5F4RA

Hiv-1 gp120 complex with bnw-iv-147
Total Genus 80
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
80
sequence length
349
structure length
335
Chain Sequence
KTTLFCASDAKAYEKEVHNVWATHACVPTDPNPQEMVLANVTENFNMWKNDMVEQMHEDIISLWDESLKPCVKLTGGSAITQACPKVSFDPIPLHYCAPAGFAILKCNNKTFNGTGPCRNVSTVQCTHGIKPVVSTQLLLNGSLAEEEIIIRSENLTNNAKTIIVHLNESVNIVCTRPNNIRQAHCNINESKWNNTLQKVGEELAKHFPSKTIKFEPSSGGDLEITTHSFNCRGEFFYCNTSDLFNGTYRNGTYNHTGRSSNGTITLQCKIKQIINMWQEVGRAIYAPPIEGEITCNSNITGLLLLRDDTETFRPGGGDMRDNWRSELYKYKVVE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition.
pubmed doi rcsb
molecule tags Viral protein
source organism Human immunodeficiency virus 1
molecule keywords ENVELOPE GLYCOPROTEIN GP120 of HIV-1 clade C
total genus 80
structure length 335
sequence length 349
chains with identical sequence C
ec nomenclature
pdb deposition date 2015-12-03
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.40.20 Mainly Beta Beta Complex HIV Envelope Protein Gp120; Chain G Human immunodeficiency virus 1, Gp160, envelope glycoprotein 5f4rA01
4YE4G 3TGTA 4LSSG 1RZKG 4DKUA 1YYMG 4JZWA 2NY7G 1RZJG 4RX4E 4RZ8A 5T33G 4JPWG 5F4RA 3U7YG 4DVSA 2I5YG 4LAJA 4LSVG 4LSPG 4DVXA 4YDLA 4S1RG 5IGXG 4RFNA 3IDXG 4H8WG 5TE7G 4R4FA 4I54A 4JM2E 5TE6G 4RWYA 5FECC 4K0AA 4OLUG 4JZZA 2NY6A 4R4NA 5F96G 4R2GA 4KA2A 5I9QA 4XNZA 3JWOA 3TIHA 4DKPA 3RJQA 5F4PA 4XMPG 4DVTA 4I53A 2NXYA 3NGBA 4JPVG 3JWDA 4LSUG 5TE4G 1G9NG 5KJRG 2BF1A 4OLXG 4XVTG 5CD5A 4XVSG 2QADA 3FUSA 4XNYG 4YFLE 4OLZG 1YYLG 4DVVA 2NY0A 2NY1A 3IDYA 2NY3A 3TGQA 4JDTG 4YDIG 5F4UA 3LQAG 2NY4A 4OM0G 4LSQG 4OM1G 5F4LA 5FA2A 5CAYG 4DKRA 3SE8G 4YDJG 2I60G 4LSTG 1G9MG 4DVWA 4DKVA 4DKOA 4J6RG 4RFOG 2B4CG 2NY5G 3TGSA 4YDKG 4P9HG 4S1QG 3TGRA 4OLVG 3HI1G 4DVRG 2NXZA 3SE9G 5F9OG 4OLYG 2NY2A 4DKQA 5F9WA 4JKPG 4OLWG 4S1SG 1GC1G 4LSRG 4JB9G
chains in the Genus database with same CATH superfamily
4YE4G 3TGTA 4LSSG 1RZKG 4DKUA 1YYMG 4JZWA 2NY7G 1RZJG 4RX4E 4RZ8A 5T33G 4JPWG 5F4RA 3U7YG 4DVSA 2I5YG 4LAJA 4LSVG 4LSPG 4DVXA 4YDLA 4S1RG 5IGXG 4RFNA 3IDXG 4H8WG 5TE7G 4R4FA 4I54A 4JM2E 5TE6G 4RWYA 5FECC 4K0AA 4OLUG 4JZZA 2NY6A 4R4NA 5F96G 4R2GA 4KA2A 5I9QA 4XNZA 3JWOA 3TIHA 4DKPA 3RJQA 5F4PA 4XMPG 4DVTA 4I53A 2NXYA 3NGBA 4JPVG 3JWDA 4LSUG 5TE4G 1G9NG 5KJRG 2BF1A 4OLXG 4XVTG 5CD5A 4XVSG 2QADA 3FUSA 4XNYG 4YFLE 4OLZG 1YYLG 4DVVA 2NY0A 2NY1A 3IDYA 2NY3A 3TGQA 4JDTG 4YDIG 5F4UA 3LQAG 2NY4A 4OM0G 4LSQG 4OM1G 5F4LA 5FA2A 5CAYG 4DKRA 3SE8G 4YDJG 2I60G 4LSTG 1G9MG 4DVWA 4DKVA 4DKOA 4J6RG 4RFOG 2B4CG 2NY5G 3TGSA 4YDKG 4P9HG 4S1QG 3TGRA 4OLVG 3HI1G 4DVRG 2NXZA 3SE9G 5F9OG 4OLYG 2NY2A 4DKQA 5F9WA 4JKPG 4OLWG 4S1SG 1GC1G 4LSRG 4JB9G
