6RLWAAA

Structure of the human 8-oxoguanine dna glycosylase hogg1 in complex with inhibitor th5487
Total Genus 110
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
110
sequence length
317
structure length
314
Chain Sequence
MGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADLRQSR
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Targeting OGG1 arrests cancer cell proliferation by mitochondrial dysfunction and replication stress
rcsb
molecule tags Dna binding protein
source organism Homo sapiens
molecule keywords N-glycosylase/DNA lyase
total genus 110
structure length 314
sequence length 317
chains with identical sequence BBB, CCC, DDD, EEE
ec nomenclature ec 4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
pdb deposition date 2019-05-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
AAA PF00730 HhH-GPD HhH-GPD superfamily base excision DNA repair protein
AAA PF07934 OGG_N 8-oxoguanine DNA glycosylase, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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