5YZG2

The cryo-em structure of human catalytic step i spliceosome (c complex) at 4.1 angstrom resolution
Total Genus 45
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
45
sequence length
545
structure length
416
Chain Sequence
DFIITASHDGHVKFWKKIEEGIELGVIESIFCSVGDDKAMKVFDVVNFDMLKLGYFPGQCEWIYCPGSEKSTGKDNQPLHIFDLNPVYKAVVSSDKSGMIEYWTGPNVNWEYKTDTDLYEFAKCKAYPTSVCFSPDGKKIATIGSDRKVRIFRFVMRVFDESLSMFTELQQMRQLPDMEFGRRMAVERELEKVDNIVFDETGHFMLGIKVINVETNRCVRILGQENIRVMQLALFQGIAKKHRAATTIEMKAVLQNIQRVSDSAIIHTSMGDIHTKLFPVECPKTVENFCVHSRNGYYNGHTFHRIIKGFMIQTGDPTGTGMGGESIWGGEFEDEFHSTLRHDRPYTLSMANAGSNTNGSQFFITVVPTPWLDNKHTVFGRVTKGMEVVQRISNVKVNPKTDKPYEDVSIINITVK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of a human catalytic step I spliceosome
pubmed doi rcsb
molecule tags Splicing
molecule keywords Pre-mRNA-processing-splicing factor 8
total genus 45
structure length 416
sequence length 545
ec nomenclature ec 5.2.1.8: Peptidylprolyl isomerase.
pdb deposition date 2017-12-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
2 PF00160 Pro_isomerase Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
2 PF00400 WD40 WD domain, G-beta repeat
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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