6WCDA

Crystal structure of xenopus laevis ape2 catalytic domain
Total Genus 105
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
105
sequence length
334
structure length
314
Chain Sequence
MKIVSWNINGIRATRVGLKETLDSLDADIICLQETKVTRDLLDEPSAIVEGYNSYFSFSRVRSGYSGVATFCKSSTTPQAAEEGLSGVFCTGSVGCYGNTEQFLEEELQSLDQEGRAVLTQHRILNCEDKEETLTVINVYCPRADPEKPERKTYKLRFYHLLQTRAEAILQNGGHVIILGDVNTSHRPLDHCDPTDLTFEENPGRQWLNQFLGDPSGLFYDSFRYFHPTQKNAFTCWCSASGARQTNYGTRIDYILGNRELVESEFLDSVIMPEVEGSDHCPVKAFMKCQPIAANKCPPLCTKYLPEFAGRQQK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease.
pubmed doi rcsb
molecule tags Hydrolase
source organism Xenopus laevis
molecule keywords DNA-(apurinic or apyrimidinic site) lyase
total genus 105
structure length 314
sequence length 334
ec nomenclature ec 4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
pdb deposition date 2020-03-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03372 Exo_endo_phos Endonuclease/Exonuclease/phosphatase family
Image from the rcsb pdb (www.rcsb.org)
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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