5F9OG

Crystal structure of broadly neutralizing vh1-46 germline-derived cd4-binding site-directed antibody ch235.09 in complex with hiv-1 clade a/e 93th057 gp120
Total Genus 90
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
90
sequence length
352
structure length
341
Chain Sequence
VWKDADTTLFCASDAKAHETEVHNVWATHACVPTDPNPQEIHLENVTENFNMWKNNMVEQMQEDVISLWDQSLQPCVKLTGGSVIKQACPKISFDPIPIHYCTPAGYVILKCNDKNFNGTGPCKNVSSVQCTHGIKPVVSTQLLLNGSLAEEEIIIRSENLTNNAKTIIVHLNKSVEINCTRPSDIRKAYCEINGTKWNKVLKQVTEKLKEHFNNKTIIFQPPSGGDLEITMHHFNCRGEFFYCNTTQLFNNTCITMKGCNGTITLPCKIKQIINMWQGTGQAMYAPPIDGKINCVSNITGILLTRDGGANNTSNETFRPGGGNIKDNWRSELYKYKVVQI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody.
pubmed doi rcsb
molecule tags Immune system
source organism Human immunodeficiency virus 1
molecule keywords clade A/E 93TH057 HIV-1 gp120 core
total genus 90
structure length 341
sequence length 352
ec nomenclature
pdb deposition date 2015-12-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
G PF00516 GP120 Envelope glycoprotein GP120
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.40.20 Mainly Beta Beta Complex HIV Envelope Protein Gp120; Chain G Human immunodeficiency virus 1, Gp160, envelope glycoprotein 5f9oG01
4P9HG 3FUSA 4JZZA 2NY0A 3LQAG 2BF1A 4LSTG 4RFNA 4OLVG 5IGXG 5CD5A 3IDXG 4JM2E 4YDJG 4RWYA 4I54A 4OLZG 4YDIG 4JZWA 4J6RG 5KJRG 4RX4E 4DKPA 5FECC 4S1SG 4RZ8A 4DKRA 2B4CG 2I60G 4JB9G 5TE6G 3HI1G 1RZJG 4DVSA 3TGTA 4I53A 5F9WA 3SE9G 3SE8G 4JPVG 3U7YG 3JWOA 4K0AA 5TE7G 2NXYA 2NY7G 4JPWG 1YYLG 4LSQG 4XVTG 3TIHA 1YYMG 2NXZA 3JWDA 4OM1G 3TGRA 4YFLE 4KA2A 4XNZA 2I5YG 4OLWG 4OLUG 4DKQA 4H8WG 5TE4G 4XMPG 4DVRG 1G9MG 4XNYG 2NY5G 5I9QA 5F4RA 3IDYA 4DKOA 4S1RG 2QADA 3TGQA 5T33G 4RFOG 4XVSG 4YDKG 2NY3A 1G9NG 4DVTA 4JKPG 4R4FA 4LSUG 3RJQA 4JDTG 4LAJA 4OM0G 4R2GA 5F4LA 4DKUA 4OLXG 2NY2A 4LSRG 4YE4G 4DVVA 4DVXA 2NY1A 4OLYG 5FA2A 4DVWA 4LSSG 3TGSA 4DKVA 1RZKG 5F4PA 5F96G 4LSPG 4LSVG 5F4UA 2NY6A 4S1QG 4YDLA 4R4NA 2NY4A 5CAYG 5F9OG 1GC1G 3NGBA
chains in the Genus database with same CATH superfamily
