5F9WA

Crystal structure of broadly neutralizing vh1-46 germline-derived cd4-binding site-directed antibody ch235 in complex with hiv-1 clade a/e 93th057 gp120
Total Genus 82
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
82
sequence length
351
structure length
342
Chain Sequence
WKDADTTLFCASDAKAHETEVHNVWATHACVPTDPNPQEIHLENVTENFNMWKNNMVEQMQEDVISLWDQSLQPCVKLTGGSVIKQACPKISFDPIPIHYCTPAGYVILKCNDKNFNGTGPCKNVSSVQCTHGIKPVVSTQLLLNGSLAEEEIIIRSENLTNNAKTIIVHLNKSVEINCTRPSNGDIRKAYCEINGTKWNKVLKQVTEKLKEHFNNKTIIFQPPSGGDLEITMHHFNCRGEFFYCNTTQLFNNTCIGMKGCNGTITLPCKIKQIINMWQGTGQAMYAPPIDGKINCVSNITGILLTRDGGANNTSNETFRPGGGNIKDNWRSELYKYKVVQI
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody.
pubmed doi rcsb
molecule tags Immune system
source organism Human immunodeficiency virus 1
molecule keywords clade A/E 93TH057 HIV-1 gp120 core
total genus 82
structure length 342
sequence length 351
chains with identical sequence G
ec nomenclature
pdb deposition date 2015-12-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00516 GP120 Envelope glycoprotein GP120
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.40.20 Mainly Beta Beta Complex HIV Envelope Protein Gp120; Chain G Human immunodeficiency virus 1, Gp160, envelope glycoprotein 5f9wA01
4LSQG 4XNZA 4JB9G 4P9HG 2NY1A 4OLZG 4DVVA 5IGXG 4LAJA 1RZJG 4S1SG 5TE4G 4XNYG 4DVTA 3TGRA 4RFNA 2NY2A 4XVSG 5TE6G 2BF1A 5F9WA 3FUSA 4DKPA 3TGSA 4DVXA 4R4FA 4OLYG 4LSRG 4R2GA 4OLUG 2QADA 2NXZA 1YYLG 2NY7G 4DKQA 4R4NA 5FA2A 5T33G 2I60G 3JWDA 4YDKG 5F4UA 4J6RG 3U7YG 4YDJG 3TGTA 4S1RG 5TE7G 4I54A 3HI1G 4I53A 3JWOA 1RZKG 4JZWA 2NY4A 4LSVG 4RX4E 4JKPG 4JM2E 1GC1G 3IDXG 5KJRG 2NY3A 2NY6A 3TIHA 4JPWG 4DKVA 4JZZA 5I9QA 4YDLA 2NXYA 4H8WG 3SE8G 5F96G 4K0AA 1G9MG 5CD5A 4OM0G 3NGBA 4S1QG 4DKOA 2NY0A 3TGQA 4RWYA 4OM1G 4LSSG 3SE9G 1YYMG 4YE4G 4OLXG 3IDYA 4OLVG 4YFLE 4JDTG 4DVSA 4DVRG 4RZ8A 5F4LA 4RFOG 4LSPG 3RJQA 4LSTG 4XVTG 5F4PA 4LSUG 2I5YG 4JPVG 4DVWA 4YDIG 5CAYG 2B4CG 4DKRA 4KA2A 1G9NG 4OLWG 4XMPG 5FECC 5F4RA 3LQAG 5F9OG 2NY5G 4DKUA
chains in the Genus database with same CATH superfamily
