5KJRG

Crystal structure of the adcc-potent antibody n60-i3 fab in complex with hiv-1 clade a/e gp120 w69a/s115w mutant and m48u1.
Total Genus 68
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
68
sequence length
353
structure length
332
Chain Sequence
VWKDADTTLFCASDAKAHETEVHNVAATHACVPTDPNPQEIHLENVTENFNMWKNNMVEQMQEDVISLWDQWLQPCVKQACPKISFDPIPIHYCTPAGYVILKCNDKNFNGTGPCKNVSSVQCTHGIKPVVSTQLLLNGSLAEEEIIIRSENLTNNAKTIIVHLNKSVEINCTRPSDIRKAYCEINGTKWNKVLKQVTEKLKEHFNNKTIIFQPPSGGDLEITMHSFNCRGEFFYCNTTQLFNNTCIKGCNGTITLPCKIKQIINMWQGTGQAMYAPPIDGKINCVSNITGILLTRDGGANNTSNETFRPGGGNIKDNWRSELYKYKVVQIE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A Highly Conserved gp120 Inner Domain Residue Modulates Env Conformation and Trimer Stability.
pubmed doi rcsb
molecule tags Viral protein/immune system/inhibitor
source organism Human immunodeficiency virus 1
molecule keywords clade A/E 93TH057 HIV-1 gp120 core
total genus 68
structure length 332
sequence length 353
ec nomenclature
pdb deposition date 2016-06-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
G PF00516 GP120 Envelope glycoprotein GP120
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.40.20 Mainly Beta Beta Complex HIV Envelope Protein Gp120; Chain G Human immunodeficiency virus 1, Gp160, envelope glycoprotein 5kjrG01
4DVXA 5TE4G 1RZKG 2NY0A 4S1RG 4YE4G 4I54A 4DVTA 4OM0G 4KA2A 4XNYG 3TGSA 4JDTG 4JB9G 4OLXG 3TGQA 5F4LA 5F4RA 4LSSG 4DKUA 4YDLA 2NXZA 5TE7G 4R4FA 5F9WA 4H8WG 3TGTA 1YYMG 3LQAG 2I5YG 4J6RG 4LAJA 4OLYG 4XVSG 3TIHA 4YFLE 1RZJG 4LSVG 5F4PA 4XVTG 2B4CG 4R2GA 2NY4A 5T33G 2NY3A 4OLVG 4DVVA 4RFNA 4DKPA 1G9MG 5F9OG 3IDXG 2I60G 3IDYA 4RWYA 4DVSA 4I53A 4R4NA 3U7YG 4P9HG 2NY1A 4OLUG 4JM2E 5IGXG 5CD5A 5F96G 4DKVA 2NY7G 3SE9G 4JZZA 2QADA 4LSUG 5KJRG 4YDKG 4LSQG 4JZWA 2NXYA 1GC1G 4RFOG 3TGRA 4K0AA 2NY5G 4XNZA 4DKQA 5CAYG 3JWDA 4RX4E 4DKRA 4JPWG 5F4UA 4RZ8A 3NGBA 3FUSA 4DKOA 5FA2A 4OLWG 4YDIG 4LSPG 4OM1G 4YDJG 4LSTG 1YYLG 3RJQA 3JWOA 2NY2A 1G9NG 4DVWA 4JPVG 2NY6A 4S1SG 5FECC 4JKPG 3HI1G 4OLZG 3SE8G 4XMPG 5TE6G 4S1QG 4DVRG 2BF1A 4LSRG 5I9QA
chains in the Genus database with same CATH superfamily
