6O3ZA

Crystal structure of rorgt with 3-cyano-n-(3-{[(3s)-4-(cyclopentanecarbonyl)-3-methylpiperazin-1-yl]methyl}-5-fluoro-2-methylphenyl)benzamide (compound 1)
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
259
structure length
255
Chain Sequence
ASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERMQIFQHLHPIVVQAAFPPLYKELFSTGHKIIHRLLQE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Discovery of [1,2,4]triazolo[1,5-a]pyridine Derivatives as Potent and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor gt (RORgt) Inverse Agonists
rcsb
molecule tags Protein binding
source organism Homo sapiens
molecule keywords RAR-related orphan receptor C isoform a variant
total genus 99
structure length 255
sequence length 259
ec nomenclature
pdb deposition date 2019-02-27
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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