6ALBA

Crebbp bromodomain in complex with cpd 30 (1-(3-(3-(1-methyl-1h-pyrazol-4-yl)isoquinolin-8-yl)-1-(tetrahydro-2h-pyran-4-yl)-1,4,6,7-tetrahydro-5h-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one)
Total Genus 55
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
55
sequence length
233
structure length
212
Chain Sequence
SRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYLCTIPRDAAYYSYQNRYHFCEKCFDPSQPQTTEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Design and Synthesis of A Biaryl Series As Inhibitors for the Bromodomains of CBP/P300
rcsb
molecule tags Protein binding/inhibitor
source organism Homo sapiens
molecule keywords CREB-binding protein
total genus 55
structure length 212
sequence length 233
ec nomenclature ec 2.3.1.48: Histone acetyltransferase.
pdb deposition date 2017-08-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00439 Bromodomain Bromodomain
A PF06001 DUF902 Domain of Unknown Function (DUF902)
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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