chains in the Genus database with same CATH topology
4YE4G 3TGTA 4LSSG 1RZKG 4DKUA 1YYMG 4JZWA 2NY7G 1RZJG 4RX4E 4RZ8A 5T33G 4JPWG 5F4RA 3U7YG 4DVSA 2I5YG 4LAJA 4LSVG 4LSPG 4DVXA 4YDLA 4S1RG 5IGXG 4RFNA 3IDXG 4H8WG 5TE7G 4R4FA 4I54A 4JM2E 5TE6G 4RWYA 5FECC 4K0AA 4OLUG 4JZZA 2NY6A 4R4NA 5F96G 4R2GA 4KA2A 5I9QA 4XNZA 3JWOA 3TIHA 4DKPA 3RJQA 5F4PA 4XMPG 4DVTA 4I53A 2NXYA 3NGBA 4JPVG 3JWDA 4LSUG 5TE4G 1G9NG 5KJRG 2BF1A 4OLXG 4XVTG 5CD5A 4XVSG 2QADA 3FUSA 4XNYG 4YFLE 4OLZG 1YYLG 4DVVA 2NY0A 2NY1A 3IDYA 2NY3A 3TGQA 4JDTG 4YDIG 5F4UA 3LQAG 2NY4A 4OM0G 4LSQG 4OM1G 5F4LA 5FA2A 5CAYG 4DKRA 3SE8G 4YDJG 2I60G 4LSTG 1G9MG 4DVWA 4DKVA 4DKOA 4J6RG 4RFOG 2B4CG 2NY5G 3TGSA 4YDKG 4P9HG 4S1QG 3TGRA 4OLVG 3HI1G 4DVRG 2NXZA 3SE9G 5F9OG 4OLYG 2NY2A 4DKQA 5F9WA 4JKPG 4OLWG 4S1SG 1GC1G 4LSRG 4JB9G
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4YE4 G;  3TGT A;  4LSS G;  1RZK G;  4DKU A;  1YYM G;  4JZW A;  2NY7 G;  1RZJ G;  4RX4 E;  4RZ8 A;  5T33 G;  4JPW G;  5F4R A;  3U7Y G;  4DVS A;  2I5Y G;  4LAJ A;  4LSV G;  4LSP G;  4DVX A;  4YDL A;  4S1R G;  5IGX G;  4RFN A;  3IDX G;  4H8W G;  5TE7 G;  4R4F A;  4I54 A;  4JM2 E;  5TE6 G;  4RWY A;  5FEC C;  4K0A A;  4OLU G;  4JZZ A;  2NY6 A;  4R4N A;  5F96 G;  4R2G A;  4KA2 A;  5I9Q A;  4XNZ A;  3JWO A;  3TIH A;  4DKP A;  3RJQ A;  5F4P A;  4XMP G;  4DVT A;  4I53 A;  2NXY A;  3NGB A;  4JPV G;  3JWD A;  4LSU G;  5TE4 G;  1G9N G;  5KJR G;  2BF1 A;  4OLX G;  4XVT G;  5CD5 A;  4XVS G;  2QAD A;  3FUS A;  4XNY G;  4YFL E;  4OLZ G;  1YYL G;  4DVV A;  2NY0 A;  2NY1 A;  3IDY A;  2NY3 A;  3TGQ A;  4JDT G;  4YDI G;  5F4U A;  3LQA G;  2NY4 A;  4OM0 G;  4LSQ G;  4OM1 G;  5F4L A;  5FA2 A;  5CAY G;  4DKR A;  3SE8 G;  4YDJ G;  2I60 G;  4LST G;  1G9M G;  4DVW A;  4DKV A;  4DKO A;  4J6R G;  4RFO G;  2B4C G;  2NY5 G;  3TGS A;  4YDK G;  4P9H G;  4S1Q G;  3TGR A;  4OLV G;  3HI1 G;  4DVR G;  2NXZ A;  3SE9 G;  5F9O G;  4OLY G;  2NY2 A;  4DKQ A;  5F9W A;  4JKP G;  4OLW G;  4S1S G;  1GC1 G;  4LSR G;  4JB9 G; 
#chains in the Genus database with same CATH topology