4P9HG 3FUSA 4JZZA 2NY0A 3LQAG 2BF1A 4LSTG 4RFNA 4OLVG 5IGXG 5CD5A 3IDXG 4JM2E 4YDJG 4RWYA 4I54A 4OLZG 4YDIG 4JZWA 4J6RG 5KJRG 4RX4E 4DKPA 5FECC 4S1SG 4RZ8A 4DKRA 2B4CG 2I60G 4JB9G 5TE6G 3HI1G 1RZJG 4DVSA 3TGTA 4I53A 5F9WA 3SE9G 3SE8G 4JPVG 3U7YG 3JWOA 4K0AA 5TE7G 2NXYA 2NY7G 4JPWG 1YYLG 4LSQG 4XVTG 3TIHA 1YYMG 2NXZA 3JWDA 4OM1G 3TGRA 4YFLE 4KA2A 4XNZA 2I5YG 4OLWG 4OLUG 4DKQA 4H8WG 5TE4G 4XMPG 4DVRG 1G9MG 4XNYG 2NY5G 5I9QA 5F4RA 3IDYA 4DKOA 4S1RG 2QADA 3TGQA 5T33G 4RFOG 4XVSG 4YDKG 2NY3A 1G9NG 4DVTA 4JKPG 4R4FA 4LSUG 3RJQA 4JDTG 4LAJA 4OM0G 4R2GA 5F4LA 4DKUA 4OLXG 2NY2A 4LSRG 4YE4G 4DVVA 4DVXA 2NY1A 4OLYG 5FA2A 4DVWA 4LSSG 3TGSA 4DKVA 1RZKG 5F4PA 5F96G 4LSPG 4LSVG 5F4UA 2NY6A 4S1QG 4YDLA 4R4NA 2NY4A 5CAYG 5F9OG 1GC1G 3NGBA
chains in the Genus database with same CATH topology
4P9HG 3FUSA 4JZZA 2NY0A 3LQAG 2BF1A 4LSTG 4RFNA 4OLVG 5IGXG 5CD5A 3IDXG 4JM2E 4YDJG 4RWYA 4I54A 4OLZG 4YDIG 4JZWA 4J6RG 5KJRG 4RX4E 4DKPA 5FECC 4S1SG 4RZ8A 4DKRA 2B4CG 2I60G 4JB9G 5TE6G 3HI1G 1RZJG 4DVSA 3TGTA 4I53A 5F9WA 3SE9G 3SE8G 4JPVG 3U7YG 3JWOA 4K0AA 5TE7G 2NXYA 2NY7G 4JPWG 1YYLG 4LSQG 4XVTG 3TIHA 1YYMG 2NXZA 3JWDA 4OM1G 3TGRA 4YFLE 4KA2A 4XNZA 2I5YG 4OLWG 4OLUG 4DKQA 4H8WG 5TE4G 4XMPG 4DVRG 1G9MG 4XNYG 2NY5G 5I9QA 5F4RA 3IDYA 4DKOA 4S1RG 2QADA 3TGQA 5T33G 4RFOG 4XVSG 4YDKG 2NY3A 1G9NG 4DVTA 4JKPG 4R4FA 4LSUG 3RJQA 4JDTG 4LAJA 4OM0G 4R2GA 5F4LA 4DKUA 4OLXG 2NY2A 4LSRG 4YE4G 4DVVA 4DVXA 2NY1A 4OLYG 5FA2A 4DVWA 4LSSG 3TGSA 4DKVA 1RZKG 5F4PA 5F96G 4LSPG 4LSVG 5F4UA 2NY6A 4S1QG 4YDLA 4R4NA 2NY4A 5CAYG 5F9OG 1GC1G 3NGBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4P9H G;  3FUS A;  4JZZ A;  2NY0 A;  3LQA G;  2BF1 A;  4LST G;  4RFN A;  4OLV G;  5IGX G;  5CD5 A;  3IDX G;  4JM2 E;  4YDJ G;  4RWY A;  4I54 A;  4OLZ G;  4YDI G;  4JZW A;  4J6R G;  5KJR G;  4RX4 E;  4DKP A;  5FEC C;  4S1S G;  4RZ8 A;  4DKR A;  2B4C G;  2I60 G;  4JB9 G;  5TE6 G;  3HI1 G;  1RZJ G;  4DVS A;  3TGT A;  4I53 A;  5F9W A;  3SE9 G;  3SE8 G;  4JPV G;  3U7Y G;  3JWO A;  4K0A A;  5TE7 G;  2NXY A;  2NY7 G;  4JPW G;  1YYL G;  4LSQ G;  4XVT G;  3TIH A;  1YYM G;  2NXZ A;  3JWD A;  4OM1 G;  3TGR A;  4YFL E;  4KA2 A;  4XNZ A;  2I5Y G;  4OLW G;  4OLU G;  4DKQ A;  4H8W G;  5TE4 G;  4XMP G;  4DVR G;  1G9M G;  4XNY G;  2NY5 G;  5I9Q A;  5F4R A;  3IDY A;  4DKO A;  4S1R G;  2QAD A;  3TGQ A;  5T33 G;  4RFO G;  4XVS G;  4YDK G;  2NY3 A;  1G9N G;  4DVT A;  4JKP G;  4R4F A;  4LSU G;  3RJQ A;  4JDT G;  4LAJ A;  4OM0 G;  4R2G A;  5F4L A;  4DKU A;  4OLX G;  2NY2 A;  4LSR G;  4YE4 G;  4DVV A;  4DVX A;  2NY1 A;  4OLY G;  5FA2 A;  4DVW A;  4LSS G;  3TGS A;  4DKV A;  1RZK G;  5F4P A;  5F96 G;  4LSP G;  4LSV G;  5F4U A;  2NY6 A;  4S1Q G;  4YDL A;  4R4N A;  2NY4 A;  5CAY G;  5F9O G;  1GC1 G;  3NGB A; 
#chains in the Genus database with same CATH topology