4LSQG 4XNZA 4JB9G 4P9HG 2NY1A 4OLZG 4DVVA 5IGXG 4LAJA 1RZJG 4S1SG 5TE4G 4XNYG 4DVTA 3TGRA 4RFNA 2NY2A 4XVSG 5TE6G 2BF1A 5F9WA 3FUSA 4DKPA 3TGSA 4DVXA 4R4FA 4OLYG 4LSRG 4R2GA 4OLUG 2QADA 2NXZA 1YYLG 2NY7G 4DKQA 4R4NA 5FA2A 5T33G 2I60G 3JWDA 4YDKG 5F4UA 4J6RG 3U7YG 4YDJG 3TGTA 4S1RG 5TE7G 4I54A 3HI1G 4I53A 3JWOA 1RZKG 4JZWA 2NY4A 4LSVG 4RX4E 4JKPG 4JM2E 1GC1G 3IDXG 5KJRG 2NY3A 2NY6A 3TIHA 4JPWG 4DKVA 4JZZA 5I9QA 4YDLA 2NXYA 4H8WG 3SE8G 5F96G 4K0AA 1G9MG 5CD5A 4OM0G 3NGBA 4S1QG 4DKOA 2NY0A 3TGQA 4RWYA 4OM1G 4LSSG 3SE9G 1YYMG 4YE4G 4OLXG 3IDYA 4OLVG 4YFLE 4JDTG 4DVSA 4DVRG 4RZ8A 5F4LA 4RFOG 4LSPG 3RJQA 4LSTG 4XVTG 5F4PA 4LSUG 2I5YG 4JPVG 4DVWA 4YDIG 5CAYG 2B4CG 4DKRA 4KA2A 1G9NG 4OLWG 4XMPG 5FECC 5F4RA 3LQAG 5F9OG 2NY5G 4DKUA
chains in the Genus database with same CATH topology
4LSQG 4XNZA 4JB9G 4P9HG 2NY1A 4OLZG 4DVVA 5IGXG 4LAJA 1RZJG 4S1SG 5TE4G 4XNYG 4DVTA 3TGRA 4RFNA 2NY2A 4XVSG 5TE6G 2BF1A 5F9WA 3FUSA 4DKPA 3TGSA 4DVXA 4R4FA 4OLYG 4LSRG 4R2GA 4OLUG 2QADA 2NXZA 1YYLG 2NY7G 4DKQA 4R4NA 5FA2A 5T33G 2I60G 3JWDA 4YDKG 5F4UA 4J6RG 3U7YG 4YDJG 3TGTA 4S1RG 5TE7G 4I54A 3HI1G 4I53A 3JWOA 1RZKG 4JZWA 2NY4A 4LSVG 4RX4E 4JKPG 4JM2E 1GC1G 3IDXG 5KJRG 2NY3A 2NY6A 3TIHA 4JPWG 4DKVA 4JZZA 5I9QA 4YDLA 2NXYA 4H8WG 3SE8G 5F96G 4K0AA 1G9MG 5CD5A 4OM0G 3NGBA 4S1QG 4DKOA 2NY0A 3TGQA 4RWYA 4OM1G 4LSSG 3SE9G 1YYMG 4YE4G 4OLXG 3IDYA 4OLVG 4YFLE 4JDTG 4DVSA 4DVRG 4RZ8A 5F4LA 4RFOG 4LSPG 3RJQA 4LSTG 4XVTG 5F4PA 4LSUG 2I5YG 4JPVG 4DVWA 4YDIG 5CAYG 2B4CG 4DKRA 4KA2A 1G9NG 4OLWG 4XMPG 5FECC 5F4RA 3LQAG 5F9OG 2NY5G 4DKUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LSQ G;  4XNZ A;  4JB9 G;  4P9H G;  2NY1 A;  4OLZ G;  4DVV A;  5IGX G;  4LAJ A;  1RZJ G;  4S1S G;  5TE4 G;  4XNY G;  4DVT A;  3TGR A;  4RFN A;  2NY2 A;  4XVS G;  5TE6 G;  2BF1 A;  5F9W A;  3FUS A;  4DKP A;  3TGS A;  4DVX A;  4R4F A;  4OLY G;  4LSR G;  4R2G A;  4OLU G;  2QAD A;  2NXZ A;  1YYL G;  2NY7 G;  4DKQ A;  4R4N A;  5FA2 A;  5T33 G;  2I60 G;  3JWD A;  4YDK G;  5F4U A;  4J6R G;  3U7Y G;  4YDJ G;  3TGT A;  4S1R G;  5TE7 G;  4I54 A;  3HI1 G;  4I53 A;  3JWO A;  1RZK G;  4JZW A;  2NY4 A;  4LSV G;  4RX4 E;  4JKP G;  4JM2 E;  1GC1 G;  3IDX G;  5KJR G;  2NY3 A;  2NY6 A;  3TIH A;  4JPW G;  4DKV A;  4JZZ A;  5I9Q A;  4YDL A;  2NXY A;  4H8W G;  3SE8 G;  5F96 G;  4K0A A;  1G9M G;  5CD5 A;  4OM0 G;  3NGB A;  4S1Q G;  4DKO A;  2NY0 A;  3TGQ A;  4RWY A;  4OM1 G;  4LSS G;  3SE9 G;  1YYM G;  4YE4 G;  4OLX G;  3IDY A;  4OLV G;  4YFL E;  4JDT G;  4DVS A;  4DVR G;  4RZ8 A;  5F4L A;  4RFO G;  4LSP G;  3RJQ A;  4LST G;  4XVT G;  5F4P A;  4LSU G;  2I5Y G;  4JPV G;  4DVW A;  4YDI G;  5CAY G;  2B4C G;  4DKR A;  4KA2 A;  1G9N G;  4OLW G;  4XMP G;  5FEC C;  5F4R A;  3LQA G;  5F9O G;  2NY5 G;  4DKU A; 
#chains in the Genus database with same CATH topology
