5F96G

Crystal structure of broadly neutralizing vh1-46 germline-derived cd4-binding site-directed antibody ch235.12 in complex with hiv-1 clade a/e 93th057 gp120
Total Genus 90
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
90
sequence length
353
structure length
339
Chain Sequence
VWKDADTTLFCASDAKAHETEVHNVWATHACVPTDPNPQEIHLENVTENFNMWKNNMVEQMQEDVISLWDQSLQPCVKLTGGSVIKQACPKISFDPIPIHYCTPAGYVILKCNDKNFNGTGPCKNVSSVQCTHGIKPVVSTQLLLNGSLAEEEIIIRSENLTNNAKTIIVHLNKSVEINCTRPSDIRKAYCEINGTKWNKVLKQVTEKLKEHFNNKTIIFQPPSGGDLEITMHHFNCRGEFFYCNTTQLFNNTCIGCNGTITLPCKIKQIINMWQGTGQAMYAPPIDGKINCVSNITGILLTRDGGANNTSNETFRPGGGNIKDNWRSELYKYKVVQIE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody.
pubmed doi rcsb
molecule tags Immune system
source organism Human immunodeficiency virus 1
molecule keywords clade A/E 93TH057 HIV-1 gp120 core
total genus 90
structure length 339
sequence length 353
ec nomenclature
pdb deposition date 2015-12-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
G PF00516 GP120 Envelope glycoprotein GP120
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.40.20 Mainly Beta Beta Complex HIV Envelope Protein Gp120; Chain G Human immunodeficiency virus 1, Gp160, envelope glycoprotein 5f96G01
4DKOA 4YDLA 2NY2A 2B4CG 4R4NA 4YE4G 3IDXG 1RZKG 5CD5A 5F9OG 1GC1G 4I53A 3TGQA 2NY4A 4RWYA 4K0AA 2NY7G 1YYMG 2NY1A 3NGBA 5IGXG 4LSRG 4YDKG 4XNYG 4DKUA 5F9WA 4OLZG 2NY3A 4LSSG 4DVSA 4I54A 5KJRG 4LSPG 5CAYG 4P9HG 4LSQG 4DKRA 2I60G 2QADA 3TIHA 1RZJG 4DVTA 5FA2A 4RX4E 3TGTA 4J6RG 3FUSA 1G9MG 4OLWG 4XNZA 4XVTG 2NY6A 3TGRA 5F4UA 4LSVG 4DVXA 4JZWA 4RZ8A 4DKQA 5F4LA 2NXYA 4JB9G 5F4RA 4OLYG 3SE8G 4R4FA 2NXZA 4LAJA 4YFLE 4JM2E 4DVRG 1YYLG 4OM1G 4RFNA 4OLUG 5TE4G 5F4PA 3HI1G 4KA2A 4YDIG 3TGSA 4S1SG 3U7YG 4DVVA 4JPVG 4OLVG 4LSTG 5FECC 3IDYA 4YDJG 1G9NG 4DKPA 5T33G 4DVWA 2NY5G 2I5YG 3LQAG 3RJQA 4LSUG 4XMPG 3JWDA 5F96G 4JDTG 4OLXG 4DKVA 5TE7G 4R2GA 2NY0A 3JWOA 4S1RG 4JZZA 2BF1A 5I9QA 4RFOG 4H8WG 3SE9G 4JKPG 4JPWG 4OM0G 4S1QG 4XVSG 5TE6G
chains in the Genus database with same CATH superfamily
