6HIRA

Solution structure of recombinant hirudin and the lys-47 (right arrow) glu mutant. a nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing study
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
49
structure length
49
Chain Sequence
VVYTDCTESGQNLCLCEGSNVCGQGNKCILGSDGEKNQCVTGEGTPEPQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Coagulation inhibitor
molecule keywords HIRUDIN VARIANT-1
publication title Solution structure of recombinant hirudin and the Lys-47----Glu mutant: a nuclear magnetic resonance and hybrid distance geometry-dynamical simulated annealing study.
pubmed doi rcsb
source organism Hirudo medicinalis
total genus 3
structure length 49
sequence length 49
ec nomenclature
pdb deposition date 1990-01-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00713 Hirudin Hirudin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.70.10.10 Mainly Beta Distorted Sandwich Thrombin Inhibitor (Hirudin); Chain I Thrombin Inhibitor (Hirudin), subunit I 6hirA00
4HTCI 1HRTI 1HICA 1E0FI 2HIRA 4HIRA 5HIRA 6HIRA 2JOOA 4MLFD 2PW8I
chains in the Genus database with same CATH superfamily
4HTCI 1HRTI 1HICA 1E0FI 2HIRA 4HIRA 5HIRA 6HIRA 2JOOA 4MLFD 2PW8I
chains in the Genus database with same CATH topology
4HTCI 1HRTI 1HICA 1E0FI 2HIRA 4HIRA 5HIRA 6HIRA 2JOOA 4MLFD 2PW8I
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4HTC I;  1HRT I;  1HIC A;  1E0F I;  2HIR A;  4HIR A;  5HIR A;  6HIR A;  2JOO A;  4MLF D;  2PW8 I; 
#chains in the Genus database with same CATH topology
 4HTC I;  1HRT I;  1HIC A;  1E0F I;  2HIR A;  4HIR A;  5HIR A;  6HIR A;  2JOO A;  4MLF D;  2PW8 I; 
#chains in the Genus database with same CATH homology
 4HTC I;  1HRT I;  1HIC A;  1E0F I;  2HIR A;  4HIR A;  5HIR A;  6HIR A;  2JOO A;  4MLF D;  2PW8 I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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