6C23C

Cryo-em structure of prc2 bound to cofactors aebp2 and jarid2 in the compact active state
Total Genus 39
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
39
sequence length
231
structure length
193
Chain Sequence
KRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEWKQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQYSDKIFEAISSMFPDKGTAEELKEKYKEL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structures of human PRC2 with its cofactors AEBP2 and JARID2.
pubmed doi rcsb
molecule tags Gene regulation
source organism Homo sapiens
molecule keywords Polycomb protein SUZ12
total genus 39
structure length 193
sequence length 231
chains with identical sequence K
ec nomenclature ec 2.1.1.43: Histone-lysine N-methyltransferase.
pdb deposition date 2018-01-05

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00856 SET SET domain
C PF11616 EZH2_WD-Binding WD repeat binding protein EZH2
C PF18118 PRC2_HTH_1 Polycomb repressive complex 2 tri-helical domain
C PF18264 preSET_CXC CXC domain
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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