4DKOA 4YDLA 2NY2A 2B4CG 4R4NA 4YE4G 3IDXG 1RZKG 5CD5A 5F9OG 1GC1G 4I53A 3TGQA 2NY4A 4RWYA 4K0AA 2NY7G 1YYMG 2NY1A 3NGBA 5IGXG 4LSRG 4YDKG 4XNYG 4DKUA 5F9WA 4OLZG 2NY3A 4LSSG 4DVSA 4I54A 5KJRG 4LSPG 5CAYG 4P9HG 4LSQG 4DKRA 2I60G 2QADA 3TIHA 1RZJG 4DVTA 5FA2A 4RX4E 3TGTA 4J6RG 3FUSA 1G9MG 4OLWG 4XNZA 4XVTG 2NY6A 3TGRA 5F4UA 4LSVG 4DVXA 4JZWA 4RZ8A 4DKQA 5F4LA 2NXYA 4JB9G 5F4RA 4OLYG 3SE8G 4R4FA 2NXZA 4LAJA 4YFLE 4JM2E 4DVRG 1YYLG 4OM1G 4RFNA 4OLUG 5TE4G 5F4PA 3HI1G 4KA2A 4YDIG 3TGSA 4S1SG 3U7YG 4DVVA 4JPVG 4OLVG 4LSTG 5FECC 3IDYA 4YDJG 1G9NG 4DKPA 5T33G 4DVWA 2NY5G 2I5YG 3LQAG 3RJQA 4LSUG 4XMPG 3JWDA 5F96G 4JDTG 4OLXG 4DKVA 5TE7G 4R2GA 2NY0A 3JWOA 4S1RG 4JZZA 2BF1A 5I9QA 4RFOG 4H8WG 3SE9G 4JKPG 4JPWG 4OM0G 4S1QG 4XVSG 5TE6G
chains in the Genus database with same CATH topology
4DKOA 4YDLA 2NY2A 2B4CG 4R4NA 4YE4G 3IDXG 1RZKG 5CD5A 5F9OG 1GC1G 4I53A 3TGQA 2NY4A 4RWYA 4K0AA 2NY7G 1YYMG 2NY1A 3NGBA 5IGXG 4LSRG 4YDKG 4XNYG 4DKUA 5F9WA 4OLZG 2NY3A 4LSSG 4DVSA 4I54A 5KJRG 4LSPG 5CAYG 4P9HG 4LSQG 4DKRA 2I60G 2QADA 3TIHA 1RZJG 4DVTA 5FA2A 4RX4E 3TGTA 4J6RG 3FUSA 1G9MG 4OLWG 4XNZA 4XVTG 2NY6A 3TGRA 5F4UA 4LSVG 4DVXA 4JZWA 4RZ8A 4DKQA 5F4LA 2NXYA 4JB9G 5F4RA 4OLYG 3SE8G 4R4FA 2NXZA 4LAJA 4YFLE 4JM2E 4DVRG 1YYLG 4OM1G 4RFNA 4OLUG 5TE4G 5F4PA 3HI1G 4KA2A 4YDIG 3TGSA 4S1SG 3U7YG 4DVVA 4JPVG 4OLVG 4LSTG 5FECC 3IDYA 4YDJG 1G9NG 4DKPA 5T33G 4DVWA 2NY5G 2I5YG 3LQAG 3RJQA 4LSUG 4XMPG 3JWDA 5F96G 4JDTG 4OLXG 4DKVA 5TE7G 4R2GA 2NY0A 3JWOA 4S1RG 4JZZA 2BF1A 5I9QA 4RFOG 4H8WG 3SE9G 4JKPG 4JPWG 4OM0G 4S1QG 4XVSG 5TE6G
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4DKO A;  4YDL A;  2NY2 A;  2B4C G;  4R4N A;  4YE4 G;  3IDX G;  1RZK G;  5CD5 A;  5F9O G;  1GC1 G;  4I53 A;  3TGQ A;  2NY4 A;  4RWY A;  4K0A A;  2NY7 G;  1YYM G;  2NY1 A;  3NGB A;  5IGX G;  4LSR G;  4YDK G;  4XNY G;  4DKU A;  5F9W A;  4OLZ G;  2NY3 A;  4LSS G;  4DVS A;  4I54 A;  5KJR G;  4LSP G;  5CAY G;  4P9H G;  4LSQ G;  4DKR A;  2I60 G;  2QAD A;  3TIH A;  1RZJ G;  4DVT A;  5FA2 A;  4RX4 E;  3TGT A;  4J6R G;  3FUS A;  1G9M G;  4OLW G;  4XNZ A;  4XVT G;  2NY6 A;  3TGR A;  5F4U A;  4LSV G;  4DVX A;  4JZW A;  4RZ8 A;  4DKQ A;  5F4L A;  2NXY A;  4JB9 G;  5F4R A;  4OLY G;  3SE8 G;  4R4F A;  2NXZ A;  4LAJ A;  4YFL E;  4JM2 E;  4DVR G;  1YYL G;  4OM1 G;  4RFN A;  4OLU G;  5TE4 G;  5F4P A;  3HI1 G;  4KA2 A;  4YDI G;  3TGS A;  4S1S G;  3U7Y G;  4DVV A;  4JPV G;  4OLV G;  4LST G;  5FEC C;  3IDY A;  4YDJ G;  1G9N G;  4DKP A;  5T33 G;  4DVW A;  2NY5 G;  2I5Y G;  3LQA G;  3RJQ A;  4LSU G;  4XMP G;  3JWD A;  5F96 G;  4JDT G;  4OLX G;  4DKV A;  5TE7 G;  4R2G A;  2NY0 A;  3JWO A;  4S1R G;  4JZZ A;  2BF1 A;  5I9Q A;  4RFO G;  4H8W G;  3SE9 G;  4JKP G;  4JPW G;  4OM0 G;  4S1Q G;  4XVS G;  5TE6 G; 
#chains in the Genus database with same CATH topology
