5VHEA

Dhx36 in complex with the c-myc g-quadruplex
Total Genus 253
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
253
sequence length
903
structure length
871
Chain Sequence
PGHLKGREIGLWYAKKQGQKNKEAERQERAVVHMDERREEQIVQLLHSVQTKTEAYIDRDSEYLLQENEPDATLDQQLLEDLQKKKTDLRYIEMQRFREKLPSYGMQKELVNMIDNHQVTVISGETGCGKTTQVTQFILDNYIERGKGSACRIVCTQPRRISAISVAERVAAERAESCGNGNSTGYQIRLQSRLPRKQGSILYCTTGIILQWLQSDPHLSSVSHIVLDEIHERNLQSDVLMTVVKDLLSYRPDLKVVLMSATLNAEKFSEYFGNCPMIHIPGFTFPVVEYLLEDIIEKIRYVPEQKGHVNRQEKYYYEAIYKERWPGYLRELRQRYSASTVDVVEMMDDEKVDLNLIAALIRYIVLEEEDGAILVFLPGWDNISTLHDLLMSQVMFKSDKFIIIPLHSLMPTVNQTQVFKRTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYHLYNSLRASLLDDYQLPEILRTPLEELCLQIKILRLGGIAHFLSRLMDPPSNEAVLLSIKHLMELNALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLGKEKVADARRKELAAATASDHLTVVNAFKGWEKAKQRGFRYEKDYCWEYFLSSNTLQMLHNMKGQFAEHLLGAGFVSSRNPQDPESNINSDNEKIIKAVICAGLYPKVAKIRLNLGKKRKMVKVYTKTDGVVAIHPKSVNVEQTEFNYNWLIYHLKMRTSSIYLYDCTEVSPYCLLFFGGDISIQKDNDQETIAVDEWIIFQSPARIAHLVKELRKELDILLQEKIESPHPVDWKDTKSRDCAVLSAIIDLIKT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36.
pubmed doi rcsb
molecule tags Hydrolase
source organism Bos taurus
molecule keywords DEAH (Asp-Glu-Ala-His) box polypeptide 36
total genus 253
structure length 871
sequence length 903
ec nomenclature ec 3.6.4.12: DNA helicase.
pdb deposition date 2017-04-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00270 DEAD DEAD/DEAH box helicase
A PF00271 Helicase_C Helicase conserved C-terminal domain
A PF04408 HA2 Helicase associated domain (HA2)
A PF07717 OB_NTP_bind Oligonucleotide/oligosaccharide-binding (OB)-fold
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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