5J7KA

Loop grafting onto a highly stable fn3 scaffold
Total Genus 12
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
93
structure length
84
Chain Sequence
GNLRVTDVTSTSVTLSWRGYPWATGYRVEYREAGGEWKEVTVPGDLSHRYTVTGLKPGTEYEFRVRAVNRPSSVSVTTGHHHHH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Circumventing the stability-function trade-off in an engineered FN3 domain.
pubmed doi rcsb
molecule tags Protein binding
source organism Synthetic construct
molecule keywords FN3con-a-lys
total genus 12
structure length 84
sequence length 93
chains with identical sequence B, C, D, E, F, G, H
ec nomenclature
pdb deposition date 2016-04-06
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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