YYM G;  3NGB A;  4RFN A;  4H8W G;  4XNY G;  5F9O G;  4DKU A;  4JPW G;  4DKV A;  4OLX G;  5F9W A;  4XVS G;  3TGS A;  4JKP G;  4YDI G;  2NY5 G;  4R4N A;  4DVT A;  4LSU G;  2QAD A;  3SE8 G;  4KA2 A;  1YYL G;  4DVR G;  3JWD A;  4S1S G;  2B4C G;  1G9N G;  2I60 G;  4JDT G;  3TGT A;  4YE4 G;  3LQA G;  1RZK G;  2I5Y G;  2NY2 A;  3FUS A;  4DVV A;  4K0A A;  3RJQ A;  5F4L A;  4JM2 E;  4LAJ A;  5KJR G;  5FEC C;  4OM0 G;  4J6R G;  4DKR A;  5F4P A;  2NY3 A;  3SE9 G;  4JB9 G;  3IDY A;  4YDK G;  2NY0 A;  4LSQ G;  2NXZ A;  4DVW A;  4DVS A;  3TIH A;  4YDL A;  5F4R A;  4I54 A;  2NXY A;  4OLY G;  3TGR A;  4DKP A;  4OLW G;  5TE6 G;  3TGQ A;  4R4F A;  4S1R G;  5F96 G;  4R2G A;  4OLU G;  4LSS G;  4JPV G;  5IGX G;  4DVX A;  4RZ8 A;  2NY1 A; 
#chains in the Genus database with same CATH topology
 5F4U A;  3HI1 G;  3IDX G;  4LSR G;  1RZJ G;  2NY4 A;  4LST G;  4DKO A;  3U7Y G;  1GC1 G;  2NY7 G;  4S1Q G;  4YDJ G;  5TE7 G;  4OM1 G;  4XNZ A;  4OLV G;  4P9H G;  4XVT G;  4DKQ A;  5CD5 A;  5FA2 A;  4JZW A;  4I53 A;  3JWO A;  4RFO G;  4LSP G;  4XMP G;  4JZZ A;  2NY6 A;  4RWY A;  1G9M G;  2BF1 A;  5T33 G;  4LSV G;  4OLZ G;  5I9Q A;  4YFL E;  5CAY G;  5TE4 G;  4RX4 E;  1YYM G;  3NGB A;  4RFN A;  4H8W G;  4XNY G;  5F9O G;  4DKU A;  4JPW G;  4DKV A;  4OLX G;  5F9W A;  4XVS G;  3TGS A;  4JKP G;  4YDI G;  2NY5 G;  4R4N A;  4DVT A;  4LSU G;  2QAD A;  3SE8 G;  4KA2 A;  1YYL G;  4DVR G;  3JWD A;  4S1S G;  2B4C G;  1G9N G;  2I60 G;  4JDT G;  3TGT A;  4YE4 G;  3LQA G;  1RZK G;  2I5Y G;  2NY2 A;  3FUS A;  4DVV A;  4K0A A;  3RJQ A;  5F4L A;  4JM2 E;  4LAJ A;  5KJR G;  5FEC C;  4OM0 G;  4J6R G;  4DKR A;  5F4P A;  2NY3 A;  3SE9 G;  4JB9 G;  3IDY A;  4YDK G;  2NY0 A;  4LSQ G;  2NXZ A;  4DVW A;  4DVS A;  3TIH A;  4YDL A;  5F4R A;  4I54 A;  2NXY A;  4OLY G;  3TGR A;  4DKP A;  4OLW G;  5TE6 G;  3TGQ A;  4R4F A;  4S1R G;  5F96 G;  4R2G A;  4OLU G;  4LSS G;  4JPV G;  5IGX G;  4DVX A;  4RZ8 A;  2NY1 A; 
#chains in the Genus database with same CATH homology
 5F4U A;  3HI1 G;  3IDX G;  4LSR G;  1RZJ G;  2NY4 A;  4LST G;  4DKO A;  3U7Y G;  1GC1 G;  2NY7 G;  4S1Q G;  4YDJ G;  5TE7 G;  4OM1 G;  4XNZ A;  4OLV G;  4P9H G;  4XVT G;  4DKQ A;  5CD5 A;  5FA2 A;  4JZW A;  4I53 A;  3JWO A;  4RFO G;  4LSP G;  4XMP G;  4JZZ A;  2NY6 A;  4RWY A;  1G9M G;  2BF1 A;  5T33 G;  4LSV G;  4OLZ G;  5I9Q A;  4YFL E;  5CAY G;  5TE4 G;  4RX4 E;  1YYM G;  3NGB A;  4RFN A;  4H8W G;  4XNY G;  5F9O G;  4DKU A;  4JPW G;  4DKV A;  4OLX G;  5F9W A;  4XVS G;  3TGS A;  4JKP G;  4YDI G;  2NY5 G;  4R4N A;  4DVT A;  4LSU G;  2QAD A;  3SE8 G;  4KA2 A;  1YYL G;  4DVR G;  3JWD A;  4S1S G;  2B4C G;  1G9N G;  2I60 G;  4JDT G;  3TGT A;  4YE4 G;  3LQA G;  1RZK G;  2I5Y G;  2NY2 A;  3FUS A;  4DVV A;  4K0A A;  3RJQ A;  5F4L A;  4JM2 E;  4LAJ A;  5KJR G;  5FEC C;  4OM0 G;  4J6R G;  4DKR A;  5F4P A;  2NY3 A;  3SE9 G;  4JB9 G;  3IDY A;  4YDK G;  2NY0 A;  4LSQ G;  2NXZ A;  4DVW A;  4DVS A;  3TIH A;  4YDL A;  5F4R A;  4I54 A;  2NXY A;  4OLY G;  3TGR A;  4DKP A;  4OLW G;  5TE6 G;  3TGQ A;  4R4F A;  4S1R G;  5F96 G;  4R2G A;  4OLU G;  4LSS G;  4JPV G;  5IGX G;  4DVX A;  4RZ8 A;  2NY1 A; 
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similar chains in the pdb database (?% sequence similarity)

 
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