4DVXA 5TE4G 1RZKG 2NY0A 4S1RG 4YE4G 4I54A 4DVTA 4OM0G 4KA2A 4XNYG 3TGSA 4JDTG 4JB9G 4OLXG 3TGQA 5F4LA 5F4RA 4LSSG 4DKUA 4YDLA 2NXZA 5TE7G 4R4FA 5F9WA 4H8WG 3TGTA 1YYMG 3LQAG 2I5YG 4J6RG 4LAJA 4OLYG 4XVSG 3TIHA 4YFLE 1RZJG 4LSVG 5F4PA 4XVTG 2B4CG 4R2GA 2NY4A 5T33G 2NY3A 4OLVG 4DVVA 4RFNA 4DKPA 1G9MG 5F9OG 3IDXG 2I60G 3IDYA 4RWYA 4DVSA 4I53A 4R4NA 3U7YG 4P9HG 2NY1A 4OLUG 4JM2E 5IGXG 5CD5A 5F96G 4DKVA 2NY7G 3SE9G 4JZZA 2QADA 4LSUG 5KJRG 4YDKG 4LSQG 4JZWA 2NXYA 1GC1G 4RFOG 3TGRA 4K0AA 2NY5G 4XNZA 4DKQA 5CAYG 3JWDA 4RX4E 4DKRA 4JPWG 5F4UA 4RZ8A 3NGBA 3FUSA 4DKOA 5FA2A 4OLWG 4YDIG 4LSPG 4OM1G 4YDJG 4LSTG 1YYLG 3RJQA 3JWOA 2NY2A 1G9NG 4DVWA 4JPVG 2NY6A 4S1SG 5FECC 4JKPG 3HI1G 4OLZG 3SE8G 4XMPG 5TE6G 4S1QG 4DVRG 2BF1A 4LSRG 5I9QA
chains in the Genus database with same CATH topology
4DVXA 5TE4G 1RZKG 2NY0A 4S1RG 4YE4G 4I54A 4DVTA 4OM0G 4KA2A 4XNYG 3TGSA 4JDTG 4JB9G 4OLXG 3TGQA 5F4LA 5F4RA 4LSSG 4DKUA 4YDLA 2NXZA 5TE7G 4R4FA 5F9WA 4H8WG 3TGTA 1YYMG 3LQAG 2I5YG 4J6RG 4LAJA 4OLYG 4XVSG 3TIHA 4YFLE 1RZJG 4LSVG 5F4PA 4XVTG 2B4CG 4R2GA 2NY4A 5T33G 2NY3A 4OLVG 4DVVA 4RFNA 4DKPA 1G9MG 5F9OG 3IDXG 2I60G 3IDYA 4RWYA 4DVSA 4I53A 4R4NA 3U7YG 4P9HG 2NY1A 4OLUG 4JM2E 5IGXG 5CD5A 5F96G 4DKVA 2NY7G 3SE9G 4JZZA 2QADA 4LSUG 5KJRG 4YDKG 4LSQG 4JZWA 2NXYA 1GC1G 4RFOG 3TGRA 4K0AA 2NY5G 4XNZA 4DKQA 5CAYG 3JWDA 4RX4E 4DKRA 4JPWG 5F4UA 4RZ8A 3NGBA 3FUSA 4DKOA 5FA2A 4OLWG 4YDIG 4LSPG 4OM1G 4YDJG 4LSTG 1YYLG 3RJQA 3JWOA 2NY2A 1G9NG 4DVWA 4JPVG 2NY6A 4S1SG 5FECC 4JKPG 3HI1G 4OLZG 3SE8G 4XMPG 5TE6G 4S1QG 4DVRG 2BF1A 4LSRG 5I9QA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4DVX A;  5TE4 G;  1RZK G;  2NY0 A;  4S1R G;  4YE4 G;  4I54 A;  4DVT A;  4OM0 G;  4KA2 A;  4XNY G;  3TGS A;  4JDT G;  4JB9 G;  4OLX G;  3TGQ A;  5F4L A;  5F4R A;  4LSS G;  4DKU A;  4YDL A;  2NXZ A;  5TE7 G;  4R4F A;  5F9W A;  4H8W G;  3TGT A;  1YYM G;  3LQA G;  2I5Y G;  4J6R G;  4LAJ A;  4OLY G;  4XVS G;  3TIH A;  4YFL E;  1RZJ G;  4LSV G;  5F4P A;  4XVT G;  2B4C G;  4R2G A;  2NY4 A;  5T33 G;  2NY3 A;  4OLV G;  4DVV A;  4RFN A;  4DKP A;  1G9M G;  5F9O G;  3IDX G;  2I60 G;  3IDY A;  4RWY A;  4DVS A;  4I53 A;  4R4N A;  3U7Y G;  4P9H G;  2NY1 A;  4OLU G;  4JM2 E;  5IGX G;  5CD5 A;  5F96 G;  4DKV A;  2NY7 G;  3SE9 G;  4JZZ A;  2QAD A;  4LSU G;  5KJR G;  4YDK G;  4LSQ G;  4JZW A;  2NXY A;  1GC1 G;  4RFO G;  3TGR A;  4K0A A;  2NY5 G;  4XNZ A;  4DKQ A;  5CAY G;  3JWD A;  4RX4 E;  4DKR A;  4JPW G;  5F4U A;  4RZ8 A;  3NGB A;  3FUS A;  4DKO A;  5FA2 A;  4OLW G;  4YDI G;  4LSP G;  4OM1 G;  4YDJ G;  4LST G;  1YYL G;  3RJQ A;  3JWO A;  2NY2 A;  1G9N G;  4DVW A;  4JPV G;  2NY6 A;  4S1S G;  5FEC C;  4JKP G;  3HI1 G;  4OLZ G;  3SE8 G;  4XMP G;  5TE6 G;  4S1Q G;  4DVR G;  2BF1 A;  4LSR G;  5I9Q A; 