 4P9H G;  3FUS A;  4JZZ A;  2NY0 A;  3LQA G;  2BF1 A;  4LST G;  4RFN A;  4OLV G;  5IGX G;  5CD5 A;  3IDX G;  4JM2 E;  4YDJ G;  4RWY A;  4I54 A;  4OLZ G;  4YDI G;  4JZW A;  4J6R G;  5KJR G;  4RX4 E;  4DKP A;  5FEC C;  4S1S G;  4RZ8 A;  4DKR A;  2B4C G;  2I60 G;  4JB9 G;  5TE6 G;  3HI1 G;  1RZJ G;  4DVS A;  3TGT A;  4I53 A;  5F9W A;  3SE9 G;  3SE8 G;  4JPV G;  3U7Y G;  3JWO A;  4K0A A;  5TE7 G;  2NXY A;  2NY7 G;  4JPW G;  1YYL G;  4LSQ G;  4XVT G;  3TIH A;  1YYM G;  2NXZ A;  3JWD A;  4OM1 G;  3TGR A;  4YFL E;  4KA2 A;  4XNZ A;  2I5Y G;  4OLW G;  4OLU G;  4DKQ A;  4H8W G;  5TE4 G;  4XMP G;  4DVR G;  1G9M G;  4XNY G;  2NY5 G;  5I9Q A;  5F4R A;  3IDY A;  4DKO A;  4S1R G;  2QAD A;  3TGQ A;  5T33 G;  4RFO G;  4XVS G;  4YDK G;  2NY3 A;  1G9N G;  4DVT A;  4JKP G;  4R4F A;  4LSU G;  3RJQ A;  4JDT G;  4LAJ A;  4OM0 G;  4R2G A;  5F4L A;  4DKU A;  4OLX G;  2NY2 A;  4LSR G;  4YE4 G;  4DVV A;  4DVX A;  2NY1 A;  4OLY G;  5FA2 A;  4DVW A;  4LSS G;  3TGS A;  4DKV A;  1RZK G;  5F4P A;  5F96 G;  4LSP G;  4LSV G;  5F4U A;  2NY6 A;  4S1Q G;  4YDL A;  4R4N A;  2NY4 A;  5CAY G;  5F9O G;  1GC1 G;  3NGB A; 
#chains in the Genus database with same CATH homology
 4P9H G;  3FUS A;  4JZZ A;  2NY0 A;  3LQA G;  2BF1 A;  4LST G;  4RFN A;  4OLV G;  5IGX G;  5CD5 A;  3IDX G;  4JM2 E;  4YDJ G;  4RWY A;  4I54 A;  4OLZ G;  4YDI G;  4JZW A;  4J6R G;  5KJR G;  4RX4 E;  4DKP A;  5FEC C;  4S1S G;  4RZ8 A;  4DKR A;  2B4C G;  2I60 G;  4JB9 G;  5TE6 G;  3HI1 G;  1RZJ G;  4DVS A;  3TGT A;  4I53 A;  5F9W A;  3SE9 G;  3SE8 G;  4JPV G;  3U7Y G;  3JWO A;  4K0A A;  5TE7 G;  2NXY A;  2NY7 G;  4JPW G;  1YYL G;  4LSQ G;  4XVT G;  3TIH A;  1YYM G;  2NXZ A;  3JWD A;  4OM1 G;  3TGR A;  4YFL E;  4KA2 A;  4XNZ A;  2I5Y G;  4OLW G;  4OLU G;  4DKQ A;  4H8W G;  5TE4 G;  4XMP G;  4DVR G;  1G9M G;  4XNY G;  2NY5 G;  5I9Q A;  5F4R A;  3IDY A;  4DKO A;  4S1R G;  2QAD A;  3TGQ A;  5T33 G;  4RFO G;  4XVS G;  4YDK G;  2NY3 A;  1G9N G;  4DVT A;  4JKP G;  4R4F A;  4LSU G;  3RJQ A;  4JDT G;  4LAJ A;  4OM0 G;  4R2G A;  5F4L A;  4DKU A;  4OLX G;  2NY2 A;  4LSR G;  4YE4 G;  4DVV A;  4DVX A;  2NY1 A;  4OLY G;  5FA2 A;  4DVW A;  4LSS G;  3TGS A;  4DKV A;  1RZK G;  5F4P A;  5F96 G;  4LSP G;  4LSV G;  5F4U A;  2NY6 A;  4S1Q G;  4YDL A;  4R4N A;  2NY4 A;  5CAY G;  5F9O G;  1GC1 G;  3NGB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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