6VEPE

Human insulin in complex with the human insulin microreceptor in turn in complex with fv 83-7
Total Genus 80
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
80
sequence length
306
structure length
293
Chain Sequence
PGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNHIVLNKDDNEECGDICPGNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A structurally minimized yet fully active insulin based on cone-snail venom insulin principles.
pubmed doi rcsb
molecule tags Hormone receptor/hormone/immune system
source organism Homo sapiens
molecule keywords Insulin chain A
total genus 80
structure length 293
sequence length 306
chains with identical sequence K, Q, W
ec nomenclature ec 2.7.10.1: Receptor protein-tyrosine kinase.
pdb deposition date 2020-01-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01030 Recep_L_domain Receptor L domain
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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