6VUJA

Crystal structure of brd4 bromodomain 1 with n-methylpyrrolidin-2-one (nmp) derivative 15c (n,n-diethyl-3',4'-dimethoxy-6-(1-methyl-5-oxopyrrolidin-3-yl)-[1,1'-biphenyl]-3-sulfonamide)
Total Genus 39
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
39
sequence length
125
structure length
125
Chain Sequence
SNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Substituted 1-methyl-4-phenylpyrrolidin-2-ones - Fragment-Based Design of N-Methylpyrrolidone-Derived Bromodomain Inhibitors using Aromatic Substitution Reactions
rcsb
molecule tags Protein binding
source organism Homo sapiens
molecule keywords Bromodomain-containing protein 4
total genus 39
structure length 125
sequence length 125
ec nomenclature
pdb deposition date 2020-02-15
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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