 4DKO A;  4YDL A;  2NY2 A;  2B4C G;  4R4N A;  4YE4 G;  3IDX G;  1RZK G;  5CD5 A;  5F9O G;  1GC1 G;  4I53 A;  3TGQ A;  2NY4 A;  4RWY A;  4K0A A;  2NY7 G;  1YYM G;  2NY1 A;  3NGB A;  5IGX G;  4LSR G;  4YDK G;  4XNY G;  4DKU A;  5F9W A;  4OLZ G;  2NY3 A;  4LSS G;  4DVS A;  4I54 A;  5KJR G;  4LSP G;  5CAY G;  4P9H G;  4LSQ G;  4DKR A;  2I60 G;  2QAD A;  3TIH A;  1RZJ G;  4DVT A;  5FA2 A;  4RX4 E;  3TGT A;  4J6R G;  3FUS A;  1G9M G;  4OLW G;  4XNZ A;  4XVT G;  2NY6 A;  3TGR A;  5F4U A;  4LSV G;  4DVX A;  4JZW A;  4RZ8 A;  4DKQ A;  5F4L A;  2NXY A;  4JB9 G;  5F4R A;  4OLY G;  3SE8 G;  4R4F A;  2NXZ A;  4LAJ A;  4YFL E;  4JM2 E;  4DVR G;  1YYL G;  4OM1 G;  4RFN A;  4OLU G;  5TE4 G;  5F4P A;  3HI1 G;  4KA2 A;  4YDI G;  3TGS A;  4S1S G;  3U7Y G;  4DVV A;  4JPV G;  4OLV G;  4LST G;  5FEC C;  3IDY A;  4YDJ G;  1G9N G;  4DKP A;  5T33 G;  4DVW A;  2NY5 G;  2I5Y G;  3LQA G;  3RJQ A;  4LSU G;  4XMP G;  3JWD A;  5F96 G;  4JDT G;  4OLX G;  4DKV A;  5TE7 G;  4R2G A;  2NY0 A;  3JWO A;  4S1R G;  4JZZ A;  2BF1 A;  5I9Q A;  4RFO G;  4H8W G;  3SE9 G;  4JKP G;  4JPW G;  4OM0 G;  4S1Q G;  4XVS G;  5TE6 G; 
#chains in the Genus database with same CATH homology
 4DKO A;  4YDL A;  2NY2 A;  2B4C G;  4R4N A;  4YE4 G;  3IDX G;  1RZK G;  5CD5 A;  5F9O G;  1GC1 G;  4I53 A;  3TGQ A;  2NY4 A;  4RWY A;  4K0A A;  2NY7 G;  1YYM G;  2NY1 A;  3NGB A;  5IGX G;  4LSR G;  4YDK G;  4XNY G;  4DKU A;  5F9W A;  4OLZ G;  2NY3 A;  4LSS G;  4DVS A;  4I54 A;  5KJR G;  4LSP G;  5CAY G;  4P9H G;  4LSQ G;  4DKR A;  2I60 G;  2QAD A;  3TIH A;  1RZJ G;  4DVT A;  5FA2 A;  4RX4 E;  3TGT A;  4J6R G;  3FUS A;  1G9M G;  4OLW G;  4XNZ A;  4XVT G;  2NY6 A;  3TGR A;  5F4U A;  4LSV G;  4DVX A;  4JZW A;  4RZ8 A;  4DKQ A;  5F4L A;  2NXY A;  4JB9 G;  5F4R A;  4OLY G;  3SE8 G;  4R4F A;  2NXZ A;  4LAJ A;  4YFL E;  4JM2 E;  4DVR G;  1YYL G;  4OM1 G;  4RFN A;  4OLU G;  5TE4 G;  5F4P A;  3HI1 G;  4KA2 A;  4YDI G;  3TGS A;  4S1S G;  3U7Y G;  4DVV A;  4JPV G;  4OLV G;  4LST G;  5FEC C;  3IDY A;  4YDJ G;  1G9N G;  4DKP A;  5T33 G;  4DVW A;  2NY5 G;  2I5Y G;  3LQA G;  3RJQ A;  4LSU G;  4XMP G;  3JWD A;  5F96 G;  4JDT G;  4OLX G;  4DKV A;  5TE7 G;  4R2G A;  2NY0 A;  3JWO A;  4S1R G;  4JZZ A;  2BF1 A;  5I9Q A;  4RFO G;  4H8W G;  3SE9 G;  4JKP G;  4JPW G;  4OM0 G;  4S1Q G;  4XVS G;  5TE6 G; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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