#chains in the Genus database with same CATH topology
 4DVX A;  5TE4 G;  1RZK G;  2NY0 A;  4S1R G;  4YE4 G;  4I54 A;  4DVT A;  4OM0 G;  4KA2 A;  4XNY G;  3TGS A;  4JDT G;  4JB9 G;  4OLX G;  3TGQ A;  5F4L A;  5F4R A;  4LSS G;  4DKU A;  4YDL A;  2NXZ A;  5TE7 G;  4R4F A;  5F9W A;  4H8W G;  3TGT A;  1YYM G;  3LQA G;  2I5Y G;  4J6R G;  4LAJ A;  4OLY G;  4XVS G;  3TIH A;  4YFL E;  1RZJ G;  4LSV G;  5F4P A;  4XVT G;  2B4C G;  4R2G A;  2NY4 A;  5T33 G;  2NY3 A;  4OLV G;  4DVV A;  4RFN A;  4DKP A;  1G9M G;  5F9O G;  3IDX G;  2I60 G;  3IDY A;  4RWY A;  4DVS A;  4I53 A;  4R4N A;  3U7Y G;  4P9H G;  2NY1 A;  4OLU G;  4JM2 E;  5IGX G;  5CD5 A;  5F96 G;  4DKV A;  2NY7 G;  3SE9 G;  4JZZ A;  2QAD A;  4LSU G;  5KJR G;  4YDK G;  4LSQ G;  4JZW A;  2NXY A;  1GC1 G;  4RFO G;  3TGR A;  4K0A A;  2NY5 G;  4XNZ A;  4DKQ A;  5CAY G;  3JWD A;  4RX4 E;  4DKR A;  4JPW G;  5F4U A;  4RZ8 A;  3NGB A;  3FUS A;  4DKO A;  5FA2 A;  4OLW G;  4YDI G;  4LSP G;  4OM1 G;  4YDJ G;  4LST G;  1YYL G;  3RJQ A;  3JWO A;  2NY2 A;  1G9N G;  4DVW A;  4JPV G;  2NY6 A;  4S1S G;  5FEC C;  4JKP G;  3HI1 G;  4OLZ G;  3SE8 G;  4XMP G;  5TE6 G;  4S1Q G;  4DVR G;  2BF1 A;  4LSR G;  5I9Q A; 
#chains in the Genus database with same CATH homology
 4DVX A;  5TE4 G;  1RZK G;  2NY0 A;  4S1R G;  4YE4 G;  4I54 A;  4DVT A;  4OM0 G;  4KA2 A;  4XNY G;  3TGS A;  4JDT G;  4JB9 G;  4OLX G;  3TGQ A;  5F4L A;  5F4R A;  4LSS G;  4DKU A;  4YDL A;  2NXZ A;  5TE7 G;  4R4F A;  5F9W A;  4H8W G;  3TGT A;  1YYM G;  3LQA G;  2I5Y G;  4J6R G;  4LAJ A;  4OLY G;  4XVS G;  3TIH A;  4YFL E;  1RZJ G;  4LSV G;  5F4P A;  4XVT G;  2B4C G;  4R2G A;  2NY4 A;  5T33 G;  2NY3 A;  4OLV G;  4DVV A;  4RFN A;  4DKP A;  1G9M G;  5F9O G;  3IDX G;  2I60 G;  3IDY A;  4RWY A;  4DVS A;  4I53 A;  4R4N A;  3U7Y G;  4P9H G;  2NY1 A;  4OLU G;  4JM2 E;  5IGX G;  5CD5 A;  5F96 G;  4DKV A;  2NY7 G;  3SE9 G;  4JZZ A;  2QAD A;  4LSU G;  5KJR G;  4YDK G;  4LSQ G;  4JZW A;  2NXY A;  1GC1 G;  4RFO G;  3TGR A;  4K0A A;  2NY5 G;  4XNZ A;  4DKQ A;  5CAY G;  3JWD A;  4RX4 E;  4DKR A;  4JPW G;  5F4U A;  4RZ8 A;  3NGB A;  3FUS A;  4DKO A;  5FA2 A;  4OLW G;  4YDI G;  4LSP G;  4OM1 G;  4YDJ G;  4LST G;  1YYL G;  3RJQ A;  3JWO A;  2NY2 A;  1G9N G;  4DVW A;  4JPV G;  2NY6 A;  4S1S G;  5FEC C;  4JKP G;  3HI1 G;  4OLZ G;  3SE8 G;  4XMP G;  5TE6 G;  4S1Q G;  4DVR G;  2BF1 A;  4LSR G;  5I9Q A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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