5Z58x

Cryo-em structure of a human activated spliceosome (early bact) at 4.9 angstrom.
Total Genus 101
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
101
sequence length
632
structure length
583
Chain Sequence
AQQKESIQAVRRSLPVFPFREELLAAIANHQVLIIEGETGSGKTTQIPQYLFEEGYTNKGMKIACTQPRRVAAMSVAARVAREMGVKLGNEVGYSIRFEDCTTVLRYMTDGMLLREFLSEPDLASYSVVMVDEAHERTLHTDILFGLIKDVARFRPELKVLVASATMDTARFSTFFDDAPVFRIPGRRFPVDIFYTKAPEADYLEACVVSVLQIHVTQGDILVFLTGQEEIEAACEMLQDRCRRLGIRELLVLPIYANLPSDMQARIFQPTPARKVVVATNIAETSLTIEGIIYVLDPGFCKQKSYNPRTGMESLTVTPCSKASANQRAGRAGRVAAGKCFRLYTAWAYQHELEETTVPEIQRTSLGNVVLLLKSLGIHDLMHFDFLDPPPYETLLLALEQLYALGALNHLGELTTSGRKMAELPVDPMLSKMILASCSEEILTVAAMLSDNARVNFFLPGGDHLVLLNVYTQWAECYENFVQFRSMRRARDVREQLEGLLERVEVGLSSCQGDYIRVRKAITAGYFYHTARGYRTVVFIHPNSQQPRWLLYHELVLTTKEFMRQVLEIESSWLLEVAPHYYK
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Structure of the human activated spliceosome in three conformational states.
pubmed doi rcsb
molecule tags Splicing
molecule keywords Pre-mRNA-processing-splicing factor 8
total genus 101
structure length 583
sequence length 632
ec nomenclature ec 3.6.4.13: RNA helicase.
pdb deposition date 2018-01-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
x PF00270 DEAD DEAD/DEAH box helicase
x PF00271 Helicase_C Helicase conserved C-terminal domain
x PF04408 HA2 Helicase associated domain (HA2)
x PF07717 OB_NTP_bind Oligonucleotide/oligosaccharide-binding (OB)-fold
Image from the rcsb pdb (www.rcsb.org)
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...