 4YE4 G;  3TGT A;  4LSS G;  1RZK G;  4DKU A;  1YYM G;  4JZW A;  2NY7 G;  1RZJ G;  4RX4 E;  4RZ8 A;  5T33 G;  4JPW G;  5F4R A;  3U7Y G;  4DVS A;  2I5Y G;  4LAJ A;  4LSV G;  4LSP G;  4DVX A;  4YDL A;  4S1R G;  5IGX G;  4RFN A;  3IDX G;  4H8W G;  5TE7 G;  4R4F A;  4I54 A;  4JM2 E;  5TE6 G;  4RWY A;  5FEC C;  4K0A A;  4OLU G;  4JZZ A;  2NY6 A;  4R4N A;  5F96 G;  4R2G A;  4KA2 A;  5I9Q A;  4XNZ A;  3JWO A;  3TIH A;  4DKP A;  3RJQ A;  5F4P A;  4XMP G;  4DVT A;  4I53 A;  2NXY A;  3NGB A;  4JPV G;  3JWD A;  4LSU G;  5TE4 G;  1G9N G;  5KJR G;  2BF1 A;  4OLX G;  4XVT G;  5CD5 A;  4XVS G;  2QAD A;  3FUS A;  4XNY G;  4YFL E;  4OLZ G;  1YYL G;  4DVV A;  2NY0 A;  2NY1 A;  3IDY A;  2NY3 A;  3TGQ A;  4JDT G;  4YDI G;  5F4U A;  3LQA G;  2NY4 A;  4OM0 G;  4LSQ G;  4OM1 G;  5F4L A;  5FA2 A;  5CAY G;  4DKR A;  3SE8 G;  4YDJ G;  2I60 G;  4LST G;  1G9M G;  4DVW A;  4DKV A;  4DKO A;  4J6R G;  4RFO G;  2B4C G;  2NY5 G;  3TGS A;  4YDK G;  4P9H G;  4S1Q G;  3TGR A;  4OLV G;  3HI1 G;  4DVR G;  2NXZ A;  3SE9 G;  5F9O G;  4OLY G;  2NY2 A;  4DKQ A;  5F9W A;  4JKP G;  4OLW G;  4S1S G;  1GC1 G;  4LSR G;  4JB9 G; 
#chains in the Genus database with same CATH homology
 4YE4 G;  3TGT A;  4LSS G;  1RZK G;  4DKU A;  1YYM G;  4JZW A;  2NY7 G;  1RZJ G;  4RX4 E;  4RZ8 A;  5T33 G;  4JPW G;  5F4R A;  3U7Y G;  4DVS A;  2I5Y G;  4LAJ A;  4LSV G;  4LSP G;  4DVX A;  4YDL A;  4S1R G;  5IGX G;  4RFN A;  3IDX G;  4H8W G;  5TE7 G;  4R4F A;  4I54 A;  4JM2 E;  5TE6 G;  4RWY A;  5FEC C;  4K0A A;  4OLU G;  4JZZ A;  2NY6 A;  4R4N A;  5F96 G;  4R2G A;  4KA2 A;  5I9Q A;  4XNZ A;  3JWO A;  3TIH A;  4DKP A;  3RJQ A;  5F4P A;  4XMP G;  4DVT A;  4I53 A;  2NXY A;  3NGB A;  4JPV G;  3JWD A;  4LSU G;  5TE4 G;  1G9N G;  5KJR G;  2BF1 A;  4OLX G;  4XVT G;  5CD5 A;  4XVS G;  2QAD A;  3FUS A;  4XNY G;  4YFL E;  4OLZ G;  1YYL G;  4DVV A;  2NY0 A;  2NY1 A;  3IDY A;  2NY3 A;  3TGQ A;  4JDT G;  4YDI G;  5F4U A;  3LQA G;  2NY4 A;  4OM0 G;  4LSQ G;  4OM1 G;  5F4L A;  5FA2 A;  5CAY G;  4DKR A;  3SE8 G;  4YDJ G;  2I60 G;  4LST G;  1G9M G;  4DVW A;  4DKV A;  4DKO A;  4J6R G;  4RFO G;  2B4C G;  2NY5 G;  3TGS A;  4YDK G;  4P9H G;  4S1Q G;  3TGR A;  4OLV G;  3HI1 G;  4DVR G;  2NXZ A;  3SE9 G;  5F9O G;  4OLY G;  2NY2 A;  4DKQ A;  5F9W A;  4JKP G;  4OLW G;  4S1S G;  1GC1 G;  4LSR G;  4JB9 G; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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