 4LSQ G;  4XNZ A;  4JB9 G;  4P9H G;  2NY1 A;  4OLZ G;  4DVV A;  5IGX G;  4LAJ A;  1RZJ G;  4S1S G;  5TE4 G;  4XNY G;  4DVT A;  3TGR A;  4RFN A;  2NY2 A;  4XVS G;  5TE6 G;  2BF1 A;  5F9W A;  3FUS A;  4DKP A;  3TGS A;  4DVX A;  4R4F A;  4OLY G;  4LSR G;  4R2G A;  4OLU G;  2QAD A;  2NXZ A;  1YYL G;  2NY7 G;  4DKQ A;  4R4N A;  5FA2 A;  5T33 G;  2I60 G;  3JWD A;  4YDK G;  5F4U A;  4J6R G;  3U7Y G;  4YDJ G;  3TGT A;  4S1R G;  5TE7 G;  4I54 A;  3HI1 G;  4I53 A;  3JWO A;  1RZK G;  4JZW A;  2NY4 A;  4LSV G;  4RX4 E;  4JKP G;  4JM2 E;  1GC1 G;  3IDX G;  5KJR G;  2NY3 A;  2NY6 A;  3TIH A;  4JPW G;  4DKV A;  4JZZ A;  5I9Q A;  4YDL A;  2NXY A;  4H8W G;  3SE8 G;  5F96 G;  4K0A A;  1G9M G;  5CD5 A;  4OM0 G;  3NGB A;  4S1Q G;  4DKO A;  2NY0 A;  3TGQ A;  4RWY A;  4OM1 G;  4LSS G;  3SE9 G;  1YYM G;  4YE4 G;  4OLX G;  3IDY A;  4OLV G;  4YFL E;  4JDT G;  4DVS A;  4DVR G;  4RZ8 A;  5F4L A;  4RFO G;  4LSP G;  3RJQ A;  4LST G;  4XVT G;  5F4P A;  4LSU G;  2I5Y G;  4JPV G;  4DVW A;  4YDI G;  5CAY G;  2B4C G;  4DKR A;  4KA2 A;  1G9N G;  4OLW G;  4XMP G;  5FEC C;  5F4R A;  3LQA G;  5F9O G;  2NY5 G;  4DKU A; 
#chains in the Genus database with same CATH homology
 4LSQ G;  4XNZ A;  4JB9 G;  4P9H G;  2NY1 A;  4OLZ G;  4DVV A;  5IGX G;  4LAJ A;  1RZJ G;  4S1S G;  5TE4 G;  4XNY G;  4DVT A;  3TGR A;  4RFN A;  2NY2 A;  4XVS G;  5TE6 G;  2BF1 A;  5F9W A;  3FUS A;  4DKP A;  3TGS A;  4DVX A;  4R4F A;  4OLY G;  4LSR G;  4R2G A;  4OLU G;  2QAD A;  2NXZ A;  1YYL G;  2NY7 G;  4DKQ A;  4R4N A;  5FA2 A;  5T33 G;  2I60 G;  3JWD A;  4YDK G;  5F4U A;  4J6R G;  3U7Y G;  4YDJ G;  3TGT A;  4S1R G;  5TE7 G;  4I54 A;  3HI1 G;  4I53 A;  3JWO A;  1RZK G;  4JZW A;  2NY4 A;  4LSV G;  4RX4 E;  4JKP G;  4JM2 E;  1GC1 G;  3IDX G;  5KJR G;  2NY3 A;  2NY6 A;  3TIH A;  4JPW G;  4DKV A;  4JZZ A;  5I9Q A;  4YDL A;  2NXY A;  4H8W G;  3SE8 G;  5F96 G;  4K0A A;  1G9M G;  5CD5 A;  4OM0 G;  3NGB A;  4S1Q G;  4DKO A;  2NY0 A;  3TGQ A;  4RWY A;  4OM1 G;  4LSS G;  3SE9 G;  1YYM G;  4YE4 G;  4OLX G;  3IDY A;  4OLV G;  4YFL E;  4JDT G;  4DVS A;  4DVR G;  4RZ8 A;  5F4L A;  4RFO G;  4LSP G;  3RJQ A;  4LST G;  4XVT G;  5F4P A;  4LSU G;  2I5Y G;  4JPV G;  4DVW A;  4YDI G;  5CAY G;  2B4C G;  4DKR A;  4KA2 A;  1G9N G;  4OLW G;  4XMP G;  5FEC C;  5F4R A;  3LQA G;  5F9O G;  2NY5 G;  4DKU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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